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公开(公告)号：US20230307094A1
公开(公告)日：2023-09-28
申请号：US17736350
申请日：2022-05-04
发明人： Chung-I LI , Meng-Ru SHEN , Yi-Shan TSAI , Peng-Chan LIN , Pei-Fang SU , Yi-Huan LIAO , Yu-Husan LAI
IPC分类号： G16B25/10 , G16B20/20 , G16B30/00 , C12Q1/6886
CPC分类号： G16B25/10 , C12Q1/6886 , G16B20/20 , G16B30/00 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158
摘要： A method for predicting cancer prognosis is disclosed, and the method comprises capturing a reference radiomics and obtaining reference pathological eigenvalues, wherein the reference pathological eigenvalues are based on pathological features of a reference patients, and the pathological features comprise genomic features, gene expression, test values or a combination of two or more thereof. Then, capturing a test radiomics and obtaining test pathological eigenvalues are performed, wherein the test pathological eigenvalues are based on pathological features of a test patients, and the pathological features comprise genomic features, gene expression, test values or a combination of two or more thereof. A mathematical formula is used to calculate a prognostic index based on the aforementioned reference radiomics, reference pathological eigenvalues, test radiomics and test pathological eigenvalues, and the prognostic change risk of the test patient is evaluated according to the prognostic index.
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公开(公告)号：US12051338B2
公开(公告)日：2024-07-30
申请号：US17152297
申请日：2021-01-19
发明人： Shu Wei Tsai , Chun-Wei Tang , Jenn-Ren Hsiao , Chou-Ching Lin
CPC分类号： G09B23/285 , B33Y80/00
摘要： The disclosure provides a human laryngeal model for simulation of endoscopic guided injection laryngoplasty surgery and for an insertion of a syringe containing a fluid. The human laryngeal model includes a laryngeal body, a seat body, and a vocal cord. The seat body is mounted to the laryngeal body. The seat body has an accommodation space. The vocal cord includes a plate and at least one bag body. The plate is stacked on the seat body, the bag body is fixed to the plate and located in the accommodation space of the seat body, and the bag body has a storage space. The vocal cord is configured for the insertion of the syringe to allow the syringe to inject the fluid into the storage space of the bag body. In addition, the disclosure also provides a human head and neck model including the human laryngeal model.
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公开(公告)号：US20220157194A1
公开(公告)日：2022-05-19
申请号：US17152297
申请日：2021-01-19
发明人： Shu Wei TSAI , Chun-Wei TANG , Jenn-Ren HSIAO , Chou-Ching LIN
摘要： The disclosure provides a human laryngeal model for simulation of endoscopic guided injection laryngoplasty surgery and for an insertion of a syringe containing a fluid. The human laryngeal model includes a laryngeal body, a seat body, and a vocal cord. The seat body is mounted to the laryngeal body. The seat body has an accommodation space. The vocal cord includes a plate and at least one bag body. The plate is stacked on the seat body, the bag body is fixed to the plate and located in the accommodation space of the seat body, and the bag body has a storage space. The vocal cord is configured for the insertion of the syringe to allow the syringe to inject the fluid into the storage space of the bag body. In addition, the disclosure also provides a human head and neck model including the human laryngeal model.
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公开(公告)号：US10271835B2
公开(公告)日：2019-04-30
申请号：US15239882
申请日：2016-08-18
发明人： Chien-Hui Ou , Huei-Hua Hsiao , Tai-Ho Li
摘要： A device for surgical ligation is provided, which comprises: a housing, where a pulling portion is provided therein; and an opening portion provided at one end of the housing and connected to the pulling portion, where a line delivery element is provided therein. The line delivery element comprises: a first arc unit having a first coupling portion and a slot thereon; a second arc unit having a second coupling portion corresponding to the first coupling portion; and a gear assembly comprising a plurality of gears engaging with each other, wherein a first gear is engaged with the pulling portion while a second gear is engaged with the second arc unit.
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公开(公告)号：US10981139B2
公开(公告)日：2021-04-20
申请号：US16572785
申请日：2019-09-17
发明人： Wei-lun Huang , Wu-chou Su , Hai-wen Chen , Te-fu Yeh , Hsisheng Teng , Chung-jen Chung
IPC分类号： B01J19/08 , H01L31/12 , C09K11/00 , B01J19/10 , B01J19/12 , G01N33/58 , B01J35/00 , B01J27/24 , B01J23/745 , B01J21/18 , B01J21/06
摘要： A semiconductor quantum dot is provided with a non-metallic substrate, and has a particle size ranged from 0.3 to 100 nm. A method of carrying out a chemical reaction or a photoluminescence reaction by using the semiconductor quantum dot is also provided. A redox reaction of a target sample is carried out, an active substance is generated, or an electron-hole pair is produced from the semiconductor quantum dot by providing the semiconductor quantum dot with a predetermined energy. Photons are released by the combination of the electron-hole pair so as to perform the photoluminescence reaction.
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公开(公告)号：US09770462B2
公开(公告)日：2017-09-26
申请号：US14874937
申请日：2015-10-05
发明人： Cheng-Yang Chou , Tien-En Kuo , Yu-Fang Huang
IPC分类号： A61K31/132 , A61K31/704 , A61K31/555 , A61K45/06
CPC分类号： A61K31/704 , A61K31/132 , A61K31/555 , A61K45/06 , A61K2300/00
摘要： A method of treating ovarian, tubal and peritoneal cancer is revealed. It comprises administering an effective amount of a pharmaceutical composition (including a copper chelator, a platinum-based chemotherapeutic agent and an anthracycline) to a subject in need thereof for reducing concentration of intracellular copper ions and promoting activation of transcription factor Sp1 and human copper transporter 1 (hCTR1).
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公开(公告)号：US10376330B2
公开(公告)日：2019-08-13
申请号：US15479460
申请日：2017-04-05
发明人： How-Ran Guo , Chao-Lin Chen , Jin-Jia Hu
摘要： A molded container for a tissue scaffold is provided. The molded container comprises a bag made from a soft material, a shape memory frame, and an inner support tube. A sealing part is disposed on the opening of the bag, and an operation window is disposed on the lower part of the bag. The sealing part is closed when no external force is applied. The shape memory frame is embedded in the bag. At least two adjustable hooks are disposed on the ends of the shape memory frame. The inner support tube is disposed on the inner bottom of the bag and selectively penetrates a molded accommodation volume for forming a tissue scaffold. The length of the inner support tube is more than the length of the molded accommodation volume. Therefore, the molded container for a tissue scaffold has features of portability, adjustability, sterility, convenience, and stability.
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公开(公告)号：US10962530B2
公开(公告)日：2021-03-30
申请号：US15842857
申请日：2017-12-14
发明人： Wei-Lun Huang , Wu-Chou Su , Hai-Wen Chen , Wei-Pang Chung , I-Ting Chiang , Te-Fu Yeh , Hsisheng Teng , Liang-Che Chen
IPC分类号： G01N33/542 , G01N33/58
摘要： A molecular probe includes a detector molecule specific to a target molecule, and at least one label linked covalently or non-covalently to the detector molecule. The label includes a catalyst for generating electrons and/or mediators from a solution. The catalyst includes a nanomaterial, an enzyme, a metal, and/or a metal complex. The mediators can accumulate in the solution for a period of time. The detector molecule and the target molecule interact with each other by a protein based or nucleotide sequence based interaction. The mediators participate in a chemical reaction that generates a signal that may be a change in optical, electromagnetic, thermodynamic or mechanical properties. Generation efficiency of the mediators is enhanced by providing an energy to the solution. The molecular probe may be used with a molecular detection assay performed on a surface. A method for assaying the target molecule using the molecular probe is also provided.
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公开(公告)号：US10806801B2
公开(公告)日：2020-10-20
申请号：US15997715
申请日：2018-06-05
申请人： NATIONAL CHENG KUNG UNIVERSITY , NATIONAL CHENG KUNG UNIVERSITY HOSPITAL , NATIONAL TAIWAN NORMAL UNIVERSITY
发明人： Wu-Chou Su , Hai-Wen Chen , Tsung-Lin Tsai , Dar-Bin Shieh , Chia-Chun Chen
IPC分类号： A61K47/68 , A61K47/69 , A61K31/137 , A61K49/18 , A61K49/04 , A61K9/51 , A61K41/00 , A61K47/58 , A61K47/59 , A61K47/54 , A61K47/60 , A61B5/055 , A61B6/03 , A61K31/661 , A61K31/662 , A61N5/10 , A61K9/00
摘要： A pharmaceutical composition includes a plurality of metal nanoparticles and at least one therapeutic agent. Each of the metal nanoparticles includes a core and a stabilizing agent coated on a surface of the core. The at least one therapeutic agent is attached to the stabilizing agent of the metal nanoparticles. Each of the therapeutic agent is an amphiphilic compound and has at least one hydrophobic chain interacting with the stabilizing agent. The pharmaceutical composition may further include a polymer shell encapsulating the metal nanoparticles and the therapeutic agent for enabling controlled release of the therapeutic agent. The pharmaceutical compositions are bifunctional and may be used for diagnosing and treating cancer. Methods for using the pharmaceutical compositions in conjunction with radiation therapy to diagnose and treat cancer are also provided.
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公开(公告)号：US10520493B2
公开(公告)日：2019-12-31
申请号：US14657128
申请日：2015-03-13
发明人： Meng-Ru Shen , Lian-Yun Chang , Yuan-Ting Sun , Jang-Yang Chang
摘要： A method for assessment of neural function by establishing an analysis module is revealed. The first step of the method is to capture images of the cultured cells with a plurality of fluorescence labeling by a fluorescence microscopy system for image analysis. The cultured cells include neurons and non-neuronal cells. Then select neurons with neurites having fluorescence labeling and exclude non-neuronal cells according to an area and a fluorescence intensity of nucleus. Also calculate an area of the neuronal cell body, a length of the neurites and a number of processes and branches to verify outgrowth of the neurites of the neurons. Next calculate a number of synaptic puncta having fluorescence labeling on the area of the neurites having fluorescence labeling defined in Step 2 to verify formation of the synaptic puncta of the neurons for assessment of neural function.
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