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公开(公告)号：US5917605A
公开(公告)日：1999-06-29
申请号：US855236
申请日：1997-05-13
CPC分类号： G01N21/6454 , G01N21/6428 , G01N21/7703 , G01N2021/6484
摘要： A fluorescence sensing device for determining the presence or concentration of an analyte in a liquid or gaseous medium is constructed of a fiber optic plate comprising optical fibers having relatively small numerical apertures. The fiber optic plate is positioned on a photodetector and has a layer of analyte permeable fluorescent matrix or coated waveguide material on its top surface. The fluorescent matrix or waveguide coating contains indicator molecules whose fluorescence is affected by the local presence of analyte. A light source emits light into the fluorescent matrix in a direction generally parallel to the top surface of the fiber optic plate. Upon absorbing light from the light source, indicator molecules in the fluorescent matrix emit fluorescent light which is transmitted through the fiber optic plate to the photodetector.
摘要翻译： 用于确定液体或气体介质中分析物的存在或浓度的荧光检测装置由包括具有相对较小数值孔径的光纤的光纤板构成。 光纤板位于光电检测器上，并且在其顶表面上具有分析物可渗透的荧光矩阵或涂覆的波导材料层。 荧光基质或波导涂层含有指示剂分子，其荧光受到分析物局部存在的影响。 光源在大致平行于光纤板的顶表面的方向上将光发射到荧光矩阵中。 在从光源吸收光时，荧光矩阵中的指示剂分子发射荧光，其通过光纤板传输到光电检测器。
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公开(公告)号：US5894351A
公开(公告)日：1999-04-13
申请号：US855234
申请日：1997-05-13
CPC分类号： G01N21/6454 , G01N21/6428 , G01N21/7703 , G01N2021/7786
摘要： A fluorescence sensing device for determining the presence or concentration of an analyte in a liquid or gaseous medium is constructed of a light-emitting diode having a hole generally perpendicular to the P-N junction, such that light is emitted from said junction into said hole. The hole is filled with a fluorescent matrix which is permeable to analyte and which contains fluorescent indicator molecules whose fluorescence is attenuated or enhanced by the presence of analyte. A photodetector is positioned at one end of the hole, such that fluorescent light received from the fluorescent indicator molecules if converted to an electrical signal that may be correlated to the presence or concentration of analyte in a gaseous or liquid medium in contact with the fluorescent matrix.
摘要翻译： 用于确定液体或气体介质中分析物的存在或浓度的荧光检测装置由具有通常垂直于P-N结的孔的发光二极管构成，使得光从所述结点发射到所述孔中。 该孔填充有可透过分析物的荧光基质，其含有荧光指示剂分子，其荧光被分析物的存在减弱或增强。 光电检测器位于孔的一端，使得从荧光指示剂分子接收的荧光如果转换成电信号，该电信号可能与与荧光矩阵接触的气体或液体介质中的分析物的存在或浓度相关 。
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公开(公告)号：US5910661A
公开(公告)日：1999-06-08
申请号：US855235
申请日：1997-05-13
CPC分类号： G01N21/6454 , G01N21/6428 , G01N21/648 , G01N21/7703
摘要： A fluorescence sensing device for determining the presence or concentration of an analyte in a liquid or gaseous medium is constructed of an optical filter, which is positioned on a photodetector and which has a thin film of analyte-permeable, fluorescent indicator molecule-containing material on its top surface. An edge-emitting, light-emitting P-N junction is positioned on the top surface of the optical filter such that the P-N junction from which light is emitted is positioned within the film. Light emitted by the fluorescent indicator molecules impacts the photodetector thereby generating an electrical signal that is related to the concentration of the analyte in the liquid or gaseous medium. Fluorescence sensing devices according to this invention are characterized by very compact sizes, fast response times and high signal-to-noise ratios.
摘要翻译： 用于确定液体或气体介质中分析物的存在或浓度的荧光检测装置由位于光电检测器上的光学滤光器构成，该滤光器具有分析物可透过的含荧光指示剂分子的材料薄膜 其顶面。 边缘发射的发光P-N结位于光滤波器的顶表面上，使得发射光的P-N结位于膜内。 由荧光指示剂分子发射的光影响光电检测器，从而产生与液体或气体介质中分析物浓度相关的电信号。 根据本发明的荧光感测装置的特征在于非常紧凑的尺寸，快速的响应时间和高的信噪比。
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公开(公告)号：US5517313A
公开(公告)日：1996-05-14
申请号：US393166
申请日：1995-02-21
CPC分类号： G01N21/6428 , G01N2021/7786
摘要： A fluorescence sensor for detecting the presence and amount of an analyte. The fluorescence sensor has a photodetector, a high pass filter located adjacent the photodetector, and a glass layer located adjacent the high pass filter. An indicator layer is located adjacent the glass layer and a light emitting diode is embedded in the indicator layer. The indicator layer has indicator molecules that provide a fluorescent emission as a result of light from the light emitting diode. The indicator layer also allows an analyte to diffuse into it and the presence of the analyte reduces the amount of light emitted from the indicator molecules that passes through the glass layer and the high pass filter and is incident upon the photodetector. Since the amount of current from the photodetector depends upon the incident light, this is used to detect the presence and amount of the analyte. In one embodiment a waveguide is also present.
摘要翻译： 用于检测分析物的存在和量的荧光传感器。 荧光传感器具有光电检测器，位于光电检测器附近的高通滤波器和位于高通滤波器附近的玻璃层。 指示层位于玻璃层附近，发光二极管嵌入在指示层中。 指示剂层具有作为来自发光二极管的光的结果提供荧光发射的指示剂分子。 指示剂层还允许分析物扩散到其中，并且分析物的存在减少了从通过玻璃层和高通滤波器并且入射到光电检测器上的指示剂分子发射的光的量。 由于来自光电检测器的电流量取决于入射光，所以用于检测分析物的存在和量。 在一个实施例中也存在波导。
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