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公开(公告)号：US20210268461A1
公开(公告)日：2021-09-02
申请号：US17204676
申请日：2021-03-17
发明人： Paul Seaman , Huw Jones , Liam MCALEER
摘要： Provided is an apparatus for producing solid polymeric microparticles, the apparatus comprising a plurality of liquid droplet generators for forming liquid droplets of a first liquid, and a nozzle for forming a jet of a second liquid, wherein the plurality of liquid droplet generators and the nozzle are arranged relative to each other such that, in use, liquid droplets from the plurality of liquid droplet generators pass through a gas into said jet of second liquid. Also provided is a process for producing solid microparticles, the process comprising: providing a first liquid comprising a solute and a solvent, the solute comprising a biocompatible polymer, the concentration of polymer in the first liquid being at least 10% w/v, ‘w’ being the weight of the polymer and ‘v’ being the volume of the solvent, providing a plurality of liquid droplet generators operable to generate liquid droplets, providing a jet of a second liquid, causing the plurality of liquid droplet generators to form liquid droplets of the first liquid, passing the liquid droplets through a gas to contact the jet of the second liquid so as to cause the solvent to exit the droplets, thus forming solid microparticles, the solubility of the solvent in the second liquid being at least 5 g of solvent per 100 ml of second liquid, the solvent being substantially miscible with the second liquid.
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公开(公告)号：US11090626B2
公开(公告)日：2021-08-17
申请号：US16077703
申请日：2017-02-22
摘要： The present invention provides a process for producing nanoparticles, comprising: providing a first liquid comprising a metal salt and at least one species of ligand having a functional group capable of binding to a metal surface, providing a second liquid comprising a reducing agent; providing at least one liquid droplet generator operable to generate liquid droplets, causing the at least one liquid droplet generator to form liquid droplets of the first liquid, passing the liquid droplets through a gas to contact the second liquid so as to cause the metal salt and the at least one species of ligand to come into contact with the reducing agent, thereby causing self-assembly of nanoparticles, said nanoparticles having a core of said metal and a corona comprising a plurality of said ligands covalently bound to the core. Also provided are nanoparticles produced by the process of the invention and use of such nanoparticles in medicine.
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公开(公告)号：US11154504B2
公开(公告)日：2021-10-26
申请号：US15780208
申请日：2016-12-16
发明人： Paul Seaman , Katharine Bamsey , Nigel Thomas , Dewi Paice
摘要： A controlled release pharmaceutical formulation is provided, comprising cyclosporine-loaded microparticles of a bioresorbable polymer comprising poly(D,L-lactide), wherein the mean diameter of the microparticles is in the range 20 μm to 40 μm. Also provided are medical uses of the pharmaceutical formulation, in particular in the treatment of uveitis, a process for production of the pharmaceutical formulation and injectable dosage forms, including those formulated for intravitreal injection.
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公开(公告)号：US10981131B2
公开(公告)日：2021-04-20
申请号：US15780211
申请日：2016-12-16
发明人： Paul Seaman , Huw Jones , Liam McAleer
摘要： Provided is an apparatus for producing solid polymeric microparticles, the apparatus comprising a plurality of liquid droplet generators for forming liquid droplets of a first liquid, and a nozzle for forming a jet of a second liquid, wherein the plurality of liquid droplet generators and the nozzle are arranged relative to each other such that, in use, liquid droplets from the plurality of liquid droplet generators pass through a gas into said jet of second liquid. Also provided is a process for producing solid microparticles, the process comprising: providing a first liquid comprising a solute and a solvent, the solute comprising a biocompatible polymer, the concentration of polymer in the first liquid being at least 10% w/v, ‘w’ being the weight of the polymer and ‘v’ being the volume of the solvent, providing a plurality of liquid droplet generators operable to generate liquid droplets, providing a jet of a second liquid, causing the plurality of liquid droplet generators to form liquid droplets of the first liquid, passing the liquid droplets through a gas to contact the jet of the second liquid so as to cause the solvent to exit the droplets, thus forming solid microparticles, the solubility of the solvent in the second liquid being at least 5 g of solvent per 100 ml of second liquid, the solvent being substantially miscible with the second liquid.
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公开(公告)号：US09625211B2
公开(公告)日：2017-04-18
申请号：US14234059
申请日：2012-07-27
CPC分类号： F26B5/12 , B01D21/2405 , B01D21/2411 , B01D21/267 , B01J2/18 , B01J19/0093
摘要： A device is provided for separating beads from a carrier fluid, the device comprising: a bead-receiving means for receiving beads dispersed in a carrier fluid, a fluid removal means operable to remove fluid from the bead-receiving means in a first fluid removal zone by the application of reduced pressure, and a bead collection means operable to remove beads from the bead-receiving means in a bead collection zone by the application of reduced pressure, the bead-receiving means being movable so that beads are movable from the first fluid removal zone to the bead collection zone.
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公开(公告)号：US09156016B2
公开(公告)日：2015-10-13
申请号：US13876773
申请日：2011-09-30
申请人： Daniel Palmer , Owen Shadick
发明人： Daniel Palmer , Owen Shadick
摘要： An apparatus for making solid beads is provided, the apparatus comprising at least one liquid droplet generator operable to generate droplets comprising a solute dissolved in a solvent, and at least one flow channel for carrying a second liquid, at least one liquid droplet generator and at least one flow channel being spaced relative to one another so that, in use, liquid droplets pass through a gas into a second liquid provided in said flow channel, the solvent being soluble in the second liquid so as to cause the solvent to exit the droplets, thus forming solid beads. A method of preparing solid beads is also provided.
摘要翻译： 提供了一种用于制造实心珠的装置，该装置包括至少一个液滴发生器，其可操作以产生包含溶解在溶剂中的溶质的液滴，以及用于承载第二液体的至少一个流动通道，至少一个液滴发生器 至少一个流动通道相对于彼此间隔开，使得在使用中，液滴通过气体进入设置在所述流动通道中的第二液体中，溶剂可溶于第二液体中，以使溶剂离开液滴 ，从而形成固体珠粒。 还提供了制备固体珠粒的方法。
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公开(公告)号：US20230077586A1
公开(公告)日：2023-03-16
申请号：US17801496
申请日：2021-02-25
发明人： Paul Seaman , Connor Davies , Louis King
摘要： The present invention comprises an apparatus and method for producing a microparticle and pharmaceutical compositions thereof. The apparatus and method rely on continuous inkjet (CIJ) printing to provide high quality microparticles at an improved rate.
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公开(公告)号：US09656228B2
公开(公告)日：2017-05-23
申请号：US12999578
申请日：2009-06-16
申请人： Daniel Palmer , Richard Calder , Owen Shadick
发明人： Daniel Palmer , Richard Calder , Owen Shadick
CPC分类号： B01J2/08 , A61K9/1647 , A61K9/1694
摘要： A method of making solid beads is disclosed, said method comprising: (i) providing a microfluidic device comprising a carrier fluid conduit and a functional fluid conduit which meet at a junction region; (ii) providing a laminar flow of a functional fluid comprising a solvent and a solute along the functional fluid conduit and providing a laminar flow of a carrier fluid along the carrier fluid conduit so as to form droplets of functional fluid in a flow of carrier fluid; (iii) cooling the segments of functional fluid in a conduit of the microfluidic device to form cooled (preferably frozen) droplets; and (iv) providing a liquid into intimate admixture with the cooled droplets so as to cause said solvent to exit said cooled droplets, thus forming solid beads. A microfluidic device for use in such a method is also disclosed.
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