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公开(公告)号：US20230003746A1
公开(公告)日：2023-01-05
申请号：US17778647
申请日：2020-11-20
发明人： Mitsuaki YAMAMOTO , Mieko OTA , Tomohisa NISHIO
IPC分类号： G01N33/82 , G01N33/544
摘要： The present invention addresses the problem of providing a method for measuring 25-hydroxy vitamin D and a measurement reagent, the method and the reagent being based on a competitive immunoassay. The present invention provides a reagent for measuring 25-hydroxy vitamin D based on a competitive immunoassay, which includes at least the following composition: (1) a Vitamin D derivative represented by the chemical formula (I) and/or (II), (2) an anti-25 hydroxy vitamin D antibody. In addition, the present invention provides a reagent for measuring vitamin D based on a competitive latex turbidimetric immunoassay (competitive LTIA) in which, in particular, a vitamin D derivative or an anti-25-hydroxy vitamin D antibody is immobilized on latex.
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公开(公告)号：US20210382041A1
公开(公告)日：2021-12-09
申请号：US17282307
申请日：2019-10-08
发明人： Shigeo TAKAYAMA , Tetsuji NAKA , Satoshi SERADA
IPC分类号： G01N33/545
摘要： An object of the present invention is to provide a measurement method and a reagent for measurement which can measure LRG in a biological sample simply in a short time. The present inventors have intensively studied to achieve the object and made findings that LRG in a biological sample can be measured simply in a short time by an immunoagglutination measurement method in which the biological sample is brought into contact with insoluble carrier particles carrying a first anti-LRG monoclonal antibody and insoluble carrier particles carrying a second anti-LRG monoclonal antibody in a liquid phase, and the invention has been thus completed.
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公开(公告)号：US20210333295A1
公开(公告)日：2021-10-28
申请号：US17294151
申请日：2019-11-15
发明人： Toshiki KAWABE , Yukio ODA
IPC分类号： G01N33/86
摘要： Excellent analysis of a coagulation characteristic of a blood sample is implemented. A method for analyzing a coagulation characteristic of a blood specimen according to the present invention includes: acquiring data for a coagulation reaction curve indicating a coagulation reaction amount of a mixed solution containing a blood sample and a reagent with respect to reaction time; calculating data for a differential curve obtained by differentiating the coagulation reaction curve; calculating information related to a center-of-gravity point of the differential curve; and evaluating the coagulation characteristic of the blood sample using the information related to the center-of-gravity point.
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公开(公告)号：US20210278422A1
公开(公告)日：2021-09-09
申请号：US17256919
申请日：2019-09-05
发明人： Kazuyuki Oishi , Hiroaki Taira , Tomonori Inoue , Ryo Takemoto
摘要： Provided is a reagent for measuring hemoglobins capable of satisfactorily causing hemolysis and measuring hemoglobins with high accuracy. The reagent for measuring hemoglobins according to the present invention is a reagent for measuring hemoglobins used for measuring hemoglobins by cation exchange liquid chromatography, including a specific nonionic surfactant or a specific amphoteric surfactant.
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公开(公告)号：US20210079456A1
公开(公告)日：2021-03-18
申请号：US16629699
申请日：2018-07-25
发明人： Hiroyuki EBINUMA , Yuriko TSUKAMOTO
IPC分类号： C12Q1/6827 , C12Q1/686
摘要： An object of the present invention is to provide a method for highly sensitively detecting, and a method for quantifying, a mutant gene (mutant allele) contained at a low frequency in a nucleic acid sample containing a wild-type allele. In one-reaction system in which a first-primers set designed to flank a mutation site of a gene of interest is mixed with a second-primers set including an ASP corresponding to the mutation, an amplification product can be obtained from a low-frequency mutant gene, and quantitativeness can be ensured, by including a competitive nucleic acid suppressing an amplification reaction from a wild-type allele of the gene, selecting a certain primer concentration condition, and controlling the cycle numbers of PCR reactions using the first and second-primers sets.
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6.发明申请公开(公告)号：US20210017290A1
公开(公告)日：2021-01-21
申请号：US17043287
申请日：2019-03-29
发明人： Tomohiro MIURA , Osamu MIYAZAKI
IPC分类号： C07K16/30 , G01N33/574
摘要： The antigen specificity of the antibody that recognizes a glycan antigen and is used as a tumor marker is not sufficient, and it has been a drawback that tumor marker detection using such an antibody is low in detection specificity, thereby deteriorating accuracy of cancer diagnosis.
To solve the object described above, the present invention provides an antibody specifically reactive with a glycan of NCC-ST-439 antigen for use as a tumor marker, and a production method thereof.-
7.发明申请公开(公告)号：US20210017263A1
公开(公告)日：2021-01-21
申请号：US17043510
申请日：2019-03-29
发明人： Tomohiro MIURA , Osamu MIYAZAKI
摘要： The antigen specificity of the antibody that recognizes a glycan antigen and is used as a tumor marker is not sufficient, and it has been a drawback that tumor marker detection using such an antibody is low in detection specificity, thereby deteriorating accuracy of cancer diagnosis.
To solve the object described above, the present invention provides an antibody specifically reactive with a glycan of DUPAN-2 antigen for use as a tumor marker, and a production method thereof.-
8.发明授权公开(公告)号：US10830771B2
公开(公告)日：2020-11-10
申请号：US15766239
申请日：2016-10-06
发明人： Yoshiyuki Kitamura , Katsumi Aoyagi
IPC分类号： G01N33/573 , G01N33/53 , C07K16/36 , C07K16/40 , C12N15/02
摘要： Disclosed is a means of enabling the construction of a more accurate PIVKA-II immunoassay system using monoclonal antibodies against human prothrombin. The PIVKA-II assay method according to the present invention comprises measuring PIVKA-II in a sample by an immunoassay using an anti-PIVKA-II antibody or an antigen-binding fragment thereof which specifically binds to PIVKA-II and a mixture of a first anti-prothrombin antibody or an antigen-binding fragment thereof which recognizes hydrophilic PIVKA-II molecules and a second anti-prothrombin antibody or an antigen-binding fragment thereof which recognizes hydrophobic PIVKA-II molecules.
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公开(公告)号：US10822357B2
公开(公告)日：2020-11-03
申请号：US15755705
申请日：2016-08-25
发明人： Shinya Yano , Yuki Wakasugi , Yosuke Iwanaga
摘要： The purpose of the present invention is to provide a protecting group which improves the solubility of a compound having a functional group protected with the protecting group in an organic solvent and which is easily separated and purified after a reaction with avoiding solidification or insolubilization. Provided is a benzyl compound represented by Formula (1) where X1 represents —CH2OR14 (where R14 represents a hydrogen atom, a halogenocarbonyl group, or an active ester-type protecting group), —CH2NHR15 (where R15 represents a hydrogen atom, a linear or branched alkyl group having 1 to 6 carbon atoms, or an aralkyl group), a halogenomethyl group, a methyl azide group, a formyl group, or an oxime; and at least one of R1, R2, R3, R4, and R5 is a group represented by Formula (2), and the remainders each represent a hydrogen atom, a halogen atom, an alkyl group having 1 to 4 carbon atoms, or an alkoxy group having 1 to 4 carbon atoms, where R6 represents a linear or branched alkylene group having 1 to 16 carbon atoms; X2 represents O or CONR16 (where R16 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms); and A represents a group represented by Formula (3), (4), (5), (6), (7), (8), (9), (10), (11), (12), or (13).
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公开(公告)号：US10422799B2
公开(公告)日：2019-09-24
申请号：US15847677
申请日：2017-12-19
发明人： Mayumi Yoshida , Mitsuaki Yamamoto , Shinya Yokokawa , Tomo Shimizu , Keigo Kono
IPC分类号： G01N33/558 , G01N33/543 , G01N33/53 , G01N33/50 , G01N33/553
摘要： A problem to be solved by the present invention is to provide an immunochromatographic test strip and a detection method using immunochromatography avoiding aggregation of colloidal gold conjugates while red blood cells in whole blood are agglutinated and then separated and removed in the case of using polybrene as a blood-agglutinating agent and the colloidal gold conjugates as a detection reagent. To solve the problem, the present inventers reviewed a past reagent configuration itself from a completely different viewpoint rather than selecting type and amount of polyanions and, as a result of extensive study on each element, the inventers surprisingly found that aggregation of colloidal gold can be suppressed by using a certain buffer solution without using neutralization by polyanions.
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