公开(公告)号：US20220282322A1

公开(公告)日：2022-09-08

申请号：US17576170

申请日：2022-01-14

Applicant: TRON-Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg-Universität Mainz gG ,  BioNTech SE

Inventor： Ugur Sahin ,  Sebastian Kreiter ,  Mustafa Diken ,  Jan Diekmann ,  Michael Koslowski ,  Cedrik Britten ,  John Christopher Castle ,  Martin Löwer ,  Bernhard Renard ,  Tana Omokoko ,  Johannes Hendrikus De Graaf

IPC: C12Q1/6869 ,  A61K39/00 ,  G16B20/00 ,  G16B40/00 ,  C12Q1/6886 ,  G16B20/20

Abstract: The present invention relates to the provision of vaccines which are specific for a patient's tumor and are potentially useful for immunotherapy of the primary tumor as well as tumor metastases. In one aspect, the present invention relates to a method for providing an individualized cancer vaccine comprising the steps: (a) identifying cancer specific somatic mutations in a tumor specimen of a cancer patient to provide a cancer mutation signature of the patient; and (b) providing a vaccine featuring the cancer mutation signature obtained in step (a). In a further aspect, the present invention relates to vaccines which are obtainable by said method.

公开(公告)号：US20220273820A1

公开(公告)日：2022-09-01

申请号：US17565921

申请日：2021-12-30

Applicant: BioNTech SE

Inventor： Ugur Sahin ,  Alptekin Güler ,  Andreas Kuhn ,  Alexander Muik ,  Annette Vogel ,  Kerstin Walzer ,  Sonja Witzel ,  Stephanie Hein ,  Özlem Türeci ,  Gábor Boros ,  Azita Josefine Mahiny ,  Jonas Reinholz ,  Katalin Karikó

IPC: A61K48/00 ,  A61K9/127 ,  A61K39/215 ,  C12N7/00

Abstract: Disclosed herein are RNA polynucleotides comprising a 5′ Cap, a 5′ UTR comprising a cap proximal sequence disclosed herein, and a sequence encoding a payload. Also disclosed herein are compositions and medical preparations comprising the same, and methods of making and using the same.

公开(公告)号：US20220249372A1

公开(公告)日：2022-08-11

申请号：US17727956

申请日：2022-04-25

Applicant: BioNTech SE ,  Tron-Translationale Onkologie an der Universitatsmedizin der Johannes Gutenberg-University Mainz Gmb

Inventor： Hossam Hefesha ,  Ugur Sahin ,  Heinrich Haas ,  Sebastian Kreiter ,  Yves Hüsemann ,  Mustafa Diken ,  Kerstin Walzer

IPC: A61K9/107 ,  A61K9/127 ,  A61K48/00 ,  A61K31/675 ,  A61K31/7105 ,  A61K9/00 ,  A61K31/663 ,  A61K45/06 ,  A61K39/395 ,  A61P35/00 ,  A61K39/00 ,  A61K47/18 ,  A61K47/24

Abstract: The present invention relates to lipid particles comprising at least one cationic lipid, at least one water-soluble therapeutically effective compound and RNA. Further, the present invention relates to a pharmaceutical composition comprising such particles. Said pharmaceutical composition is useful for inducing an immune response. It is also useful in a prophylactic and/or therapeutic treatment of a disease involving an antigen. Furthermore, the present invention relates to a method for producing the particles.