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77 条记录 (耗时 0.03 秒)

    Guidewire
    1.
    发明申请
    Guidewire 审中-公开

    公开(公告)号：US20200146688A1

    公开(公告)日：2020-05-14

    申请号：US16743092

    申请日：2020-01-15

    申请人： PneumRx, Inc.

    发明人： Timothy Machold ,  Mark Mathis ,  Verna Rodriguez ,  Scott Kaarto

    IPC分类号： A61B17/12 ,  A61M25/09

    摘要： Embodiments include a transition section for coupling a distal section and a proximal section of the guidewire. The transition section includes a main body having a first outer diameter; proximal and distal pin extensions having second and third outer diameters, wherein the proximal pin extension is configured to be fixed to the proximal section of the guidewire, and the distal pin extension is configured to be inserted into and fixed to the distal section of the guidewire. The distal pin extension includes a bore for receiving an inner core of the distal section of the guidewire. The first outer diameter may be greater than the second and third outer diameters. Also disclosed are methods of manufacturing a guidewire with such a transition section.

    Lung Volume Reduction Apparatus and Methods
    2.
    发明申请
    Lung Volume Reduction Apparatus and Methods 审中-公开

    公开(公告)号：US20190350588A1

    公开(公告)日：2019-11-21

    申请号：US16417183

    申请日：2019-05-20

    申请人： PneumRx, Inc.

    发明人： Verna Rodriguez ,  Kinman Hong

    IPC分类号： A61B17/12 ,  A61B1/267 ,  A61F2/04

    摘要： The invention provides improved medical devices, therapeutic treatment systems, and treatment methods for treatment of the lung. The invention includes methods, systems, and devices for applying a first lung volume reduction action to the functionally impaired lung tissue so as to reduce its volume to less than a pre-treatment volume; and applying a pro-inflammatory stimulus to the functionally impaired lung tissue having reduced volume, that stimulus being sufficient to induce fibrosis in the functionally impaired lung tissue. The pro-inflammatory stimulus may be separate and additional to that of the lung volume reduction action.

    Torque alleviating intra-airway lung volume reduction compressive implant structures
    3.
    发明授权
    Torque alleviating intra-airway lung volume reduction compressive implant structures 有权

    公开(公告)号：US10188397B2

    公开(公告)日：2019-01-29

    申请号：US15192085

    申请日：2016-06-24

    申请人： PneumRx, Inc.

    发明人： Jaime Vasquez ,  Mark L. Mathis ,  Timothy Machold ,  Andrew Stein

    IPC分类号： A61B17/08 ,  A61B17/12

    摘要： A device for enhancing the breathing efficiency of a patient is provided. The implantable device may include a deployed configuration with one or more helical sections with proximal end in a stand-off proximal end configuration. The stand-off proximal end configuration may reduce migration of the deployed device and may preserve implant tissue compression. Alternative configurations may include two or more helical sections with a transition section disposed between the two or more helical sections. A device may include a right-handed helical section and a left-handed helical section and the transition section comprises a switchback transition section. The switchback section may provide greater control of the device during deployment by limiting recoiling forces of a device comprising a spring material. The deployed device may compress the lung to increase a gas filling resistance of the compressed portion of the lung, and/or increase tension and elastic recoil in other portions of the lung.

    Cross-Sectional Modification During Deployment of an Elongate Lung Volume Reduction Device
    7.
    发明申请
    Cross-Sectional Modification During Deployment of an Elongate Lung Volume Reduction Device 有权
    在延长肺容积减少装置的部署过程中的横断面修改

    公开(公告)号：US20150073563A1

    公开(公告)日：2015-03-12

    申请号：US14225892

    申请日：2014-03-26

    申请人： PNEUMRX, INC.

    发明人： Mark L. Mathis ,  Patrick Wu ,  David Lehrberg ,  Jaime Vasquez ,  Erin McGurk ,  Ronald Dieck ,  Andrew Stein

    IPC分类号： A61B17/12 ,  A61F2/04

    CPC分类号： A61B17/12104 ,  A61B1/2676 ,  A61B17/10 ,  A61B17/12022 ,  A61B17/12031 ,  A61B17/1214 ,  A61B17/12145 ,  A61B17/1215 ,  A61B17/12168 ,  A61B17/12172 ,  A61B17/1219 ,  A61B2017/00867 ,  A61B2017/1205 ,  A61F2/04 ,  A61F2002/043

    摘要： Elongate implant structures can be introduced into an airway system to a target airway axial region, often to apply lateral bending and/or compression forces against the lung tissue from within the airways for an extended period of time. Structures or features of the implants may inhibit tissue reactions that might otherwise allow portions of the device to eventually traverse through the wall of the airway. The devices may enhance the area bearing laterally on the tissue of a surrounding airway lumen wall. Embodiments may have features which increase the device friction with the airway to allow the device to grip the surrounding airway as the device is deployed. An appropriate adhesive may be introduced around the device in the lung. Hydrophilic material may inhibit biofilm formation, or features which induce some tissue ingrowth (stimulation of tissue growth) may enhance implanted device supported.

    摘要翻译： 细长的植入物结构可被引入到目标气道轴向区域的气道系统中，经常在气道内长时间施加横向弯曲和/或压缩力对肺组织。 植入物的结构或特征可以抑制组织反应，否则可能会使装置的部分最终穿过气道的壁。 这些装置可以增强在周围气道腔壁的组织上横向承受的面积。 实施例可以具有增加与气道的装置摩擦的特征，以允许装置在装置展开时夹紧周围气道。 可能在肺内的装置周围引入适当的粘合剂。 亲水材料可能抑制生物膜形成，或引起一些组织向内生长（刺激组织生长）的特征可以增强植入装置的支持。

    GLUE COMPOSITION FOR LUNG VOLUME REDUCTION
    9.
    发明申请
    GLUE COMPOSITION FOR LUNG VOLUME REDUCTION 审中-公开
    用于肺容量减少的GLUE组合物

    公开(公告)号：US20140073588A1

    公开(公告)日：2014-03-13

    申请号：US13855596

    申请日：2013-04-02

    申请人： PneumRx, Inc.

    发明人： Glen Gong ,  Ronald Dieck

    IPC分类号： A61K38/55

    CPC分类号： A61K38/55 ,  A61K38/57 ,  A61K47/6425 ,  A61K47/66 ,  A61K51/088 ,  B82Y5/00

    摘要： The present invention relates to methods and compositions for sealing localized regions of damaged lung tissue to reduce overall lung volume. The glue compositions provide a glue featuring an adhering moiety coupled to one or more other moieties including, for example, a cross-linkable moiety and/or one other adhering moiety. The methods and compositions of the invention find use, for example, in treating pulmonary conditions, such as emphysema.

    摘要翻译： 本发明涉及用于密封损伤的肺组织的局部区域以减少整体肺容积的方法和组合物。 粘合剂组合物提供了胶粘剂，其特征在于连接至一个或多个其它部分的粘合部分，包括例如可交联部分和/或一个其它粘合部分。 本发明的方法和组合物可用于例如治疗肺部疾病如肺气肿。