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公开(公告)号：US10160739B2
公开(公告)日：2018-12-25
申请号：US15646375
申请日：2017-07-11
申请人： Aventis Pharma S.A.
发明人： Pascal Billot , Marielle Dufraigne , Hagit Elmaleh , Fabrice Mangin , Patricia Rortais , Lionel Zaske , Alexandre Giuliani
IPC分类号： C07D305/14
摘要： The invention relates to anhydrides, solvates and ethanol hetero-solvates and hydrates of dimethoxy docetaxel or (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenyl-propionate of 4-acetoxy-2α-benzoyloxy-5β,20-epoxy-1-hydroxy-7β, 10β-dimethoxy-9-oxo-tax-11-ene-13α-yle, and to the preparation thereof.
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公开(公告)号：US20120277235A1
公开(公告)日：2012-11-01
申请号：US13436545
申请日：2012-03-30
申请人： Karl Theodor Kraemer , Manfred Bohn
发明人： Karl Theodor Kraemer , Manfred Bohn
IPC分类号： A61K31/4166 , A61K31/505 , A61P17/14 , A61K31/53 , A61P17/00 , A61K31/421 , A61K31/4545
CPC分类号： A61K31/421 , A61K8/49 , A61K8/4946 , A61K9/06 , A61K9/7007 , A61K9/7015 , A61K31/4166 , A61K45/06 , A61Q5/00 , A61Q5/006 , A61Q5/008 , A61Q7/00 , A61Q7/02 , A61Q19/00 , C07D233/70 , C07D263/06
摘要： A composition comprising at least one physiologically tolerated film forming agent, at least one physiologically tolerated solvent, at least one plasticizer and a compound of the formula I or a stereoisomeric form or a physiologically tolerated salt of any of the foregoing. The composition is suitable for treatment of androgenic alopecia or hirsutism, that is, for avoiding undesirable hair growth, and for treatment of seborrhea and acne, and can furthermore be employed in cosmetics.
摘要翻译： 一种组合物，其包含至少一种生理上耐受的成膜剂，至少一种生理上耐受的溶剂，至少一种增塑剂和式I化合物或上述任何一种的立体异构体形式或生理上耐受的盐。 该组合物适用于治疗雄激素性脱发或多毛症，即避免不期望的头发生长，以及治疗脂溢性皮炎和痤疮，并且还可用于化妆品中。
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公开(公告)号：US08258328B2
公开(公告)日：2012-09-04
申请号：US12915966
申请日：2010-10-29
CPC分类号： A61K31/566 , A61K31/58
摘要： The subject of the invention is a method for preparing compounds of general formula (I): in which A, Z, R3 are as defined in the description, and the intermediate compounds for carrying out this method.
摘要翻译： 本发明的主题是制备通式（I）的化合物的方法：其中A，Z，R 3如说明书中所定义，和用于实施该方法的中间体化合物。
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公开(公告)号：US20110263522A1
公开(公告)日：2011-10-27
申请号：US13173268
申请日：2011-06-30
IPC分类号： A61K31/704 , A61P35/02 , A61P35/00
CPC分类号： A61K31/4745 , A61K31/335 , A61K31/337 , A61K31/505 , A61K31/525 , A61K31/66 , A61K31/675 , A61K31/7048 , A61K31/7072 , A61K33/24 , A61K38/20 , A61K38/21 , A61K38/50 , A61K45/06 , C07D305/14 , C12Y305/01001 , Y10S514/836 , Y10S514/922 , A61K31/28 , A61K2300/00
摘要： Antitumor combinations comprising a taxane and at least one antibiotic for treating neoplastic diseases are described.
摘要翻译： 描述了包含紫杉烷和至少一种用于治疗肿瘤疾病的抗生素的抗肿瘤组合。
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5.发明授权Pyrrolo(2,3-b) pyridine derivatives, the preparation and the pharmaceutical use thereof in the form of kinase inhibitors 失效吡咯（2,3-b）吡啶衍生物，其制备方法及其在激酶抑制剂形式中的用途公开(公告)号：US07968566B2
公开(公告)日：2011-06-28
申请号：US12410135
申请日：2009-03-24
申请人： Sylvie Wentzler , Youssef El-Ahmad , Bruno Filoche-Romme , Conception Nemecek , Corinne Venot , Augustin Hittinger
发明人： Sylvie Wentzler , Youssef El-Ahmad , Bruno Filoche-Romme , Conception Nemecek , Corinne Venot , Augustin Hittinger
IPC分类号： C07D401/14 , A61K31/437
CPC分类号： C07D471/04
摘要： Novel compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein R, R1, R2, R3, R4, R5, and R6 have the meanings given in the description, pharmaceutical compositions comprising said compounds and use thereof as protein kinase inhibitors.
摘要翻译： 式（I）的新型化合物或其药学上可接受的盐，其中R，R 1，R 2，R 3，R 4，R 5和R 6具有说明书中给出的含义，包含所述化合物的药物组合物及其作为蛋白激酶抑制剂的用途。
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6.发明授权Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them 有权来自肝素的多糖的组合物，其制备方法和含有它们的药物组合物公开(公告)号：US07812007B2
公开(公告)日：2010-10-12
申请号：US11096146
申请日：2005-04-01
IPC分类号： A61K31/727 , C08B37/10
CPC分类号： C08B37/0078 , A61K31/727 , C08B37/0075
摘要： Alkali and alkali-earth metal salts of polysaccharides derived from heparin, their method of preparation and the pharmaceutical compositions containing them.
摘要翻译： 由肝素衍生的多糖的碱金属和碱土金属盐，其制备方法和含有它们的药物组合物。
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公开(公告)号：US07772003B2
公开(公告)日：2010-08-10
申请号：US10228959
申请日：2002-08-28
CPC分类号： C07J41/0055
摘要： Transfecting compounds which include an aminoglycoside linked to a lipid via a spacer, and their polyguanidylated derivatives are provided. These compounds are useful for the in vitro, ex vivo, or in vivo transfection of nucleic acids into various cell types.
摘要翻译： 提供了包括通过间隔基与脂质连接的氨基糖苷类及其聚胍基化衍生物的化合物。 这些化合物可用于核酸进入各种细胞类型的体外，离体或体内转染。
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8.发明授权Cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors 失效环状尿素衍生物，其制备方法及其作为激酶抑制剂的药物用途公开(公告)号：US07759379B2
公开(公告)日：2010-07-20
申请号：US11627518
申请日：2007-01-26
申请人： Hartmut Strobel , Sven Ruf , Dominique Lesuisse , Conception Nemecek , Youssef El-Ahmad , Stefan Guessregen , Anne Lebrun , Kurt Ritter , Didier Benard , Augustin Hittinger , Hervé Bouchard
发明人： Hartmut Strobel , Sven Ruf , Dominique Lesuisse , Conception Nemecek , Youssef El-Ahmad , Stefan Guessregen , Anne Lebrun , Kurt Ritter , Didier Benard , Augustin Hittinger , Hervé Bouchard
IPC分类号： C07D239/02 , A61K31/505 , A61P43/00
CPC分类号： C07D403/04
摘要： The invention relates to compounds of formula (I): in which R1, R2, L1, X, R3, A, R4, R4′, R4″, R4″′, R5, Y and L2 are as herein defined, salts and prodrugs thereof, to their use as protein kinase inhibitors, and to methods of treating diseases comprising adminstration thereof.
摘要翻译： 本发明涉及式（I）化合物：其中R1，R2，L1，X，R3，A，R4，R4'，R4“，R4”'，R5，Y和L2如本文所定义， 作为蛋白激酶抑制剂的用途，以及治疗包括其施用的疾病的方法。
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9.发明申请ANTITUMOUR COMBINATIONS CONTAINING A VEGF INHIBITING AGENT AND IRINOTECAN 审中-公开含有VEGF抑制剂和IRINOTECAN的抗肿瘤药物组合公开(公告)号：US20100160233A1
公开(公告)日：2010-06-24
申请号：US12651767
申请日：2010-01-04
IPC分类号： A61K38/16 , A61K31/4375
CPC分类号： A61K39/3955 , A61K31/4745 , A61K38/16 , A61K2300/00
摘要： Disclosed are antitumor combinations of VEGF inhibitors with Irinotecan and the use thereof in the treatment of neoplastic diseases.
摘要翻译： 公开了VEGF抑制剂与伊立替康的抗肿瘤组合及其在治疗肿瘤性疾病中的用途。
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10.发明授权Method for determining specific groups constituting heparins or low molecular weight heparins 有权确定构成肝素或低分子量肝素的特定组的方法公开(公告)号：US07687274B2
公开(公告)日：2010-03-30
申请号：US12007695
申请日：2008-01-14
申请人： Christian Viskov , Pierre Mourier
发明人： Christian Viskov , Pierre Mourier
CPC分类号： B01D15/366 , B01D15/363 , B01J2220/54 , C08B37/0078 , G01N2030/8813 , Y10T436/143333
摘要： The invention provides methods for analyzing heparins, low-molecular-weight heparins, ultralow-molecular-weight heparins, and oligosaccharides by high performance liquid chromatography a stationary phase dynamically coated with a quaternary ammonium salt. The methods of the invention may be used to analyze samples without pre-treatment or to analyze samples that have been partially or exhaustively depolymerised and, optionally, reduced. Specific saccharides can be detected.
摘要翻译： 本发明提供了通过高效液相色谱分析动态涂覆有季铵盐的固定相来分析肝素，低分子量肝素，超低分子量肝素和寡糖的方法。 本发明的方法可用于分析样品而无需预处理或分析已部分或全面解聚并任选还原的样品。 可以检测特异性糖。
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