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公开(公告)号：US11408004B2
公开(公告)日：2022-08-09
申请号：US14741164
申请日：2015-06-16
申请人： CuRNA, Inc.
IPC分类号： C12N15/11 , C12N15/113 , A61K31/7088
摘要： The present invention relates to antisense oligonucleotide that modulate the expression of and/or function of a Sirtuin (SIRT), in particular, by targeting natural antisense polynucleotides of a Sirtuin (SIRT). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of Sirtuins (SIRT)s.
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公开(公告)号：US10934546B2
公开(公告)日：2021-03-02
申请号：US16739266
申请日：2020-01-10
申请人： CuRNA, Inc.
IPC分类号： C12N15/11 , C12N15/113
摘要： The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of a Sirtuin (SIRT), in particular, by targeting natural antisense polynucleotides of a Sirtuin (SIRT). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of Sirtuins (SIRT)s.
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公开(公告)号：US10435690B2
公开(公告)日：2019-10-08
申请号：US15847283
申请日：2017-12-19
申请人： CuRNA, Inc.
发明人： Joseph Collard , Olga Khorkova Sherman , Carlos Coito , Gang Shen
IPC分类号： C12N15/113 , A61K31/7088 , C12N15/10 , G01N33/53
摘要： The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Alpha-L-Iduronidase (IDUA), in particular, by targeting natural antisense polynucleotides of Alpha-L-Iduronidase (IDUA). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of IDUA.
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公开(公告)号：US10370657B2
公开(公告)日：2019-08-06
申请号：US15364050
申请日：2016-11-29
申请人： CuRNA, Inc.
IPC分类号： C12N15/113 , A61K31/713 , C07K14/78 , A61L27/36
摘要： The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of a Collagen gene, in particular, by targeting natural antisense polynucleotides of a Collagen gene. The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of Collagen genes.
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公开(公告)号：US10358646B2
公开(公告)日：2019-07-23
申请号：US14533371
申请日：2014-11-05
申请人： CuRNA, Inc.
IPC分类号： C12N15/11 , C12N15/113 , A61K31/712 , C12Q1/6886
摘要： The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Tumor Suppressor genes, in particular, by targeting natural antisense polynucleotides of Tumor Suppressor genes. The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of Tumor Suppressor genes.
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公开(公告)号：US10358645B2
公开(公告)日：2019-07-23
申请号：US15684587
申请日：2017-08-23
申请人： CuRNA, Inc.
IPC分类号： C12N15/113 , C07K14/505 , C12Q1/6883
摘要： Oligonucleotide compounds modulate expression and/or function of Erythropoietin (EPO) polynucleotides and encoded products thereof. Methods for treating diseases associated with Erythropoietin (EPO) comprise administering one or more oligonucleotide compounds designed to inhibit the EPO natural antisense transcript to patients.
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公开(公告)号：US10000752B2
公开(公告)日：2018-06-19
申请号：US13988063
申请日：2011-11-17
IPC分类号： C12N15/11 , C12N15/113 , A61K31/00 , A61K31/7088 , A61K31/7115
CPC分类号： C12N15/113 , A61K31/00 , A61K31/7088 , A61K31/7115 , C12N15/111 , C12N2310/113 , C12N2310/3231 , C12N2310/3341 , C12N2310/344 , C12N2310/321 , C12N2310/3521 , C12N2310/111 , C12N2330/10
摘要： Provided herein are compositions, compounds, and methods of modulating gene expression. In certain embodiments described herein is a composition, wherein the composition comprises an antagoNAT. In some embodiments, the antagoNAT is an oligonucleotide comprising modified and unmodified sugar subunits, wherein the antagoNAT hybridizes with a natural antisense transcript. Certain embodiments of the present invention provide a method for modulating gene expression in a cell comprising contacting the cell with an antagoNAT. In some embodiments, the method includes forming a hybrid comprising the antagoNAT and a natural antisense transcript of the gene, wherein the hybrid sterically blocks the normal function of the natural antisense transcript.
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公开(公告)号：US09834767B2
公开(公告)日：2017-12-05
申请号：US14582412
申请日：2014-12-24
申请人： CuRNA, Inc.
IPC分类号： C12N15/113 , A61K31/7088 , A61K31/712 , A61K31/7125 , C12Q1/68
CPC分类号： C12N15/113 , A61K31/7088 , C12N2310/113 , C12N2310/14 , C12Q1/6876 , C12Q2600/136 , C12Q2600/178
摘要： The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Interferon Regulatory Factor 8 (IRF8), in particular, by targeting natural antisense polynucleotides of Interferon Regulatory Factor 8 (IRF8). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of IRF8.
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公开(公告)号：US20170145411A1
公开(公告)日：2017-05-25
申请号：US15270752
申请日：2016-09-20
申请人： CuRNA, Inc.
IPC分类号： C12N15/113 , G01N25/04 , C12Q1/68
CPC分类号： C12N15/113 , C12N2310/113 , C12N2310/14 , C12N2310/312 , C12N2310/313 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12Q1/6876 , C12Q2600/136 , C12Q2600/178 , G01N25/04
摘要： The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Nuclear factor (erythroid-derived 2)-like 2 (NRF2), in particular, by targeting natural antisense polynucleotides of Nuclear factor (erythroid-derived 2)-like 2 (NRF2). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of NRF2.
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10.发明授权公开(公告)号：US09267136B2
公开(公告)日：2016-02-23
申请号：US14534323
申请日：2014-11-06
申请人： CuRNA, Inc.
IPC分类号： C07H21/04 , C12N15/113 , A61K31/7088 , C12Q1/68
CPC分类号： C12N15/113 , A61K31/7088 , C12N2310/11 , C12Q1/6813
摘要： The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of a Pancreatic Developmental gene, in particular, by targeting natural antisense polynucleotides of a Pancreatic Developmental gene. The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of Pancreatic Developmental genes.
摘要翻译： 本发明涉及调节胰腺发育基因表达和/或功能的反义寡核苷酸，特别是通过靶向胰腺发育基因的天然反义多核苷酸。 本发明还涉及这些反义寡核苷酸的鉴定及其在治疗与胰腺发育基因表达相关的疾病和病症中的用途。
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