公开(公告)号：US07449471B2

公开(公告)日：2008-11-11

申请号：US11677862

申请日：2007-02-22

申请人： Andreas Gypser ,  Thomas Grote ,  Anja Schwögler ,  Joachim Rheinheimer ,  Frank Schieweck ,  Jordi Tormo i Blasco ,  Ingo Rose ,  Peter Schäfer ,  Markus Gewehr ,  Wassilios Grammenos ,  Bernd Müller ,  Eberhard Ammermann ,  Siegfried Strathmann ,  Gisela Lorenz ,  Reinhard Stierl

发明人： Andreas Gypser ,  Thomas Grote ,  Anja Schwögler ,  Joachim Rheinheimer ,  Frank Schieweck ,  Jordi Tormo i Blasco ,  Ingo Rose ,  Peter Schäfer ,  Markus Gewehr ,  Wassilios Grammenos ,  Bernd Müller ,  Eberhard Ammermann ,  Siegfried Strathmann ,  Gisela Lorenz ,  Reinhard Stierl

IPC分类号： C07D239/42 ,  C07D239/30 ,  A61K31/505 ,  A61K31/506 ,  A01N43/54

CPC分类号： C07D239/42 ,  C07D239/47 ,  C07D239/48 ,  C07D239/52 ,  C07D403/12

摘要： 5-Phenylpyrimidines of the formula I in which the substituents and the index are as defined below: R1,R2 are hydrogen, alkyl, haloalkyl, cycloalkyl, halocycloalkyl, alkenyl, haloalkenyl, alkynyl or haloalkynyl, and R1 and R2 together with the nitrogen atom to which they are attached may also form a saturated or unsaturated ring which may be interrupted by an ether, thio, sulfoxyl or sulfonyl group and may be substituted by one to four groups Ra and/or Rb; R3 is hydrogen, halogen, cyano, alkyl, haloalkyl, alkoxy, haloalkoxy or alkenyloxy; R4 is hydrogen, halogen, cyano, hydroxyl, mercapto, azido, alkyl, alkenyl, alkynyl, haloalkyl, alkoxy, alkenyloxy, alkynyloxy, haloalkoxy, alkylthio, alkenylthio, alkynylthio, haloalkylthio, —ON═CRaRb, —CRc═NORa, —NRcN═CRaRb, —NRaRb, —NRcNRaRb, —NORa, —NRcC(═NRc′)NRaRb, —NRcC(═O)NRaRb, —NRaC(═O)Rc, —NRaC(═NORc)Rc′, —OC(═O)Rc, —C(═NORc)NRaRb, —CRc(═NNRaRb), —C (═O)NRaRb or —C(═O)Rc; in which Ra, Rb and Rc are as defined in the description; X is halogen, alkyl, alkoxy or haloalkyl; and m is an integer from 1 to 5 ; processes for preparing these compounds, compositions comprising them and their use for controlling harmful fungi are described.

公开(公告)号：US07094894B2

公开(公告)日：2006-08-22

申请号：US10513030

申请日：2003-04-30

申请人： Jordi Tormo i Blasco ,  Carsten Blettner ,  Bernd Müller ,  Markus Gewehr ,  Wassilios Grammenos ,  Thomas Grote ,  Andreas Gypser ,  Joachim Rheinheimer ,  Peter Schäfer ,  Frank Schieweck ,  Anja Schwögler ,  Eberhard Ammermann ,  Siegfried Strathmann ,  Gisela Lorenz ,  Reinhard Stierl

发明人： Jordi Tormo i Blasco ,  Carsten Blettner ,  Bernd Müller ,  Markus Gewehr ,  Wassilios Grammenos ,  Thomas Grote ,  Andreas Gypser ,  Joachim Rheinheimer ,  Peter Schäfer ,  Frank Schieweck ,  Anja Schwögler ,  Eberhard Ammermann ,  Siegfried Strathmann ,  Gisela Lorenz ,  Reinhard Stierl

IPC分类号： C07D487/04 ,  A01N43/90 ,  C07C69/618

CPC分类号： C07D487/04 ,  A01N43/90 ,  C07C69/65

摘要： Disclosed are a method for producing fungicidal triazolopyrimidine compounds, agents containing said compounds, and the use thereof for controlling harmful fungi. Also disclosed are triazolopyrimidines of formula (I), in which the substituents have the following meaning: L1 represents alkyl; L2 represents halogen; L3represents hydrogen or halogen; X represents halogen, cyano, alkyl, alkoxy, or haloalkoxy; R1, R2 represent hydrogen, alkyl, haloalkyl, cycloalkyl, alkenyl, alkadienyl, alkinyl, or cycloalkinyl, phenyl, naphthyl, or a five-unit to ten-unit saturated, partially unsaturated, or aromatic heterocycle containing one to four heteroatoms from the group O, N, or S, R1 and R2 can also form a five-unit or six-unit ring along with the nitrogen atom to which they are linked. Said ring can be interrupted and/or substituted by an atom from the group O, N, and S while R1 and/or R2 can be substituted according to the description. The invention also relates to methods and intermediate products for producing said compounds, agents containing said compounds, and the use thereof for controlling harmful fungi

摘要翻译： 公开了生产杀真菌三唑并嘧啶化合物的方法，含有所述化合物的试剂及其用于控制​​有害真菌的用途。 还公开了式（I）的三唑并嘧啶，其中取代基具有以下含义：L 1表示烷基; L 2表示卤素; L 3表示氢或卤素; X表示卤素，氰基，烷基，烷氧基或卤代烷氧基; R 1，R 2代表氢，烷基，卤代烷基，环烷基，烯基，链二烯基，炔基或环炔基，苯基，萘基或五个单元至十个单元 饱和的，部分不饱和的或含有一至四个O，N或S杂原子的杂环，R 1和R 2也可以形成五单元或 六单元环与它们所连接的氮原子一起。 所述环可以被O，N和S基团的原子中断和/或取代，而R 1和/或R 2可以根据描述被取代 。 本发明还涉及用于生产所述化合物的方法和中间产物，含有所述化合物的试剂及其用于控制​​有害真菌的用途

公开(公告)号：US06855718B2

公开(公告)日：2005-02-15

申请号：US10416467

申请日：2001-11-09

申请人： Jordi Tormo i Blasco ,  Klaus Ditrich ,  Hubert Sauter ,  Oliver Cullmann ,  Markus Gewehr ,  Wassilios Grammenos ,  Bernd Müller ,  Thomas Grote ,  Andreas Gypser ,  Joachim Rheinheimer ,  Ingo Rose ,  Peter Schäfer ,  Frank Schieweck ,  Eberhard Ammermann ,  Siegfried Strathmann ,  Gisela Lorenz ,  Reinhard Stierl

发明人： Jordi Tormo i Blasco ,  Klaus Ditrich ,  Hubert Sauter ,  Oliver Cullmann ,  Markus Gewehr ,  Wassilios Grammenos ,  Bernd Müller ,  Thomas Grote ,  Andreas Gypser ,  Joachim Rheinheimer ,  Ingo Rose ,  Peter Schäfer ,  Frank Schieweck ,  Eberhard Ammermann ,  Siegfried Strathmann ,  Gisela Lorenz ,  Reinhard Stierl

IPC分类号： A01N43/90 ,  C07B53/00 ,  C07C209/62 ,  C07C211/03 ,  C07D487/04

CPC分类号： C07D487/04 ,  A01N43/90

摘要： A 7-(R)-Aminotriazolopyrimidines of formula I where the substituents and index are as defined below: R1 is hydrogen or methyl; R2 is methyl; R3 is C2-C10-alkyl, C1-C4-alkoxymethyl, C3-C10-cycloalkyl; Y is halogen, cyano, C1-C4-alkyl or C1-C4-alkoxy; where * is a center of chirality in the R configuration, processes for their preparation, compositions comprising them and their use for controlling harmful fungi.

摘要翻译： 式I的7-（R） - 氨基三唑并嘧啶，其中取代基和指数如下所定义：R 1是氢或甲基; R 2是甲基; R 3是C 2 -C 10 - 烷基，C 1 -C 4 - 烷氧基甲基，C 3 -C 10 - 环烷基; Y是卤素，氰基，C 1 -C 4 - 烷基或C 1 -C 4 - 烷氧基;其中*是R构型的手性中心，其制备方法，包含它们的组合物及其用途 用于控制有害真菌。

公开(公告)号：US07465735B2

公开(公告)日：2008-12-16

申请号：US10495280

申请日：2002-11-15

申请人： Andreas Gypser ,  Thomas Grote ,  Anja Schwögler ,  Joachim Rheinheimer ,  Frank Schieweck ,  Jordi Tormo i Blasco ,  Ingo Rose ,  Peter Schäfer ,  Markus Gewehr ,  Wassilios Grammenos ,  Bernd Müller ,  Eberhard Ammermann ,  Siegfried Strathmann ,  Gisela Lorenz ,  Reinhard Stierl

发明人： Andreas Gypser ,  Thomas Grote ,  Anja Schwögler ,  Joachim Rheinheimer ,  Frank Schieweck ,  Jordi Tormo i Blasco ,  Ingo Rose ,  Peter Schäfer ,  Markus Gewehr ,  Wassilios Grammenos ,  Bernd Müller ,  Eberhard Ammermann ,  Siegfried Strathmann ,  Gisela Lorenz ,  Reinhard Stierl

IPC分类号： C07D239/42 ,  C07D239/46 ,  C07D239/48 ,  C07D239/52 ,  C07D401/12 ,  C07D403/12 ,  A61K31/505 ,  A61K31/506 ,  A01N43/54

CPC分类号： C07D239/42 ,  C07D239/47 ,  C07D239/48 ,  C07D239/52 ,  C07D403/12

摘要： 5-Phenylpyrimidines, their preparation, compositions comprising them and their use 5-Phenylpyrimidines of the formula I in which the substituents and the index are as defined below: R1,R2 are hydrogen, alkyl, haloalkyl, cycloalkyl, halocycloalkyl, alkenyl, haloalkenyl, alkynyl or haloalkynyl, and R1 and R2 together with the nitrogen atom to which they are attached may also form a saturated or unsaturated ring which may be interrupted by an ether, thio, sulfoxyl or sulfonyl group and may be substituted by one to four groups Ra and/or Rb; R3 is hydrogen, halogen, cyano, alkyl, haloalkyl, alkoxy, haloalkoxy or alkenyloxy; R4 is hydrogen, halogen, cyano, hydroxyl, mercapto, azido, alkyl, alkenyl, alkynyl, haloalkyl, alkoxy, alkenyloxy, alkynyloxy, haloalkoxy, alkylthio, alkenylthio, alkynylthio, haloalkylthio, —ON═CRaRb, —CRc═NORa, —NRcN═CRaRb, —NRaRb, —NRcNRaRb, —NORa, —NRcC(═NRc′)NRaRb, —NRcC(═O)NRaRb, —NRaC(═O)Rc, —NRaC(═NORc)Rc′, —OC(═O)Rc, —C(═NORc)NRaRb, —CRc(═NNRaRb), —C(═O)NRaRb or —C(═O)Rc; in which Ra, Rb and Rc are as defined in the description; X is halogen, alkyl, alkoxy or haloalkyl; and m is an integer from 1 to 5; processes for preparing these compounds, compositions comprising them and their use for controlling harmful fungi are described.

摘要翻译： 其中取代基和指数如下定义的式I的5-苯基嘧啶：R1，R2是氢，烷基，卤代烷基，环烷基，卤代环烷基，烯基，卤代烯基，炔基或卤代炔基，R1和R2与氮原子一起 它们所连接的也可以形成可被醚，硫代，亚砜基或磺酰基中断的饱和或不饱和环，并且可以被一至四个基团R a和/或R b取代; R3是氢，卤素，氰基，烷基，卤代烷基，烷氧基，卤代烷氧基或烯氧基; R4是氢，卤素，氰基，羟基，巯基，叠氮基，烷基，烯基，炔基，卤代烷基，烷氧基，烯氧基，炔氧基，卤代烷氧基，烷硫基，烯硫基，炔硫基，卤代烷硫基，-ON-CRaRb，-CRc-NORa，-NRcN -CRaRb，-NRaRb，-NRcNRaRb，-NORa，-NRcC（-NRc'）NRaRb，-NRcC（-O）NRaRb，-NRaC（-O）Rc，-NRaC（-NORc）Rc'，-OC（ - O）R c，-C（-NOR c）NR a R b，-CR c（-NNR a R b）， - C（-O）NR a R b或-C（-O）R c; 其中Ra，Rb和Rc如说明书中所定义; X是卤素，烷基，烷氧基或卤代烷基; m为1〜5的整数。 描述了制备这些化合物的方法，包含它们的组合物及其用于控制​​有害真菌的用途。

公开(公告)号：US07763622B2

公开(公告)日：2010-07-27

申请号：US10532719

申请日：2003-11-04

申请人： Jordi Tormo i Blasco ,  Carsten Blettner ,  Bernd Müller ,  Markus Gewehr ,  Wassilios Grammenos ,  Thomas Grote ,  Andreas Gypser ,  Joachim Rheinheimer ,  Peter Schäfer ,  Frank Schieweck ,  Anja Schwögler ,  Eberhard Ammermann ,  Siegfried Strathmann ,  Ulrich Schöfl ,  Reinhard Stierl

发明人： Jordi Tormo i Blasco ,  Carsten Blettner ,  Bernd Müller ,  Markus Gewehr ,  Wassilios Grammenos ,  Thomas Grote ,  Andreas Gypser ,  Joachim Rheinheimer ,  Peter Schäfer ,  Frank Schieweck ,  Anja Schwögler ,  Eberhard Ammermann ,  Siegfried Strathmann ,  Ulrich Schöfl ,  Reinhard Stierl

IPC分类号： A01N43/90 ,  A61K31/519 ,  C07D471/00 ,  C07D487/00 ,  C07D491/00

CPC分类号： C07C69/65 ,  A01N43/90 ,  C07D487/04

摘要： Substituted 6-(2-halogenphenyl)-triazolopyrimidines of formula I in which R1 denote alkyl, alkenyl, alkynyl, alkadienyl, haloalkyl, haloalkenyl, cycloalkyl, phenyl, naphthyl, or a 5- or 6-membered saturated, unsaturated, or aromatic heterocycle, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, wherein R1 and R2 radicals may be substituted as defined in the description, R2 denote hydrogen, or a group mentioned for R1; or R1 and R2 together with the interjacent nitrogen atom represent a 5- or 6-membered heterocycle, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, which ring may be substituted as defined in the description; Hal is halogen; L1, L3 independently denote hydrogen, halogen, or alkyl; L2 is hydrogen, halogen, haloalkyl, or NH2, NHRb, or N(Rb)2, wherein Rb is as defined in the description, wherein at least one from L1, L2, and L3 is not hydrogen; X is halogen, cyano, alkyl, alkoxy, haloalkoxy or alkenyloxy. processes for their preparation, compositions containing them and to their use for combating phytopathogenic fungi.

摘要翻译： 取代的式I的6-（2-卤代苯基） - 三唑并嘧啶，其中R 1表示烷基，烯基，炔基，链二烯基，卤代烷基，卤代烯基，环烷基，苯基，萘基或5-或6-元饱和，不饱和或芳族杂环 含有一至四个氮原子或一至三个氮原子和一个硫或氧原子，其中R 1和R 2基团可以如说明书中所定义而被取代，R 2表示氢或R 1所提及的基团; 或R1和R2与相邻的氮原子一起表示含有1-4个氮原子或一至三个氮原子和一个硫或氧原子的5-或6-元杂环，该环可以如说明书中所定义而被取代; 卤素是卤素; L 1，L 3独立地表示氢，卤素或烷基; L2是氢，卤素，卤代烷基或NH2，NHRb或N（Rb）2，其中Rb如说明书中所定义，其中L1，L2和L3中的至少一个不是氢; X是卤素，氰基，烷基，烷氧基，卤代烷氧基或烯氧基。 其制备方法，含有它们的组合物及其用于对抗植物病原真菌的用途。

公开(公告)号：US07320975B2

公开(公告)日：2008-01-22

申请号：US10505146

申请日：2003-02-06

申请人： Frank Schieweck ,  Jordi Tormo i Blasco ,  Thomas Grote ,  Andreas Gypser ,  Bernd Müller ,  Joachim Rheinheimer ,  Ingo Rose ,  Peter Schäfer ,  Wassilios Grammenos ,  Markus Gewehr ,  Anja Schwögler ,  Carsten Blettner ,  Eberhard Ammermann ,  Siegfried Strathmann ,  Gisela Lorenz ,  Reinhard Stierl

发明人： Frank Schieweck ,  Jordi Tormo i Blasco ,  Thomas Grote ,  Andreas Gypser ,  Bernd Müller ,  Joachim Rheinheimer ,  Ingo Rose ,  Peter Schäfer ,  Wassilios Grammenos ,  Markus Gewehr ,  Anja Schwögler ,  Carsten Blettner ,  Eberhard Ammermann ,  Siegfried Strathmann ,  Gisela Lorenz ,  Reinhard Stierl

IPC分类号： C07D401/04 ,  A01N43/54

CPC分类号： C07D401/04

摘要： The invention relates to 2-(2-pyridyl)-5-phenyl-6-aminopyrimidines of formula I, wherein the substitutes and the index have the following meaning: R1 represents halogen, hydroxy, hyano, hxo, nitro, amino, mercapto, alkyl, halogenalkyl, alkenyl, alkinyl, cycloalkyl, alkoxy, halogenalkoxy, carboxyl, alkoxycarbonyl, carbamoyl, alkylaminocarbonyl, dialkylamincarbonyl, morpholinocarbonyl, pyrrolidinocarbonyl, alkylcarbonylamino, alkylamino. dialkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, hydroxysulfonyl, aminosulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl; m=0 or 1-4; R2 represents hydrogen, halogen, cyano, alkyl, halogenalkyl or alkoxy; R3, R4 represents hydrogen, alkyl, halogenalkyl, cycloalkyl, halogencycloalkyl, alkenyl, halogenalkenyl, cycloalkenyl, alkinyl, halogenalkinyl or cycloalkinyl, R3 and R4 together with the nitrogen atom to which they are connected, form a five or six-membered ring which is interrupted by an atom from the group O, N or S and/or can be substituted according to the description; R5 represents halogen, alkyl or halogenalkyl; R6 represents hydrogen or one of the known groups in R5; R7, R8 represent hydrogen, halogen, alkyl or halogenalkyl; R9 represents hydrogen, halogen, hydroxy, cyano, alkyl, alkoxy, cycloalkoxy, halogenalkoxy, alkoxycarbonyl or alkylaminocarbonyl. The invention also relates to a method and intermediate product for the production of said compound in addition to the use thereof for combating undesirable plants

摘要翻译： 本发明涉及式I的2-（2-吡啶基）-5-苯基-6-氨基嘧啶，其中取代基和指数具有以下含义：R 1表示卤素，羟基，杂环基， 烷氧基，烷氧基羰基，氨基甲酰基，烷基氨基羰基，二烷基氨基羰基，吗啉代羰基，吡咯烷基羰基，烷基羰基氨基，烷基氨基。 二烷基氨基，烷硫基，烷基亚磺酰基，烷基磺酰基，羟基磺酰基，氨基磺酰基，烷基氨基磺酰基，二烷基氨基磺酰基; m = 0或1-4; R 2表示氢，卤素，氰基，烷基，卤代烷基或烷氧基; R 3，R 4表示氢，烷基，卤代烷基，环烷基，卤代烷基，烯基，卤代烯基，环烯基，炔基，卤代炔基或环炔基，R 3 O 和R 4与它们连接的氮原子一起形成5或6元环，其被来自基团O，N或S的原子和/或可被取代 根据说明; R 5表示卤素，烷基或卤代烷基; R 6表示氢或R 5中的已知基团之一; R 7，R 8表示氢，卤素，烷基或卤代烷基; R 9表示氢，卤素，羟基，氰基，烷基，烷氧基，环烷氧基，卤代烷氧基，烷氧基羰基或烷基氨基羰基。 本发明还涉及用于生产所述化合物的方法和中间产物，除了其用于对抗不期望的植物之外

公开(公告)号：US07148227B2

公开(公告)日：2006-12-12

申请号：US10508409

申请日：2003-03-19

申请人： Jordi Tormo i Blasco ,  Carsten Blettner ,  Bernd Müller ,  Markus Gewehr ,  Wassilios Grammenos ,  Thomas Grote ,  Andreas Gypser ,  Joachim Rheinheimer ,  Peter Schäfer ,  Frank Schieweck ,  Anja Schwögler ,  Eberhard Ammermann ,  Siegfried Strathmann ,  Gisela Lorenz ,  Reinhard Stierl ,  Ulrich Schöfl

发明人： Jordi Tormo i Blasco ,  Carsten Blettner ,  Bernd Müller ,  Markus Gewehr ,  Wassilios Grammenos ,  Thomas Grote ,  Andreas Gypser ,  Joachim Rheinheimer ,  Peter Schäfer ,  Frank Schieweck ,  Anja Schwögler ,  Eberhard Ammermann ,  Siegfried Strathmann ,  Gisela Lorenz ,  Reinhard Stierl ,  Ulrich Schöfl

IPC分类号： A61K31/519 ,  C07D487/04 ,  C07C69/738

CPC分类号： C07D487/04 ,  A01N43/90 ,  C07C255/57

摘要： The invention relates to triazolopyrimidines of formula (I), in which the substituents are defined as follows: L1 represents cyano, S(═O)nA1 or C(═O)A2, wherein A1 stands for hydrogen, hydroxy, alkyl, alkylamino or dialkylamino; A2 stands for C1–C8 alkoxy, C1–C6 haloalkoxy or one of the groups named in A1; and n stands for 0, 1 or 2; L2, L3 represent hydrogen or halogen; L4, L5 represent hydrogen, halogen or alkyl; X represents halogen, cyano, alkyl, haloalkyl, alkoxy or haloalkoxy; R1 represents alkyl, haloalkyl, cycloalkyl, halocycloalkyl, alkenyl, alkadienyl, haloalkenyl, cycloalkenyl, alkynyl, haloalkynyl or cycloalkynyl, phenyl, naphthyl, or a five to ten-membered saturated, partially unsaturated or aromatic heterocyclus containing between one and four heteroatoms from the group containing O, N or S; R2 represents hydrogen or R1; R1 and R2 can form, together with the nitrogen atom to which they are bonded, a five or six-membered ring, which can be interrupted and/or substituted by an atom from the group O, N and S; whereby R1 and/or R2 can be substituted in accordance with the description. The invention also relates to methods and intermediate products for producing said compounds, to agents containing the latter and to the use of said compounds for combating harmful fungi.

摘要翻译： 本发明涉及式（I）的三唑并嘧啶，其中取代基定义如下：L 1表示氰基，S（-O）n A 1 或其中A 1代表氢，羟基，烷基，烷基氨基或二烷基氨基;或C（= O） A 2代表C 1 -C 8烷氧基，C 1 -C 6烷基，C 1 -C 6 - >卤代烷氧基或在A 中命名的基团之一; 而n代表0,1或2; L 2，L 3表示氢或卤素; L 4，L 5代表氢，卤素或烷基; X表示卤素，氰基，烷基，卤代烷基，烷氧基或卤代烷氧基; R 1表示烷基，卤代烷基，环烷基，卤代环烷基，烯基，链烯基，卤代烯基，环烯基，炔基，卤代炔基或环炔基，苯基，萘基或五至十元饱和，部分不饱和或芳族杂环 含有一个至四个来自含有O，N或S的基团的杂原子; R 2表示氢或R 1; R 1和R 2可以与它们所键合的氮原子一起形成五元或六元环，其可被中断和/或被 来自O，N和S族的原子; 其中R 1和/或R 2可以根据描述被取代。 本发明还涉及用于生产所述化合物的方法和中间产物，含有后者的试剂和所述化合物用于防治有害真菌的用途。

公开(公告)号：US06767923B2

公开(公告)日：2004-07-27

申请号：US10282023

申请日：2002-10-29

申请人： Ingo Rose ,  Jordi Tormo i Blasco ,  Markus Gewehr ,  Wassilios Grammenos ,  Bernd Müller ,  Joachim Rheinheimer ,  Peter Schäfer ,  Frank Schieweck ,  Thomas Grote ,  Andreas Gypser ,  Eberhard Ammermann ,  Gisela Lorenz ,  Reinhard Stierl ,  Siegfried Strathmann ,  Paul Carter ,  Jürgen Curtze

发明人： Ingo Rose ,  Jordi Tormo i Blasco ,  Markus Gewehr ,  Wassilios Grammenos ,  Bernd Müller ,  Joachim Rheinheimer ,  Peter Schäfer ,  Frank Schieweck ,  Thomas Grote ,  Andreas Gypser ,  Eberhard Ammermann ,  Gisela Lorenz ,  Reinhard Stierl ,  Siegfried Strathmann ,  Paul Carter ,  Jürgen Curtze

IPC分类号： A61K31215

CPC分类号： C07C323/25 ,  A01N31/16 ,  C07C43/23 ,  C07C69/017

摘要： Benzhydryl derivatives of the formula I, where the index and the variables are as defined below: X is oxygen or sulfur; R1, R3 are halogen, cyano, nitro, hydroxyl, mercapto, amino, alkyl, alkenyl, alkynyl, alkoxy, alkenyloxy, alkynyloxy, alkylcarbonyloxy, formyloxy, alkylthio, alkenylthio, alkynylthio, alkylamino, dialkylamino, alkylcarbonyl or formyl, where the carbon atoms in the radicals mentioned may be partially or fully halogenated; R2 is halogen, cyano, nitro, hydroxyl, mercapto, amino, alkyl, alkoxy, haloalkyl or haloalkoxy, where the groups R2 may be different if n=2; R4 is alkyl, alkenyl or alkynyl, where the carbon atoms in these radicals may be unsubstituted or partially or fully halogenated; R5, R6 are hydroxyl, alkyl, alkenyl, haloalkyl, haloalkenyl, alkoxy, alkenyloxy, haloalkoxy, haloalkenyloxy, cycloalkyl, cycloalkylalkyl, cycloalkoxy or cycloalkylalkoxy; n is 0, 1 or 2; processes for preparing the compounds I, compositions comprising them and their use for controlling phytopathogenic harmful fungi are described.

摘要翻译： 式I的二苯甲基衍生物，其中指数和变量如下定义：X是氧或硫; R 1，R 3是卤素，氰基，硝基，羟基，巯基，氨基，烷基，烯基， 炔基，烷氧基，烯氧基，炔氧基，烷基羰基氧基，甲酰氧基，烷硫基，烯硫基，炔硫基，烷基氨基，二烷基氨基，烷基羰基或甲酰基，其中所述基团中的碳原子可以被部分或完全卤化; R 2是卤素，氰基， 硝基，羟基，巯基，氨基，烷基，烷氧基，卤代烷基或卤代烷氧基，其中如果n = 2，基团R 2可以不同; R 4是烷基，烯基或炔基，其中这些基团中的碳原子 R 5为羟基，烷基，烯基，卤代烷基，卤代烯基，烷氧基，烯氧基，卤代烷氧基，卤代烯氧基，环烷基，环烷基烷基，环烷氧基或环烷基烷氧基; n为0,1或 2;制备化合物I的方法，包含它们的组合物及其用途 描述了植物病原性有害真菌。

公开(公告)号：US07307172B2

公开(公告)日：2007-12-11

申请号：US10484250

申请日：2002-07-16

申请人： Jordi Tormo i Blasco ,  Hubert Sauter ,  Bernd Müller ,  Markus Gewehr ,  Wassilios Grammenos ,  Thomas Grote ,  Andreas Gypser ,  Joachim Rheinheimer ,  Ingo Rose ,  Peter Schäfer ,  Frank Schieweck ,  Eberhard Ammermann ,  Siegfried Strathmann ,  Gisela Lorenz ,  Reinhard Stierl ,  Günter Krummel

发明人： Jordi Tormo i Blasco ,  Hubert Sauter ,  Bernd Müller ,  Markus Gewehr ,  Wassilios Grammenos ,  Thomas Grote ,  Andreas Gypser ,  Joachim Rheinheimer ,  Ingo Rose ,  Peter Schäfer ,  Frank Schieweck ,  Eberhard Ammermann ,  Siegfried Strathmann ,  Gisela Lorenz ,  Reinhard Stierl ,  Günter Krummel

IPC分类号： A61K31/41 ,  A01N43/653 ,  C07D249/00

CPC分类号： C07D487/04 ,  A01N43/90

摘要： The invention relates to 7-amino triazolopyrimidines of formula (I), in which the substituents have the following meanings: R1, R2 represent hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, naphthyl; or 5-membered or 6-membered heterocyclyl containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom; or 5-membered or 6-membered heteroaryl containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, or R1 and R2 can, together with the nitrogen atom, which binds them, form a 5-membered or 6-membered ring containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom; R3 represents alkyl, alkenyl, alkynyl, cycloalkyl, phenylalkyl and alkyl halide; whereby R3 and R2 can be unsubstituted or partially or completely substituted according to the description; X represents halogen, cyano, alkoxy, alkyl halide, phenyl or phenyl that is substituted by Ra. The invention also relates to methods and intermediate products for producing said compounds, to agents containing the same, and to their use.

摘要翻译： 本发明涉及式（I）的7-氨基三唑并嘧啶，其中取代基具有以下含义：R 1，R 2表示氢，烷基，烯基，炔基 ，环烷基，苯基，萘基; 或含有1至4个氮原子或1至3个氮原子和1个硫或氧原子的5元或6元杂环基; 或含有1至4个氮原子或1至3个氮原子和1个硫或氧原子的5元或6元杂芳基，或R 1和R 2可以， 与它们结合的氮原子一起形成含有一至四个氮原子或一至三个氮原子和一个硫或氧原子的五元或六元环; R 3表示烷基，烯基，炔基，环烷基，苯基烷基和烷基卤; 根据描述，R 3和R 2可以是未取代的或部分或完全取代的; X表示卤素，氰基，烷氧基，烷基卤，苯基或被R a取代的苯基。 本发明还涉及用于生产所述化合物的方法和中间产物，含有该化合物的试剂及其用途。

公开(公告)号：US07038047B2

公开(公告)日：2006-05-02

申请号：US10483599

申请日：2002-07-08

申请人： Jordi Tormo i Blasco ,  Hubert Sauter ,  Bernd Müller ,  Markus Gewehr ,  Wassilios Grammenos ,  Thomas Grote ,  Andreas Gypser ,  Joachim Rheinheimer ,  Ingo Rose ,  Peter Schäfer ,  Frank Schieweck ,  Michael Rack ,  Eberhard Ammermann ,  Siegfried Strathmann ,  Gisela Lorenz ,  Reinhard Stierl

发明人： Jordi Tormo i Blasco ,  Hubert Sauter ,  Bernd Müller ,  Markus Gewehr ,  Wassilios Grammenos ,  Thomas Grote ,  Andreas Gypser ,  Joachim Rheinheimer ,  Ingo Rose ,  Peter Schäfer ,  Frank Schieweck ,  Michael Rack ,  Eberhard Ammermann ,  Siegfried Strathmann ,  Gisela Lorenz ,  Reinhard Stierl

IPC分类号： C07D487/04 ,  C07C69/612 ,  A01N43/90

CPC分类号： C07D487/04 ,  A01N43/90

摘要： Substituted 6-(2-methoxy-phenyl)-triazolopyrimidines of formula I in which R1 and R2 independently denote hydrogen or alkyl, alkenyl, alkynyl, or alkadienyl, haloalkyl, haloalkenyl, cycloalkyl, phenyl, naphthyl, or 5- or 6-membered heterocyclyl, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, or 5- or 6-membered heteroaryl, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, or where R1 and R2 radicals may be unsubstituted or substituted as defined in the description, or R1 and R2 together with the interjacent nitrogen atom represent a 5- or 6-membered heterocyclic ring, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, which may be substituted; L1, L2 independently denote hydrogen or halogen, provided that at least one from L1 or L2 is halogen; X is halogen, cyano, alkyl, alkoxy, haloalkoxy or alkenyloxy; processes for their preparation, compositions containing them and to their use for combating phytopathogenic fungi.

摘要翻译： 其中R 1和R 2的取代的6-（2-甲氧基 - 苯基） - 三唑并嘧啶独立地表示氢或烷基，烯基，炔基或链二烯基，卤代烷基 含有1-4个氮原子或一至三个氮原子和一个硫或氧原子的卤代烯基，环烷基，苯基，萘基或5-或6-元杂环基，或含有一至四个的5-或6-元杂芳基 氮原子或一至三个氮原子和一个硫或氧原子，或其中R 1和R 2基团可以是未取代的或如说明书中定义的取代的，或R R 1和R 2与中间的氮原子一起表示含有1-4个氮原子或一至三个氮原子和一个硫原子的5-或6-元杂环 或氧原子，其可以被取代; L 1，L 2，L 2独立地表示氢或卤素，条件是至少一个L 1或L 2， 是卤素; X是卤素，氰基，烷基，烷氧基，卤代烷氧基或烯氧基; 其制备方法，含有它们的组合物及其用于对抗植物病原真菌的用途。