公开(公告)号：US20070145262A1

公开(公告)日：2007-06-28

申请号：US11454364

申请日：2006-06-16

申请人： Yu-Chong Tai ,  Jun Xie ,  Darron Young

发明人： Yu-Chong Tai ,  Jun Xie ,  Darron Young

IPC分类号： H01J49/00

CPC分类号： H01J49/165 ,  H01J49/0018

摘要： A microfluidic device including at least one microfabricated electrochemical flow cell and method of manufacturing such a device are disclosed herein. The electrochemical cell comprising at least a substrate, wherein the substrate has a front face and a back face; a channel wall bonded to the front face of the substrate without using a spacer, wherein the wall and the substrate define a microchannel having an inlet for receiving a fluid and an outlet for transmitting the fluid; a plurality of electrodes inside the microchannel, wherein said plurality of electrodes comprises one or more working electrodes and one or more counter electrodes, wherein the fluid flows over the surface of the plurality of electrodes and wherein optionally a length of the microchannel over the one or more working electrodes is greater than a height of the microchannel over the one or more working electrodes. Other peripherals may also be included in the microfluidic device of the current invention, including an electrospray ionization (ESI) nozzle, one or more detectors, a chromatographic column, etc. each of which may be microfluidically coupled to the electrochemical flow cells to create more complicated analytic devices.

摘要翻译： 本文公开了包括至少一个微加工电化学流动池的微流体装置及其制造方法。 所述电化学电池至少包括衬底，其中所述衬底具有正面和背面; 通道壁，其不使用间隔件结合到所述基板的前表面，其中所述壁和所述基板限定具有用于接收流体的入口和用于传输所述流体的出口的微通道; 微通道内的多个电极，其中所述多个电极包括一个或多个工作电极和一个或多个反电极，其中所述流体流过所述多个电极的表面，并且其中可选地，所述微通道的长度在所述一个或多个 更多的工作电极大于在一个或多个工作电极上的微通道的高度。 其他外围设备也可以包括在本发明的微流体装置中，包括电喷雾离子化（ESI）喷嘴，一个或多个检测器，色谱柱等，其中每一个可以微流体耦合到电化学流动池以产生更多的 复杂的分析设备。

公开(公告)号：US20070134782A1

公开(公告)日：2007-06-14

申请号：US11625258

申请日：2007-01-19

申请人： Yu-Chong TAI ,  Sang-Wook Lee

发明人： Yu-Chong TAI ,  Sang-Wook Lee

IPC分类号： C12N13/00 ,  C12M1/42

CPC分类号： C12M47/06 ,  C12N1/066 ,  C12N13/00

摘要： A micromachined cell lysis device with electrodes that are spaced by less than 10 μm from one another. The cells are attracted to the space between the electrodes and then lysed.

摘要翻译： 具有彼此间隔小于10um的电极的微加工细胞裂解装置。 细胞被吸引到电极之间的空间，然后裂解。

公开(公告)号：US20060282128A1

公开(公告)日：2006-12-14

申请号：US11414139

申请日：2006-04-28

申请人： Yu-Chong Tai ,  Damien Rodger ,  Wen Li ,  Mark Humayun ,  James Weiland ,  Hossein Ameri

发明人： Yu-Chong Tai ,  Damien Rodger ,  Wen Li ,  Mark Humayun ,  James Weiland ,  Hossein Ameri

IPC分类号： A61N1/00

CPC分类号： A61N1/0543 ,  A61F9/08 ,  A61N1/36046 ,  Y10T29/49002 ,  Y10T29/49128 ,  Y10T29/4913 ,  Y10T29/49156 ,  Y10T29/49224

摘要： Intraocular retinal prosthesis systems and methods for fabricating the same are provided. In one aspect, fabrication of all or multiple components of a prosthesis device or system are combined into a single monolithic fabrication process. Also, many such entire systems can be fabricated simultaneously in a single microfabrication processing run. A prosthesis device includes a cable region that connects an electrode array region with a power and data management region. The electrode array region includes one or more arrays of exposed electrodes, and the power and data management region includes various power and control elements. The power and data management elements, in one aspect, include an RF coil or coils and circuit arrangements and/or chips configured to provide drive signals to the electrodes via a cable and receive power and signals from the RF coil or coils. Each region includes elements fabricated on or in a single polymer layer during the same fabrication process.

摘要翻译： 提供了眼内视网膜假体系统及其制造方法。 在一个方面，假体装置或系统的全部或多个部件的制造被组合成单个整体制造工艺。 此外，许多这样的整个系统可以在单个微细加工处理运行中同时制造。 假体装置包括将电极阵列区域与功率和数据管理区域连接的电缆区域。 电极阵列区域包括一个或多个暴露电极阵列，功率和数据管理区域包括各种功率和控制元件。 功率和数据管理元件在一个方面包括RF线圈或线圈以及经配置以通过电缆向电极提供驱动信号并且从RF线圈或线圈接收功率和信号的电路布置和/或芯片。 每个区域包括在相同的制造过程中在单个聚合物层上或在单个聚合物层中制造的元件。

公开(公告)号：US07090471B2

公开(公告)日：2006-08-15

申请号：US10757973

申请日：2004-01-13

申请人： Jun Xie ,  Jason Shih ,  Yu-Chong Tai

发明人： Jun Xie ,  Jason Shih ,  Yu-Chong Tai

IPC分类号： F04B17/03 ,  E03B1/00

CPC分类号： B81C1/00119 ,  B81B2201/036 ,  B81B2203/0127 ,  B81B2203/0338 ,  F04B43/043 ,  F04B43/082 ,  F04B43/12 ,  Y10T137/87692

摘要： An electrostatic fluid regulating device and methods. The device has a substrate. The device also has a first electrode coupled to the substrate. The device has a polymer based diaphragm. A second electrode is coupled to the diaphragm. A polymer based fluid chamber is coupled to the diaphragm. The device also has an inlet coupled to the polymer based fluid chamber and an outlet coupled to the polymer based fluid chamber.

摘要翻译： 一种静电流体调节装置及方法。 该装置具有基板。 该器件还具有耦合到衬底的第一电极。 该装置具有基于聚合物的隔膜。 第二电极耦合到隔膜。 基于聚合物的流体室耦合到隔膜。 该装置还具有连接到基于聚合物的流体室的入口和连接到基于聚合物的流体室的出口。

公开(公告)号：US20060057597A1

公开(公告)日：2006-03-16

申请号：US10985841

申请日：2004-11-09

申请人： Yu-Chong Tai ,  Chi-Yuan Shih ,  Siyang Zheng

发明人： Yu-Chong Tai ,  Chi-Yuan Shih ,  Siyang Zheng

IPC分类号： C40B40/08 ,  C40B40/10

CPC分类号： B01L3/502707 ,  B01L3/00 ,  B01L3/502753 ,  B01L3/502776 ,  B01L2300/0663

摘要： A method for processing nanoparticles using a self assembly mechanism. The method includes flowing a first reactant species through a first channel region, which has a predetermined dimension including a first width and a first depth. The method includes flowing a second reactant species through a second channel region, which also has a predetermined dimension including a second width and a second depth. The method includes outputting the first reactant species through a first orifice exiting the first channel region and outputting the second reactant species through a second orifice exiting the second channel region. Additionally, the method forms an interface region along a first predetermined length in a third channel, which couples the first orifice to the second orifice at the interface region. The method contacts one or more of the first reactant species with one or more of the second reactant species at the interface region to form a combined species of the one or more first reactant species and the one or more second reactant species. The method also transfers the combined species of the one or more first reactant and the one or more second reactant species from the first predetermined length to a second predetermined length of the third channel region.

摘要翻译： 使用自组装机构处理纳米颗粒的方法。 该方法包括使第一反应物种流过第一通道区，第一通道区具有包括第一宽度和第一深度的预定尺寸。 该方法包括使第二反应物种流过第二通道区，第二通道区也具有包括第二宽度和第二深度的预定尺寸。 该方法包括通过离开第一通道区域的第一孔输出第一反应物种，并通过离开第二通道区的第二孔输出第二反应物种。 此外，该方法在第三通道中形成沿着第一预定长度的界面区域，其在接口区域处将第一孔口耦合到第二孔口。 该方法在界面区域将一种或多种第一反应物种与一种或多种第二反应物种接触，以形成一种或多种第一反应物种和一种或多种第二种反应物种的组合物种。 该方法还将一种或多种第一反应物和一种或多种第二反应物种类的组合物质从第一预定长度转移到第三通道区域的第二预定长度。

公开(公告)号：US06994950B2

公开(公告)日：2006-02-07

申请号：US10391122

申请日：2003-03-18

申请人： Yu-Chong Tai ,  Qing He

发明人： Yu-Chong Tai ,  Qing He

IPC分类号： G03F7/00

CPC分类号： B81C1/00333 ,  B01L3/502707 ,  B01L2200/0668 ,  B01L2200/12 ,  B01L2300/0896 ,  B81C1/00182 ,  B81C1/00476 ,  B81C2201/0108 ,  B82Y30/00 ,  G01N30/6095 ,  G01N2030/562 ,  G01N2030/6056

摘要： MEMs devices are integrally fabricated with included micro or nanoparticles by providing a mixture of a sacrificial material and a multiplicity of particles, disposing the mixture onto a substrate, fabricating a MEMs structure on the substrate including at least part of the mixture, so that at least some of the mixture is enclosed in the MEMs structure, removing the sacrificial material, and leaving at least some of the multiplicity of particles substantially free and enclosed in the MEMs structure. The step of fabricating a MEMs structure is quite general and is contemplated as including one or a multiplicity of additional steps for creating some type of structure in which the particles, which may be microbeads or nanobeads, are included. A wide variety of useful applications for MEMs integrated with micro or nanoparticles are available.

公开(公告)号：US20060018360A1

公开(公告)日：2006-01-26

申请号：US10973938

申请日：2004-10-25

申请人： Yu-Chong Tai ,  Matthieu Liger ,  Scott Miserendino ,  Satoshi Konishi

发明人： Yu-Chong Tai ,  Matthieu Liger ,  Scott Miserendino ,  Satoshi Konishi

IPC分类号： G01J5/00

CPC分类号： G01J5/20

摘要： A method (and resulting structure) for fabricating a sensing device. The method includes providing a substrate comprising a surface region and forming an insulating material overlying the surface region. The method also includes forming a film of carbon based material overlying the insulating material and treating to the film of carbon based material to pyrolyzed the carbon based material to cause formation of a film of substantially carbon based material having a resistivity ranging within a predetermined range. The method also provides at least a portion of the pyrolyzed carbon based material in a sensor application and uses the portion of the pyrolyzed carbon based material in the sensing application. In a specific embodiment, the sensing application is selected from chemical, humidity, piezoelectric, radiation, mechanical strain or temperature.

摘要翻译： 一种用于制造感测装置的方法（和结果）。 该方法包括提供包括表面区域并形成覆盖表面区域的绝缘材料的基板。 该方法还包括形成覆盖绝缘材料的碳基材料薄膜，并处理碳基材料薄膜以热解碳基材料，以形成电阻率范围在预定范围内的基本上碳基材料的薄膜。 该方法还在传感器应用中提供热解碳基材料的至少一部分，并且在感测应用中使用部分热解碳基材料。 在具体实施例中，感测应用选自化学，湿度，压电，辐射，机械应变或温度。

公开(公告)号：US20060003090A1

公开(公告)日：2006-01-05

申请号：US11130814

申请日：2005-05-16

申请人： Damien Rodger ,  Mark Humayun ,  Yu-Chong Tai ,  James Weiland

发明人： Damien Rodger ,  Mark Humayun ,  Yu-Chong Tai ,  James Weiland

IPC分类号： B05D5/12

CPC分类号： H05K1/032 ,  A61N1/04 ,  A61N1/0543 ,  A61N1/0551 ,  H05K1/0393 ,  H05K3/0041 ,  H05K3/007 ,  H05K3/048 ,  H05K3/467 ,  H05K3/4682 ,  H05K2201/0179 ,  H05K2203/016

摘要： Method for manufacturing a parylene-based electrode array that includes an underlying parylene layer, one or more patterned electrode layers comprising a conductive material such as a metal, and one or more overlying parylene layers. The overlying parylene is etched away or otherwise processed to expose the electrodes where stimulation or recording is to occur. All other conductive material in the device is occluded from the environment by the two layers of parylene surrounding it.

摘要翻译： 制造聚对二甲苯基电极阵列的方法，其包括下面的聚对二甲苯层，一个或多个图案化的电极层，包括导电材料如金属和一个或多个上覆的聚对二甲苯层。 将上覆的聚对二甲苯蚀刻掉或以其他方式处理，以暴露要进行刺激或记录的电极。 器件中的所有其他导电材料都被周围的两层聚对二甲苯从环境中吸收。

公开(公告)号：US20050268722A1

公开(公告)日：2005-12-08

申请号：US11148124

申请日：2005-06-07

申请人： Yu-Chong Tai ,  Ellis Meng ,  Po-Jui Chen ,  Damien Rodger ,  Mark Humayun

发明人： Yu-Chong Tai ,  Ellis Meng ,  Po-Jui Chen ,  Damien Rodger ,  Mark Humayun

IPC分类号： A61B3/16 ,  G01L7/04 ,  G01L7/08

CPC分类号： A61B3/16 ,  A61B2562/02 ,  A61B2562/028 ,  G01L7/045

摘要： A biocompatible, mechanical, micromachined pressure sensor and methods of manufacturing such a pressure sensor are provided. The pressure sensor of the current invention comprises a high-aspect-ratio curved-tube structure fabricated through a one-layer parylene process. The pressure sensor of the current invention requires zero power consumption and indicates the pressure variation by changes of the in situ in-plane motion of the sensor, which can be gauged externally by a direct and convenient optical observation. In one embodiment, the pressure sensor of the current invention has been shown to work as an IOP sensor for eye implantation where the intraocular in-plane motion of the sensor can be recorded from outside of the eye, such that the intraocular pressure in glaucoma patients can be constantly monitored.

摘要翻译： 提供生物相容的，机械的，微加工的压力传感器以及制造这种压力传感器的方法。 本发明的压力传感器包括通过一层聚对二甲苯工艺制造的高纵横比弯曲管结构。 本发明的压力传感器需要零功率消耗，并且通过传感器的原位面内运动的变化来指示压力变化，其可以通过直接和方便的光学观察在外部测量。 在一个实施例中，本发明的压力传感器已经被证明可用作眼睛植入的IOP传感器，其中可以从眼睛外部记录传感器的眼内平面内运动，使得青光眼患者的眼内压 可以不断监控。

公开(公告)号：US06945116B2

公开(公告)日：2005-09-20

申请号：US10802667

申请日：2004-03-16

申请人： Jun Xie ,  Jason Shih ,  Yu-Chong Tai

发明人： Jun Xie ,  Jason Shih ,  Yu-Chong Tai

IPC分类号： G01N27/22 ,  G01N27/447 ,  G01L9/12

CPC分类号： G01N27/226 ,  B81B7/02 ,  B81B2201/0292 ,  B81B2201/058 ,  G01L9/0042 ,  G01L9/0072

摘要： A microfluidic device and method for capacitive sensing. The device includes a fluid channel including an inlet at a first end and an outlet at a second end, a cavity region coupled to the fluid channel, and a polymer based membrane coupled between the fluid channel and the cavity region. Additionally, the device includes a first capacitor electrode coupled to the membrane, a second capacitor electrode coupled to the cavity region and physically separated from the first capacitor electrode by at least the cavity region, and an electrical power source coupled between the first capacitor electrode and the second capacitor electrode and causing an electric field at least within the cavity region. The polymer based membrane includes a polymer.

摘要翻译： 用于电容感测的微流体装置和方法。 该装置包括流体通道，其包括在第一端处的入口和在第二端处的出口，耦合到流体通道的空腔区域以及耦合在流体通道和腔区域之间的基于聚合物的膜。 另外，该器件包括耦合到膜的第一电容器电极，耦合到空腔区域的第二电容器电极，并且至少通过腔区域与第一电容器电极物理分离;以及电源，耦合在第一电容器电极和 所述第二电容器电极至少在所述腔区域内引起电场。 基于聚合物的膜包括聚合物。