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公开(公告)号:US20110275880A1
公开(公告)日:2011-11-10
申请号:US13135696
申请日:2011-07-12
申请人: Bran Ferren , W. Daniel Hillis , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人: Bran Ferren , W. Daniel Hillis , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
CPC分类号: A61B1/00156 , A61B1/00158 , A61B1/041 , A61B5/0031 , A61B5/0059 , A61B5/04001 , A61B5/05 , A61B5/07 , A61B5/14539 , A61B5/4839 , A61N1/02 , A61N1/32 , A61N1/37205
摘要: Lumen-traveling biological interface devices and associated methods and systems are described. Lumen-traveling biological interface devices capable of traveling within a body lumen may include a propelling mechanism to produce movement of the lumen-traveling device within the lumen, electrodes or other electromagnetic transducers for detecting biological signals and electrodes, coils or other electromagnetic transducers for delivering electromagnetic stimuli to stimulus responsive tissues. Lumen-traveling biological interface devices may also include additional components such as sensors, an active portion, and/or control circuitry.
摘要翻译: 描述了流明生物界面装置及相关方法和系统。 能够在体腔内行进的流明的生物界面装置可以包括用于产生管腔中的内腔行进装置的运动的推进机构,用于检测生物信号的电极或其它电磁换能器以及用于传送的电极,线圈或其它电磁换能器 对刺激反应组织的电磁刺激。 流明生物界面装置还可以包括诸如传感器,有效部分和/或控制电路的附加部件。
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公开(公告)号:US20100068808A1
公开(公告)日:2010-03-18
申请号:US12322367
申请日:2009-01-30
申请人: Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人: Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
CPC分类号: C07K16/32 , A61K38/1703 , A61K38/1732 , A61K47/60 , A61K47/6871 , A61K47/6901 , B82Y5/00 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C01B21/0648 , C01B32/168 , C01B32/174 , C01B2202/02 , C01B2202/34 , C01B2202/36 , C01P2004/13 , Y02A50/473 , Y10S977/743 , Y10S977/75 , Y10S977/762 , Y10S977/788 , Y10S977/795 , Y10S977/848 , Y10S977/896 , Y10S977/915
摘要: Devices, compositions, and methods are described which provide a tubular nanostructure or a composite tubular nanostructure targeted to a lipid bilayer membrane. The tubular nanostructure includes a hydrophobic surface region flanked by two hydrophilic surface regions. The tubular nanostructure is configured to interact with a lipid bilayer membrane and form a pore in the lipid bilayer membrane. The tubular nanostructure may be targeted by including at least one ligand configured to bind to one or more cognates on the lipid bilayer membrane of a target cell.
摘要翻译: 描述了提供靶向脂质双层膜的管状纳米结构或复合管状纳米结构的装置,组合物和方法。 管状纳米结构包括侧面有两个亲水表面区域的疏水表面区域。 管状纳米结构被配置为与脂质双层膜相互作用并在脂质双层膜中形成孔。 管状纳米结构可以通过包括至少一种被配置成结合靶细胞的脂质双层膜上的一个或多个同源物的配体来靶向。
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公开(公告)号:US20110177154A1
公开(公告)日:2011-07-21
申请号:US12283907
申请日:2008-09-15
申请人: Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人: Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
IPC分类号: A61K9/127 , C07K7/64 , C07D321/00 , C07H21/00 , C07K14/00 , C07H7/00 , C07C229/00 , C08G63/48 , C07K16/00 , C12N9/14 , A61K9/14 , A61K38/02 , A61K38/16 , A61K31/335 , A61K31/7088 , A61K38/14 , A61K39/395 , A61K38/12 , A61P43/00 , B82Y5/00
CPC分类号: C07K16/32 , A61K38/1703 , A61K38/1732 , A61K47/60 , A61K47/6871 , A61K47/6901 , B82Y5/00 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C01B21/0648 , C01B32/168 , C01B32/174 , C01B2202/02 , C01B2202/34 , C01B2202/36 , C01P2004/13 , Y02A50/473 , Y10S977/743 , Y10S977/75 , Y10S977/762 , Y10S977/788 , Y10S977/795 , Y10S977/848 , Y10S977/896 , Y10S977/915
摘要: Devices, compositions, and methods are described which provide a tubular nanostructure or a composite tubular nanostructure targeted to a lipid bilayer membrane. The tubular nanostructure includes a hydrophobic surface region flanked by two hydrophilic surface regions. The tubular nanostructure is configured to interact with a lipid bilayer membrane and form a pore in the lipid bilayer membrane. The tubular nanostructure may be targeted by including at least one ligand configured to bind to one or more cognates on the lipid bilayer membrane of a target cell.
摘要翻译: 描述了提供靶向脂质双层膜的管状纳米结构或复合管状纳米结构的装置,组合物和方法。 管状纳米结构包括侧面有两个亲水表面区域的疏水表面区域。 管状纳米结构被配置为与脂质双层膜相互作用并在脂质双层膜中形成孔。 管状纳米结构可以通过包括至少一种被配置成结合靶细胞的脂质双层膜上的一个或多个同源物的配体来靶向。
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公开(公告)号:US20120053666A1
公开(公告)日:2012-03-01
申请号:US13135694
申请日:2011-07-12
申请人: Bran Ferren , W. Daniel Hillis , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人: Bran Ferren , W. Daniel Hillis , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
IPC分类号: A61N1/05
CPC分类号: A61B1/00156 , A61B1/00158 , A61B1/041 , A61B5/0031 , A61B5/0059 , A61B5/04001 , A61B5/05 , A61B5/07 , A61B5/14539 , A61B5/4839 , A61N1/02 , A61N1/32 , A61N1/37205
摘要: Lumen-traveling biological interface devices and associated methods and systems are described. Lumen-traveling biological interface devices capable of traveling within a body lumen may include a propelling mechanism to produce movement of the lumen-traveling device within the lumen, electrodes or other electromagnetic transducers for detecting biological signals and electrodes, coils or other electromagnetic transducers for delivering electromagnetic stimuli to stimulus responsive tissues. Lumen-traveling biological interface devices may also include additional components such as sensors, an active portion, and/or control circuitry.
摘要翻译: 描述了流明生物界面装置及相关方法和系统。 能够在体腔内行进的流明的生物界面装置可以包括用于产生管腔中的内腔行进装置的运动的推进机构,用于检测生物信号的电极或其它电磁换能器以及用于传送的电极,线圈或其它电磁换能器 对刺激反应组织的电磁刺激。 流明生物界面装置还可以包括诸如传感器,有效部分和/或控制电路的附加部件。
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公开(公告)号:US20100069606A1
公开(公告)日:2010-03-18
申请号:US12283908
申请日:2008-09-15
申请人: Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人: Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
IPC分类号: C07K2/00 , C07K16/00 , C07H1/00 , C07H21/04 , C07D323/00 , C07C69/00 , C07C229/00 , C07C49/00 , C07C47/00 , C07C43/00 , C07K14/42
CPC分类号: C07K16/32 , A61K38/1703 , A61K38/1732 , A61K47/60 , A61K47/6871 , A61K47/6901 , B82Y5/00 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C01B21/0648 , C01B32/168 , C01B32/174 , C01B2202/02 , C01B2202/34 , C01B2202/36 , C01P2004/13 , Y02A50/473 , Y10S977/743 , Y10S977/75 , Y10S977/762 , Y10S977/788 , Y10S977/795 , Y10S977/848 , Y10S977/896 , Y10S977/915
摘要: Devices, compositions, and methods are described which provide a tubular nanostructure targeted to a lipid bilayer membrane. The targeted tubular nanostructure can have a surface region configured to pass through a lipid bilayer membrane of a cell, a hydrophobic surface region flanked by two hydrophilic surface regions configured to form a pore in a lipid bilayer membrane of a cellular organelle, and at least one ligand configured to bind one or more cognates on the lipid bilayer membrane of the cellular organelle. The target cell can be, for example, a tumor cell, an infected cell, or a diseased cell in a subject. The tubular nanostructure can form a pore in the lipid bilayer membrane of the cellular organelle, e.g., mitochondria, which can permit transit or translocation of at least one compound across the membrane and cause cell death of the target cell.
摘要翻译: 描述了提供靶向脂质双层膜的管状纳米结构的装置,组合物和方法。 目标管状纳米结构可以具有被配置为穿过细胞的脂质双层膜的表面区域,侧壁有两个亲水性表面区域的疏水性表面区域,所述疏水性表面区域配置成在细胞器官细胞器的脂质双层膜中形成孔,以及至少一个 配体被配置为结合细胞器的脂质双层膜上的一个或多个同源物。 靶细胞可以是例如受试者中的肿瘤细胞,感染细胞或患病细胞。 管状纳米结构可以在细胞器(例如线粒体)的脂质双层膜中形成孔,其可以允许至少一种化合物跨过膜的转运或易位并导致靶细胞的细胞死亡。
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公开(公告)号:US20130170017A1
公开(公告)日:2013-07-04
申请号:US13385689
申请日:2012-02-29
申请人: Kenneth G. Caldeira , Peter L. Hagelstein , Roderick A. Hyde , Edward K.Y. Jung , Jordin T. Kare , Nathan P. Myhrvold , John Brian Pendry , David Schurig , Clarence T. Tegreene , Charles Whitmer , Lowell L. Wood, JR.
发明人: Kenneth G. Caldeira , Peter L. Hagelstein , Roderick A. Hyde , Edward K.Y. Jung , Jordin T. Kare , Nathan P. Myhrvold , John Brian Pendry , David Schurig , Clarence T. Tegreene , Charles Whitmer , Lowell L. Wood, JR.
IPC分类号: G02F1/29
CPC分类号: G02B25/001 , A61B3/0075 , A61B3/1015 , G02B26/06 , G02B27/005 , G02C2202/22
摘要: Exemplary methods, systems and components enable an enhanced direct-viewing optical device to include customized adjustments that accommodate various optical aberrations of a current user. A real-time adjustment of transformable optical elements is sometimes based on predetermined corrective optical parameters associated with a current user. Customized optical elements are incorporated with the direct-viewing optical device to produce a specified change in optical wavefront at an exit pupil. Possible transformable or replacement optical elements may have refractive and/or reflective and/or diffractive and/or transmissive characteristics that are selected based on current performance viewing factors for a given field of view of the direct-viewing device. Some embodiments enable dynamic repositioning and/or transformation of corrective optical elements responsive to a detected shift of a tracked gaze direction of a current user. Replacement corrective optical elements may be fabricated for current usage or retained in inventory for possible future usage in the direct-viewing device.
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公开(公告)号:US20110286748A1
公开(公告)日:2011-11-24
申请号:US12800665
申请日:2010-05-19
申请人: Howard Lee Davidson , James R. Hamilton , Roderick A. Hyde , Arne Josefsberg , Edward K.Y. Jung , Jordin T. Kare , Robert W. Lord , Kenneth Lustig , William Henry Mangione-Smith , Michael Manos , Craig J. Mundie , Nathan P. Myhrvold , Richard F. Rashid , Burton Smith , Clarence T. Tegreene , Robert V. Welland , Charles Whitmer , Lowell L. Wood, JR.
发明人: Howard Lee Davidson , James R. Hamilton , Roderick A. Hyde , Arne Josefsberg , Edward K.Y. Jung , Jordin T. Kare , Robert W. Lord , Kenneth Lustig , William Henry Mangione-Smith , Michael Manos , Craig J. Mundie , Nathan P. Myhrvold , Richard F. Rashid , Burton Smith , Clarence T. Tegreene , Robert V. Welland , Charles Whitmer , Lowell L. Wood, JR.
IPC分类号: H04B10/00
CPC分类号: H04B10/1149
摘要: A data center for executing a data processing application includes processing units, sub-units or servers. Each of the processing units, sub-units or servers can execute a part or all of the data processing application. The processing units, sub-units or servers are electrical disjoint with respect to data communications, but can communicate with each other over free space optical links.
摘要翻译: 用于执行数据处理应用的数据中心包括处理单元,子单元或服务器。 每个处理单元,子单元或服务器可以执行数据处理应用的一部分或全部。 处理单元,子单元或服务器对于数据通信而言是电不相交的,但是可以通过自由空间光链路彼此通信。
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公开(公告)号:US20110150491A1
公开(公告)日:2011-06-23
申请号:US12804120
申请日:2010-07-13
申请人: Howard Lee Davidson , James R. Hamilton , Roderick A. Hyde , Arne Josefsberg , Edward K.Y. Jung , Jordin T. Kare , Robert W. Lord , Kenneth Lustig , William Henry Manglone-Smith , Michael Manos , Craig J. Mundie , Nathan P. Myhrvold , Richard F. Rashid , Burton Smith , Clarence T. Tegreene , Robert V. Welland , Charles Whitmer , Lowell L. Wood, JR.
发明人: Howard Lee Davidson , James R. Hamilton , Roderick A. Hyde , Arne Josefsberg , Edward K.Y. Jung , Jordin T. Kare , Robert W. Lord , Kenneth Lustig , William Henry Manglone-Smith , Michael Manos , Craig J. Mundie , Nathan P. Myhrvold , Richard F. Rashid , Burton Smith , Clarence T. Tegreene , Robert V. Welland , Charles Whitmer , Lowell L. Wood, JR.
IPC分类号: H04B10/00
CPC分类号: H04B10/1149
摘要: A data center for executing a data processing application includes processing units, sub-units or servers. Each of the processing units, sub-units or servers can execute a part or all of the data processing application. The processing units, sub-units or servers are electrical disjoint with respect to data communications, but can communicate with each other over free space optical links.
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公开(公告)号:US20110150490A1
公开(公告)日:2011-06-23
申请号:US12655818
申请日:2010-01-06
申请人: Howard Lee Davidson , James R. Hamilton , Roderick A. Hyde , Arne Josefsberg , Edward K.Y. Jung , Jordin T. Kare , Robert W. Lord , Kenneth Lustig , William Henry Mangione-Smith , Michael Manos , Craig J. Mundie , Nathan P. Myhrvold , Richard F. Rashid , Burton Smith , Clarence T. Tegreene , Robert V. Welland , Charles Whitmer , Lowell L. Wood, JR.
发明人: Howard Lee Davidson , James R. Hamilton , Roderick A. Hyde , Arne Josefsberg , Edward K.Y. Jung , Jordin T. Kare , Robert W. Lord , Kenneth Lustig , William Henry Mangione-Smith , Michael Manos , Craig J. Mundie , Nathan P. Myhrvold , Richard F. Rashid , Burton Smith , Clarence T. Tegreene , Robert V. Welland , Charles Whitmer , Lowell L. Wood, JR.
IPC分类号: H04B10/00
CPC分类号: H04B10/1149
摘要: A data center for executing a data processing application includes processing units, sub-units or servers. Each of the processing units, sub-units or servers can execute a part or all of the data processing application. The processing units, sub-units or servers are electrical disjoint with respect to data communications, but can communicate with each other over free space optical links.
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公开(公告)号:US20110150473A1
公开(公告)日:2011-06-23
申请号:US12804132
申请日:2010-07-13
申请人: Howard Lee Davidson , James R. Hamilton , Roderick A. Hyde , Arne Josefsberg , Edward K.Y. Jung , Jordin T. Kare , Robert W. Lord , Kenneth Lustig , William Henry Mangione-Smith , Michael Manos , Craig J. Mundie , Nathan P. Myhrvold , Richard F. Rashid , Burton Smith , Clarence T. Tegreene , Robert V. Welland , Charles Whitmer , Lowell L. Wood, JR.
发明人: Howard Lee Davidson , James R. Hamilton , Roderick A. Hyde , Arne Josefsberg , Edward K.Y. Jung , Jordin T. Kare , Robert W. Lord , Kenneth Lustig , William Henry Mangione-Smith , Michael Manos , Craig J. Mundie , Nathan P. Myhrvold , Richard F. Rashid , Burton Smith , Clarence T. Tegreene , Robert V. Welland , Charles Whitmer , Lowell L. Wood, JR.
IPC分类号: H04J14/00
CPC分类号: H04J14/0227 , H04B10/1149 , H04J14/0257 , H04J14/0275 , H04J14/0282 , H04J14/0284 , H04J14/0286 , H04J14/06
摘要: A data center for executing a data processing application includes processing units, sub-units or servers. Each of the processing units, sub-units or servers can execute a part or all of the data processing application. The processing units, sub-units or servers are electrical disjoint with respect to data communications, but can communicate with each other over free space optical links.
摘要翻译: 用于执行数据处理应用的数据中心包括处理单元,子单元或服务器。 每个处理单元,子单元或服务器可以执行数据处理应用的一部分或全部。 处理单元,子单元或服务器对于数据通信而言是电不相交的,但是可以通过自由空间光链路彼此通信。
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