Method for producing protein composition, and protein composition

    公开(公告)号:US11969512B2

    公开(公告)日:2024-04-30

    申请号:US17336672

    申请日:2021-06-02

    摘要: A method for producing a protein composition containing a protein (A), a radical scavenger (RS), and at least one hydrogen-bond-formable compound (HC) selected from the group consisting of amino acids, peptides, and proteins other than the protein (A). The method including a sterilization step of radiosterilizing an unsterilized protein composition, wherein the unsterilized protein composition contains the protein (A), the radical scavenger (RS), and the hydrogen-bond-formable compound (HC), the protein (A) contains at least one functional group selected from the group consisting of sulfide, amide, hydroxyl, amino, and carboxyl groups, the hydrogen-bond-formable compound (HC) contains at least one functional group selected from the group consisting of sulfide, amide, hydroxyl, amino, and carboxyl groups, the at least one functional group in the protein (A) is capable of binding to the at least one functional group in the hydrogen-bond-formable compound (HC) via a hydrogen bond.

    VISCOSITY INDEX IMPROVER COMPOSITION AND LUBRICATING OIL COMPOSITION

    公开(公告)号:US20230340357A1

    公开(公告)日:2023-10-26

    申请号:US18021222

    申请日:2021-08-20

    摘要: The present invention aims to provide a viscosity index improver composition capable of providing a lubricant composition that has an excellent viscosity index improving effect, excellent antifoaming properties, and excellent persistence of the antifoaming properties. The present invention relates to a viscosity index improver composition, containing: a (co)polymer (A) containing a monomer (a) represented by the following formula (1) as an essential monomer; a C18-C40 chain aliphatic alcohol (B); and a base oil,





    wherein R1 is a hydrogen atom or a methyl group; -X1- is a group represented by —O— or —NH—; R2 is a C2-C4 alkylene group; R3 and R4 are each independently a C8-C24 linear or branched alkyl group; and p is an integer of 0 to 20, with each R2 being optionally the same as or different from each other when p is 2 or greater.

    Antistatic agent
    8.
    发明授权

    公开(公告)号:US11655370B2

    公开(公告)日:2023-05-23

    申请号:US17790849

    申请日:2022-01-13

    IPC分类号: C08L53/00 C08L87/00 C08K5/42

    摘要: Provided is an antistatic agent (Z) containing:



    a block polymer (A) having a block of a hydrophobic polymer (a) and a block of a hydrophilic polymer (b) as structure units; and
    a sulfonate (S),
    the sulfonate (S) being a salt of an alkylbenzenesulfonic acid anion which has a C6-C18 alkyl group,
    the sulfonate (S) including at least two alkylbenzenesulfonates different in the number of carbon atoms of the alkyl group in the anion,
    the sulfonate (S) satisfying the following formula:

    0.40≤W(n)/[W(n−1)+W(n)+W(n+1)]≤0.90

    wherein n is the number of carbon atoms of the alkyl group in the anion of an alkylbenzenesulfonate accounting for the highest proportion by weight in the sulfonate (S); W(n) is a weight of said alkylbenzenesulfonate; and W(n−1) and W(n+1) are respectively a weight of an alkylbenzenesulfonate containing an anion having an alkyl group with (n−1) carbon atoms and a weight of an alkylbenzenesulfonate containing an anion having an alkyl group with (n+1) carbon atoms.

    Composition for cell transplant, and method for cell transplant

    公开(公告)号:US11648279B2

    公开(公告)日:2023-05-16

    申请号:US16973625

    申请日:2019-05-09

    IPC分类号: A61K35/34 A61K38/16

    CPC分类号: A61K35/34 A61K38/164

    摘要: Provided are a composition for cell transplant and a method for cell transplant, both of which enable a myocardial tissue to favorably retain cardiac myocytes and/or cardiac progenitors and can improve the persistence and proliferation of transplanted cells. The composition for cell transplant of the present invention is a composition for cell transplant, containing cells and an aqueous solution containing a protein (A), the cells including a cardiac myocyte and/or a cardiac progenitor, the protein (A) having a degree of hydrophobicity of 0.2 to 1.2, the protein (A) containing a polypeptide chain (Y) and/or a polypeptide chain (Y′), the protein (A) containing 1 to 100 polypeptide chains as a total of the polypeptide chain (Y) and the polypeptide chain (Y′), the polypeptide chain (Y) being a polypeptide chain having 2 to 100 continuous amino acid sequences (X), the amino acid sequence (X) having any one of a VPGVG sequence (1) corresponding to an amino acid sequence of SEQ ID NO: 1, a GVGVP sequence (2) corresponding to an amino acid sequence of SEQ ID NO: 2, a GPP sequence, a GAP sequence, and a GAHGPAGPK sequence (3) corresponding to an amino acid sequence of SEQ ID NO: 3, the polypeptide chain (Y′) being a polypeptide chain having a structure in which 0.1 to 5% amino acid residues in the polypeptide chain (Y) are replaced by a lysine residue and/or an arginine residue and including 1 to 100 residues as a total of the lysine residue and the arginine residue.

    BRONCHIAL EMBOLIZATION MATERIAL
    10.
    发明申请

    公开(公告)号:US20220409779A1

    公开(公告)日:2022-12-29

    申请号:US17781280

    申请日:2020-11-27

    摘要: A material for endobronchial occlusion capable of repairing or replacing tissue is disclosed. The material contains a protein (A), wherein the protein (A) contains at least one of a polypeptide chain (Y) or a polypeptide chain (Y′), a total number of the polypeptide chain (Y) and the polypeptide chain (Y′) in the protein (A) is 1 to 100, the polypeptide chain (Y) is a polypeptide chain consisting of 2 to 200 tandem repeats of at least one amino acid sequence (X) among an amino acid sequence VPGVG, an amino acid sequence GVGVP 4, GPP, GAP, and an amino acid sequence GAHGPAGPK, the polypeptide chain (Y′) is a polypeptide chain in which each of a total of 5% or less of amino acids in the polypeptide chain (Y) is replaced by at least one of a lysine residue or an arginine residue, with a total number of the lysine and arginine residues being 1 to 100.