公开(公告)号：US08645075B2

公开(公告)日：2014-02-04

申请号：US12634628

申请日：2009-12-09

Applicant: Kalyanasundaram Subramanian ,  Sowmya Raghavan ,  Anupama Rajan Bhat ,  Sonali Das ,  Jyoti Bajpai Dikshit ,  Rajeev Kumar ,  Narasimha Mandyam Krishnakumar ,  Nalini Rajeshwara ,  Rajesh Radhakrishnan ,  Srivatsan Raghunathan

Inventor： Kalyanasundaram Subramanian ,  Sowmya Raghavan ,  Anupama Rajan Bhat ,  Sonali Das ,  Jyoti Bajpai Dikshit ,  Rajeev Kumar ,  Narasimha Mandyam Krishnakumar ,  Nalini Rajeshwara ,  Rajesh Radhakrishnan ,  Srivatsan Raghunathan

IPC: G06F7/00

CPC classification number: G06F19/12 ,  G06F19/20

Abstract: The attached disclosure provides a systems approach based on mathematical modelling of the kinetics of essential biochemical pathways involved in organ homeostasis. When this in silico model is coupled with in-vitro and/or in-vivo measurements to quantify drug-induced perturbations, a powerful platform that allows accurate and mechanistic-level prediction of drug-induced organ injury can be generated. The method described in this disclosure demonstrates that several physiological situations can also be accurately modelled in addition to the effect of perturbations induced by drugs. It can also be used along with high-throughput “omics” data to generate testable hypotheses leading to informed decision-making in drug development.

Abstract translation: 所附的公开提供了基于涉及器官稳态的必需生物化学途径的动力学的数学建模的系统方法。 当这种计算机模型与体外和/或体内测量结合以量化药物诱导的摄动时，可以产生允许药物诱导的器官损伤的准确和机械级预测的强大平台。 本公开中描述的方法证明，除了由药物引起的扰动的影响之外，还可以精确地建模几种生理情况。 它还可以与高通量“omics”数据一起使用，以产生可靠的假设，从而在药物开发中做出明智的决策。

公开(公告)号：US20100179798A1

公开(公告)日：2010-07-15

申请号：US12634628

申请日：2009-12-09

Applicant: Kalyanasundaram Subramanian ,  Sowmya Raghavan ,  Anupama Rajan Bhat ,  Sonali Das ,  Jyoti Bajpai Dikshit ,  Rajeev Kumar ,  Narasimha Mandyam Krishnakumar ,  Nalini Rajeshwara ,  Rajesh Radhakrishnan ,  Srivatsan Raghunathan

Inventor： Kalyanasundaram Subramanian ,  Sowmya Raghavan ,  Anupama Rajan Bhat ,  Sonali Das ,  Jyoti Bajpai Dikshit ,  Rajeev Kumar ,  Narasimha Mandyam Krishnakumar ,  Nalini Rajeshwara ,  Rajesh Radhakrishnan ,  Srivatsan Raghunathan

IPC: G06G7/48

CPC classification number: G06F19/12 ,  G06F19/20

Abstract: The attached disclosure provides a systems approach based on mathematical modelling of the kinetics of essential biochemical pathways involved in organ homeostasis. When this in silico model is coupled with in-vitro and/or in-vivo measurements to quantify drug-induced perturbations, a powerful platform that allows accurate and mechanistic-level prediction of drug-induced organ injury can be generated. The method described in this disclosure demonstrates that several physiological situations can also be accurately modelled in addition to the effect of perturbations induced by drugs. It can also be used along with high-throughput “omics” data to generate testable hypotheses leading to informed decision-making in drug development.

Abstract translation: 所附的公开提供了基于涉及器官稳态的必需生物化学途径的动力学的数学建模的系统方法。 当这种计算机模型与体外和/或体内测量结合以量化药物诱导的摄动时，可以产生允许药物诱导的器官损伤的准确和机械级预测的强大平台。 本公开中描述的方法证明，除了由药物引起的扰动的影响之外，还可以精确地建模几种生理情况。 它还可以与高通量“omics”数据一起使用，以产生可靠的假设，从而在药物开发中做出明智的决策。