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105 条记录 (耗时 0.068 秒)

    Substituted pyrroline kinase inhibitors
    87.
    发明申请
    Substituted pyrroline kinase inhibitors 审中-公开
    取代的吡咯啉激酶抑制剂

    公开(公告)号：US20090093515A1

    公开(公告)日：2009-04-09

    申请号：US12284452

    申请日：2008-09-22

    申请人： Han-Cheng Zhang ,  Bruce E. Maryanoff ,  Hong Ye

    发明人： Han-Cheng Zhang ,  Bruce E. Maryanoff ,  Hong Ye

    IPC分类号： A61K31/437

    CPC分类号： C07D471/04

    摘要： The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.

    摘要翻译： 本发明涉及用作激酶或双重激酶抑制剂的新型取代的吡咯啉化合物以及用于治疗或改善激酶或双重激酶介导的病症的方法。

    Indazole peptidomimetics as thrombin receptor antagonists
    89.
    发明授权
    Indazole peptidomimetics as thrombin receptor antagonists 有权
    吲唑类似物作为凝血酶受体拮抗剂

    公开(公告)号：US07417030B2

    公开(公告)日：2008-08-26

    申请号：US11393529

    申请日：2006-03-30

    申请人： Han-Cheng Zhang ,  Bruce E. Maryanoff ,  Anjali Pandey ,  Robert M. Scarborough

    发明人： Han-Cheng Zhang ,  Bruce E. Maryanoff ,  Anjali Pandey ,  Robert M. Scarborough

    IPC分类号： A61K38/00 ,  A61K31/416 ,  C07K5/00 ,  C07D277/04

    CPC分类号： C07K5/06078 ,  A61K31/416 ,  A61K38/00

    摘要： The invention is directed to novel indazole peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, Angiogenesis related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted indazole peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.

    摘要翻译： 本发明涉及可用作治疗与血栓形成，再狭窄，高血压，心力衰竭，心律失常，炎症，心绞痛，中风，动脉粥样硬化，缺血性疾病，血管发生相关疾病，癌症相关的疾病的凝血酶受体拮抗剂的新型吲唑拟肽化合物 ，和神经变性疾病。 还公开了包含本发明的取代的吲唑肽模拟物的药物组合物和治疗由凝血酶受体介导的病症的方法。

    Tricyclic indanyls as integrin inhibitors
    90.
    发明授权
    Tricyclic indanyls as integrin inhibitors 有权
    三环茚满酮作为整合素抑制剂

    公开(公告)号：US07351711B2

    公开(公告)日：2008-04-01

    申请号：US10900764

    申请日：2004-07-28

    申请人： William A. Kinney ,  Diane K. Luci ,  Bruce E. Maryanoff

    发明人： William A. Kinney ,  Diane K. Luci ,  Bruce E. Maryanoff

    IPC分类号： C07D401/12 ,  C07D471/04 ,  A61K31/435

    CPC分类号： C04B35/632 ,  C07D401/12 ,  C07D471/04

    摘要： The present invention is directed to substituted indanyl compounds of Formula (I): Useful for treating integrin-mediated disorders such as, but not limited to unstable angina, thromboemboic disorders, osteoporosis, growth and metastasis of malignant tumors, diabetic retinopathy, arthritis, viral disease and surgical adhesions.

    摘要翻译： 本发明涉及式（I）的取代的茚满基化合物：可用于治疗整联蛋白介导的病症，例如但不限于不稳定性心绞痛，血栓栓塞障碍，骨质疏松症，恶性肿瘤的生长和转移，糖尿病性视网膜病变，关节炎，病毒 疾病和手术粘连。