Response regulator polynucleotides
    81.
    发明授权
    Response regulator polynucleotides 失效
    响应调节多核苷酸

    公开(公告)号:US5962259A

    公开(公告)日:1999-10-05

    申请号:US771783

    申请日:1996-12-20

    摘要: Novel response regulator polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides and polypeptides for the treatment of infection, particularly bacterial infections. Antagonists against such the polypeptides of the invention and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence the nucleic acid sequences and the polypeptides of the invention in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding response regulators and for detecting the polypeptide in a host.

    摘要翻译: 公开了新型的响应调节剂多肽和编码这种多肽的DNA(RNA)以及通过重组技术产生此类多肽的方法。 还公开了利用这种多核苷酸和多肽治疗感染,特别是细菌感染的方法。 还公开了抗这些本发明多肽的拮抗剂及其作为治疗感染,特别是细菌感染的治疗剂的用途。 还公开了用于检测与宿主中本发明的核酸序列和多肽相关的疾病的诊断测定法。 还公开了用于检测编码响应调节剂的多核苷酸和用于在宿主中检测多肽的诊断测定。

    DNA molecules and vectors regarding clavulanic acid biosynthesis enzymes
    84.
    发明授权
    DNA molecules and vectors regarding clavulanic acid biosynthesis enzymes 失效
    关于克拉维酸生物合成酶的DNA分子和载体

    公开(公告)号:US5759831A

    公开(公告)日:1998-06-02

    申请号:US159950

    申请日:1993-12-01

    CPC分类号: C12N15/52 C12P17/188

    摘要: DNA sequences obtained from S. clavuligerus, recombinant vectors incorporating such sequences and hosts transformed with such vectors are disclosed. The DNA comprises one or more genes encoding one or more enzymes involved in the biosynthesis of clavulanic acid and may be used to improve the yield of clavulanic acid produced by clavulanic acid-producing organisms such as S. clavuligerus ATCC 27064.

    摘要翻译: 公开了从S.clavuligerus获得的DNA序列,结合这样的序列的重组载体和用这些载体转化的宿主。 DNA包含编码参与克拉维酸生物合成的一种或多种酶的一种或多种基因,并且可用于提高由克拉维酸产生生物体如克拉维氏菌ATCC 27064产生的克拉维酸的产量。

    FtsH from Staphylococcus aureus
    86.
    发明授权
    FtsH from Staphylococcus aureus 失效
    来自金黄色葡萄球菌的FtsH

    公开(公告)号:US06573066B1

    公开(公告)日:2003-06-03

    申请号:US08816177

    申请日:1997-03-12

    IPC分类号: C12P2106

    CPC分类号: C07K14/31 A61K38/00 A61K39/00

    摘要: The invention provides ftsH polypeptides, polynucleotides encoding ftsH polypeptides and related polynucleotides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic methods for detecting Staphylococcus aureus.

    摘要翻译: 本发明提供ftsH多肽,编码ftsH多肽的多核苷酸和相关多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了用于检测金黄色葡萄球菌的诊断方法。

    Fibronectin binding proteins
    87.
    发明授权
    Fibronectin binding proteins 失效
    纤连蛋白结合蛋白

    公开(公告)号:US06461614B1

    公开(公告)日:2002-10-08

    申请号:US09490011

    申请日:2000-01-21

    IPC分类号: A61K3902

    摘要: The invention provides Fibronectin Binding Protein polypeptides and DNA (RNA) encoding Fibronectin Binding Protein polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Fibronectin Binding Protein polypeptides to screen for antibacterial compounds.

    摘要翻译: 本发明提供纤连蛋白结合蛋白多肽和编码纤连蛋白结合蛋白多肽的DNA(RNA)和通过重组技术产生这种多肽的方法。 还提供了利用纤连蛋白结合蛋白多肽筛选抗菌化合物的方法。

    Compounds
    89.
    发明授权
    Compounds 失效
    化合物

    公开(公告)号:US06284489B1

    公开(公告)日:2001-09-04

    申请号:US09347333

    申请日:1999-07-02

    IPC分类号: C12P2106

    CPC分类号: C12N9/93 A61K38/00 A61K39/00

    摘要: The invention provides tyrS polypeptides and DNA (RNA) encoding tyrS polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tyrS polypeptides to screen for antibacterial compounds.

    摘要翻译: 本发明提供了tyrS多肽和编码tyrS多肽的DNA(RNA),以及通过重组技术产生此类多肽的方法。 还提供了利用tyrS多肽筛选抗菌化合物的方法。

    Glutamyl-tRNA synthetase from Staphylococcus aureus
    90.
    发明授权
    Glutamyl-tRNA synthetase from Staphylococcus aureus 失效
    来自金黄色葡萄球菌的谷氨酰-tRNA合成酶

    公开(公告)号:US06218159B1

    公开(公告)日:2001-04-17

    申请号:US08913578

    申请日:1997-09-16

    IPC分类号: C12N900

    摘要: The invention provides glutamyl-tRNA synthetase polypeptides and DNA (RNA) encoding glutamyl-tRNA synthetase polypeptides from Staphylococcus aureus. The invention also provides methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such polypeptides for protection against infection, particularly bacterial infections.

    摘要翻译: 本发明提供谷氨酰-tRNA合成酶多肽和编码来自金黄色葡萄球菌的谷氨酰-tRNA合成酶多肽的DNA(RNA)。 本发明还提供了通过重组技术产生这种多肽的方法。 还提供了利用这些多肽来保护免受感染,特别是细菌感染的方法。