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公开(公告)号：US4018593A
公开(公告)日：1977-04-19
申请号：US588472
申请日：1975-06-19
申请人： Hans Muller
发明人： Hans Muller
摘要： A microorganism is cultivated with a liquid-containing culture medium so as to obtain a protein-containing cellular product. The latter is then recovered from the culture medium. Thereafter, the liquid portion of the culture medium is treated so as to obtain a first fraction which contains proteins and a second fraction which is substantially free of proteins and contains an active substance or active substances. The treatment of the liquid portion of the culture medium may include ultrafiltration, filtration through a molecular sieve, precipitation or solvent extraction. The active substances present in the second fraction may include growth factors and growth inhibitors for the microorganism. Certain of these growth factors and growth inhibitors are useful in the cultivation of green plants and the second fraction may be utilized for this purpose. On the other hand, all or part of the second fraction may be recycled for use in the cultivation of the microorganism. Aside from the recovery of active substances which is achieved by separating the liquid portion of the culture medium into first and second fractions, there is achieved the result that water pollution due to discharge of the culture medium may be reduced since the biochemical oxygen demand of the culture medium is decreased by removal of the proteins therefrom, that is, by recovering the protein content of the culture medium as a separate fraction.
摘要翻译： 用含液体培养基培养微生物以获得含蛋白质的细胞产物。 然后从培养基中回收后者。 此后，处理培养基的液体部分以获得含有蛋白质的第一级分和基本上不含蛋白质并含有活性物质或活性物质的第二级分。 培养基的液体部分的处理可以包括超滤，通过分子筛过滤，沉淀或溶剂萃取。 存在于第二级分中的活性物质可以包括微生物的生长因子和生长抑制剂。 这些生长因子和生长抑制剂中的某些可用于绿色植物的培养，并且第二级分可用于该目的。 另一方面，全部或部分第二级分可以再循环用于微生物的培养。 除了通过将培养基的液体部分分离成第一和第二馏分而获得的活性物质的回收之外，实现了由于培养基的生物化学需氧量而导致的由于培养基排出而导致的水污染的结果 通过从其中除去蛋白质，即通过以单独级分回收培养基的蛋白质含量来降低培养基。
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公开(公告)号：US4017565A
公开(公告)日：1977-04-12
申请号：US661026
申请日：1976-02-24
申请人： Hans Muller
发明人： Hans Muller
CPC分类号： B01F3/04617 , C12M27/02 , C12M27/24 , Y10S261/75
摘要： An upright vessel for the liquid phase has a cylindrical baffle located in it extending upwardly from the lower region of the vessel. The baffle has a lower open end at which an impeller is located and an upper open end which is formed with a constriction. A member provided with passages through which the gaseous phase is discharged, is located in the constriction so that the passages discharge the gaseous phase at the narrowest cross-section of an annular clearance formed between the constriction and the member.
摘要翻译： 用于液相的直立容器具有位于其中的圆柱形挡板，其从容器的下部区域向上延伸。 挡板具有下部开口端，叶片位于该开口端，上开口端形成有收缩部。 设置有通过其排出气体的通道的构件位于收缩部中，使得通道在形成在收缩部和构件之间的环形间隙的最窄截面处排出气相。
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公开(公告)号：US3982642A
公开(公告)日：1976-09-28
申请号：US634173
申请日：1975-11-21
申请人： Hans Muller
发明人： Hans Muller
CPC分类号： B65G1/0464 , A46D1/00 , B65H31/3045 , B65H2301/321 , B65H2301/42242 , B65H2301/42254
摘要： Method of storing and transporting individual paper sheets abutting against each other to form a staple of sheets, in which a precompressed staple of sheets resting between upright support members on a support surface of a first magazine is gripped at opposite ends by clamping jaws of a gripper, which compresses the staple further to a self-supporting body, whereafter the body is lifted from between the support members of the first magazine and transported between support members of a second magazine, spaced from the first, at which the body is then relaxed by removing the clamping jaws; and an arrangement for carrying out the method.
摘要翻译： 存储和运送各个纸张彼此抵靠以形成片材的方法，其中通过夹持器的夹爪夹住搁置在第一盒的支撑表面上的直立支撑件之间的片材的预压缩订书钉在相对端处 ，其将钉子进一步压缩到自支撑体，之后主体从第一仓的支撑构件之间被提升并且在与第一仓间隔开的第二仓的支撑构件之间传送，然后身体然后通过 拆下夹爪; 以及执行该方法的装置。
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84.发明授权
公开(公告)号：US3968257A
公开(公告)日：1976-07-06
申请号：US585291
申请日：1975-06-09
申请人： Hans Muller
发明人： Hans Muller
摘要： Processes for the production of essentially solid nutriments and fodders containing a high content of proteins by the cultivation of a yeast on a liquid culture medium consisting of whey containing at least a substantial portion of its original soluble proteins and thereafter separating from the resulting brew the solids consisting of yeast cells and the original soluble proteins or products of the original soluble proteins by means of an ultrafilter provided with one or more membranes that are essentially impervious to soluble proteins and subsequently drying the said solids.The preliminary separation of the soluble proteins from the whey by centrifugal separation or by ultrafiltration, as described in the prior art, is avoided. In such prior ultrafiltration processes, the membranes of the ultrafilter become clogged with the soluble proteins, thereby retarding and ultimately stopping the filtration. The brew that is produced in accordance with the processes of the present invention which contains yeast cells together with the original soluble proteins or products thereof can be separated in an ultrafilter at a faster rate than the soluble proteins could have been preliminarily separated from the whey and the ultrafilter membranes do not become clogged with the solids that are thus separated.
摘要翻译： 通过在含有至少大部分原始可溶性蛋白质的乳清组成的液体培养基上培养酵母以生产含有高含量蛋白质的基本上固体营养物质和饲料的方法，然后从所得酿造物中分离出固体 由酵母细胞和原始可溶性蛋白质或原始可溶性蛋白质的产物通过提供一种或多种基本上不可渗透可溶性蛋白质并随后干燥所述固体的膜的超滤器组成。
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公开(公告)号：US3962041A
公开(公告)日：1976-06-08
申请号：US559156
申请日：1975-03-17
申请人： Hans Muller , Werner Stumpp
发明人： Hans Muller , Werner Stumpp
CPC分类号： G01N21/534 , C12M41/36 , G01N21/03 , G01N2021/054 , G01N21/11
摘要： From a vessel in which micro-organisms grow in a liquid medium containing gas bubbles, a sample is withdrawn into an exterior measuring chamber by means of suction. Gas bubbles are allowed to escape from the sample and thereafter the opacity or turbidity of the sample is measured by passing a light beam through it.
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公开(公告)号：US20080056849A1
公开(公告)日：2008-03-06
申请号：US11896374
申请日：2007-08-31
申请人： Hans Muller
发明人： Hans Muller
CPC分类号： B42C9/02 , Y10T156/12 , Y10T156/17
摘要： An arrangement performs backlining or headbanding of a spine of a book block conveyed on a conveying section of a book production line through a backlining station. A feeding device feeds backlining material in a transfer direction perpendicular to a book block conveying direction. A unit includes a cross cutter to cut the backlining material into backlining sections, a transfer mechanism to transfer the backlining sections onto the book block spine, and a support table to support the backlining section being transferred onto the book block spine. A guide element is disposed above and at a distance to a book block spine in a production position, which guide element is advanced to bridge the book production line to transfer the backlining material through the book production line to allow at least one of outfitting or retrofitting of the backlining station.
摘要翻译： 一种装置通过背衬工位在书本生产线的输送部分上传送的书本的书脊的背衬或头带。 馈送装置沿着与书本块传送方向垂直的传送方向馈送背衬材料。 单元包括用于将背衬材料切割成背衬部分的交叉切割器，用于将背衬部分转移到书芯脊柱上的传送机构，以及支撑台，用于支撑背衬部分被转印到书本书脊上。 引导元件设置在生产位置上的书脊脊的上方和远处，该引导元件被推进以桥接书本生产线以将背衬材料传送通过书本生产线，以允许至少一个out装或改装 的背板站。
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公开(公告)号：US20050014943A1
公开(公告)日：2005-01-20
申请号：US10838986
申请日：2004-05-04
申请人： Alvin Glasky , Heinrich Bollinger , Hans Muller
发明人： Alvin Glasky , Heinrich Bollinger , Hans Muller
IPC分类号： A61P25/28 , C07D233/88 , C07D233/90 , C07D473/30 , C07D473/10
CPC分类号： C07D233/90 , C07D473/30
摘要： An improved method of synthesis of a 9-substituted hypoxanthine derivative comprises the steps of: (1) reacting aminocyanacetamide with triethyl orthoformate to form an imidoester derivative of aminocyanacetamide; (2) forming a compound having a reactive amino group on a hydrocarbyl moiety, the hydrocarbyl moiety being linked through an amide group to a physiologically active moiety or an esterified derivative of a physiologically active moiety including therein an esterified benzoyl group; (3) reacting the imidoester with the compound having the reactive amino group on the hydrocarbyl moiety to form a derivative of 5-aminoimidazole-4-carboxamide substituted at the 1-position with a hydrocarbyl moiety linked through an amide group to a physiologically active moiety including therein an optionally esterified benzoyl group; (4) forming the six-membered heterocyclic ring of the purine moiety of the hypoxanthine by reacting the derivative of 5-aminoimidazole-4-carboxamide formed in step (3) with triethyl orthoformate to form a 9-substituted hypoxanthine compound substituted at the 9-position with a hydrocarbyl moiety linked through an amide group to a physiologically active moiety including therein an optionally esterified benzoyl group; and (5) hydrolyzing the ester of the optionally esterified benzoyl group if present.
摘要翻译： 合成9-取代的次黄嘌呤衍生物的改进方法包括以下步骤：（1）使氨基异氰酸乙酰胺与原甲酸三乙酯反应形成氨基异氰酸乙酰胺的酰亚胺酯衍生物; （2）在烃基部分上形成具有反应性氨基的化合物，烃基部分通过酰胺基与生理活性部分或生理活性部分的酯化衍生物连接，其中包括酯化苯甲酰基; （3）使亚氨酯与在烃基部分上具有反应性氨基的化合物反应，以形成在1-位被取代的5-氨基咪唑-4-甲酰胺的衍生物，其中烃基部分通过酰胺基连接到生理活性部分 其中包括任选酯化的苯甲酰基; （4）通过使步骤（3）中形成的5-氨基咪唑-4-甲酰胺的衍生物与原甲酸三乙酯反应形成在9位被取代的9-取代的次黄嘌呤化合物，形成次黄嘌呤嘌呤部分的六元杂环 - 具有通过酰胺基团连接到生理活性部分的烃基部分，其中包括任选酯化的苯甲酰基; 和（5）水解任意酯化的苯甲酰基的酯（如果存在）。
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公开(公告)号：US5871459A
公开(公告)日：1999-02-16
申请号：US835345
申请日：1997-04-07
申请人： Hans Muller
发明人： Hans Muller
CPC分类号： A61M1/3681 , A61M1/304 , A61M1/32 , A61M1/0003 , A61M2202/0216 , A61M5/155
摘要： In an apparatus for the extra-corporal treatment of blood wherein blood is supplied from a body to a vacuum bottle via a conduit and an insertion spike, the insertion spike is in communication, by way of a gas hose, with a pressure compensation bag from which a predetermined amount of gas can be supplied to the insertion spike for foaming the blood in the vacuum bottle, whereby no excess pressure can be generated in the vacuum bottle. The blood conduit further includes a quartz glass portion to permit UV irradiation of the blood while passing therethrough.
摘要翻译： 在用于血液的体外处理的装置中，其中血液通过管道和插入尖端从身体供应到真空瓶，所述插入尖端通过气体软管与压力补偿袋连通， 可以将预定量的气体供给到插入尖端以使真空瓶中的血液发泡，从而在真空瓶中不会产生过大的压力。 血液导管还包括石英玻璃部分，以允许在通过血液时对血液进行紫外线照射。
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公开(公告)号：US5770147A
公开(公告)日：1998-06-23
申请号：US751056
申请日：1996-11-15
申请人： Hans Muller
发明人： Hans Muller
CPC分类号： A61M1/3681 , A61M1/3616 , A61M1/025 , A61M2206/14
摘要： In an apparatus for the irradiation of body fluids by ultraviolet light in a containment for receiving the body fluids which is disposed in the radiation range of an ultraviolet light source, the containment includes baffle means arranged so as to subject the body fluids circulated through the containment to turbulence whereby the body fluid in the containment is uniformly exposed to the UV radiation.
摘要翻译： 在用于通过紫外线照射体液的设备中，用于接纳设置在紫外光源的辐射范围内的体液的容纳物中，所述容纳物包括挡板装置，所述挡板装置被布置成使经由所述容纳物循环的体液 以使遏制物中的体液均匀地暴露于紫外线辐射。
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90.发明授权
公开(公告)号：US5388616A
公开(公告)日：1995-02-14
申请号：US278184
申请日：1994-07-21
申请人： Hans Muller , Hermann Suerbaum
发明人： Hans Muller , Hermann Suerbaum
IPC分类号： F16L55/165 , F16L55/179 , F16L55/16
CPC分类号： F16L55/179 , F16L55/1651
摘要： An invertible tubular substrate of resin-permeated fibrous material is surrounded by an impermeable tubular film which, in turn, is surrounded by an impermeable tubular calibrating element. One end of the substrate is inserted into one end of a pipe which is to be lined from the inside, and the assembly of substrate, film and calibrating element is thereupon inverted into the pipe wherein the substrate is immediately adjacent the internal surface of the pipe and surrounds the film. The calibrating element is separable from the film and can be withdrawn from the interior of the inverted film by a flexible cord. The resin in the substrate sets upon inversion and maintains the inverted substrate in contact with the internal surface of the pipe.
摘要翻译： 树脂渗透的纤维材料的可逆管状基材被不可渗透的管状膜包围，该不透水的管状膜又被不可渗透的管状校准元件包围。 将基板的一端插入从内侧排列的管的一端，然后将基板，膜和校准元件的组装倒入管中，其中基板紧邻管的内表面 并围绕电影。 校准元件可以与膜分离，并且可以通过柔性绳从反相膜的内部取出。 基板中的树脂反转设置，并保持反转的基板与管的内表面接触。
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