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公开(公告)号：US20240319487A1
公开(公告)日：2024-09-26
申请号：US18598162
申请日：2024-03-07
发明人： Nils Langholz , Markus Sticker , Thomas Nobis
CPC分类号： G02B21/367 , G02B21/04 , G02B21/361
摘要： According to a method for autofocusing on a microscopic sample, measurement light having a local structure is generated. The measurement light is coupled into the microscope beam path, whereby the measurement light is incident on, and reflected by, the sample. The measurement light reflected by the sample is output from the microscope beam path and split among a plurality of component beam paths which pass over optical paths of different lengths to image the reflected measurement light, whereby a plurality of measurement images assigned to different focus positions on the microscope beam path are obtained. At least the measurement image which comes closest to an ideal image of the local structure of the measurement light is selected. Depending on the focus position assigned to the selected measurement image, a focus position to be used on the microscope beam path for the purpose of microscopic imaging of the sample is set.
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公开(公告)号：US12099174B2
公开(公告)日：2024-09-24
申请号：US17498339
申请日：2021-10-11
发明人： Daniel Haase , Manuel Amthor , Markus Sticker , Sebastian Backs , Thomas Ohrt , Christian Dietrich
CPC分类号： G02B21/0052 , G02B21/06 , G02B21/367 , G06N20/00
摘要： A method for generating an overview image of a sample which is arranged in an observation volume of a microscope by means of a sample carrier is proposed, wherein the sample carrier is illuminated by a first illumination, wherein a preliminary overview image is generated using the first illumination and an overview camera of the microscope, wherein an overview image illumination is chosen on the basis of the preliminary overview image, wherein the sample carrier is illuminated by the overview illumination, and wherein the overview image is generated using the overview image illumination and the overview camera.
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公开(公告)号：US20240312760A1
公开(公告)日：2024-09-19
申请号：US18606665
申请日：2024-03-15
发明人： Bjoern Gamm
摘要： In a method for operating a particle beam microscope, an image of an object region is generated by virtue of a particle beam being directed to a multiplicity of incidence locations within the object region. Particles are detected and a data record is generated. The data record represents the image by a field of pixels, with a position of the pixel in the field representing the incidence location and a pixel value of the pixel representing an intensity of the detected particles at the incidence location. In order to generate an image with an increased number of pixels, at least two images of the object region are generated in succession with a fewer number of pixels and the data records representing the at least two images are supplied to an image processing program which generates the data record representing the image with the greater number of pixels therefrom.
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公开(公告)号：US20240304410A1
公开(公告)日：2024-09-12
申请号：US18600212
申请日：2024-03-08
发明人： Erik Essers
IPC分类号： H01J37/26 , H01J37/14 , H01J37/147 , H01J37/244
CPC分类号： H01J37/26 , H01J37/14 , H01J37/147 , H01J37/244 , H01J2237/049 , H01J2237/141 , H01J2237/1415 , H01J2237/2443
摘要： An electron beam microscope comprises an electron beam source, a beam tube, a magnetic objective lens, an object holder, a scintillator arrangement, a detector arrangement and a potential supply system. The power supply system supplies: i) the object holder with a potential U1; ii) the beam tube with a potential U2; iii) a pole end of the objective lens with a potential U3; iv) a scintillator body of the scintillator arrangement with a potential; and v) a light detector of the detector arrangement with a potential U5, such that:
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公开(公告)号：US20240266139A1
公开(公告)日：2024-08-08
申请号：US18431498
申请日：2024-02-02
发明人： Ramu Pradip
IPC分类号： H01J37/08 , H01J37/244
CPC分类号： H01J37/08 , H01J37/244 , H01J2237/24585 , H01J2237/24592
摘要： Operating an ion beam source comprises operating the ion beam source in a beam generation mode and operating the ion beam source in a decontamination mode. Operating in beam generation mode includes generating an ion beam from ions emitted from a tip. Operating in decontamination mode includes supplying power to a heating wire to raise the temperature of the heating wire to a decontamination temperature, measuring a change over time of a physical property indicating a temperature of the heating wire while the power is supplied to the heating wire, and displaying an indication based on the measured change over time of the physical property and/or storing a change value based on the measure change over time of the physical property. The ion beam source comprises the heating wire, a metal reservoir mechanically connected to the heating wire, and the tip mechanically connected to the metal reservoir.
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公开(公告)号：US20240257313A1
公开(公告)日：2024-08-01
申请号：US18423154
申请日：2024-01-25
IPC分类号： G06T5/50 , G06V10/141
CPC分类号： G06T5/50 , G06V10/141 , G06T2207/20221
摘要： Generating an overview image of an object includes, during a first capture duration, scanning regions of the object along a trajectory with illumination radiation, where the trajectory is chosen individually on the basis of properties of the object. First images of the object which together with position data (x, y, z) of an absolute distance measurement system are stored as an individual overview image are captured during the scanning of the trajectory. During a second capture duration, at least regions of the object are scanned with illumination radiation, and second images are captured; regions of the object which have already been imaged during the first capture duration are not imaged again. The first images captured during the first capture duration and the second images captured during the second capture duration are merged to form a resultant overview image of the object.
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公开(公告)号：US12033343B2
公开(公告)日：2024-07-09
申请号：US17689022
申请日：2022-03-08
发明人： Lars Omlor , Timo Stich , Christian Dietrich
IPC分类号： G06T7/593 , H04N13/271
CPC分类号： G06T7/593 , H04N13/271 , G06T2207/10012 , G06T2207/20212
摘要： Stereoscopy in which at least one image of a scene is recorded from a first viewing angle, and at least one image of the scene is recorded from a second viewing angle. The scene is recorded multiple times from the first viewing angle. A first combination image is obtained from the various images recorded from the first viewing angle, said combination image according to the stipulation of a comparison algorithm having smaller differences in relation to at least one image also recorded from the second viewing angle or smaller differences in relation to a second combination image obtained from the images from the second viewing angle than each individual image recorded from the first viewing angle. An image of the scene with the depth information is obtained from the first combination image and at least one image from the second viewing angle or the second combination image.
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公开(公告)号：US20240177349A1
公开(公告)日：2024-05-30
申请号：US18519244
申请日：2023-11-27
发明人： Manuel AMTHOR , Daniel HAASE , Ralf WOLLESCHENSKY
CPC分类号： G06T7/90 , G16B30/00 , G16B40/20 , G06T2207/10024 , G06T2207/10056 , G06T2207/20081 , G06T2207/20084 , G06T2207/30024 , G06T2207/30204
摘要： A method for preparing data for identifying analytes in a sample, in which in an experiment one or more analytes are colored with markers in multiple coloring rounds, the markers in each case being specific for a certain set of analytes, detecting the multiple markers using a camera, which for each coloring round generates at least one image containing multiple pixels and color values assigned thereto, the image including colored signals and uncolored signals, wherein a colored signal is a pixel having a color value that originates from a marker, and an uncolored signal is a pixel having a color value that is not based on a marker, and storing the color information of the particular coloring rounds for evaluating the color information.
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公开(公告)号：US20240177311A1
公开(公告)日：2024-05-30
申请号：US18519257
申请日：2023-11-27
发明人： Manuel AMTHOR , Daniel HAASE , Ralf WOLLESCHENSKY
IPC分类号： G06T7/00 , C12Q1/6816 , G06T7/10 , G06T7/90
CPC分类号： G06T7/0012 , G06T7/10 , G06T7/90 , C12Q1/6816 , G06T2207/10024 , G06T2207/10056 , G06T2207/20081 , G06T2207/30024 , G06T2207/30204
摘要： A method for preparing data for identifying analytes by coloring one or more analytes with markers in multiple coloring rounds, the markers in each case being specific for a certain set of analytes, detecting multiple markers using a camera, which for each coloring round generates at least one image that includes multiple pixels and that may contain color information of one or more markers, and storing the images of the particular coloring rounds stored for evaluating the color information,
wherein
the color values determined in the individual coloring rounds are clustered, according to their intensity values, in local or global clusters with similar intensity values, and only the clustered data are stored.-
公开(公告)号：US20240177310A1
公开(公告)日：2024-05-30
申请号：US18519249
申请日：2023-11-27
发明人： Manuel AMTHOR , Daniel HAASE , Ralf WOLLESCHENSKY
IPC分类号： G06T7/00
CPC分类号： G06T7/0012 , G06T2207/10056 , G06T2207/10064 , G06T2207/20081
摘要： A method for preparing data for identifying analytes by coloring one or more analytes with markers in multiple coloring rounds, the markers in each case being specific for a certain set of analytes, detecting multiple markers using a camera, which for each coloring round generates at least one image containing multiple pixels and color values assigned thereto, which may contain color information of one or more markers, and storing the color information of the particular coloring rounds for evaluating the color information, a data point in each case including one or more contiguous pixels in the images of the multiple coloring rounds that are assigned to the same location in a sample.
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