公开(公告)号：US12076319B2

公开(公告)日：2024-09-03

申请号：US16700910

申请日：2019-12-02

申请人： Achillion Pharmaceuticals, Inc.

发明人： Mingjun Huang ,  Dharaben Patel ,  Steven D. Podos

IPC分类号： A61K31/506 ,  A61K39/00 ,  A61K39/395 ,  A61P7/00 ,  C07K16/18

CPC分类号： A61K31/506 ,  A61K39/3955 ,  A61P7/00 ,  C07K16/18 ,  A61K2039/505 ,  C07K2317/76 ,  A61K39/3955 ,  A61K2300/00

摘要： Provided herein are methods for treating a subject with PNH comprising administering to a subject a therapeutically effective amount of complement component C5 (C5) inhibitor, complement component C3 (C3) inhibitor, or complement factor B (CFB) inhibitor in combination with a therapeutically effective amount of small molecule complement factor D (CFD) inhibitor of Formula I or Formula II, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20240199583A1

公开(公告)日：2024-06-20

申请号：US18418560

申请日：2024-01-22

申请人： Achillion Pharmaceuticals, Inc.

发明人： Jason Allan Wiles ,  Avinash S. Phadke ,  Milind Deshpande ,  Atul Agarwal ,  Dawei Chen ,  Venkat Rao Gadhachanda ,  Akihiro Hashimoto ,  Godwin Pais ,  Qiuping Wang ,  Xiangzhu Wang ,  William Greenlee

IPC分类号： C07D403/04 ,  A61P1/16 ,  A61P29/00 ,  A61P37/00 ,  C07D401/14 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D487/22 ,  C07D493/04 ,  C07D513/04 ,  C07D519/00 ,  C07F9/6558

CPC分类号： C07D403/04 ,  A61P1/16 ,  A61P29/00 ,  A61P37/00 ,  C07D401/14 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D487/22 ,  C07D493/04 ,  C07D513/04 ,  C07D519/00 ,  C07F9/65583

摘要： Compounds, methods of use, and processes for making inhibitors of complement Factor D are provided comprising Formula I, I″ and I′″ or a pharmaceutically acceptable salt or composition thereof. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade. The inhibitors of Factor D described herein reduces the excessive activation of complement.

公开(公告)号：US12006307B2

公开(公告)日：2024-06-11

申请号：US17872104

申请日：2022-07-25

申请人： Achillion Pharmaceuticals, Inc.

发明人： Jason Allan Wiles ,  Avinash S. Phadke ,  Milind Deshpande ,  Atul Agarwal ,  Dawei Chen ,  Venkat Rao Gadhachanda ,  Akihiro Hashimoto ,  Godwin Pais ,  Qiuping Wang ,  Xiangzhu Wang ,  Joel Charles Barrish ,  William Greenlee ,  Kyle J. Eastman

IPC分类号： C07D401/14 ,  C07D403/06 ,  C07D403/10 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04 ,  C07D493/04 ,  C07D495/04 ,  C07D513/04 ,  C07F9/6558

CPC分类号： C07D401/14 ,  C07D403/06 ,  C07D403/10 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04 ,  C07D493/04 ,  C07D495/04 ,  C07D513/04 ,  C07F9/65583

摘要： Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, and Formula IV or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.

公开(公告)号：US11649229B2

公开(公告)日：2023-05-16

申请号：US17134909

申请日：2020-12-28

申请人： Achillion Pharmaceuticals, Inc.

发明人： Jason Allan Wiles ,  Avinash S. Phadke ,  Milind Deshpande ,  Atul Agarwal ,  Dawei Chen ,  Venkat Rao Gadhachanda ,  Akihiro Hashimoto ,  Godwin Pais ,  Qiuping Wang ,  Xiangzhu Wang ,  William Greenlee

IPC分类号： A61K31/416 ,  A61K31/437 ,  A61K31/5025 ,  C07D231/56 ,  C07D401/14 ,  C07D471/04 ,  C07D487/04 ,  A61P1/00 ,  A61P1/16 ,  A61P27/02 ,  C07D413/14 ,  C07D403/14 ,  C07D401/12 ,  C07D405/14 ,  C07D413/12 ,  C07D513/04 ,  C07F9/6558

CPC分类号： C07D413/14 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D413/12 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04 ,  C07F9/65583

摘要： Compounds, methods of use, and processes for making inhibitors of complement Factor D are provided comprising Formula I, I″ and I′″ or a pharmaceutically acceptable salt or composition thereof. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade. The inhibitors of Factor D described herein reduces the excessive activation of complement.

公开(公告)号：US20230022157A1

公开(公告)日：2023-01-26

申请号：US17267362

申请日：2019-08-20

申请人： Achillion Pharmaceuticals, Inc.

发明人： Jason Allan Wiles ,  Venkat Rao Gadhachanda ,  Kyle J. Eastman ,  Godwin Pais

IPC分类号： C07D403/14 ,  C07D401/14 ,  C07D491/052 ,  C07D471/04 ,  C07D487/04 ,  C07D451/02 ,  C07D405/14 ,  C07D409/14 ,  C07D519/00

摘要： Compounds, methods of use, and processes for making inhibitors of complement factor D or a pharmaceutically acceptable salt or composition thereof are provided. The inhibitors described herein target factor D and inhibit or regulate the complement cascade. The inhibitors of factor D described herein reduce the excessive activation of complement.

公开(公告)号：US20220396563A1

公开(公告)日：2022-12-15

申请号：US17366670

申请日：2021-07-02

申请人： Achillion Pharmaceuticals, Inc.

发明人： Jason Allan WILES ,  Avinash S. PHADKE ,  Milind DESHPANDE ,  Atul AGARWAL ,  Dawei CHEN ,  Venkat Rao GADHACHANDA ,  Akihiro HASHIMOTO ,  Godwin PAIS ,  Qiuping WANG ,  Xiangzhu WANG ,  Joel Charles BARRISH ,  William GREENLEE ,  Kyle J. EASTMAN

IPC分类号： C07D401/14 ,  C07D403/14 ,  C07D409/14 ,  C07D471/04 ,  C07D471/08 ,  C07D491/107 ,  C07D498/10 ,  C07F5/02

摘要： Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, Formula IV, and Formula V, or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.

公开(公告)号：US20220315562A1

公开(公告)日：2022-10-06

申请号：US17835098

申请日：2022-06-08

申请人： Achillion Pharmaceuticals, Inc.

发明人： Jason Allan WILES ,  Avinash S. PHADKE ,  Milind DESHPANDE ,  Atul AGARWAL ,  Dawei CHEN ,  Venkat Rao GADHACHANDA ,  Akihiro HASHIMOTO ,  Godwin PAIS ,  Qiuping WANG ,  Xiangzhu WANG ,  William GREENLEE

IPC分类号： C07D403/04 ,  C07D401/14 ,  C07D403/14 ,  C07D471/04 ,  C07D413/14 ,  C07F9/6558 ,  C07D417/14 ,  C07D487/04 ,  C07D519/00 ,  C07D403/12 ,  C07D407/14 ,  C07D409/14 ,  C07D403/10 ,  C07D513/04 ,  C07D487/22 ,  A61P37/00 ,  A61P1/16 ,  A61P29/00 ,  C07D405/14 ,  C07D493/04

摘要： Compounds, methods of use, and processes for making inhibitors of complement Factor D are provided comprising Formula I, I″ and I′″ or a pharmaceutically acceptable salt or composition thereof. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade. The inhibitors of Factor D described herein reduces the excessive activation of complement.

公开(公告)号：US20210115034A1

公开(公告)日：2021-04-22

申请号：US17134909

申请日：2020-12-28

申请人： Achillion Pharmaceuticals, Inc.

发明人： Jason Allan Wiles ,  Avinash S. Phadke ,  Milind Deshpande ,  Atul Agarwal ,  Dawei Chen ,  Venkat Rao Gadhachanda ,  Akihiro Hashimoto ,  Godwin Pais ,  Qiuping Wang ,  Xiangzhu Wang ,  William Greenlee

IPC分类号： C07D413/14 ,  C07D471/04 ,  C07D403/14 ,  C07D401/12 ,  C07D487/04 ,  C07D401/14 ,  C07D405/14 ,  C07D413/12 ,  C07D513/04 ,  C07F9/6558

摘要： Compounds, methods of use, and processes for making inhibitors of complement Factor D are provided comprising Formula I, I″ and I′″ or a pharmaceutically acceptable salt or composition thereof. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade. The inhibitors of Factor D described herein reduces the excessive activation of complement.

公开(公告)号：US10919884B2

公开(公告)日：2021-02-16

申请号：US15905461

申请日：2018-02-26

申请人： Achillion Pharmaceuticals, Inc.

发明人： Jason Allan Wiles ,  Avinash S. Phadke ,  Milind Deshpande ,  Atul Agarwal ,  Dawei Chen ,  Venkat Rao Gadhachanda ,  Akihiro Hashimoto ,  Godwin Pais ,  Qiuping Wang ,  Xiangzhu Wang ,  William Greenlee

IPC分类号： A61K31/416 ,  A61K31/437 ,  A61K31/5025 ,  C07D231/56 ,  C07D401/14 ,  C07D471/04 ,  C07D487/04 ,  C07D413/14 ,  C07D403/14 ,  C07D401/12 ,  C07D405/14 ,  C07D413/12 ,  C07D513/04 ,  C07F9/6558

摘要： Compounds, methods of use, and processes for making inhibitors of complement Factor D are provided comprising Formula I, I″ and I′″ or a pharmaceutically acceptable salt or composition thereof. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade. The inhibitors of Factor D described herein reduces the excessive activation of complement.

公开(公告)号：US20200071301A1

公开(公告)日：2020-03-05

申请号：US16555914

申请日：2019-08-29

申请人： Achillion Pharmaceuticals, Inc.

发明人： Jason Allan Wiles ,  Avinash S. Phadke ,  Milind Deshpande ,  Atul Agarwal ,  Dawei Chen ,  Venkat Rao Gadhachanda ,  Akihiro Hashimoto ,  Godwin Pais ,  Qiuping Wang ,  Xiangzhu Wang ,  Joel Charles Barrish ,  William Greenlee ,  Kyle J. Eastman

IPC分类号： C07D401/14 ,  C07F5/02 ,  C07D471/08 ,  C07D471/04 ,  C07D403/14 ,  C07D409/14 ,  C07D491/107 ,  C07D498/10

摘要： Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, Formula IV, and Formula V, or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.