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    Assays
    1.
    发明授权
    Assays 有权
    测定

    公开(公告)号：US08906303B2

    公开(公告)日：2014-12-09

    申请号：US12922383

    申请日：2009-03-16

    申请人： Eugen Ermantraut ,  Thomas Kaiser ,  Jens Tuchscheerer ,  Vico Baier ,  Torsten Schulz ,  Anke Wöstemeyer

    发明人： Eugen Ermantraut ,  Thomas Kaiser ,  Jens Tuchscheerer ,  Vico Baier ,  Torsten Schulz ,  Anke Wöstemeyer

    IPC分类号： G01N21/00 ,  B01L3/00

    CPC分类号： G01N33/58 ,  B01L3/50273 ,  B01L2200/025 ,  B01L2200/0684 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/0481 ,  Y10T436/25

    摘要： A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone comprising a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence of each analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction at each test zone is indicative of the presence in the sample of a target analyte. Capillary structures of the devices or used in the methods may comprise a matrix and the devices may comprise control elements and methods for assaying of sample may use corresponding controlling activities.

    摘要翻译： 描述了用于分析多种分析物中的每一种的样品的方法。 该方法包括使间隔开的测试区域的阵列与液体样品（例如全血）接触。 测试区域设置在微流体装置的通道内。 通道由至少一个柔性壁和可以是柔性的第二壁限定。 每个测试区域包含对各个目标分析物特异的探针化合物。 微流体装置被压缩以减小通道的厚度，其是通道内的壁的内表面之间的距离。 每个分析物的存在通过光学检测在相应位置处的内表面之间的距离减小的多个测试区域中的每一个处的相互作用来确定。 每个测试区域的相互作用表明样品中目标分析物的存在。 装置的毛细结构或方法中使用的毛细管结构可以包括基质，并且装置可以包括控制元件和用于测定样品的方法可以使用相应的控制活动。

    Assay devices and methods for the detection of analytes
    2.
    发明申请
    Assay devices and methods for the detection of analytes 有权
    用于检测分析物的检测装置和方法

    公开(公告)号：US20110071038A1

    公开(公告)日：2011-03-24

    申请号：US12385805

    申请日：2009-07-14

    申请人： Eugen Ermantraut ,  Torsten Schulz ,  Thomas Ellinger ,  Daniel Weicherding

    发明人： Eugen Ermantraut ,  Torsten Schulz ,  Thomas Ellinger ,  Daniel Weicherding

    IPC分类号： C40B30/04 ,  C40B60/12

    CPC分类号： B01L3/502707 ,  B01L2300/0636 ,  B01L2300/069 ,  B01L2300/0877 ,  B01L2400/0481 ,  C12Q1/6834

    摘要： The present invention relates to devices and methods for performing assays, especially for determining the presence and/or amount of one or more analytes. In particular, the invention relates to a device for the detection of analytes, comprising a reversibly compressible matrix located between a first surface and a second surface, wherein the second surface is located opposite to the first surface, and wherein the distance between the first surface and the second surface is variable. The invention also relates to a corresponding method using such a device for the detection of one or more species of analytes.

    摘要翻译： 本发明涉及用于进行测定的装置和方法，特别是用于确定一种或多种分析物的存在和/或量。 特别地，本发明涉及一种用于检测分析物的装置，包括位于第一表面和第二表面之间的可逆压缩基质，其中第二表面位于与第一表面相对的位置，并且其中第一表面 并且第二表面是可变的。 本发明还涉及使用这种装置用于检测一种或多种分析物的相应方法。

    Assays
    8.
    发明授权
    Assays 有权
    测定

    公开(公告)号：US08349616B2

    公开(公告)日：2013-01-08

    申请号：US12516070

    申请日：2007-11-22

    申请人： Torsten Schulz ,  Thomas Kaiser ,  Thomas Uhlig ,  Klaus Peter Möbius ,  Alexander Von Schenk Zu Schweinsberg

    发明人： Torsten Schulz ,  Thomas Kaiser ,  Thomas Uhlig ,  Klaus Peter Möbius ,  Alexander Von Schenk Zu Schweinsberg

    IPC分类号： G01N21/00

    CPC分类号： G01N33/54386 ,  B01L3/5027 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0825 ,  B01L2400/0406 ,  B01L2400/0481 ,  Y10T436/2575

    摘要： A method for assaying a sample for each of multiple analysis is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones are disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone includes a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence of each analyte is determined by optically detecting an interaction at each of multiple zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction at each test zone is indicative of the presence in the sample of a target analyte.

    摘要翻译： 描述了用于分析多个分析中的每一个的样品的方法。 该方法包括使间隔开的测试区域的阵列与液体样品（例如全血）接触。 测试区域设置在微流体装置的通道内。 通道由至少一个柔性壁和可以是柔性的第二壁限定。 每个测试区域包括对各个目标分析物特异的探针化合物。 微流体装置被压缩以减小通道的厚度，其是通道内的壁的内表面之间的距离。 每个分析物的存在通过光学检测在相应位置处的内表面之间的距离减小的多个区域中的相互作用来确定。 每个测试区域的相互作用表明样品中目标分析物的存在。