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公开(公告)号：US20240360932A1
公开(公告)日：2024-10-31
申请号：US18647006
申请日：2024-04-26
发明人： Andreas PREDIGER , Tim Schenke
CPC分类号： F16L33/225 , F16L33/18
摘要： A clamping device for fluidically and mechanically connecting two hose barbs. The clamping device includes a seal and a locking mechanism, wherein the locking mechanism can be transferred from a mounting condition to an assembled condition. In the mounting condition, the hose barbs can be inserted into the clamping device, while in the assembled condition, those hose barbs are locked in place in a position in which free ends of the hose barbs face each other and a seal coaxially aligns and fluid-tightly connects the free ends.
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公开(公告)号：US12129458B2
公开(公告)日：2024-10-29
申请号：US17126482
申请日：2020-12-18
发明人： Christian Manzke
CPC分类号： C12M29/04 , B01D63/081 , B01D63/082 , B01D63/084 , B01D65/022 , C12M23/40 , C12M41/00 , B01D2313/105 , B01D2313/18 , B01D2313/243 , B01D2321/346
摘要： A filter system (100) for biopharmaceutical processes includes: at least one filter unit (10); and at least one distributor plate (200), against which the filter unit rests. A tubeless distributor unit (202) is arranged within the distributor plate and is fluidically connected to the filter unit. The distributor unit guides the fluid to be filtered to the filter unit and/or receives and discharges the filtered fluid from the filter unit. The distributor unit includes at least one active control element (232; 238), with which a fluid flow (14) through the distributor unit) and the filter unit is controlled in an open loop flow or a closed loop flow. The fluid connection between the filter unit and the distributor plate is tubeless. Also provided are a distributor plate (200) for a filter system (100) for biopharmaceutical processes and a method for producing a filter system (100) for biopharmaceutical processes.
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公开(公告)号：US12129457B2
公开(公告)日：2024-10-29
申请号：US16648656
申请日：2018-09-06
IPC分类号： C12M1/00
摘要： A container (1, 1b) of a bioreactor (1a, 1b) has a container interior (22) designed for being filled with a medium (8) including a photoreactive material, and designed for at least partially triggering a photochemical reaction of the photoreactive material. The container (1, 1b) has at least one illuminant receiving pouch (11) that is at least partially transparent for an electromagnetic radiation (14), and that is arranged on a illuminant opening (12) within the container interior (22) and is designed to receive at least one illuminant (15, 15a, 15b, 15c, 15d, 15e) from an outer side (A) through the illuminant opening (12, 12a, 12b). The illuminant at least partially irradiates the medium (8) such that the photochemical reaction of the photoreactive material can be triggered by electromagnetic radiation (14) emitted by the illuminant and the illuminant is isolated in relation to the medium (8) by the illuminant receiving pouch (11).
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公开(公告)号：US20240261754A1
公开(公告)日：2024-08-08
申请号：US18420145
申请日：2024-01-23
发明人： Karl Pflanz , Florian Hebenstreit , Andreas Pickl
CPC分类号： B01J20/14 , A61L2/081 , B01D37/02 , B01J20/28004 , B01J20/28016 , B01J20/2805 , B01J20/3028 , B65B55/02 , B65D65/40 , C12M47/02 , C12M47/10 , A61L2202/21
摘要： The present invention relates to a diatomaceous earth composition with a low endotoxin content, comprising an agglomerated mixture of calcined diatomaceous earth particles and water, wherein the mass ratio of calcined diatomaceous earth particles and water is in the range of 1:1.0 to 1:2.0, and wherein the endotoxin content of the diatomaceous earth composition is equal to or less than 0.5 EU/mL. In a further aspect, the present invention relates to a method for producing the diatomaceous earth composition with a low endotoxin content. In another aspect, the present invention relates to the use of the diatomaceous earth composition with a low endotoxin content as a precoat agent for the precoat filtration in biopharmaceutical applications.
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公开(公告)号：US11939561B2
公开(公告)日：2024-03-26
申请号：US16438815
申请日：2019-06-12
发明人： Diana Kronenberg
IPC分类号： B65B5/04 , B01F27/072 , B01F27/191 , B01F27/88 , B01F27/91 , B01F33/453 , B01F35/513 , B65B25/00 , B65D6/24 , B65D19/38 , B65D19/40 , B65D77/00 , B65D77/04 , C12M1/00 , C12M1/12 , B01F101/44
CPC分类号： C12M23/26 , B01F27/0723 , B01F27/0724 , B01F27/191 , B01F27/88 , B01F27/91 , B01F33/4531 , B01F35/513 , B65B5/04 , B65B25/00 , B65D11/1873 , B65D19/385 , B65D19/40 , B65D77/003 , B65D77/0466 , C12M23/14 , C12M23/28 , C12M25/06 , B01F2101/44 , B65D2519/00532
摘要： A packaging for a flexible container, in particular for a disposable bag for use in a bioreactor, including a bottom part for fixing a first portion of the container, a ceiling part for fixing an opposite second portion of the container, a receiving space which on a first side is defined by the bottom part and on an opposite second side is defined by the ceiling part, and struts arranged between the bottom part and the ceiling part, which fix a defined distance between the bottom part and the ceiling part.
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6.发明公开公开(公告)号：US20240069499A1
公开(公告)日：2024-02-29
申请号：US18271905
申请日：2021-11-25
CPC分类号： G05B11/011 , G01J3/0291
摘要： A device assembly for controlling an integrated continuous pharmaceutical or biopharmaceutical manufacturing process including a first process equipment for performing a first process step; a second process equipment for performing a second process step subsequent to the first process step; a single measuring unit for measurement of a set of signals of a liquid process medium at a single location, the measured signals depending on first and second parameters; and an evaluation and control unit for evaluating the measured signals to determine values of the first and second parameters. The evaluation and control unit determines first and second corrective feedback based on the values of the first and second parameters, respectively. The evaluation and control unit controls the first process step by providing the first corrective feedback to the first process equipment and controls the second process step by providing the second corrective feedback to the second process equipment.
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公开(公告)号：US11913949B2
公开(公告)日：2024-02-27
申请号：US15315553
申请日：2015-04-28
IPC分类号： G01N33/543 , G01N33/76
CPC分类号： G01N33/54388 , G01N33/76 , B01L2300/0883 , G01N2333/59
摘要： The present invention relates to a multiparameter lateral flow strip (1), comprising a microporous membrane layer (2) supported on a liquid-impermeable support layer (3), for lateral flow of a liquid through the microporous membrane layer (2), wherein the microporous membrane layer (2) has two or more flow lanes (4) in the direction of lateral flow, wherein said two or more flow lanes (4) are separated by hydrophobic separation channels (5), and wherein each of said two or more flow lanes (4) comprises a detection spot (6) including a binding agent, wherein said two or more flow lanes (4) are isomorphic lanes. Furthermore, the present invention relates to a multiparameter lateral flow immunoassay device comprising said multiparameter lateral flow membrane (1), the use of said multiparameter configured lateral flow membrane (1) in an immunological test, as well as to a method for the manufacture of said multiparameter configured lateral flow membrane (1).
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公开(公告)号：US20240001371A1
公开(公告)日：2024-01-04
申请号：US18037154
申请日：2021-11-16
发明人： Johannes WORTMEYER , Thomas LOEWE , Florian MIETH
摘要： A method for ensuring a microbiological purity of a single-use device for carrying out a biotechnological process, the single-use device including at least one gamma-sterilizable component which is formed from materials suitable for a sterilization by gamma radiation, and at least one non-gamma-sterilizable subunit which contains a material unsuitable for a sterilization by gamma radiation. Both the component and the subunit each have an area that comes into contact with a process medium when the biotechnological process is carried out. The method includes the steps of sterilizing the gamma-sterilizable component by gamma radiation; protecting the medium-contacting area of the gamma-sterilizable component by a sterile barrier; sterilizing the non-gamma-sterilizable subunit with superheated steam; protecting the medium-contacting area of the non-gamma-sterilizable subunit by a sterile barrier; removing the sterile barriers; and mounting the gamma-sterilized component and the superheated steam-sterilized subunit in the single-use device immediately after removing the sterile barriers.
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公开(公告)号：US20230412391A1
公开(公告)日：2023-12-21
申请号：US18029225
申请日：2021-09-16
CPC分类号： H04L9/3247 , H04L9/3239 , H04L9/50
摘要： Various embodiments relate to a digital control unit of a bioprocess arrangement for controlling a bioprocess, wherein the digital control unit comprises a local data storage and a local processor unit, wherein the digital control unit comprises a bioprocess interface for sending and receiving bioprocess control data, wherein the digital control unit is configured to execute a bioprocess control routine via the local processor unit to control the bioprocess, wherein in the bioprocess control routine, the digital control unit generates bioprocess data from the actuator data and/or the sensor data and/or the user control command data. It is proposed that the digital control unit is configured to execute a signing routine via the local processor unit and that in the signing routine, the digital control unit digitally signs documentation data, derived from the bioprocess data, by generating a digital signature.
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公开(公告)号：US11827874B2
公开(公告)日：2023-11-28
申请号：US17156701
申请日：2021-01-25
CPC分类号： C12M29/26 , C12M23/14 , C12M23/22 , C12M23/26 , C12M23/28 , C12M23/38 , C12M23/48 , C12M27/02 , C12M41/00 , C12M41/12
摘要： A bioreactor (1; 2; 3) includes a receiving container (10) for receiving a disposable bag (44). A bottom surface (11) of the receiving container (10) is designed to support the disposable bag (44) in the receiving container (10). An outlet opening (5) is formed in the bottom surface (11) and tapers down with respect to the ground for receiving a drain port (45) of the disposable bag (44). The drain port is complementary to the outlet opening (5).
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