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294 条记录 (耗时 0.028 秒)

    Dimeric azacyclic compounds and their use
    81.
    发明授权
    Dimeric azacyclic compounds and their use 失效
    二甲基氮杂化合物及其用途

    公开(公告)号：US07674899B2

    公开(公告)日：2010-03-09

    申请号：US10586838

    申请日：2005-02-01

    申请人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Østergaard Nielsen ,  Tino Dyhring Jørgensen ,  Daniel B Timmermann

    发明人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Østergaard Nielsen ,  Tino Dyhring Jørgensen ,  Daniel B Timmermann

    IPC分类号： C07D487/00 ,  C07D243/00 ,  C07D241/04 ,  C07D295/00 ,  C07D233/00 ,  C07D233/02

    摘要： This invention relates to novel azacyclic derivatives and their use as pharmaceuticals. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及新型的氮杂环十二烷衍生物及其作为药物的用途。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

    Novel oxadiazole derivatives and their medical use
    82.
    发明申请
    Novel oxadiazole derivatives and their medical use 有权
    新型恶二唑衍生物及其医疗用途

    公开(公告)号：US20090312347A1

    公开(公告)日：2009-12-17

    申请号：US11919146

    申请日：2006-04-24

    申请人： Bjarne H. Dahl ,  Dan Peters ,  Gunnar M. Olsen ,  Daniel B. Timmermann ,  Susanne Jørgensen

    发明人： Bjarne H. Dahl ,  Dan Peters ,  Gunnar M. Olsen ,  Daniel B. Timmermann ,  Susanne Jørgensen

    IPC分类号： A61K31/4245 ,  A61K31/497 ,  A61K31/437 ,  C07D413/14 ,  C07D413/04 ,  A61P25/00

    CPC分类号： C07D413/04 ,  C07D413/14 ,  C07D417/14

    摘要： This invention relates to novel oxadiazole derivatives, which are found to be modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及新的恶二唑衍生物，其被发现是烟碱乙酰胆碱受体的调节剂。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

    Azabicyclic aryl derivatives
    83.
    发明授权
    Azabicyclic aryl derivatives 失效
    偶氮二芳基衍生物

    公开(公告)号：US07514450B2

    公开(公告)日：2009-04-07

    申请号：US10591871

    申请日：2005-05-10

    申请人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Østergaard Nielsen ,  Tino Dyhring Jørgensen ,  Daniel B. Timmermann

    发明人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Østergaard Nielsen ,  Tino Dyhring Jørgensen ,  Daniel B. Timmermann

    IPC分类号： A01N43/90 ,  A61K31/44 ,  C07D453/02

    CPC分类号： C07D453/02

    摘要： This invention relates to novel azabicyclic aryl derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及在尼古丁乙酰胆碱受体中被发现是胆碱能配体的新的氮杂双环芳基衍生物。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

    1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivative and its medical use
    84.
    发明授权
    1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivative and its medical use 失效
    1,4-二氮杂 - 双环[3.2.2]壬基嘧啶基衍生物及其医疗用途

    公开(公告)号：US08148365B2

    公开(公告)日：2012-04-03

    申请号：US12299106

    申请日：2007-05-29

    申请人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Østergaard Nielsen ,  Daniel B Timmermann ,  Steven Charles Loechel

    发明人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Østergaard Nielsen ,  Daniel B Timmermann ,  Steven Charles Loechel

    IPC分类号： A61K31/55 ,  C07D223/14

    CPC分类号： C07D471/08

    摘要： This invention relates to a novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivative and its use in the manufacture of pharmaceutical compositions. The compound of the invention is found to be a cholinergic ligand at the nicotinic acetylcholine receptors.Due to its pharmacological profile the compound of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及新的1,4-二氮杂双环[3.2.2]壬基嘧啶基衍生物及其在制备药物组合物中的用途。 发现本发明的化合物是烟碱乙酰胆碱受体的胆碱能配体。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或病症多种多样 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

    1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use
    85.
    发明授权
    1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use 有权
    1,4-二氮杂双环[3.2.2]壬基恶二唑基衍生物及其医疗用途

    公开(公告)号：US08101598B2

    公开(公告)日：2012-01-24

    申请号：US12861420

    申请日：2010-08-23

    申请人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Østergaard Nielsen ,  Daniel B. Timmermann ,  Steven Charles Loechel

    发明人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Østergaard Nielsen ,  Daniel B. Timmermann ,  Steven Charles Loechel

    IPC分类号： A61P25/00 ,  A61K31/551 ,  C07D471/08

    CPC分类号： C07D471/08

    摘要： This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors.Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及新的1,4-二氮杂 - 双环[3.2.2]壬基恶二唑基衍生物及其在制备药物组合物中的用途。 发现本发明的化合物是烟碱乙酰胆碱受体的胆碱能配体。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

    1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use
    86.
    发明授权
    1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use 有权
    1,4-二氮杂双环[3.2.2]壬基恶二唑基衍生物及其医疗用途

    公开(公告)号：US07807667B2

    公开(公告)日：2010-10-05

    申请号：US12300060

    申请日：2007-05-29

    申请人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Østergaard Nielsen ,  Daniel B Timmermann ,  Steven Charles Loechel

    发明人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Østergaard Nielsen ,  Daniel B Timmermann ,  Steven Charles Loechel

    IPC分类号： A61P25/00 ,  A61K31/551 ,  C07D471/08

    CPC分类号： C07D471/08

    摘要： This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors.Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及新的1,4-二氮杂 - 双环[3.2.2]壬基恶二唑基衍生物及其在制备药物组合物中的用途。 发现本发明的化合物是烟碱乙酰胆碱受体的胆碱能配体。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

    Diazabicyclic aryl derivatives as cholinergic receptor modulators
    87.
    发明授权
    Diazabicyclic aryl derivatives as cholinergic receptor modulators 失效
    二氮杂双环芳基衍生物作为胆碱能受体调节剂

    公开(公告)号：US07662808B2

    公开(公告)日：2010-02-16

    申请号：US10586836

    申请日：2005-02-01

    申请人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Østergaard Nielsen ,  Tino Dyhring Jørgensen ,  Daniel B Timmermann

    发明人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Østergaard Nielsen ,  Tino Dyhring Jørgensen ,  Daniel B Timmermann

    IPC分类号： A01N43/00 ,  A61K31/33 ,  C07D487/00

    CPC分类号： C07D471/08

    摘要： This invention relates to novel diazabicyclic aryl derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemicals substances.

    摘要翻译： 本发明涉及新的二氮杂双环芳基衍生物，其在烟碱乙酰胆碱受体和单胺受体和转运蛋白的调节剂中被发现是胆碱能配体。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

    N-ACYLHYDRAZONE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS
    90.
    发明申请
    N-ACYLHYDRAZONE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS 有权
    N-乙酰胆碱衍生物有用作为非线性乙酰胆碱受体的调节剂

    公开(公告)号：US20100280092A1

    公开(公告)日：2010-11-04

    申请号：US12743836

    申请日：2008-11-19

    申请人： Antonio Nardi ,  Jeppe Kejser Christensen ,  Dan Peters ,  Tino Dyhring

    发明人： Antonio Nardi ,  Jeppe Kejser Christensen ,  Dan Peters ,  Tino Dyhring

    IPC分类号： A61K31/405 ,  C07D209/20 ,  A61P25/00 ,  A61P25/28 ,  A61P25/24 ,  A61P25/22 ,  A61P9/12 ,  A61P9/06 ,  A61P29/00 ,  A61P25/30

    CPC分类号： C07D209/18 ,  C07D209/30 ,  C07D409/12

    摘要： This invention relates to N-acylhydrazone derivatives, which are found to be useful as modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及N-酰腙衍生物，其被发现可用作烟碱型乙酰胆碱受体的调节剂。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或病症多种多样 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。