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    Compounds and methods for identifying activated platelets
    86.
    发明授权
    Compounds and methods for identifying activated platelets 失效
    用于鉴定活化血小板的化合物和方法

    公开(公告)号：US5646000A

    公开(公告)日：1997-07-08

    申请号：US315034

    申请日：1994-09-29

    申请人： Bohumil Bednar ,  Melissa Egbertson ,  Robert J. Gould ,  George D. Hartman ,  Jules A. Shafer

    发明人： Bohumil Bednar ,  Melissa Egbertson ,  Robert J. Gould ,  George D. Hartman ,  Jules A. Shafer

    IPC分类号： C07D401/06 ,  C07D405/14 ,  C07D491/22 ,  C07D495/04 ,  G01N33/569 ,  G01N33/80 ,  G01N33/86 ,  G01N33/567 ,  C07D401/14

    CPC分类号： C07D401/06 ,  C07D405/14 ,  C07D495/04 ,  G01N33/56966 ,  G01N33/80 ,  G01N33/86 ,  G01N2500/00 ,  Y10S436/80 ,  Y10S436/811

    摘要： The invention is directed to a series of novel compounds, and their pharmaceutically acceptable salts, of the formula ##STR1## wherein R is C.sub.0-6 alkyl substituted with R.sup.5 or a mono or polycyclic aromatic or heteroaromatic system comprised of 5 or 6-membered aromatic or heteroaromatic rings that are either unsubstituted or substituted with one or more of R.sup.1 and R.sup.2 ; R.sup.1 and R.sup.2 are independently C.sub.1-6 alkyl, carboxyl, hydroxyl, azido, nitro, amino, C.sub.1-6 alkylamino, C.sub.1-6 dialkylamino, arylamino, aryl C.sub.1-6 alkylamino, hydroxysulfonyl or arylazo; aryl is a phenyl or naphthyl ring which is unsubstituted or substituted with one or more of R.sup.3 and R.sup.4 ; R.sup.3 and R.sup.4 are independently C.sub.1-6 alkyl, azido, nitro, amino, C.sub.1-6 dialkylamino or hydroxysulfonyl; R.sup.5 is ##STR2## provided that when R is an unsubstituted monocyclic ring, the monocyclic ring is not phenyl or pyridyl. Such compounds are useful as fluorescent probes for identifying antiplatelet agents which selectively bind to activated platelets.

    摘要翻译： 本发明涉及一系列新颖的化合物及其药学上可接受的盐，其中R是被R 5取代的C 1-6烷基或由5或6元芳族的单或多环芳族或杂芳族体系 或未被取代或被一个或多个R 1和R 2取代的杂芳环; R 1和R 2独立地是C 1-6烷基，羧基，羟基，叠氮基，硝基，氨基，C 1-6烷基氨基，C 1-6二烷基氨基，芳基氨基，芳基C 1-6烷基氨基，羟基磺酰基或芳基偶氮; 芳基是未被取代或被一个或多个R 3和R 4取代的苯基或萘基环; R 3和R 4独立地为C 1-6烷基，叠氮基，硝基，氨基，C 1-6二烷基氨基或羟基磺酰基; R5是或，条件是当R是未取代的单环时，单环不是苯基或吡啶基。 这样的化合物可用作识别选择性结合活化血小板的抗血小板剂的荧光探针。