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    Drug Condensation Aerosols And Kits
    7.
    发明申请
    Drug Condensation Aerosols And Kits 有权
    药物冷凝气溶胶和试剂盒

    公开(公告)号：US20140060525A1

    公开(公告)日：2014-03-06

    申请号：US14078679

    申请日：2013-11-13

    申请人： Alexza Pharmaceuticals, Inc.

    发明人： Ron L. Hale ,  Craig C. Hodges ,  Peter M. Lloyd ,  Amy T. Lu ,  Daniel J. Myers ,  Joshua D. Rabinowitz ,  Martin J. Wensley ,  Jeffrey A. McKinney ,  Alejandro C. Zaffaroni

    IPC分类号： A61M11/04

    CPC分类号： A61K9/0004 ,  A61K9/007 ,  A61K9/0078 ,  A61K9/12 ,  A61K31/4468 ,  A61K31/519 ,  A61K31/5415 ,  A61K31/5517 ,  A61K31/553 ,  A61M11/002 ,  A61M11/005 ,  A61M11/04 ,  A61M11/041 ,  A61M11/042 ,  A61M11/047 ,  A61M15/00 ,  A61M2207/00

    摘要： The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1-3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0.05 and 20 μm, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided. The device contained in the kit typically, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Also disclosed, are methods for using these aerosols and kits.

    摘要翻译： 本发明提供用于治疗疾病和/或间歇或急性病症的新型凝结气溶胶。 这些凝结气溶胶几乎没有或没有热解降解产物，其特征在于MMAD为1-3微米。 这些气溶胶是通过在使薄膜上的气体通过膜的同时，快速加热涂覆有厚度为0.05至20微米的药物薄膜的基材，以形成用于吸入的理想颗粒尺寸的颗粒。 还提供了包含药物和用于产生冷凝气溶胶的装置的试剂盒。 包含在试剂盒中的装置通常具有用于加热药物的元件，其作为膜被涂覆在基底上并且当药物以气溶胶形式施用时含有治疗有效剂量的药物，以及允许蒸气冷却的元件 以形成气溶胶。 还公开了使用这些气溶胶和试剂盒的方法。

    DELIVERY OF DRUG AMINES THROUGH AN INHALATION ROUTE
    8.
    发明申请
    DELIVERY OF DRUG AMINES THROUGH AN INHALATION ROUTE 审中-公开
    通过吸入路线输送药物

    公开(公告)号：US20110245493A1

    公开(公告)日：2011-10-06

    申请号：US13078525

    申请日：2011-04-01

    申请人： Joshua D. RABINOWITZ ,  Alejandro C. Zaffaroni

    发明人： Joshua D. RABINOWITZ ,  Alejandro C. Zaffaroni

    IPC分类号： C07D223/28 ,  C07D215/00 ,  C07D213/38 ,  C07D489/12 ,  C07C225/12 ,  C07D401/14 ,  C07D417/06 ,  C07D241/04 ,  C07D401/04 ,  G01N30/06

    CPC分类号： A61K9/007 ,  A61K9/0073 ,  A61M11/001 ,  A61M11/041 ,  A61M15/00 ,  Y10S514/958

    摘要： The present invention relates to the delivery of drug amines through an inhalation route. Specifically, it relates to aerosols containing drug amines that are used in inhalation therapy. In one aspect of the present invention, a method of delivering an amine drug in an aerosol form is provided. The method comprises: a) heating a coating, which includes an amine drug salt on a substrate contained in a device to a temperature sufficient to volatilize the amine drug from the coating, h) by said heating, forming an amine drug vapor, and c) during said heating, drawing air through said device, condensing said vapor to form aerosol particles containing less than 10% degradation products of the compound.

    摘要翻译： 本发明涉及通过吸入途径递送药物胺。 具体地说，它涉及用于吸入治疗的含有药物胺的气溶胶。 在本发明的一个方面，提供了以气雾剂形式递送胺药物的方法。 该方法包括：a）将包含在装置中的基质上的胺药物盐的涂层加热到足以使胺药物从涂层挥发的温度，h）通过加热形成胺药物蒸气，和c ），通过所述装置吸入空气，冷凝所述蒸气以形成含有少于10％化合物降解产物的气溶胶颗粒。