公开(公告)号：US20120165794A1

公开(公告)日：2012-06-28

申请号：US12976761

申请日：2010-12-22

申请人： Mark S. Ortiz ,  Christopher J. Hess ,  Jason L. Harris ,  James W. Voegele ,  Mark S. Zeiner ,  Mark D. Overmyer ,  Joseph B. Kraimer ,  Jeff Shimizu ,  Rocco Crivelli ,  Yanik Tardy ,  Thierry Utard ,  Juergen Burger ,  Toralf Bork ,  Martin Pfleiderer ,  Olivier Chossat

发明人： Mark S. Ortiz ,  Christopher J. Hess ,  Jason L. Harris ,  James W. Voegele ,  Mark S. Zeiner ,  Mark D. Overmyer ,  Joseph B. Kraimer ,  Jeff Shimizu ,  Rocco Crivelli ,  Yanik Tardy ,  Thierry Utard ,  Juergen Burger ,  Toralf Bork ,  Martin Pfleiderer ,  Olivier Chossat

IPC分类号： A61M31/00

CPC分类号： A61B1/041 ,  A61B1/00147 ,  A61F5/0013 ,  A61M31/002

摘要： Devices and related methods are provided for the controlled delivery of a therapeutic to a targeted location within a body. More particularly, methods and devices are provided for controlling the rate of passage of an orally administered pill through a body, as well as for controlling the delivery of a therapeutic within the pill at a specific location within the body. Various types of devices, generally referred to herein as “catchers,” are provided that can actively catch a pill as it passes through a body. The catcher can hold the pill at a specific location within the body until a predetermined event occurs, such as partial or complete administration of a therapeutic within the pill. The catcher can then release the pill upon command and/or upon the occurrence of the predetermined event to allow the pill to pass out of the body. In other embodiments, various types of pills are provided that can actively engage a catcher and remain engaged with the catcher until a predetermined event occurs.

公开(公告)号：US20110295151A1

公开(公告)日：2011-12-01

申请号：US13104282

申请日：2011-05-10

申请人： Gregory J. Bakos ,  Edward G. Chekan ,  Denzel Z. Herrera-Davis ,  Jason L. Harris ,  Gary L. Long ,  Rudolph H. Nobis ,  Mark S. Ortiz ,  Mark D. Overmyer ,  David N. Plescia ,  Randy J. Seeley ,  William B. Weisenburgh, II ,  Tamara S. Vetro Widenhouse ,  Mark S. Zeiner ,  Andrew M. Zwolinski

发明人： Gregory J. Bakos ,  Edward G. Chekan ,  Denzel Z. Herrera-Davis ,  Jason L. Harris ,  Gary L. Long ,  Rudolph H. Nobis ,  Mark S. Ortiz ,  Mark D. Overmyer ,  David N. Plescia ,  Randy J. Seeley ,  William B. Weisenburgh, II ,  Tamara S. Vetro Widenhouse ,  Mark S. Zeiner ,  Andrew M. Zwolinski

IPC分类号： A61M37/00 ,  A61P3/00 ,  A61K9/00 ,  A61F2/04 ,  A61K49/00 ,  A61P3/04 ,  A61B10/02 ,  A61M5/00 ,  A61K35/55 ,  A61K9/20

CPC分类号： C12N5/0679 ,  A61K35/12 ,  A61K35/38 ,  A61L27/14 ,  A61L27/3882 ,  A61L27/58 ,  A61L31/04 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/64

摘要： L-cells may be introduced in the gastrointestinal tract. L-cells are used in the digestive process to produce a more efficient and lasting means of regulating feelings of satiation in a patient. Desired metabolic effects may be achieved by manipulating L-cells via delivery sites, frequency of delivery, or type of biological substance delivered.

摘要翻译： L细胞可能被引入胃肠道。 L细胞用于消化过程，以产生更有效和持久的调节患者饱腹感的手段。 所需的代谢作用可以通过经由递送部位操纵L细胞，递送频率或递送的生物物质的类型来实现。

公开(公告)号：US20100114145A1

公开(公告)日：2010-05-06

申请号：US12261096

申请日：2008-10-30

申请人： THOMAS E. ALBRECHT ,  Jason L. Harris ,  Mark S. Ortiz ,  Mark S. Zeiner ,  Amy L. Marcotte ,  Daniel F. Dlugos, JR.

发明人： THOMAS E. ALBRECHT ,  Jason L. Harris ,  Mark S. Ortiz ,  Mark S. Zeiner ,  Amy L. Marcotte ,  Daniel F. Dlugos, JR.

IPC分类号： A61M29/00

CPC分类号： A61F5/0046

摘要： A device, including an implant for placement within a hollow body organ. The implant includes a member having an undeployed shape for delivery within a hollow body and one or more deployed shapes for implantation therein. The member has sufficient rigidity in its deployed shape to exert an outward force against an interior of the hollow body so as to bring together two substantially opposing surfaces of the hollow body. The device includes a means for changing the deployed shape of the member while implanted within the hollow body. The means includes an antenna configured to wirelessly communicate with an external device. The external device is configured to communicate telemetrically with the member. The device further includes at least one means to limit rotational movement of the antenna relative at least one of the member and the external device.

摘要翻译： 一种装置，包括用于放置在中空身体器官内的植入物。 植入物包括具有用于在中空体内递送的未展开形状的构件和用于植入其中的一个或多个展开形状。 该构件在其展开形状上具有足够的刚度以向中空体的内部施加向外的力，以将中空体的两个基本相对的表面组合在一起。 该装置包括用于在植入中空体内时改变构件的展开形状的装置。 该装置包括配置成与外部设备无线通信的天线。 外部设备被配置为与成员进行遥测通信。 该装置还包括至少一个装置，用于限制天线相对于构件和外部装置中的至少一个的旋转运动。

公开(公告)号：US20100114144A1

公开(公告)日：2010-05-06

申请号：US12261093

申请日：2008-10-30

申请人： Thomas E. ALBRECHT ,  Jason L. Harris ,  Mark S. ORTIZ ,  Mark S. ZEINER ,  Daniel F. Dlugos, JR.

发明人： Thomas E. ALBRECHT ,  Jason L. Harris ,  Mark S. ORTIZ ,  Mark S. ZEINER ,  Daniel F. Dlugos, JR.

IPC分类号： A61M29/02

CPC分类号： A61F5/0036 ,  A61F5/0046

摘要： An implant for placement within a hollow body organ. The implant includes an implantable distension device having an undeployed shape for delivery within a hollow body and one or more deployed shapes for implantation therein. The implantable distension device has sufficient rigidity in its deployed shape to exert an outward force against an interior of the hollow body so as to bring together two substantially opposing surfaces of the hollow body. The implant includes a powered means for changing the deployed shape of the implantable distension device while implanted within the hollow body. The implant also includes an implantable sensing device in communication with the implantable distension device and configured to sense a parameter related to the implantable distension device and to communicate the parameter to a filter, the filter transmits a selected portion of the parameter to a data storage device.

摘要翻译： 用于放置在中空身体器官内的植入物。 植入物包括具有用于在中空体内递送的未部署形状的植入式扩张装置和用于植入其中的一种或多种展开形状。 可植入膨胀装置的展开形状具有足够的刚性，以向中空体的内部施加向外的力，从而将中空体的两个基本相对的表面组合在一起。 植入物包括用于在植入在中空体内时改变可植入膨胀装置的展开形状的动力装置。 所述植入物还包括与所述可植入扩张装置通信并被配置为感测与所述可植入膨胀装置相关的参数并且将所述参数传递到过滤器的可植入感测装置，所述过滤器将所述参数的选定部分发送到数据存储装置 。

公开(公告)号：US09119615B2

公开(公告)日：2015-09-01

申请号：US13326625

申请日：2011-12-15

申请人： Kevin D. Felder ,  Lawrence Crainich ,  Justin W. Sherrill ,  Jason L. Harris ,  Mark S. Zeiner ,  Brian F. DiNardo

发明人： Kevin D. Felder ,  Lawrence Crainich ,  Justin W. Sherrill ,  Jason L. Harris ,  Mark S. Zeiner ,  Brian F. DiNardo

IPC分类号： A61B17/068 ,  A61B17/072

CPC分类号： A61B17/068 ,  A61B17/00234 ,  A61B17/0686 ,  A61B17/072 ,  A61B17/07207 ,  A61B90/361 ,  A61B2017/00278 ,  A61B2017/00314 ,  A61B2017/00327 ,  A61B2017/00349 ,  A61B2017/00353 ,  A61B2017/00818 ,  A61B2017/00862 ,  A61B2017/0647 ,  A61B2017/07271 ,  A61B2017/07278 ,  A61B2017/2926 ,  A61B2017/2936 ,  A61B2017/2941 ,  A61B2017/2943 ,  A61B2017/2944 ,  A61B2017/308 ,  A61F5/0083

摘要： Devices and methods are provided for forming and securing a tissue plication. More particularly, the devices and methods of the present invention can be used to create multiple tissue folds on an anterior and posterior wall of a stomach cavity to reduce the volume thereof. In one aspect, a tissue acquisition and fixation system is described that includes a staple applying assembly having first and second jaws, and a tissue acquisition member that extends substantially parallel to a plane running through the first and second jaws. The tissue acquisition member is effective to engage and position tissue between the first and second jaws, and the jaws are effective to apply at least one staple to the tissue engaged therebetween.

摘要翻译： 提供了用于形成和固定组织浸液的装置和方法。 更具体地，本发明的装置和方法可用于在胃腔的前壁和后壁上产生多个组织折叠以减小其体积。 在一个方面，描述了一种组织采集和固定系统，其包括具有第一和第二钳口的缝合钉施加组件，以及基本上平行于穿过第一和第二钳口的平面延伸的组织采集构件。 组织采集构件有效地在第一和第二钳口之间接合和定位组织，并且钳口有效地将至少一个钉施加到接合在其间的组织。

公开(公告)号：US09113867B2

公开(公告)日：2015-08-25

申请号：US13326643

申请日：2011-12-15

申请人： Kevin D. Felder ,  Lawrence Crainich ,  Justin W. Sherrill ,  Jason L. Harris ,  Mark S. Zeiner ,  Brian F. DiNardo

发明人： Kevin D. Felder ,  Lawrence Crainich ,  Justin W. Sherrill ,  Jason L. Harris ,  Mark S. Zeiner ,  Brian F. DiNardo

IPC分类号： A61B17/068 ,  A61B17/072 ,  A61B17/00 ,  A61B19/00 ,  A61B17/064 ,  A61B17/29 ,  A61B17/30 ,  A61F5/00

CPC分类号： A61B17/068 ,  A61B17/00234 ,  A61B17/0686 ,  A61B17/072 ,  A61B17/07207 ,  A61B90/361 ,  A61B2017/00278 ,  A61B2017/00314 ,  A61B2017/00327 ,  A61B2017/00349 ,  A61B2017/00353 ,  A61B2017/00818 ,  A61B2017/00862 ,  A61B2017/0647 ,  A61B2017/07271 ,  A61B2017/07278 ,  A61B2017/2926 ,  A61B2017/2936 ,  A61B2017/2941 ,  A61B2017/2943 ,  A61B2017/2944 ,  A61B2017/308 ,  A61F5/0083

摘要： Devices and methods are provided for forming and securing a tissue plication. More particularly, the devices and methods of the present invention can be used to create tissue folds on an anterior and posterior wall of a stomach cavity to reduce the volume thereof. In one aspect, a tissue acquisition and fixation system is disclosed that includes an elongate shaft, an end effector coupled to the elongate shaft and having first and second jaws, and a tissue acquisition member coupled to the end effector by a linkage assembly. At least a portion of the linkage assembly and tissue acquisition member are slidably movable in a direction parallel to a longitudinal axis of the jaws. Further, the tissue acquisition member is vertically movable relative to the end effector such that a distance between a longitudinal axis of the tissue acquisition member and the jaws can be adjusted.

摘要翻译： 提供了用于形成和固定组织浸液的装置和方法。 更具体地，本发明的装置和方法可用于在胃腔的前壁和后壁上产生组织褶皱，以减小其体积。 在一个方面，公开了一种组织采集和固定系统，其包括细长轴，连接到细长轴并具有第一和第二钳口的端部执行器，以及通过连杆组件联接到末端执行器的组织采集构件。 连杆组件和组织采集构件的至少一部分可在平行于钳口的纵向轴线的方向上可滑动地移动。 此外，组织采集构件相对于末端执行器可垂直移动，使得可以调节组织采集构件的纵向轴线与夹爪之间的距离。

公开(公告)号：US08812100B2

公开(公告)日：2014-08-19

申请号：US13468858

申请日：2012-05-10

申请人： James W. Voegele ,  Thomas E. Albrecht ,  Tamara C. Baynham ,  David Cagle ,  Anthony R. DiUbaldi ,  Jason L. Harris ,  Michael A. Murray ,  Mark S. Zeiner ,  Jacob Crabtree

发明人： James W. Voegele ,  Thomas E. Albrecht ,  Tamara C. Baynham ,  David Cagle ,  Anthony R. DiUbaldi ,  Jason L. Harris ,  Michael A. Murray ,  Mark S. Zeiner ,  Jacob Crabtree

IPC分类号： A61N1/00

CPC分类号： A61N1/36017 ,  A61N1/0408 ,  A61N1/0456 ,  A61N1/0476 ,  A61N1/0492 ,  A61N1/205 ,  A61N1/36014 ,  A61N1/36085

摘要： Self-positioning of at least a portion of a transdermal electrical stimulation patch within a target area (e.g., supraclavicular fossa region) of a human body to activate a depot of brown adipose tissue therein. An electric field is generated using the electrical stimulation patch to activate the brown adipose tissue within the supraclavicular fossa region of the body. The patch is self-positioned using one or more anatomical points (e.g., anatomical landmarks and/or anatomical features) or markings on the body. Brown adipose tissue may also be activated by applying an electrical signal to a body piercing partially implanted proximate a target area in which the tissue is disposed.

摘要翻译： 至少一部分透皮电刺激贴片在人体的目标区域（例如，锁骨上窝窝区域）内自我定位，以激活其中的棕色脂肪组织储存库。 使用电刺激贴片产生电场以激活身体锁骨内窝内的棕色脂肪组织。 贴片使用人体上的一个或多个解剖点（例如解剖学标记和/或解剖特征）或标记进行自定位。 褐色脂肪组织也可以通过将电信号施加到靠近其中设置组织的目标区域部分植入的身体来激活。

公开(公告)号：US20130304175A1

公开(公告)日：2013-11-14

申请号：US13468858

申请日：2012-05-10

申请人： James W. Voegele ,  Thomas E. Albrecht ,  Tamara C. Baynham ,  David Cagle ,  Jacob Crabtree ,  Anthony R. DiUbaldi ,  Jason L. Harris ,  Michael A. Murray ,  Mark S. Zeiner

发明人： James W. Voegele ,  Thomas E. Albrecht ,  Tamara C. Baynham ,  David Cagle ,  Jacob Crabtree ,  Anthony R. DiUbaldi ,  Jason L. Harris ,  Michael A. Murray ,  Mark S. Zeiner

IPC分类号： A61N1/04

CPC分类号： A61N1/36017 ,  A61N1/0408 ,  A61N1/0456 ,  A61N1/0476 ,  A61N1/0492 ,  A61N1/205 ,  A61N1/36014 ,  A61N1/36085

摘要： Self-positioning of at least a portion of a transdermal electrical stimulation patch within a target area (e.g., supraclavicular fossa region) of a human body to activate a depot of brown adipose tissue therein. An electric field is generated using the electrical stimulation patch to activate the brown adipose tissue within the supraclavicular fossa region of the body. The patch is self-positioned using one or more anatomical points (e.g., anatomical landmarks and/or anatomical features) or markings on the body. Brown adipose tissue may also be activated by applying an electrical signal to a body piercing partially implanted proximate a target area in which the tissue is disposed.

摘要翻译： 至少一部分透皮电刺激贴片在人体的目标区域（例如，锁骨上窝窝区域）内自我定位，以激活其中的棕色脂肪组织储存库。 使用电刺激贴片产生电场以激活身体锁骨内窝内的棕色脂肪组织。 贴片使用人体上的一个或多个解剖点（例如解剖学标记和/或解剖特征）或标记进行自定位。 褐色脂肪组织也可以通过将电信号施加到靠近其中设置组织的目标区域部分植入的身体来激活。

公开(公告)号：US20130153622A1

公开(公告)日：2013-06-20

申请号：US13326634

申请日：2011-12-15

申请人： Kevin D. Felder ,  Lawrence Crainich ,  Justin W. Sherrill ,  Jason L. Harris ,  Mark S. Zeiner

发明人： Kevin D. Felder ,  Lawrence Crainich ,  Justin W. Sherrill ,  Jason L. Harris ,  Mark S. Zeiner

IPC分类号： A61B17/068

CPC分类号： A61B17/068 ,  A61B17/00234 ,  A61B17/0686 ,  A61B17/072 ,  A61B17/07207 ,  A61B90/361 ,  A61B2017/00278 ,  A61B2017/00314 ,  A61B2017/00327 ,  A61B2017/00349 ,  A61B2017/00353 ,  A61B2017/00818 ,  A61B2017/00862 ,  A61B2017/0647 ,  A61B2017/07271 ,  A61B2017/07278 ,  A61B2017/2926 ,  A61B2017/2936 ,  A61B2017/2941 ,  A61B2017/2943 ,  A61B2017/2944 ,  A61B2017/308 ,  A61F5/0083

摘要： Devices and methods are provided for forming and securing a tissue plication. More particularly, the devices and methods of the present invention can be used to create multiple tissue folds on an anterior and posterior wall of a stomach cavity to reduce the volume thereof. In one aspect, a method of acquiring and fixating tissue is disclosed that includes inserting a surgical device having first and second jaws and a tissue acquisition member into a body lumen, positioning the device in a first position in which the jaws extend substantially parallel to a tissue surface, drawing tissue through the jaws by moving the tissue acquisition member away from the jaws, and driving at least one fastener through the tissue disposed between the jaws.

摘要翻译： 提供了用于形成和固定组织浸液的装置和方法。 更具体地，本发明的装置和方法可用于在胃腔的前壁和后壁上产生多个组织折叠以减小其体积。 一方面，公开了一种获取和固定组织的方法，包括将具有第一和第二钳口的外科手术装置和组织采集构件插入体腔，将装置定位在第一位置，其中钳口基本上平行于 组织表面，通过将组织采集构件移离爪而将组织穿过夹爪，并且通过设置在夹爪之间的组织驱动至少一个紧固件。

公开(公告)号：US20110295056A1

公开(公告)日：2011-12-01

申请号：US13104223

申请日：2011-05-10

申请人： Jeffrey L. Aldridge ,  Michael S. Cropper ,  Denzel Z. Herrera-Davis ,  Daniel F. Dlugos, JR. ,  Jason L. Harris ,  John V. Hunt ,  Prasanna Malaviya ,  Jeffrey D. Messerly ,  Mark S. Ortiz ,  Mark D. Overmyer ,  Galen C. Robertson ,  Frederick E. Shelton, IV ,  Foster B. Stulen ,  Suzanne Thompson ,  James W. Voegele ,  Lauren S. Weaner ,  Christopher W. Widenhouse ,  Tamara S. Vetro Widenhouse ,  David C. Yates ,  Mark S. Zeiner

发明人： Jeffrey L. Aldridge ,  Michael S. Cropper ,  Denzel Z. Herrera-Davis ,  Daniel F. Dlugos, JR. ,  Jason L. Harris ,  John V. Hunt ,  Prasanna Malaviya ,  Jeffrey D. Messerly ,  Mark S. Ortiz ,  Mark D. Overmyer ,  Galen C. Robertson ,  Frederick E. Shelton, IV ,  Foster B. Stulen ,  Suzanne Thompson ,  James W. Voegele ,  Lauren S. Weaner ,  Christopher W. Widenhouse ,  Tamara S. Vetro Widenhouse ,  David C. Yates ,  Mark S. Zeiner

IPC分类号： A61F2/04

CPC分类号： A61F5/0083 ,  A61B17/00234 ,  A61B17/064 ,  A61B17/12136 ,  A61B17/12159 ,  A61B17/1355 ,  A61B2017/00035 ,  A61B2017/00557 ,  A61B2017/00632 ,  A61B2017/00818 ,  A61B2017/00898 ,  A61B2017/1142 ,  A61F5/004 ,  A61F5/0056

摘要： Devices and methods for modifying stomach volume include the formation of intragastric slots for wrapping one or more portions of the fundus therethrough with minimal interference with nerves and vasculature flow. Intragastric space occupying devices expand with environmental changes brought about by natural conditions inherent to the digestive cycle such as with changes in pH. Extragastric volume occupying balloons are placed into folded stomach sections. The balloons are fluidly coupled to external gastric filling devices. In yet another set of embodiments, methods and devices provide adjustable gastric volume reduction fundal wraps. In one embodiment, a device is placed in the fundus for Nissen fundoplication and permits postoperative adjustment to reach desired weight loss. Intragastric and extragastric balloons are optionally incorporated.

摘要翻译： 用于改变胃体积的装置和方法包括形成胃内狭槽，用于以最小的神经和脉管系统流动的干扰来包裹眼底的一个或多个部分。 内部空间占据装置随着消化循环固有的自然条件（如pH变化）带来的环境变化而扩大。 腹腔积气囊放置在折叠的胃部。 气囊流体地联接到外部胃灌注装置。 在另一组实施方案中，方法和装置提供可调节的胃体积减少基底包裹。 在一个实施例中，将装置放置在眼底以进行尼森眼底切开术，并允许术后调整以达到期望的体重减轻。 肠内和胃内气囊任选并入。