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公开(公告)号：US20200254259A1
公开(公告)日：2020-08-13
申请号：US16090088
申请日：2017-03-31
申请人： Cyberonics, Inc.
发明人： Imad LIBBUS , Bruce H. KENKNIGHT , Christine HENRY
摘要： A method for assessing a patient's suitability for receiving a vagus nerve stimulation therapy includes receiving a criterion regarding the patient's suitability for receiving a vagus nerve stimulation therapy; controlling a stimulation device to provide stimulation to a vagus nerve of the patient; receiving, from a sensor, response data indicative of a physiological response of the patient to the stimulation of the vagus nerve; and determining the patient's suitability for receiving the vagus nerve stimulation therapy based on the criterion and the physiological response of the patient to the stimulation.
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公开(公告)号：US10195438B2
公开(公告)日：2019-02-05
申请号：US15783941
申请日：2017-10-13
摘要： Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for recording the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time.
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公开(公告)号：US20180345013A1
公开(公告)日：2018-12-06
申请号：US16102471
申请日：2018-08-13
申请人： Cyberonics, Inc.
发明人： Stephen Bolea , Wondimeneh Tesfayesus , John Beck , Thomas Hoegh , Robert Atkinson , Sidney Hauschild
CPC分类号： A61N1/3611 , A61B2017/248 , A61F5/566 , A61N1/3601
摘要： Devices and methods for improving the coupling between the soft palate and the genioglossus. This may be accomplished, for example, but shortening or stiffening the palatoglossal arch. Improved coupling between the soft palate and the genioglossus may be beneficial to a patient suffering from obstructive sleep apnea (OSA) as a stand-alone procedure, or in combination procedures and devices that cause anterior displacement of the tongue such as hypoglossal nerve stimulation, genioglossus advancement surgery, mandibular advancement surgery, mandibular advancement (oral) appliances, etc.
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4.发明申请公开(公告)号：US20180099144A1
公开(公告)日：2018-04-12
申请号：US15721542
申请日：2017-09-29
申请人： Cyberonics, Inc.
发明人： Timothy L. SCOTT
IPC分类号： A61N1/36 , A61B5/0476 , A61B5/00
CPC分类号： A61N1/361 , A61B5/0476 , A61B5/4047 , A61B5/4094 , A61N1/36082 , A61N1/36114
摘要： Disclosed herein are methods, systems, and apparatus for treating a medical condition in a patient using an implantable medical device (IMD). The IMD is capable of generating a first electrical signal for treating a medical condition, for example epilepsy. The first electrical signal relates to a long term therapy during a first time period in which there is no indication that the patient's brain is in an stable state, the first electrical signal being a microburst stimulation signal. The implantable device is also capable of generating a second electrical signal for treating the medical condition. The second electrical signal relates to a short term therapy during a second time period, in response to an indication that the patient's brain is in an unstable state. The second electrical signal in one example, may be a conventional stimulation signal.
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公开(公告)号：US09918670B2
公开(公告)日：2018-03-20
申请号：US15449405
申请日：2017-03-03
申请人： Cyberonics, Inc.
发明人： Shivkumar Sabesan
IPC分类号： A61B5/00 , A61B5/0456 , A61B5/0205 , A61N1/36 , A61B5/024 , A61B5/0488 , A61B5/053 , A61B5/11
CPC分类号： A61B5/4094 , A61B5/0006 , A61B5/01 , A61B5/0205 , A61B5/02055 , A61B5/024 , A61B5/02405 , A61B5/0456 , A61B5/0488 , A61B5/05 , A61B5/053 , A61B5/1118 , A61B5/4809 , A61B5/4842 , A61B5/4866 , A61B5/7282 , A61N1/36064 , A61N1/36139 , G06F19/00
摘要： A method includes receiving heartbeat data of a patient and receiving activity data of the patient. The activity data includes one or more activity values that are related to an activity level of the patient and that are measured independently of the heartbeat data. The method further includes determining a value of a weighting factor based on the activity data. The method also includes determining modified heartbeat data by applying the weighting factor to at least a portion of the heartbeat data. The method also includes detecting a seizure event based on the modified heartbeat data.
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公开(公告)号：US09913982B2
公开(公告)日：2018-03-13
申请号：US13106460
申请日：2011-05-12
申请人： Stephen L. Bolea , Thomas B. Hoegh , Brian D. Kuhnley , Dale G. Suilmann , Bruce J. Persson , John P. Beck , Sidney F. Hauschild , Wondimeneh Tesfayesus , Jason J. Skubitz , Mark R. Bosshard , Daniel A. Parrish , Robert E. Atkinson
发明人： Stephen L. Bolea , Thomas B. Hoegh , Brian D. Kuhnley , Dale G. Suilmann , Bruce J. Persson , John P. Beck , Sidney F. Hauschild , Wondimeneh Tesfayesus , Jason J. Skubitz , Mark R. Bosshard , Daniel A. Parrish , Robert E. Atkinson
CPC分类号： A61N1/3601 , A61B5/0809 , A61B5/0826 , A61B5/4818 , A61N1/0556 , A61N1/3611 , A61N1/36132 , A61N1/36139 , A61N1/3615 , A61N1/37235
摘要： Devices, systems and methods of neurostimulation for treating obstructive sleep apnea. The system is adapted to send an electrical signal from an implanted neurostimulator through a stimulation lead to a patient's nerve at an appropriate phase of the respiratory cycle based on input from a respiration sensing lead. External components are adapted for wireless communication with the neurostimulator. The neurostimulator is adapted to deliver therapeutic stimulation based on inputs.
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公开(公告)号：US09898656B2
公开(公告)日：2018-02-20
申请号：US12020450
申请日：2008-01-25
申请人： David Snyder , Kent W. Leyde , John F. Harris
发明人： David Snyder , Kent W. Leyde , John F. Harris
IPC分类号： A61B5/04 , G06K9/00 , A61B5/0482 , A61B5/0476 , G06F19/00 , G06F19/24 , A61B5/00
CPC分类号： G06K9/00496 , A61B5/0006 , A61B5/0476 , A61B5/0482 , A61B5/4094 , G06F19/00 , G06F19/24 , G06F19/30 , G06F19/3418 , G16H40/67 , G16H50/20 , G16H50/70
摘要： The invention provides a method of monitoring a subject's neurological condition. In some embodiments, the method includes the steps of analyzing a physiological signal (such as an EEG) from a subject to determine if the subject is in a contra-ictal condition; and if the subject is in a contra-ictal condition, providing an indication (e.g., to the subject and/or to a caregiver) that the subject is in the contra-ictal condition, such as by activating a green light or other visible output. In some embodiments, if the subject is in a pro-ictal condition, the method includes the step of providing an indication (such as a red light) that the subject is in the pro-ictal condition. The invention also provides neurological system monitors.
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8.发明申请公开(公告)号：US20180001091A1
公开(公告)日：2018-01-04
申请号：US15706946
申请日：2017-09-18
申请人： CYBERONICS, INC.
发明人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
IPC分类号： A61N1/36 , A61B5/0245 , A61B5/0456 , A61B5/042 , A61B5/00 , A61B5/0464 , A61N1/362
CPC分类号： A61N1/36114 , A61B5/0245 , A61B5/042 , A61B5/0456 , A61B5/0464 , A61B5/4836 , A61B5/686 , A61N1/36053 , A61N1/36139 , A61N1/3621
摘要： An implantable neurostimulator-implemented method for managing tachyarrhythmias through vagus nerve stimulation is provided. An implantable neurostimulator, including a pulse generator, is configured to deliver electrical therapeutic stimulation in a manner that results in creation and propagation (in both afferent and efferent directions) of action potentials within neuronal fibers of a patient's cervical vagus nerve. Operating modes of the pulse generator are stored. A maintenance dose of the electrical therapeutic stimulation is delivered to the vagus nerve via the pulse generator to restore cardiac autonomic balance through continuously-cycling, intermittent and periodic electrical pulses. A restorative dose of the electrical therapeutic stimulation is delivered to prevent initiation of or disrupt tachyarrhythmia through periodic electrical pulses delivered at higher intensity than the maintenance dose. The patient's normative physiology is monitored via a physiological sensor, and upon sensing a condition indicative of tachyarrhythmia, is switched to delivering the restorative dose to the vagus nerve.
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9.发明申请公开(公告)号：US20170319854A1
公开(公告)日：2017-11-09
申请号：US15600519
申请日：2017-05-19
IPC分类号： A61N1/36
CPC分类号： A61N1/36139 , A61N1/36053 , A61N1/36114 , A61N1/3615
摘要： Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. This neural fulcrum zone corresponds to a combination of stimulation parameters at which autonomic engagement is achieved, while the tachycardia-inducing stimulation effects are offset by the bradycardia-inducing effects, thereby minimizing side effects such as significant heart rate changes while providing a therapeutic level of stimulation.
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公开(公告)号：US09808626B2
公开(公告)日：2017-11-07
申请号：US15267922
申请日：2016-09-16
CPC分类号： A61N1/36114 , A61N1/36053 , A61N1/36135 , A61N1/36139 , A61N1/3615 , A61N1/37217 , A61N1/37264
摘要： Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for monitoring the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time and a control system for adjusting stimulation parameters to maintain stimulation in the neural fulcrum zone based on detected changes in the physiological response to stimulation.
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