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公开(公告)号：US20240327410A1
公开(公告)日：2024-10-03
申请号：US18673909
申请日：2024-05-24
发明人： Michael K. Ameriks , Gang Chen , Chaofeng Huang , Brian Ngo Laforteza , Suchitra Ravula , Wei Zhang
IPC分类号： C07D471/18 , C07D519/00
CPC分类号： C07D471/18 , C07D519/00
摘要： Bridged compounds of Formula (I) and Formula (II), pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with MGL modulation, such as those associated with pain, psychiatric disorders, neurological disorders (including, but not limited to major depressive disorder, treatment resistant depression, anxious depression, bipolar disorder), cancers and eye conditions.
wherein R2, R3 R4, R5 and R6 are defined herein.-
公开(公告)号：US12098146B2
公开(公告)日：2024-09-24
申请号：US16751803
申请日：2020-01-24
IPC分类号： C07D413/04 , A61K31/166 , A61K31/175 , A61K31/436 , A61K31/4439 , A61K31/453 , A61K31/4545 , A61K31/475 , A61K31/495 , A61K31/497 , A61K31/501 , A61K31/55 , A61K45/06 , A61P35/00 , A61P35/04 , C07D237/22 , C07D401/06 , C07D401/12 , C07D403/12 , C07D413/14 , C07D417/14
CPC分类号： C07D413/14 , A61P35/04 , C07D401/06 , C07D401/12 , C07D403/12 , C07D413/04 , C07D417/14 , A61K31/495
摘要： The present invention features compounds useful in the treatment of neurological disorders and primary brain cancer. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders and primary brain cancer.
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公开(公告)号：US20240307322A1
公开(公告)日：2024-09-19
申请号：US18661125
申请日：2024-05-10
发明人： Jingli Wang , Michael Cannamela , Hong Yan , Rochelle Kleinberg
IPC分类号： A61K31/135 , A61K9/00 , A61M5/315
CPC分类号： A61K31/135 , A61K9/0043 , A61K9/008 , A61M5/31533
摘要： The present invention provides devices and methods for treating depression in a patient, comprising administering to the patient in need of the treatment a therapeutically effective amount of esketamine. In some embodiments, the depression is major depressive disorder or treatment resistant depression. In other embodiments, the therapeutically effective amount is clinically proven safe and/or effective. Also provided are methods to mitigate the risk or misuse or abuse of esketamine, instructions for use of the esketamine product, and methods for selling a drug product containing esketamine.
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公开(公告)号：US20240299365A1
公开(公告)日：2024-09-12
申请号：US18654424
申请日：2024-05-03
IPC分类号： A61K31/423 , A61K31/403 , A61K31/435 , A61P25/00
CPC分类号： A61K31/423 , A61K31/403 , A61K31/435 , A61P25/00
摘要： The disclosure relates to certain uses and methods of use of 3.1.0 and 4.1.0 azabicycle compounds of Formula (I), wherein X, Y, R1, R2a, and R2b are defined herein, and pharmaceutical compositions containing them, in the treatment of autism spectrum disorder, including Asperger's syndrome.
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公开(公告)号：US20240279281A1
公开(公告)日：2024-08-22
申请号：US18412678
申请日：2024-01-15
发明人： Stephanie A. BARROS , Santhosh Francis Neelamkavil , Chengzao SUN , Boying Guo , Charles Hendrick , David Marcoux , Sandeep Somani , Tho Thieu , Jing Zhang , Danila Branca , Roberto Costante , Ashok Bhandari , Gregory Thomas Bourne , Brian Troy Frederick
摘要： The present disclosure relates to peptide inhibitors of the interleukin-23 receptor (IL-23R) or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions, methods and/or uses for treatment of autoimmune inflammation and related diseases and disorders.
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![5-OXO-PYRIDO[2,3-D]PYRIDAZIN-6(5H)-YL ACETAMIDES](/abs-image/US/2024/08/22/US20240279223A1/abs.jpg.150x150.jpg)
公开(公告)号：US20240279223A1
公开(公告)日：2024-08-22
申请号：US18572243
申请日：2022-06-30
发明人： Daniel OEHLRICH , Michael Eric MURATORE , Laura PEREZ BENITO , Joseph Elisabeth LEENAERTS , Gary John TRESADERN , Michiel Luc M VAN GOOL , Nina VAN OPDENBOSCH , Mohamed LAMKANFI
IPC分类号： C07D471/04 , A61K31/5025 , A61K31/506 , C07D519/00
CPC分类号： C07D471/04 , A61K31/5025 , A61K31/506 , C07D519/00
摘要： The invention relates to novel compounds for use as inhibitors of NLRP3 inflammasone production, wherein such compounds are as defined by compounds of formula (I) and wherein the integers R1, R2 and R3 are defined in the description, and where the compounds may be useful as medicaments, for instance for use in the treatment of a disease or disorder that is associated with NLRP3 inflammasome activity.
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公开(公告)号：US12053474B2
公开(公告)日：2024-08-06
申请号：US17941464
申请日：2022-09-09
发明人： Ruth Milz , Frank Wiegand , Panna Sanga , John Louie
IPC分类号： A61K31/519 , A61K9/00 , A61K47/10 , A61K47/26 , A61P3/04
CPC分类号： A61K31/519 , A61K9/0019 , A61K47/10 , A61K47/26 , A61P3/04
摘要： The present invention provides a method of treating patients with long acting injectable paliperidone palmitate formulations.
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公开(公告)号：US12037644B2
公开(公告)日：2024-07-16
申请号：US16136201
申请日：2018-09-19
IPC分类号： A61P35/00 , A61K31/415 , A61K31/498 , C12Q1/6886
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/156
摘要： Disclosed herein are methods of identifying a cancer patient that will be responsive to treatment with a fibroblast growth factor receptor (FGFR) inhibitor and methods of treating cancer patients. The methods involve evaluating a biological sample from the patient for the presence of one or more FGFR mutants from a FGFR mutant gene panel. Kits and primers for identifying the presence of one or more FGFR mutant genes in a biological sample are also disclosed herein.
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公开(公告)号：US20240228465A1
公开(公告)日：2024-07-11
申请号：US18428046
申请日：2024-01-31
发明人： Guozhang Xu , Tho V. Thieu , Zhijie Liu , Micheal D. Gaul
IPC分类号： C07D401/14
CPC分类号： C07D401/14
摘要： The present invention provides imidazole substituted pyridine N-oxide derivatives, stereoisomers, isotopologues, isotopomers and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing said compounds and the use of said compounds in the treatment and/or prophylaxis of thromboembolic disorders, inflammatory disorders and diseases or conditions in which plasma kallikrein activity is implicated.
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公开(公告)号：US20240199605A1
公开(公告)日：2024-06-20
申请号：US18475499
申请日：2023-09-27
发明人： Wendy Eccles , Michael D. Hack , William M. Jones , Paul J. Krawczuk , Alec D. Lebsack , Daniel J. Pippel , Alexander R. Rovira , Ronald L. Wolin
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The present invention relates to compounds that inhibit NIK and pharmaceutical compositions comprising such compounds and methods of using the same. These compounds and pharmaceutical compositions are envisaged to be useful for preventing or treating diseases such as cancer (such as B-cell malignancies including leukemias, lymphomas and myeloma), inflammatory disorders, autoimmune disorders, immunodermatologic disorders such as palmoplantar pustulosis and hidradenitis suppurativa, and metabolic disorders such as obesity and diabetes.
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