Encased polymer nanofiber-based electronic nose

    公开(公告)号:US11714075B2

    公开(公告)日:2023-08-01

    申请号:US17032614

    申请日:2020-09-25

    发明人: David S. Ensor Li Han

    IPC分类号: G01N33/00 G01N27/12 G01N27/22

    摘要: A chemical sensor and a system and method for sensing a chemical species. The chemical sensor includes a plurality of nanofibers whose electrical impedance varies upon exposure to the chemical species, a substrate supporting and electrically isolating the fibers, a set of electrodes connected to the plurality of fibers at spatially separated points to permit the electrical impedance of the plurality of fibers to be measured, and a membrane encasing the fibers and having a thickness ranging from 50 μm to 5.0 mm. The system includes the chemical sensor, an impedance measuring device coupled to the electrodes and configured to determine an electrical impedance of the plurality of fibers, and an analyzer configured to identify the chemical species based on a change in the electrical impedance.

    METHOD AND APPARATUS FOR SPATIAL CONTROL OF CELLULAR GROWTH

    公开(公告)号:US20230094662A1

    公开(公告)日:2023-03-30

    申请号:US18053238

    申请日:2022-11-07

    IPC分类号: C12M1/00 B29C64/40 C12N5/00

    摘要: A three-dimensional cell growth containment article is described, which includes a molded body channelized by removal of sacrificial channelizing element(s) therefrom, so that the molded body contains one or more channel(s) therein, with a matrix material in at least one of such channel(s) that is supportive of three-dimensional cell growth in the matrix material. A method for making such articles is also described, in which a molded body is formed with one or more sacrificial channelizing element(s) therein, following which the sacrificial channelizing element(s) are removed. The three-dimensional cell growth containment articles of the present disclosure may be utilized in any applications in which there exists a need to reproducibly generate three-dimensional cellular structures, e.g., islet transplantation for diabetes treatment, transplantation of hormone secreting cells, cellular scaffolds for wound healing, and generation of tissue engineering structures to regain structural usefulness for orthopedic applications.