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公开(公告)号:US07842787B2
公开(公告)日:2010-11-30
申请号:US11928880
申请日:2007-10-30
申请人: Andrew George Popplewell , Simon Peter Tickle , Karen Zinkewich-Peotti , Robert Kendall Morrison
发明人: Andrew George Popplewell , Simon Peter Tickle , Karen Zinkewich-Peotti , Robert Kendall Morrison
IPC分类号: C07K16/00
CPC分类号: C07K16/2863 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565
摘要: There are disclosed antibody molecules containing at least on CDR derived from a mouse monoclonal antibody having specificity for human KDR. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases in which VEGF and/or KDR are implicated.
摘要翻译: 公开了至少含有来源于对人KDR具有特异性的小鼠单克隆抗体的CDR的抗体分子。 还公开了CDR移植抗体,其中至少一个CDR是杂交CDR。 进一步公开的是编码抗体分子链,载体,转化的宿主细胞的链DNA序列以及抗体分子用于治疗其中涉及VEGF和/或KDR的疾病的用途。
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公开(公告)号:US20090269840A1
公开(公告)日:2009-10-29
申请号:US11928880
申请日:2007-10-30
申请人: Andrew George Popplewell , Simon Peter Tickle , Karen Zinkewich-Peotti , Robert Kendall Morrison
发明人: Andrew George Popplewell , Simon Peter Tickle , Karen Zinkewich-Peotti , Robert Kendall Morrison
CPC分类号: C07K16/2863 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565
摘要: There are disclosed antibody molecules containing at least on CDR derived from a mouse monoclonal antibody having specificity for human KDR. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases in which VEGF and/or KDR are implicated.
摘要翻译: 公开了至少含有来源于对人KDR具有特异性的小鼠单克隆抗体的CDR的抗体分子。 还公开了CDR移植抗体,其中至少一个CDR是杂交CDR。 进一步公开的是编码抗体分子链,载体,转化的宿主细胞的链DNA序列以及抗体分子用于治疗其中涉及VEGF和/或KDR的疾病的用途。
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