公开(公告)号：US20050233014A1

公开(公告)日：2005-10-20

申请号：US11069836

申请日：2005-03-01

申请人： Steve Lee ,  Richard Hynson ,  Ke-Qin Zhang ,  Wu-Zhou Li ,  Jing Zhou

发明人： Steve Lee ,  Richard Hynson ,  Ke-Qin Zhang ,  Wu-Zhou Li ,  Jing Zhou

IPC分类号： A61K31/198 ,  A61K36/48 ,  A61K35/78

CPC分类号： A61K31/198 ,  A61K36/48 ,  A61K2300/00

摘要： The present invention is directed to novel compositions of bio-active compounds comprising 4-hydroxyisoleucine and one or more compounds selected from the group of amino acids, alkaloids, glycosides, volatile oils, saponins, sapogenins, mannans, flavonoids, fatty acids, vitamins and provitamins, minerals, and carbohydrates. Preferably, the novel compositions of bio-active compounds include 4-hydroxyisoleucine and one or more amino acids selected from the group consisting of arginine, aspartate, threonine, serine, glutamate, proline, glycine, alanine, cysteine, valine, methionine, isoleucine, leucine, tryptophan, phenylalanine, ornithine, proline, lysine, histidine, and gamma-aminobutyrate. The composition of bio-active compounds preferably include between about ten percent and about seventy percent of 4-hydroxyisoleucine and between about twenty percent and about forty percent of other amino acids. The bio-active compounds of the novel composition of the present invention may be derived, isolated, and/or extracted from Fenugreek seeds. A preferred method for extracting the bio-active compounds from Fenugreek seeds includes the steps of: (1) providing a plurality of Fenugreek seeds; (2) preparing the Fenugreek seeds; and (3) extracting a novel composition of bio-active compounds from the Fenugreek seeds, which include a preliminary extraction step and a secondary extraction step. The compositions of bio-active compounds have been found to be helpful in restoring healthy energy balance in humans and animals, aiding in weight management efforts, and for balancing blood sugar levels by way of assisting the body to make more efficient use of existing (i.e., endogenous) insulin.

摘要翻译： 本发明涉及包含4-羟基异亮氨酸和一种或多种选自氨基酸，生物碱，糖苷，挥发性油，皂角苷，皂甙元，甘露聚糖，类黄酮，脂肪酸，维生素和/或其中的一种或多种化合物的生物活性化合物的新组合物， 维生素，矿物质和碳水化合物。 优选地，生物活性化合物的新组合物包括4-羟基异亮氨酸和一种或多种选自精氨酸，天冬氨酸，苏氨酸，丝氨酸，谷氨酸，脯氨酸，甘氨酸，丙氨酸，半胱氨酸，缬氨酸，甲硫氨酸，异亮氨酸， 亮氨酸，色氨酸，苯丙氨酸，鸟氨酸，脯氨酸，赖氨酸，组氨酸和γ-氨基丁酸。 生物活性化合物的组成优选包括约10％至约70％的4-羟基异亮氨酸和约20％至约40％的其它氨基酸。 本发明的新型组合物的生物活性化合物可以从胡芦巴种子中衍生，分离和/或提取。 从葫芦巴种子提取生物活性化合物的优选方法包括以下步骤：（1）提供多种葫芦巴种子; （2）准备葫芦巴种子; （3）从葫芦巴种子中提取生物活性化合物的新组合物，其中包括初步提取步骤和二次提取步骤。 已经发现生物活性化合物的组合有助于恢复人和动物中的健康能量平衡，帮助体重管理工作，以及通过协助身体更有效地利用现有的（例如， ，内源性）胰岛素。

公开(公告)号：US20050226948A1

公开(公告)日：2005-10-13

申请号：US11068733

申请日：2005-03-01

申请人： Steve Lee ,  Richard Hynson ,  Ke-Qin Zhang ,  Wu-Zhou Li ,  Jing Zhou

发明人： Steve Lee ,  Richard Hynson ,  Ke-Qin Zhang ,  Wu-Zhou Li ,  Jing Zhou

IPC分类号： A61K31/198 ,  A61K31/401 ,  A61K31/4745 ,  A61K36/48 ,  A61K35/78

CPC分类号： A61K31/4745 ,  A61K31/198 ,  A61K31/401 ,  A61K36/48 ,  A61K2300/00

摘要： The present invention is directed to novel compositions of bio-active compounds comprising 4-hydroxyisoleucine and one or more compounds selected from the group of amino acids, alkaloids, glycosides, volatile oils, saponins, sapogenins, mannans, flavonoids, fatty acids, vitamins and provitamins, minerals, and carbohydrates. Preferably, the novel compositions of bio-active compounds include 4-hydroxyisoleucine and one or more amino acids selected from the group consisting of arginine, aspartate, threonine, serine, glutamate, proline, glycine, alanine, cysteine, valine, methionine, isoleucine, leucine, tryptophan, phenylalanine, ornithine, proline, lysine, histidine, and gamma-aminobutyrate. The composition of bio-active compounds preferably include between about ten percent and about seventy percent of 4-hydroxyisoleucine and between about twenty percent and about forty percent of other amino acids. The bio-active compounds of the novel composition of the present invention may be derived, isolated, and/or extracted from Fenugreek seeds. A preferred method for extracting the bio-active compounds from Fenugreek seeds includes the steps of: (1) providing a plurality of Fenugreek seeds; (2) preparing the Fenugreek seeds; and (3) extracting a novel composition of bio-active compounds from the Fenugreek seeds, which include a preliminary extraction step and a secondary extraction step. The compositions of bio-active compounds have been found to be helpful in restoring healthy energy balance in humans and animals, aiding in weight management efforts, and for balancing blood sugar levels by way of assisting the body to make more efficient use of existing (i.e., endogenous) insulin.

摘要翻译： 本发明涉及包含4-羟基异亮氨酸和一种或多种选自氨基酸，生物碱，糖苷，挥发性油，皂角苷，皂甙元，甘露聚糖，类黄酮，脂肪酸，维生素和/或其中的一种或多种化合物的生物活性化合物的新组合物， 维生素，矿物质和碳水化合物。 优选地，生物活性化合物的新组合物包括4-羟基异亮氨酸和一种或多种选自精氨酸，天冬氨酸，苏氨酸，丝氨酸，谷氨酸，脯氨酸，甘氨酸，丙氨酸，半胱氨酸，缬氨酸，甲硫氨酸，异亮氨酸， 亮氨酸，色氨酸，苯丙氨酸，鸟氨酸，脯氨酸，赖氨酸，组氨酸和γ-氨基丁酸。 生物活性化合物的组合物优选包括约10％至约70％的4-羟基异亮氨酸和约20％至约40％的其它氨基酸。 本发明的新型组合物的生物活性化合物可以从胡芦巴种子中衍生，分离和/或提取。 从葫芦巴种子提取生物活性化合物的优选方法包括以下步骤：（1）提供多种葫芦巴种子; （2）准备葫芦巴种子; （3）从葫芦巴种子中提取生物活性化合物的新组合物，其中包括初步提取步骤和二次提取步骤。 已经发现生物活性化合物的组合有助于恢复人和动物中的健康能量平衡，帮助体重管理工作，以及通过协助身体更有效地利用现有的（例如， ，内源性）胰岛素。