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公开(公告)号：US20240335505A1
公开(公告)日：2024-10-10
申请号：US18271503
申请日：2022-02-10
IPC分类号： A61K38/17 , A01K67/0275 , A61K31/409 , A61K48/00 , A61P21/00 , C12N5/077 , C12N15/113 , C12N15/115 , C12Q1/6876
CPC分类号： A61K38/1709 , A01K67/0275 , A61K31/409 , A61K48/0033 , A61P21/00 , C12N5/0658 , C12N15/113 , C12N15/115 , C12Q1/6876 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12N2310/531 , C12N2506/1323 , C12N2510/00 , C12Q2600/124 , C12Q2600/156
摘要： The present invention relates generally to the field of long non-coding RNAs and transcription factors and modulation of their expression for use in medicine and agriculture, such as the treatment and prevention of diseases associated with muscle atrophy and the production of livestock. More particularly, the invention provides agonists of Cytor, a long non-coding RNA, e.g. agents that increase the amount of Cytor RNA in skeletal muscle as well as antagonists for Teadl, a transcription factor, e.g. agents that decrease the amount of Teadl RNA or protein in skeletal muscle and their use in therapy.
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2.发明授权公开(公告)号：US12104751B2
公开(公告)日：2024-10-01
申请号：US17601824
申请日：2020-03-24
发明人： Noris Gallandat , Andreas Züttel
CPC分类号： F17C5/06 , F17C13/025 , F17C13/026 , F17C2203/0648 , F17C2221/011 , F17C2223/036 , F17C2227/0157 , F17C2227/0339 , F17C2250/043 , F17C2250/0439 , F17C2260/031 , F17C2265/065
摘要： The present relates to a combined hydrogen storage-compression unit suitable for the filling of high-pressure (350 bar and beyond) hydrogen vessels. It includes a containment vessel filled with a hydrogen storage alloy, a heating system, a cooling system and a thermal management system. The same shall be connected directly to the hydrogen supply (e.g. an electrolyser) on one side and to the end consumer on the other side. Moreover, it offers the possibility for intermediate storage of at least one time the maximal quantity of hydrogen that is to be supplied at high pressure in a single step.
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公开(公告)号：US20240249939A1
公开(公告)日：2024-07-25
申请号：US18566563
申请日：2021-06-03
CPC分类号： H01L21/02645 , C01B32/25 , C23C16/27 , H01L21/02389 , H01L21/02527 , C01P2002/82 , C01P2002/85 , C01P2004/03
摘要： The present invention concerns a diamond device or structure comprising at least one supporting layer or material including at least one or a plurality of support structures inside the at least one supporting layer or material; a plurality of recesses defined by the at least one or the plurality of support structures; and at least one diamond micro-seed and a plurality of diamond nano-seeds located in each recess or in the plurality of recesses.
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公开(公告)号：US20240239039A1
公开(公告)日：2024-07-18
申请号：US18561433
申请日：2022-05-17
IPC分类号： B29C64/129 , B29C64/232 , B29C64/241 , B29C64/255 , B29C64/264 , B33Y10/00 , B33Y30/00
CPC分类号： B29C64/129 , B29C64/232 , B29C64/241 , B29C64/255 , B29C64/264 , B33Y10/00 , B33Y30/00
摘要： A method of volumetric manufacturing a three-dimensional object or article by illuminating a non-transparent and/or absorptive photosensitive material with light patterns from multiple angles. The method including the steps of capturing at least one fluorescence or scattering snapshot for one or a set of different illuminating projected patterns in the said photo-sensitive material, obtaining therefrom at least one physical parameter describing the light propagation through the photosensitive material, and computing a set of optimized projected patterns with the aid of the at least one physical parameter. The optimized projected patterns are used for volumetric manufacturing the three-dimensional object or article. A device for performing the method is further described.
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公开(公告)号：US20240230659A9
公开(公告)日：2024-07-11
申请号：US18556778
申请日：2022-04-22
发明人： Christoph MERTEN , Anna GRAB
CPC分类号： G01N33/586 , B01L3/502784 , B01L2300/087
摘要： The invention provides a method for quantifying the number of target entities that were successfully encapsulated into a microfluidic compartment such as a microfluidic droplet. The invention is predicated upon a continuous quantifiable detectable signal corresponding to the quantity of entities encapsulated in a microfluidic compartment. The present invention is useful in the context of high throughput microfluidic screening approaches which require thorough signal normalization in order to reliably improve signal to noise ratio and to reliably identify screening hits.
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公开(公告)号：US20240185582A1
公开(公告)日：2024-06-06
申请号：US18275191
申请日：2021-01-30
IPC分类号： G06V10/774 , G06V10/762 , G06V10/77 , G06V10/776 , G06V10/82
CPC分类号： G06V10/7753 , G06V10/762 , G06V10/7715 , G06V10/776 , G06V10/82
摘要： The present invention proposes a method for detecting anomalous or out-of-distribution images in a machine learning system (1) comprising a pre-training network with a first encoder, and an anomaly detection network with a second encoder. The system is first pre-trained by training the pre-training network, and then subsequently fine-tuned by training the anomaly detection network. According to one example, during pre-training, only unlabelled training images are used, while during fine-tuning, a small fraction of labelled training images is used in addition to unlabelled training images. The method can be applied to both single and multi-domain image data.
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7.发明授权公开(公告)号：US11993017B2
公开(公告)日：2024-05-28
申请号：US17291115
申请日：2019-11-05
发明人： Paul Delrot , Damien Loterie , Christophe Moser
IPC分类号： B29C64/268 , B29C64/135 , B29C64/282 , B33Y10/00 , B33Y30/00
CPC分类号： B29C64/268 , B29C64/135 , B29C64/282 , B33Y10/00 , B33Y30/00
摘要： A method of fabricating a three-dimensional article comprises providing a spatially coherent light source (101, 201), generating from the light source (101, 201), patterns of light based on computed tomographic projections of the three-dimensional article, and projecting the patterns of light into a photoresponsive medium. The projecting is configured to define a three-dimensional dose distribution, thereby locally altering the phase of the photoresponsive medium and creating the article.
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公开(公告)号：US20240115229A1
公开(公告)日：2024-04-11
申请号：US18264243
申请日：2022-02-01
CPC分类号： A61B8/065 , A61B8/42 , A61B8/4411 , A61B8/4472 , A61B8/4477 , A61B8/4494 , A61B8/488 , A61B8/54 , A61B8/56 , A61B90/06 , A61B2090/061 , A61B2562/0247 , A61B2562/0271 , A61B2562/16
摘要： A cardiovascular monitoring system for measuring at least cardiac output comprises an implantable unit (2) configured for placement in a section of artery of a patient and a portable external unit (1) configured for mounting against or close to a patient's skin for bidirectional communication with the implantable unit. A cross-sectional area measurement sensor (8) includes at least one elastic conductive loop (15, 15a, 15b) and an electronic circuit (16) connected to the conductive loop configured to measure an inductance value of the conductive loop. At least one ultrasound transducer (7,11) is further configured to measure a velocity of blood flow based on a Doppler effect.
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公开(公告)号：US20230402250A1
公开(公告)日：2023-12-14
申请号：US18331568
申请日：2023-06-08
发明人： Paolo CATTANEO , Fabrizio CARBONE , Bruce WEAVER , Alexey SAPOZHNIK , Thomas LA GRANGE , Yujia YANG , Arslan Sajid RAJA , Tobias KIPPENBERG
IPC分类号： H01J37/22 , H01J37/244 , H01J37/28 , H01J37/20
CPC分类号： H01J37/226 , H01J37/244 , H01J37/28 , H01J37/20 , H01J2237/24485 , H01J2237/2802
摘要： The present invention concerns an energy dispersion calibration method for calibrating an electron spectrometer of an electron spectrometer system including at least one electron emission source, electron optics and the electron spectrometer. The method comprising:
obtaining, providing or receiving at least one electron energy loss spectrum produced by electrons of the electron spectrometer system exchanging energy with at least one resonant optical mode of an optical resonator into which light at a resonant wavelength is coupled;
calculating or providing a Fourier transform of the at least one electron energy loss spectrum or a part of the at least one electron energy loss spectrum;
determining or providing an energy dispersion (ΔE) of the electron spectrometer according to the equation
Δ
E
=
f
E
hc
λ
N
or
Δ
E
=
f
E
E
p
N
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公开(公告)号：US20230393135A1
公开(公告)日：2023-12-07
申请号：US18032920
申请日：2021-11-02
IPC分类号： G01N33/569
CPC分类号： G01N33/56983 , G01N2469/20 , G01N2333/165 , G01N2500/02
摘要： The invention provides an in vitro method for the cell-free quantification of virus neutralizing activity, such as the SARS-CoV-2 neutralizing activity, of biological samples and kit for carrying out the method. The invention also provides a method of screening biological samples or collections of molecules to identify neutralizing antibodies or antiviral drugs.
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