公开(公告)号：US4111196A

公开(公告)日：1978-09-05

申请号：US660678

申请日：1976-02-23

申请人： Lionel C. R. Emmett

发明人： Lionel C. R. Emmett

IPC分类号： A61F6/14 ,  A61F6/18 ,  A61F5/46

CPC分类号： A61F6/142 ,  A61F6/18

摘要： An intrauterine contraceptive device made from plastic having a C-shape or Omega-shape to enable it to lie in the uterine cavity. Lines of predetermined length are attached at one of their ends respectively to enlargement portions of the terminal ends of the device and with their other ends fastened by a plastic bead and aid in insertion, removal and as a telltale marker. The device can include a metallic contraceptive material such as copper. One embodiment uses copper wire, which can be of selected different diameter, wound on the body of the device and retained against slippage by serrations on the body. A tubular inserter with appropriate grips and a cervical abutment flange is used to receive the IUD in elongated deformation. The device is slipped through the tubular inserter by a plunger and as the IUD emerges from the upper end of the tube, strain on one of the lines caused by abutment of the bead on the lower end of the tube positively bows and pulls the emerging IUD into a substantially circular configuration within the plane of the fundal cavity, the inserter having been appropriately oriented during the preliminary insertion steps.

公开(公告)号：US4069307A

公开(公告)日：1978-01-17

申请号：US582353

申请日：1975-05-30

申请人： Takeru Higuchi ,  Anwar Hussain

发明人： Takeru Higuchi ,  Anwar Hussain

IPC分类号： A61F6/14 ,  A61K9/00 ,  A61K9/26 ,  A61K9/70 ,  A61M31/00

CPC分类号： A61K9/7084 ,  A61F6/14 ,  A61F6/142 ,  A61K9/0004 ,  A61K9/0036 ,  A61K9/0039 ,  A61K9/0051 ,  A61M31/002

摘要： Drug-delivery device for releasing a drug at a continuous and controlled rate for a prolonged period of time is comprised of a shaped body of polymeric material containing a pharmaceutically acceptable drug and permeable to passage of the drug by diffusion. The polymeric material is an ethylene-vinyl acetate copolymer having a vinyl acetate content of about 4 to 80% by weight and a melt index of about 0.1 to 1000 grams per 10 minutes.

摘要翻译： 用于以连续和受控的速率长时间释放药物的药物递送装置由含有药学上可接受的药物并且可透过药物通过扩散而可渗透的成形体的聚合材料构成。 聚合物材料是乙酸乙烯酯含量为约4-80重量％，熔体指数为约0.1-1000克/ 10分钟的乙烯 - 乙酸乙烯酯共聚物。

公开(公告)号：US4038978A

公开(公告)日：1977-08-02

申请号：US549584

申请日：1975-02-13

申请人： John McLean Morris ,  John P. Bennett ,  Josef E. Kercso

发明人： John McLean Morris ,  John P. Bennett ,  Josef E. Kercso

IPC分类号： A61F6/14 ,  A61F5/46

CPC分类号： A61F6/144 ,  A61F6/148

摘要： An intrauterine device providing a membrane to cover substantially the entire surface of the uterine cavity, said device having a Y- or V-shaped resilient member with two diverging arms, a membrane covering the entire area between the diverging arms and, in addition, extending above an imaginary line passing through the terminal ends of the arms, and a flexible tail or string connected to the intersection of the arms for aiding in the removal of the device from the uterus when desired. The ends of the diverging arms have enlarged end portions and the arms are of unequal length so that the arms may be resiliently collapsed and placed in a tubular inserter with the enlarged end portions longitudinally spaced in the inserter.

摘要翻译： 一种子宫内装置，其提供膜以基本上覆盖子宫腔的整个表面，所述装置具有Y形或V形弹性构件，其具有两个发散臂，膜覆盖发散臂之间的整个区域，此外，延伸 在穿过臂的终端的假想线上方，以及连接到臂的相交处的柔性尾部或弦，用于在需要时帮助从子宫移除装置。 发散臂的端部具有扩大的端部并且臂具有不等长度，使得臂可以弹性地折叠并放置在管状插入器中，其中扩大的端部在插入器中纵向间隔开。

公开(公告)号：US4019633A

公开(公告)日：1977-04-26

申请号：US597020

申请日：1975-07-18

申请人： Nathan Roth

发明人： Nathan Roth

IPC分类号： A61F6/14 ,  A61F6/18 ,  B65D5/02 ,  B65D5/50 ,  B65D83/10

CPC分类号： B65D5/0245 ,  A61F6/14 ,  A61F6/18 ,  B65D5/0209 ,  B65D5/503 ,  Y10S206/815

摘要： A package for an intrauterine device-intrauterine device inserter combination and a "pillow pack" carton for the package are disclosed. The package consists of three elements: (1) a thermoformed plastic tray having an elongated, relatively deep cavity for holding the combination, a convexly curved marginal ledge about the cavity, an end wall extending downwardly from each end of the ledge, and a flange extending outwardly from the bottom of each end wall; (2) a cover that fits over the cavity and has the same curvature as the marginal ledge; and (3) an adhesive coating on the inner side of the cover by which the cover is attached to the ledge over the cavity. The package is enveloped in a paper carton that has a bottom wall on which the package bottom rests, a pair of end walls, each of which has an inwardly extending section that overlies one of the flanges of the package tray whereby the package is held firmly in place, and a pair of flaps that are foldably connected to the longitudinal edges of the bottom wall and fold over the top of the package in an overlapping, interlocking fashion.

摘要翻译： 公开了一种用于子宫内装置 - 子宫内装置插入器组合的包装和用于包装的“枕头包装”纸盒。 该包装由三个元件组成：（1）热成型塑料托盘，其具有用于保持该组合的细长相对较深的空腔，围绕该空腔的凸形弯曲的边缘，从壁架的每个端部向下延伸的端壁，以及凸缘 从每个端壁的底部向外延伸; （2）盖子，该盖子适合于空腔并具有与边缘相同的曲率; 和（3）在盖的内侧上的粘合剂涂层，通过该粘合剂涂层将盖附接到腔上的凸缘。 该包装被包装在纸盒中，该纸盒具有一个底壁，一个包装底部搁置着的底壁，一对端壁，每个端壁具有一个向内延伸的部分，该部分覆盖着包装托盘的一个凸缘， 以及一对可折叠地连接到底壁的纵向边缘并且以重叠的互锁方式折叠在包装的顶部上的折翼。

公开(公告)号：US3996933A

公开(公告)日：1976-12-14

申请号：US621958

申请日：1975-10-14

申请人： Morton Gutnick

发明人： Morton Gutnick

IPC分类号： A61F6/14 ,  A61F5/46

CPC分类号： A61F6/144

摘要： An intrauterine contraceptive device comprising an elongated shank having divergent convoluted portions at its distal end, said convoluted portions being generally sinusoidal in nature, said device having incorporated in said shank a permanent magnet and having a substantial portion of its surface covered with a biologically inert, silicone elastomeric material which may contain an analgaesic or anti-fertility agent which is gradually eleased in utero. In a preferred embodiment of the invention, the proximal end, of the shank contains a pair of downwardly extending divergent, resilient legs which tend to prevent inadvertent expulsion of the device. In another preferred embodiment, the lower end of the device is also formed with one or more small refillable containers for certain types of medication which are released gradually into the vagina and the lower end of the uterus over a prolonged period of time for the prevention and cure of such venereal diseases as gonorrhea, syphilis, trichomonas vaginalis and moniliasis.

摘要翻译： 一种子宫内避孕装置，包括在其远端具有发散性褶皱部分的细长柄，所述回旋部分本质上大体上是正弦的，所述装置在所述柄中并入永磁体，并且其表面的大部分被生物惰性， 有机硅弹性体材料，其可以含有在子宫内逐渐排列的分析性或抗生育剂。 在本发明的优选实施例中，柄的近端包含一对向下延伸的发散的弹性腿，其倾向于防止装置的意外排出。 在另一个优选实施例中，装置的下端还形成有用于某些类型的药物的一个或多个小的可再填充容器，这些容器在延长的时间段内逐渐释放到阴道和子宫的下端，用于预防和 治疗诸如淋病，梅毒，阴道毛滴虫和韧带等性病。

公开(公告)号：US3977404A

公开(公告)日：1976-08-31

申请号：US611504

申请日：1975-09-08

申请人： Felix Theeuwes

发明人： Felix Theeuwes

IPC分类号： A61F6/14 ,  A61F9/00 ,  A61K9/00 ,  A61K9/26 ,  A61K9/52 ,  A61M31/00

CPC分类号： A61K9/0004 ,  A61F6/144 ,  A61F9/0017

摘要： An osmotic device for delivering an active agent is disclosed. The device is comprised of a wall surrounding in at least a part, a reservoir containing agent. The wall is formed of a material permeable to an external fluid and impermeable to agent. The reservoir is formed of a microporous material permeable to agent and fluid, and having at least one micropore that is a passageway for release of agent. The agent is soluble in the fluid and exhibits an osmotic pressure gradient against the fluid, or the agent has limited solubility in the fluid and is admixed with an osmotically effective compound soluble in fluid that exhibits an osmotic pressure gradient against fluid. In operation, agent is released by fluid permeating through the wall into the reservoir producing a solution of agent or a solution of compound containing agent, which solution in either instance is released through the micropore to the exterior of the device.

公开(公告)号：US3957042A

公开(公告)日：1976-05-18

申请号：US570794

申请日：1975-04-23

申请人： Stanislaw Krzaklewski ,  Andrzej Reszczynski ,  Henryk Suski

发明人： Stanislaw Krzaklewski ,  Andrzej Reszczynski ,  Henryk Suski

IPC分类号： A61F6/14 ,  A61F5/46 ,  A61M7/00

CPC分类号： A61F6/142

摘要： A spatial intrauterine contraceptive insert which after being introduced by means of a normal inserter into the uterus cavity takes on by itself the appearance of a spatial body.The insert has two arms 1, 2, the ends of which are connected permanently and formed into two spatial spirals along axes 4, 5 that intersect in an acute angle. In cross-section, the arms 1, 2 take on the shape of a circle. The parts of the arms 1, 2 which are formed as spirals of about 11/2 turns have the appearance of a mirror image. Near the end of the first turn of the spiral the arms 1 and 2 are immobilized by means of a link 6 made of copper. At the juncture point of said arms there is provided a thread 7 for facilitating the removal of the insert from the uterus.

摘要翻译： 在通过正常插入器引入到子宫腔中之后的空间子宫内避孕插入物本身承受空间体的外观。

公开(公告)号：US3935860A

公开(公告)日：1976-02-03

申请号：US499185

申请日：1974-08-21

申请人： Seymour Hoff

发明人： Seymour Hoff

IPC分类号： A61F6/14 ,  A61F5/46

CPC分类号： A61F6/144

摘要： Intrauterine device with restrictor for maintaining device in uterine cavity having a transverse member and a dependent member connected to the transverse member at a locus on the dependent member with a restrictor on the dependent member for keeping the shape of the device in a resting uterus or a contracting uterus; thereby substantially eliminating the incident of involuntary expulsion from the uterus.

摘要翻译： 具有限制器的子宫内装置用于在子宫腔中保持装置，其具有横向构件和从属构件连接到在所述从属构件上的位置处的横向构件的依赖构件，在所述从属构件上具有限制器，用于将所述装置的形状保持在静止的子宫或 收缩子宫 从而大大消除了非自愿从子宫开除的事件。

公开(公告)号：US3934580A

公开(公告)日：1976-01-27

申请号：US522966

申请日：1974-11-11

申请人： Rene Cournut

发明人： Rene Cournut

IPC分类号： A61F13/20 ,  A61F6/14 ,  A61K9/00 ,  A61M31/00 ,  A61F5/46

CPC分类号： A61F6/142 ,  A61F6/148 ,  A61K9/0039 ,  A61M31/00

摘要： The invention is directed to an active intrauterine device comprising a hydrophobic substrate of high mechanical resiliency, wherein the substrate including within the volume thereof inclusions of polymerizied hydrophilic substances grafted on the hydrophobic substrate and cross-linked, and in which water-soluble chemical agents have been stored previously, these agents being adapted to perfuse through the hydrophobic substrate when the latter is placed in an aqueous medium.

摘要翻译： 本发明涉及一种活性子宫内装置，其包括具有高机械弹性的疏水性基质，其中所述基质在其体积内包含接枝在疏水性底物上并交联的聚合亲水性物质的夹杂物，并且其中水溶性化学试剂具有 先前已经储存，当这些药剂置于水性介质中时，这些药剂适于通过疏水性底物灌注。

公开(公告)号：US3933152A

公开(公告)日：1976-01-20

申请号：US443338

申请日：1974-02-19

申请人： Thomas S. Moulding

发明人： Thomas S. Moulding

IPC分类号： A61F6/14 ,  A61F5/46

CPC分类号： A61F6/148 ,  A61F6/142

摘要： An intrauterine contraceptive device is provided which is inserted into a uterus in a collapsed position and is held in an expanded position by introduction of a self-hardening liquid plastic into the device after it is positioned within the uterus. In one embodiment the device is provided with an inflatable membrane for positioning it within the uterus prior to insertion of the liquid plastic, after which the membrane is deflated and in some instances removed. In another embodiment the device comprises a plastic tube with a resilient rod therein which may be deformed to insert the device in the uterus and after being positioned therein a liquid self-hardening plastic is introduced into the tube to hold the resilient rod in an expanded position that conforms to the uterine cavity. In still another embodiment, the rod is arranged to telescope in a tubular member which tubular member can be filled with self-hardening liquid plastic to force the rod out of the end of the tubular member and against a wall of the uterus and to hold it permanently in that position. In addition a tubular member may be provided an angular connection thereof which can be filled with the self-hardening liquid plastic to form a more rigid structure after the device is positioned in the uterus. If desired, a resistance heating element can be provided within the device to melt or soften the plastic so that the device can be removed from the uterus at a later time.

摘要翻译： 提供宫内避孕装置，其插入到塌陷位置的子宫中，并且在定位在子宫内之后，通过将自硬化液体塑料引入装置而将其保持在扩张位置。 在一个实施例中，该装置设置有可膨胀膜，用于在插入液体塑料之前将其定位在子宫内，此后膜被放气并且在某些情况下被移除。 在另一个实施例中，该装置包括塑料管，其中具有弹性杆，其可以变形以将装置插入子宫中，并且在定位之后，将液体自硬塑料引入管中以将弹性杆保持在扩张位置 符合子宫腔。 在另一个实施例中，杆被布置成在管状构件中望远镜，该管状构件可以用自硬化液体塑料填充，以迫使杆从管状构件的端部并抵靠子宫壁并保持 永久在那个位置。 此外，管状构件可以设置成其角度连接，其可以在自身硬化液体塑料填充以在装置定位在子宫中之后形成更刚性的结构。 如果需要，可以在装置内设置电阻加热元件以熔化或软化塑料，使得可以在稍后时间将该装置从子宫移除。