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13 条记录 (耗时 0.072 秒)

    Nucleic encoding interleukin-1 receptor antagonist-like proteins and uses thereof
    1.
    发明申请
    Nucleic encoding interleukin-1 receptor antagonist-like proteins and uses thereof 审中-公开
    核编码白细胞介素-1受体拮抗剂样蛋白及其用途

    公开(公告)号：US20040208872A1

    公开(公告)日：2004-10-21

    申请号：US10735354

    申请日：2003-12-12

    申请人： Amgen, Inc., A Corporation of the State of Delaware

    发明人： Andrew A. Welcher ,  Roland Luethy ,  Shuqian Jing

    IPC分类号： A61K039/395 ,  C07H021/04 ,  C07K014/47

    CPC分类号： C07K14/54 ,  A01K2217/05 ,  C07K2319/00 ,  C12N2799/021

    摘要： The present invention provides novel Interleukin-1 Receptor Antagonist-Like (IL-1ra-L) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing IL-1ra-L polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with IL-1ra-L polypeptides.

    摘要翻译： 本发明提供了新的白细胞介素-1受体拮抗剂样（IL-1ra-L）多肽和编码该多肽的核酸分子。 本发明还提供选择性结合剂，载体，宿主细胞和用于产生IL-1ra-L多肽的方法。 本发明还提供用于诊断，治疗，改善和/或预防与IL-1ra-L多肽相关的疾病，病症和病症的药物组合物和方法。

    Her-2 receptor tyrosine kinase molecules and uses thereof
    5.
    发明申请
    Her-2 receptor tyrosine kinase molecules and uses thereof 审中-公开
    Her-2受体酪氨酸激酶分子及其用途

    公开(公告)号：US20030228606A1

    公开(公告)日：2003-12-11

    申请号：US10412804

    申请日：2003-04-11

    申请人： Amgen Inc., A Corporation of the State of Delaware

    发明人： Suzanna Tatarewicz ,  Shuqian Jing

    IPC分类号： C12Q001/68 ,  C07H021/04 ,  C12N009/12 ,  C12P021/02 ,  C12N005/06

    CPC分类号： C07K14/71 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00

    摘要： The present invention provides HER-2 Receptor Tyrosine Kinase polypeptides and nucleic acid molecules encoding the same. Specifically, the present invention relates to splice variants of HER-2 (HER-2sv). The invention also provides selective binding agents, vectors, host cells, and methods for producing HER-2sv polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with HER-2sv polypeptides.

    摘要翻译： 本发明提供HER-2受体酪氨酸激酶多肽和编码其的核酸分子。 具体地，本发明涉及HER-2（HER-2sv）的剪接变体。 本发明还提供选择性结合剂，载体，宿主细胞和用于产生HER-2sv多肽的方法。 本发明还提供用于诊断，治疗，改善和/或预防与HER-2sv多肽相关的疾病，病症和病症的药物组合物和方法。

    G-protein coupled receptor molecules and uses thereof
    7.
    发明申请
    G-protein coupled receptor molecules and uses thereof 审中-公开
    G蛋白偶联受体分子及其用途

    公开(公告)号：US20030171541A1

    公开(公告)日：2003-09-11

    申请号：US10076260

    申请日：2002-02-14

    申请人： Amgen Inc., A Corporation of the State of Delaware

    发明人： Steven G. Elliott ,  Norma Rogers ,  Leigh Anne Busse

    IPC分类号： C07K014/705 ,  C12P021/02 ,  C12N005/06 ,  C07H021/04

    CPC分类号： C07K14/705 ,  A61K38/00

    摘要： The present invention provides G-Protein Coupled Receptor (GPCR) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing GPCR polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with GPCR polypeptides.

    摘要翻译： 本发明提供了G蛋白偶联受体（GPCR）多肽和编码它们的核酸分子。 本发明还提供选择性结合剂，载体，宿主细胞和用于产生GPCR多肽的方法。 本发明还提供用于诊断，治疗，改善和/或预防与GPCR多肽相关的疾病，病症和病症的药物组合物和方法。

    Tumore endothelial market 7alpha molecules and uses thereof
    8.
    发明申请
    Tumore endothelial market 7alpha molecules and uses thereof 审中-公开
    肿瘤内皮细胞市场7α分子及其用途

    公开(公告)号：US20030092025A1

    公开(公告)日：2003-05-15

    申请号：US10156487

    申请日：2002-05-28

    申请人： Amgen, Inc., A Corporation of the State of Delaware

    发明人： Todd Juan ,  Michael Brian Bass ,  Jonathan Daniel Oliner

    IPC分类号： C12Q001/68 ,  G01N033/574 ,  C07H021/04 ,  C12N009/00 ,  C12P021/02 ,  C12N005/06

    CPC分类号： C07K14/4748 ,  A61K38/00

    摘要： The present invention provides Tumor Endothelial Marker 7null (TEM7null) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing TEM7null polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with TEM7null polypeptides.

    摘要翻译： 本发明提供肿瘤内皮标记7α（TEM7alpha）多肽和编码该多肽的核酸分子。 本发明还提供选择性结合剂，载体，宿主细胞和用于产生TEM7alpha多肽的方法。 本发明还提供用于诊断，治疗，改善和/或预防与TEM7alpha多肽相关的疾病，病症和病症的药物组合物和方法。