公开(公告)号：US3970694A

公开(公告)日：1976-07-20

申请号：US484063

申请日：1974-06-28

申请人： Masayoshi Minai ,  Yoshio Suzuki ,  Noritaka Hamma ,  Eiichi Murayama ,  Shunji Aono

发明人： Masayoshi Minai ,  Yoshio Suzuki ,  Noritaka Hamma ,  Eiichi Murayama ,  Shunji Aono

IPC分类号： A61K31/19 ,  A61K31/215 ,  A61K31/22 ,  A61P3/06 ,  A61P9/10 ,  C07C51/00 ,  C07C59/125 ,  C07C59/68 ,  C07C59/70 ,  C07C67/00 ,  C07C69/712 ,  C07C63/33

CPC分类号： C07C59/70 ,  C07C59/68 ,  C07C69/712 ,  Y10S514/824

摘要： Novel compounds having the formula, ##SPC1##Wherein R.sub.1, R.sub.2 and R.sub.3 are each independently hydrogen or a C.sub.1 -C.sub.4 alkyl; n is an integer of 4-6; and Y is hydrogen or a group of the formula ##EQU1## wherein R.sub.1, R.sub.2 and R.sub.3 are as defined above. These compounds are produced, for example, by reacting a bisphenolic compound of the formula, ##SPC2##With chloroform and a ketone compound of the formula,R.sub.1 -- CO -- R.sub.2in the presence of an alkali. Alternatively, they are produced by reacting the bisphenolic compound with .alpha.-halogeno- or .alpha.-hydroxycarboxylic acid derivative of the formula, ##EQU2## wherein R.sub.1, R.sub.2, and R.sub.3 are as defined above, and X is a halogen or hydroxyl. The novel compounds are anti-atherosclerosis agents useful for lowering elevated levels of cholesterol or lipids.

摘要翻译： 具有式WHEREIN R1，R2和R3的新型化合物各自独立地为氢或C1-C4烷基; n为4-6的整数; 并且Y是氢或式R1R2 ANGLE -C-COOR3的基团，其中R1，R2和R3如上定义。