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公开(公告)号：US11542480B2
公开(公告)日：2023-01-03
申请号：US16645120
申请日：2018-09-10
申请人： NIPRO CORPORATION
发明人： Takashi Kimura , Yasushi Tani
摘要： A mutant glycine oxidase is obtained by substituting at least one wild-type amino acid sequence derived from thermophilic bacteria belonging to the family Bacillus with another amino acid, and has the following enzyme properties. Molecular weight: 40,000±2,000 daltons by SDS-PAGE. Optimum temperature: 45° C. under the condition of pH 8.5 in presence of pyrophosphate. Optimum pH: pH 8.0 under the condition of 37° C. in presence of pyrophosphate. Thermal stability: Stable up to 70° C. under the condition of pH 8.5 while retaining for 1 hour in presence of pyrophosphate. pH Stability: Stable in the range of pH 5.5 to 10.0 under the condition of 4° C. while retaining for 24 hours in presence of pyrophosphate. Specific activity: 1.2 units/mg or more. Kinetic constant Km: 0.2 mM or less.
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公开(公告)号：US11529165B2
公开(公告)日：2022-12-20
申请号：US16530615
申请日：2019-08-02
申请人： Nipro Corporation
IPC分类号： A61B17/3207 , A61B8/12 , A61B8/00 , A61B17/22 , A61B90/00
摘要： To provide a catheter having a simple structure capable of excising an atheroma in a blood vessel and capable of obtaining ultrasonic images of a blood vessel.
[Solution] A catheter 10 has a shaft 11 having an opening 20 in a part of the side wall on the distal end side, a cutter 12 which is located in the vicinity of the opening 20 in the internal space of the shaft 11 and which can move in the axial direction 101 of the shaft 11, a balloon 23 which is disposed on the side opposite to the opening 20 with respect to the axis of the shaft 11 and which outwardly expands from the side wall of the shaft 11, and a phased array ultrasound probe 17 disposed along the circumferential direction 102 of the outer peripheral surface of the side wall in the vicinity of the opening 20 at least on the same side as the side where the opening 20 is provided with respect to the axis of the shaft 11.-
公开(公告)号：US20220370294A1
公开(公告)日：2022-11-24
申请号：US17774190
申请日：2020-11-05
申请人： NIPRO CORPORATION
发明人： Yukihiro YABE
IPC分类号： A61J1/20
摘要： A syringe-shaped spraying device includes: a syringe-shaped spraying device main body including a barrel that stores a liquid medicine, a plunger having a front end inserted in the barrel with a gasket being attached to the front end, and a nozzle that is provided with a spraying hole for spraying the liquid medicine and that is connected to a front end of the barrel; a vial adapter having a transfer needle to pierce a vial that stores a liquid medicine so as to suction the liquid medicine; and a connection adapter that is attached to the syringe-shaped spraying device main body and that connects the vial adapter to the syringe-shaped spraying device main body.
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公开(公告)号：US11331454B2
公开(公告)日：2022-05-17
申请号：US16306624
申请日：2017-06-02
申请人： NIPRO CORPORATION
发明人： Yoshiei Ono , Kohzo Ishikura , Tatsuya Kudo , Takeshi Yamaguchi
摘要： The present invention provides a needle tip protector of a novel structure for an indwelling needle, which enables improvements in safety, etc. as compared with conventional needle tip protectors. A needle tip protector 10 for an indwelling needle includes a tubular peripheral wall 58, and is externally attached over a needle hub 22 of an indwelling needle 16 and moved toward a needle tip 14 side so as to cover the needle tip 14. Detents 74, 74, which are to be detained with the needle hub 22 at a position in a movement of the protector toward the needle tip 14 side of the indwelling needle 16 so as to inhibit backward movement of the protector to the proximal end side of the indwelling needle 16 and to prevent the needle tip 14 from being reexposed, are formed within an inside enclosed by the peripheral wall 58, and are integrally molded with the peripheral wall 58.
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公开(公告)号：US20210347674A1
公开(公告)日：2021-11-11
申请号：US17271416
申请日：2019-08-29
申请人： NIPRO CORPORATION
发明人： Michael DROESSLER
摘要： A glass tube is treated with laser cutting for separating a hollow glass body from the glass tube. A laser beam used for laser cutting is focused on a wall of the glass tube.
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公开(公告)号：US11123264B2
公开(公告)日：2021-09-21
申请号：US16313410
申请日：2017-06-27
发明人： Norio Nakatsuji , Hirofumi Suemori , Tsuneo Takahashi , Eihachiro Kawase , Atsushi Taguchi , Ryo Tomii
摘要： A biological sample or drug stored inside a frozen storage container is not susceptible to contamination. The frozen storage container includes a container body with an internal space, and a partition wall which divides the internal space at least into a first space and a second space. In the container body, the first space is liquid-tightly sealed, the second space has an opening which is in communication with the outside, and the second space is liquid-tightly sealable by welding the container body. A frozen storage container system includes the frozen storage container; and a needle member which includes a needle tip portion capable of being inserted into the internal space of the container body and capable of piercing the partition wall, and has a flow path which is opened at the needle tip portion and is opened at a base end portion opposite to the needle tip portion.
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公开(公告)号：US10987493B2
公开(公告)日：2021-04-27
申请号：US15544946
申请日：2016-02-19
申请人： NIPRO CORPORATION
发明人： Yoshihiko Sano , Katsuhiro Hiejima
IPC分类号： A61M25/09
摘要： Provided is a guide wire having a novel structure, with which it is possible to improve production efficiency and to effectively prevent large irregularities from forming on an outer circumferential surface of a core wire. Further provided is a guide wire having a novel structure, with which it is possible to more meticulously set bending rigidity to a distal end portion thereof. In a guide wire having a coil externally mounted about a distal end portion of a core wire, a proximal end portion of the coil is integrally joined to the core wire during formation of the coil. Furthermore, in a guide wire having a coil externally mounted about a distal end portion of a core wire, a cross-sectional shape of a wire that constitutes the coil varies in a lengthwise direction of the coil.
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公开(公告)号：US20200375767A1
公开(公告)日：2020-12-03
申请号：US16495021
申请日：2018-03-22
申请人： NIPRO CORPORATION
发明人： Koji AKIMOTO
摘要： A stent having a line-shaped body that extends helically in a circumferential direction while reciprocating in an axial direction by continuously alternating straight parts and curved parts, wherein the plurality of straight parts in the line-shaped body have a substantially constant thickness throughout the entire stent, and a certain number of the plurality of curved parts in the line-shaped body have different thicknesses.
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公开(公告)号：US20200166525A1
公开(公告)日：2020-05-28
申请号：US16631619
申请日：2018-07-24
申请人： Toru HASEGAWA , NIPRO CORPORATION
发明人： Toru HASEGAWA , Hiroshi YOSHIDA , Yoshinori KOSOKU
摘要： Provided is a method for aiding diagnosis of a neurodegenerative disease in a subject with a light physical burden. The method for aiding diagnosis of the neurodegenerative disease, comprising: a first assessment step of assessing a risk of the neurodegenerative disease based on an amount of homocysteine acid in a biological sample obtained from the subject; a second assessment step of assessing a risk of the neurodegenerative disease based on an amount of an inflammatory factor, a pituitary gland secretion, or an autonomic nerve secretion in the biological sample obtained from the subject or based on a measured value obtained from a brain image of the subject; and a step of determining whether the subject has the neurodegenerative disease based on the results of the first assessment and the second assessment.
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