公开(公告)号：US4000279A

公开(公告)日：1976-12-28

申请号：US596493

申请日：1975-07-16

申请人： John Lawrence Hughes ,  Robert Chung-Huan Liu

发明人： John Lawrence Hughes ,  Robert Chung-Huan Liu

IPC分类号： C07D215/38 ,  A61K31/47

CPC分类号： C07D215/38 ,  Y10S514/93

摘要： A pharmaceutical preparation consisting of a pharmaceutical grade carrier and a therapeutically active amount of an aromatic guanidine compound having the formula: ##STR1## or a non-toxic acid addition salt thereof are found to have biologically useful activity. These guanidine preparations and salts are shown to be active as vasoconstrictor agents and obtain useful biological results when deployed with a pharmaceutically acceptable carrier for administration to a host, e.g., man, requiring vasoconstrictive therapy.