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    ENANTIOPURE QUINUCLIDINYLOXY PYRIDAZINES AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS
    81.
    发明申请
    ENANTIOPURE QUINUCLIDINYLOXY PYRIDAZINES AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS 审中-公开
    纯化喹啉吡啶吡啶并使用它作为NICOTINIC乙酰胆碱受体配体

    公开(公告)号：US20100227869A1

    公开(公告)日：2010-09-09

    申请号：US12160402

    申请日：2007-02-13

    申请人： Dan Peters ,  Daniel B. Timmermann ,  Gunnar M. Olsen ,  Elsebet Østergaard Nielsen ,  Tino Dyhring

    发明人： Dan Peters ,  Daniel B. Timmermann ,  Gunnar M. Olsen ,  Elsebet Østergaard Nielsen ,  Tino Dyhring

    IPC分类号： A61K31/501 ,  C07D403/12 ,  A61P25/00 ,  A61P29/00 ,  A61P1/00 ,  A61P9/12 ,  A61P15/00 ,  A61P17/00

    CPC分类号： C07D453/02

    摘要： This invention relates to novel enantiopure azabicyclo pyridazinyloxy derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及新型对映纯氮氮杂双环哒嗪氧基衍生物，其被发现是烟碱乙酰胆碱受体的胆碱能配体和单胺受体和转运蛋白的调节剂。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

    Diazabicyclic aryl derivatives and their medical use
    85.
    发明授权
    Diazabicyclic aryl derivatives and their medical use 失效
    二氮杂双环芳基衍生物及其医疗用途

    公开(公告)号：US07750011B2

    公开(公告)日：2010-07-06

    申请号：US11884345

    申请日：2006-02-13

    申请人： Dan Peters ,  Daniel B. Timmermann ,  Gunnar M. Olsen ,  Elsebet Østergaard Nielsen ,  Tino Dyhring

    发明人： Dan Peters ,  Daniel B. Timmermann ,  Gunnar M. Olsen ,  Elsebet Østergaard Nielsen ,  Tino Dyhring

    IPC分类号： C07D403/04 ,  C07D401/04 ,  C07D409/04 ,  C07D405/14 ,  A61K31/501 ,  A61K31/497 ,  A61P21/00 ,  A61P5/00 ,  A61P25/00 ,  A61P29/00

    CPC分类号： C07D487/08

    摘要： This invention relates to novel diazabicyclic aryl derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及在尼古丁乙酰胆碱受体和单胺受体和转运蛋白的调节剂中被发现是胆碱能配体的新的二氮杂双环芳基衍生物。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

    3,9-diazabicyclo[3.3.1]nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
    89.
    发明授权
    3,9-diazabicyclo[3.3.1]nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors 失效
    3,9-二氮杂双环[3.3.1]壬烷衍生物及其作为单胺神经递质再摄取抑制剂的用途

    公开(公告)号：US07700596B2

    公开(公告)日：2010-04-20

    申请号：US12161905

    申请日：2007-02-09

    申请人： Dan Peters ,  John Paul Redrobe ,  Elsebet Østergaard Nielsen

    发明人： Dan Peters ,  John Paul Redrobe ,  Elsebet Østergaard Nielsen

    IPC分类号： A61K31/495

    CPC分类号： C07D471/08

    摘要： 3,9-diazabicyclo[3.3.1]nonane derivatives, useful as monoamine neurotransmitter re-uptake inhibitors. Also, use of these compounds in a method for therapy and in pharmaceutical compositions comprising the compounds. The 3,9-diazabicyclo[3.3.1]nonane derivatives have the formula wherein Ra and Rb are as described in the application. Also disclosed are stereoisomers and pharmaceutically acceptable salts of the compounds.

    摘要翻译： 3,9-二氮杂双环[3.3.1]壬烷衍生物，可用作单胺神经递质再摄取抑制剂。 此外，在治疗方法中使用这些化合物和包含该化合物的药物组合物。 3,9-二氮杂双环[3.3.1]壬烷衍生物具有下式其中Ra和Rb如申请中所述。 还公开了化合物的立体异构体和药学上可接受的盐。

    3-heteroaryl-3,9-diazabicyclo[3.3.1]nonane derivatives as nicotinic acetylcholine receptor agonists
    90.
    发明授权
    3-heteroaryl-3,9-diazabicyclo[3.3.1]nonane derivatives as nicotinic acetylcholine receptor agonists 有权
    3-杂芳基-3,9-二氮杂双环[3.3.1]壬烷衍生物作为烟碱乙酰胆碱受体激动剂

    公开(公告)号：US07687523B2

    公开(公告)日：2010-03-30

    申请号：US12087004

    申请日：2007-02-09

    申请人： Dan Peters ,  Daniel B. Timmermann ,  Gunnar M. Olsen ,  Elsebet Østergaard Nielsen ,  Jeppe Kejser Christensen

    发明人： Dan Peters ,  Daniel B. Timmermann ,  Gunnar M. Olsen ,  Elsebet Østergaard Nielsen ,  Jeppe Kejser Christensen

    IPC分类号： A61K31/44

    CPC分类号： C07D471/08

    摘要： Compounds of the class 3,9-diaza-bicyclo [3.3.1]nonane derivatives. The compounds correspond to structural Formula (I): wherein Ra is hydrogen or optionally substituted alkyl and Rb is a monocyclic heteroaryl group. The compounds are useful in the treatment, prevention, or alleviation of diseases or disorders or conditions that are responsive to modulation of nicotinic acetylcholine receptors, including cognitive disorders, Alzheimer's disease, attention deficit hyperactivity disorder (ADHD), Tourette's syndrome, Bipolar Disorder, obsessive compulsive disorders (OCD), narcolepsy, senile dementia, autism, Parkinson'disease, Amyotrophic Lateral Sclerosis, epilepsy, and diabetic neuropathy.

    摘要翻译： 3,9-二氮杂双环[3.3.1]壬烷衍生物的化合物。 化合物对应于结构式（I）：其中R a是氢或任选取代的烷基，R b是单环杂芳基。 这些化合物可用于治疗，预防或缓解对烟碱乙酰胆碱受体调节，包括认知障碍，阿尔茨海默病，注意力缺陷多动障碍（ADHD），Tourette综合征，双相障碍，强迫症的疾病或病症或病症 强迫症（OCD），发作性睡病，老年痴呆，自闭症，帕金森病，肌萎缩性侧索硬化，癫痫和糖尿病性神经病变。