公开(公告)号：US3998946A

公开(公告)日：1976-12-21

申请号：US570569

申请日：1975-04-23

申请人： Richard M. Condie ,  Luis H. Toledo-Pereyra

发明人： Richard M. Condie ,  Luis H. Toledo-Pereyra

IPC分类号： A61K35/16 ,  A61K35/14

CPC分类号： A61K35/16

摘要： A method of treating blood plasma or fractionated plasma products with fumed colloidal silica to remove fibrinogen without polymerization to fibrin, to remove the plasminogen-plasmin proteolytic enzyme system, to remove cholesterol and lipoproteins and reduce triglycerides, while maintaining plasma coagulation factor II at pretreatment levels and leaving immunoglobulins and other protein constitutents unaffected, and the resulting product. Plasma products treated with fumed silica may be subjected to long-term storage for a year or more without loss of its biologically active support properties, thereby circumventing the problem of hepatitis. The treated plasma products, either fresh or after long-term storage, may be used as a perfusion support media for organ perfusion, for treatment of hemmorrhagic shock and similar purposes for which untreated plasma and fractionated plasma products are customarily used, with equal or superior effectiveness.

摘要翻译： 一种使用热解胶体二氧化硅处理血浆或分级血浆产物以除去纤维蛋白原而不聚合成纤维蛋白的方法，以除去纤溶酶原 - 纤溶酶蛋白水解酶系统，以除去胆固醇和脂蛋白并减少甘油三酯，同时将血浆凝固因子II保持在预处理水平 并使免疫球蛋白和其他蛋白质组分不受影响，以及所得产物。 用煅制二氧化硅处理的等离子体产品可以长期储存一年或更长时间，而不会损失其生物活性支持性能，从而规避了肝炎的问题。 经处理的血浆产品，新鲜或长期储存后，可用作器官灌注的灌注支持介质，用于治疗出血性休克和类似目的，通常使用未经处理的血浆和分级血浆产品，具有相等或优于 有效性