公开(公告)号：US5817657A

公开(公告)日：1998-10-06

申请号：US748294

申请日：1996-11-13

申请人： Charles M. Beasley, Jr. ,  Jiban Kumar Chakrabarti ,  Terrence Michael Hotten ,  David Edward Tupper

发明人： Charles M. Beasley, Jr. ,  Jiban Kumar Chakrabarti ,  Terrence Michael Hotten ,  David Edward Tupper

IPC分类号： A61K31/551 ,  A61K31/5513 ,  A01N43/62

CPC分类号： A61K31/551 ,  A61K31/5513

摘要： 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno-�2,3-b!�1,5!benzodiazepine, or an acid salt thereof, has pharmaceutical properties, and is of particular use in the treatment of disorders relating to the use of psychoactive substances. The compound has the following structure: ##STR1##

摘要翻译： 2-甲基-4-（4-甲基-1-哌嗪基）-10H-噻吩并[2,3-b] [1,5]苯并二氮杂或其酸式盐具有药物性质，具有特别的用途 在治疗与使用精神活性物质有关的疾病方面。 该化合物具有以下结构：

公开(公告)号：US5817656A

公开(公告)日：1998-10-06

申请号：US748293

申请日：1996-11-13

申请人： Charles M. Beasley, Jr. ,  Jiban Kumar Chakrabarti ,  Terrence Michael Hotten ,  David Edward Tupper

发明人： Charles M. Beasley, Jr. ,  Jiban Kumar Chakrabarti ,  Terrence Michael Hotten ,  David Edward Tupper

IPC分类号： A61K31/551 ,  A61K31/5513 ,  A01N43/62

CPC分类号： A61K31/551 ,  A61K31/5513

摘要： 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno-�2,3-b!�1,5!benzodiazepine, or an acid salt thereof, has pharmaceutical properties, and is of particular use in the treatment of mental disorders. The compound has the following structure: ##STR1##

摘要翻译： 2-甲基-4-（4-甲基-1-哌嗪基）-10H-噻吩并[2,3-b] [1,5]苯并二氮杂或其酸式盐具有药物性质，具有特别的用途 在治疗精神障碍。 该化合物具有以下结构：

公开(公告)号：US6034078A

公开(公告)日：2000-03-07

申请号：US886847

申请日：1997-07-01

申请人： John Fairhurst ,  Terrence Michael Hotten ,  David Edward Tupper ,  David Taiwai Wong

发明人： John Fairhurst ,  Terrence Michael Hotten ,  David Edward Tupper ,  David Taiwai Wong

IPC分类号： C07D495/04 ,  A61K31/55

CPC分类号： C07D495/04

摘要： Pharmaceutical compounds of the formula ##STR1## in which R.sup.1 is hydrogen or halo, and R.sup.2 is C.sub.1-10 alkyl, C.sub.2-10 alkenyl, C.sub.2-10 alkynyl, C.sub.3-6 cycloalkyl optionally substituted by 1 to 3 C.sub.1-4 alkyl groups, C.sub.3-6 cycloalkyl-C.sub.1-4 alkyl in which the cycloalkyl group is optionally substituted by 1 to 3 C.sub.1-4 alkyl groups, or optionally substituted phenyl-C.sub.1-4 alkyl; or a salt thereof. Such compounds are useful for treating a disorder of the central nervous system which is associated with the modulation of a 5-HT.sub.3 receptor.

摘要翻译： 下式的药物化合物，其中R 1是氢或卤素，且R 2是C 1-10烷基，C 2-10烯基，C 2-10炔基，任选被1至3个C 1-4烷基取代的C 3-6环烷基，C 3-6 环烷基-C 1-4烷基，其中环烷基任选被1至3个C 1-4烷基取代，或任选取代的苯基-C 1-4烷基; 或其盐。 这样的化合物可用于治疗与5-HT 3受体的调节相关的中枢神经系统病症。

公开(公告)号：US5736541A

公开(公告)日：1998-04-07

申请号：US686989

申请日：1996-07-25

申请人： Charles Arthur Bunnell ,  Barry Arnold Hendriksen ,  Samuel Dean Larsen

发明人： Charles Arthur Bunnell ,  Barry Arnold Hendriksen ,  Samuel Dean Larsen

IPC分类号： A61K31/00 ,  A61K31/55 ,  A61P25/18 ,  C07B63/00 ,  C07D495/04 ,  A01N43/62 ,  C07D243/10

CPC分类号： C07D495/04

摘要： The invention provides Form II, a pharmaceutically elegant, stable polymorph of olanzapine useful for treating a condition selected from the group consisting of a psychotic condition, mild anxiety and gastrointestinal conditions.

摘要翻译： 本发明提供了形式II，其是用于治疗选自精神病状，轻度焦虑和胃肠病症的病症的奥氮平的药学上优雅稳定的多晶型物。

公开(公告)号：US5817655A

公开(公告)日：1998-10-06

申请号：US748292

申请日：1996-11-13

申请人： Jiban Kumar Chakrabarti ,  Terrence Micharl Hotten ,  David Edward Tupper

发明人： Jiban Kumar Chakrabarti ,  Terrence Micharl Hotten ,  David Edward Tupper

IPC分类号： A01N43/62 ,  A61K31/551 ,  A61K31/5513 ,  C07D243/10

CPC分类号： A61K31/551 ,  A61K31/5513

摘要： 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno -�2,3-b!�1,5!benzodiazepine, or an acid salt thereof, has pharmaceutical properties, and is of particular use in the treatment of disorders of the central nervous system. The compound has the following structure: ##STR1##

摘要翻译： 2-甲基-4-（4-甲基-1-哌嗪基）-10H-噻吩并[2,3-b] [1,5]苯并二氮杂或其酸式盐具有药物性质，特别适用于 治疗中枢神经系统疾病。 该化合物具有以下结构：

公开(公告)号：US20230136885A1

公开(公告)日：2023-05-04

申请号：US17798690

申请日：2021-02-05

申请人： Eli Lilly and Company

发明人： Thomas John BLEISCH ,  Douglas Linn GERNERT ,  Freddie Craig STEVENS

IPC分类号： C07D487/04

摘要： The present invention provides a compound of Formula (I) wherein R is (II) or (III), or a pharmaceutically acceptable salt thereof, useful for treating psoriasis, systemic lupus erythematosus, or type 1 diabetes.

公开(公告)号：US20230135992A1

公开(公告)日：2023-05-04

申请号：US17912341

申请日：2021-03-22

申请人： Eli Lilly and Company ,  Board of Regents, The University of Texas System

发明人： Nathan Arthur BROOKS ,  Courtney DINARDO ,  Raymond GILMOUR ,  Marina KONOPLEVA ,  Vivian SALAMA

IPC分类号： A61K31/5365 ,  C07K16/28 ,  A61K9/00 ,  A61P35/02

摘要： The present invention relates to combination therapy with a mutant IDH inhibitor of Formula (I) and a Bcl-2 inhibitor, for the treatment of cancer.

公开(公告)号：US11629156B2

公开(公告)日：2023-04-18

申请号：US17202867

申请日：2021-03-16

申请人： Eli Lilly and Company

发明人： Renato Alejandro Bauer ,  Serge Louis Boulet ,  Timothy Paul Burkholder ,  Raymond Gilmour ,  Patric James Hahn ,  Zoran Rankovic

IPC分类号： C07D498/04 ,  A61P35/02

摘要： A compound, as defined herein, or pharmaceutical composition containing the compound, for use in treating IDH1 or IDH2 mutant cancer and having the structure: (I).

公开(公告)号：US20230079438A1

公开(公告)日：2023-03-16

申请号：US17993489

申请日：2022-11-23

申请人： Eli Lilly and Company

发明人： Tonya Lee Chalfant ,  Carrie Jannean Page ,  Tony Y. Zhang ,  Robert Louis Ternik ,  Matthew Scott Thomas ,  Jacob Luisi ,  Michael P. Squillace

IPC分类号： B65D23/08 ,  A61J1/14 ,  B65D23/10 ,  B65D23/12

摘要： A gripping attachment (10) is disclosed which facilitates the handling of a medication bottle (12). The medication bottle includes a container (14) having a cylindrical wall (16) extending parallel to a longitudinal axis. The container is closed at one end by a base wall (18) and has an opposed open end. The container receives a cap (20) on the open end to enclose the container. The gripping attachment comprises a sleeve portion (22) having a sleeve wall (24) defining an internal, cylindrical surface configured to removably attach to the container wall. The gripping attachment further comprises a leverage component connected to the sleeve portion to facilitate gripping the sleeve portion.

公开(公告)号：US20230061806A1

公开(公告)日：2023-03-02

申请号：US17886863

申请日：2022-08-12

申请人： Eli Lilly and Company

发明人： David Andrew COATES ,  Yizheng CAO

IPC分类号： C07D498/04

摘要： Solid forms including 7-[[(1S)-1-[4-[(1S)-2-cyclopropyl-1-(4-prop-2-enoylpiperazin-1-yl)ethyl]phenyl]ethyl]amino]-1-ethyl-4H-pyrimido[4,5-d][1,3]oxazin-2-one and a dihydroxybenzoic acid selected from 2,5-dihydroxybenzoic acid, 2,4-dihydroxybenzoic acid, and 2,3-dihydroxybenzoic acid are provided, as well as pharmaceutical compositions including the solid forms, methods for using the solid forms in treating cancer patients, and methods of making the solid forms.