利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

104 条记录 (耗时 0.037 秒)

    14094, a novel human trypsin family member and uses thereof
    76.
    发明授权
    14094, a novel human trypsin family member and uses thereof 有权
    14094，一种新型人胰蛋白酶家族成员及其用途

    公开(公告)号：US07071004B1

    公开(公告)日：2006-07-04

    申请号：US09846512

    申请日：2001-05-01

    申请人： Rachel Meyers ,  Kyle J. Macbeth

    发明人： Rachel Meyers ,  Kyle J. Macbeth

    IPC分类号： G01N33/53

    CPC分类号： A61K38/17 ,  A61K47/6871 ,  A61K51/1075 ,  A61K2039/505 ,  C07K16/40 ,  C12N9/6427 ,  G01N33/573 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/57449 ,  G01N2333/96433 ,  G01N2500/00

    摘要： The invention provides isolated nucleic acids molecules, designated 14094 nucleic acid molecules, which encode a novel trypsin family member. Elevated expression of 14094 mRNA was detected in breast, ovarian, lung, and liver cancers compared to normal cells derived from these tissues. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 14094 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 14094 gene has been introduced or disrupted. The invention still further provides isolated 14094 proteins, fusion proteins, antigenic peptides and anti-14094 antibodies. Therapeutic and diagnostic methods utilizing compositions of the invention to, for example, treat, prevent, and/or diagnose neoplastic conditions, are also provided.

    摘要翻译： 本发明提供编码新型胰蛋白酶家族成员的分离的核酸分子，命名为14094个核酸分子。 与来自这些组织的正常细胞相比，在乳腺癌，卵巢癌，肺癌和肝癌中检测到14094个mRNA的表达升高。 本发明还提供了反义核酸分子，含有14094个核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及14094基因导入或破坏的非人类转基因动物。 本发明还进一步提供了分离的14094蛋白，融合蛋白，抗原肽和抗-144094抗体。 还提供了利用本发明组合例如治疗，预防和/或诊断肿瘤病症的治疗和诊断方法。

    USE OF PROTEIN TYROSINE PHOSPHATASE ZETA AS A BIOMOLECULAR TARGET IN THE TREATMENT AND VISUALIZATION OF BRAIN TUMORS
    78.
    发明申请
    USE OF PROTEIN TYROSINE PHOSPHATASE ZETA AS A BIOMOLECULAR TARGET IN THE TREATMENT AND VISUALIZATION OF BRAIN TUMORS 失效
    蛋白酪氨酸磷酸化酶ZETA作为生物分子靶在脑肿瘤的治疗和可视化中的应用

    公开(公告)号：US20020146370A1

    公开(公告)日：2002-10-10

    申请号：US09816703

    申请日：2001-03-23

    申请人： AGY THERAPEUTICS

    发明人： Sabine Mueller ,  Thorsten Melcher ,  Daniel J. Chin

    IPC分类号： A61K051/00 ,  A61M036/14

    CPC分类号： A61K51/1093 ,  A61K47/6871 ,  A61K51/1075

    摘要： The present invention relates to the use of proteins which are differentially expressed in primary brain tumor tissues, as compared to normal brain tissues, as biomolecular targets for brain tumor treatment therapies. Specifically, the present invention relates to the use of immunotherapeutic and immunoimaging agents which specifically bind to human protein tyrosine phosphatase-zeta (PTPnull) for the treatment and visualization of brain tumors in patients. The present invention also provides compounds and pharmaceutically acceptable compositions for administration in the methods of the invention.

    摘要翻译： 本发明涉及与正常脑组织相比，在原发性脑肿瘤组织中差异表达的蛋白质作为脑肿瘤治疗疗法的生物分子靶标的用途。 具体地，本发明涉及特异性结合人蛋白质酪氨酸磷酸酶ζ（PTP＆xgr）的免疫治疗和免疫成像剂用于治疗和观察患者脑肿瘤的用途。 本发明还提供了用于本发明方法中给药的化合物和药学上可接受的组合物。

    Compositions and methods for identifying and targeting cancer cells of alimentary canal origin
    80.
    发明申请
    Compositions and methods for identifying and targeting cancer cells of alimentary canal origin 审中-公开
    用于鉴定和靶向消化道起源的癌细胞的组合物和方法

    公开(公告)号：US20010036635A1

    公开(公告)日：2001-11-01

    申请号：US09819247

    申请日：2001-03-27

    发明人： Scott A. Waldman ,  Jason Park ,  Stephanie Schulz

    IPC分类号： C12Q001/68 ,  A61K051/00 ,  G01N033/574 ,  A61K031/7048 ,  A61K031/7034

    CPC分类号： A61K39/0011 ,  A61K9/127 ,  A61K31/7034 ,  A61K31/7048 ,  A61K47/6871 ,  A61K51/1075 ,  C07K16/3046 ,  C07K16/40 ,  C12N15/113 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/57407 ,  G01N33/57419 ,  G01N33/57446 ,  G01N2333/988

    摘要： Screening and diagnostic reagents, kits and methods for metastatic colorectal cancer or primary and/or metastatic stomach or esophageal cancer are disclosed. Compounds, compositions and methods of treating patients with metastatic colorectal cancer or stomach or esophageal cancer and for imaging metastatic colorectal cancer or stomach or esophageal tumors in vivo are disclosed. Compositions and methods for delivering active compounds such as drugs, gene therapeutics and antisense compounds to metastatic colorectal cancer or stomach or esophageal cells are disclosed. Vaccines compositions and methods of for treating and preventing metastatic colorectal cancer or primary and/or metastatic stomach or esophageal cancer are disclosed.

    摘要翻译： 公开了用于转移性结直肠癌或原发性和/或转移性胃或食管癌的筛选和诊断试剂，试剂盒和方法。 公开了治疗患有转移性结肠直肠癌或胃或食管癌的患者以及体内成像转移性结直肠癌或胃或食管肿瘤的化合物，组合物和方法。 公开了用于将活性化合物如药物，基因治疗剂和反义化合物递送至转移性结肠直肠癌或胃或食管细胞的组合物和方法。 公开了用于治疗和预防转移性结肠直肠癌或原发性和/或转移性胃或食管癌的疫苗组合物和方法。