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72 条记录 (耗时 0.057 秒)

    Urea derivatives and uses thereof
    2.
    发明授权
    Urea derivatives and uses thereof 有权

    公开(公告)号：US11352343B2

    公开(公告)日：2022-06-07

    申请号：US16900657

    申请日：2020-06-12

    申请人： Kala Pharmaceuticals, Inc.

    发明人： Winston Zapanta Ong ,  Pawel Wojciech Nowak ,  John Thomas Feutrill ,  Jinsoo Kim

    IPC分类号： C07D413/14 ,  A61P35/00 ,  C07D403/10 ,  A61K9/00 ,  A61K9/14 ,  C07D471/04 ,  C07D231/56 ,  C07D401/04 ,  C07D403/04 ,  A61K31/416

    摘要： The present invention provides novel compounds of any one of Formulae (I)-(III), and pharmaceutical compositions thereof. Also provided are particles (e.g., nanoparticles) comprising compounds of Formula (I)-(III) and pharmaceutical compositions thereof that are mucus penetrating. The invention also provides methods and kits for using the inventive compounds, and pharmaceutical compositions thereof, for treating and/or preventing diseases associated with abnormal or pathological angiogenesis and/or aberrant signaling of a growth factor (e.g., vascular endothelial growth factor (VEGF)), such as proliferative diseases (e.g., cancers, benign neoplasms, inflammatory diseases, autoimmune diseases) and ocular diseases (e.g., macular degeneration, glaucoma, diabetic retinopathy, retinoblastoma, edema, uveitis, dry eye, blepharitis, and post-surgical inflammation) in a subject in need thereof.

    Crystalline forms of a therapeutic compound and uses thereof
    6.
    发明授权
    Crystalline forms of a therapeutic compound and uses thereof 有权

    公开(公告)号：US10253045B2

    公开(公告)日：2019-04-09

    申请号：US15529969

    申请日：2015-11-24

    申请人： Kala Pharmaceuticals, Inc.

    发明人： Tadeas Liska ,  Elizabeth Enlow ,  Jinsoo Kim ,  Winston Ong

    IPC分类号： C07D519/00 ,  A61K31/5025 ,  A61P27/02

    摘要： Disclosed herein are certain crystalline forms of Compound 5, N-(5-((2-(4-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butanamido)imidazo[1,2-0]pyridazin-6-yl)oxy)-2-methylphenyl)-1,3-dimethyl-1/-/-pyrazole-5-carboxamide, as well as pharmaceutical compositions comprising the crystalline forms. The present disclosure further relates to methods for treating or preventing diseases or disorders using the crystalline forms or pharmaceutical compositions thereof in a subject in need thereof, including diseases or disorders associated with abnormal or pathological angiogenesis and/or aberrant signaling of a growth factor signaling pathway (e.g., vascular endothelial growth factor (VEGF)), such as proliferative diseases and ocular diseases.

    COMPOSITIONS AND METHODS FOR OPHTHALMIC AND/OR OTHER APPLICATIONS
    10.
    发明申请
    COMPOSITIONS AND METHODS FOR OPHTHALMIC AND/OR OTHER APPLICATIONS 有权

    公开(公告)号：US20160228358A9

    公开(公告)日：2016-08-11

    申请号：US14070506

    申请日：2013-11-02

    申请人： Kala Pharmaceuticals, Inc.

    发明人： Alexey Popov ,  Elizabeth M. Enlow ,  Hongming Chen ,  James Bourassa

    IPC分类号： A61K9/00 ,  A61K31/56 ,  A61K9/50

    CPC分类号： A61K9/0048 ,  A61K9/5031 ,  A61K9/5123 ,  A61K9/5138 ,  A61K9/5146 ,  A61K31/56

    摘要： Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and/or the back of the eye.