公开(公告)号：US12286479B2

公开(公告)日：2025-04-29

申请号：US17239512

申请日：2021-04-23

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Irving H. Fox ,  Catherine Scholz ,  Erica Helen Jenkins ,  Maria Rosario

IPC: A61K39/00 ,  A61K9/00 ,  A61K39/395 ,  A61K47/12 ,  A61K47/14 ,  A61K47/18 ,  A61K47/26 ,  C07K16/28

Abstract: Antibody formulations are described comprising a mixture of an anti-α4β7 antibody, an antioxidant or chelator, and at least one free amino acid. The disclosed formulations may have improved stability, reduced aggregate formation, or both. The present invention further provides a safe dosing regimen of these antibody formulations that is easy to follow, and which results in a therapeutically effective amount of the anti-α4β7 antibody in vivo.

公开(公告)号：US12281073B2

公开(公告)日：2025-04-22

申请号：US18347345

申请日：2023-07-05

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Tatsuhiko Fujimoto ,  Kentaro Rikimaru ,  Koichiro Fukuda ,  Hiromichi Sugimoto ,  Takahiro Matsumoto ,  Norihito Tokunaga ,  Mariko Hirozane

IPC: C07D213/61 ,  A61P25/00 ,  C07D211/24 ,  C07D211/36 ,  C07D211/56 ,  C07D213/30 ,  C07D213/74 ,  C07D213/75 ,  C07D215/44 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/06 ,  C07D409/12 ,  C07D413/06 ,  C07D417/06 ,  C07D417/14

Abstract: Provided is a substituted piperidine compound having an orexin type 2 receptor agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as a prophylactic or therapeutic agent for narcolepsy.

公开(公告)号：US12258540B2

公开(公告)日：2025-03-25

申请号：US16760608

申请日：2018-10-30

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Jean-Baptiste Farcet ,  Johanna Kindermann ,  Björn Tille ,  Thomas R. Kreil

IPC: C11D3/43 ,  C07K14/765 ,  C07K16/06 ,  C08G59/14 ,  C11D1/72 ,  C11D3/36 ,  C12N7/00

Abstract: The present invention relates to methods for inactivating a lipid-enveloped virus using environmentally compatible detergents, and to methods for preparing a biopharmaceutical drug using environmentally compatible detergents. The invention also provides environmentally compatible detergents.

公开(公告)号：US12257277B2

公开(公告)日：2025-03-25

申请号：US18096853

申请日：2023-01-13

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Christian Fiedler ,  Eva Fritscher ,  Meinhard Hasslacher ,  Dominik Mittergradnegger ,  Tanvir Tabish

IPC: A61K35/76 ,  A61K9/00 ,  A61K9/19 ,  A61K31/195 ,  A61K47/18 ,  A61K47/26 ,  A61P7/00 ,  A61P7/04

Abstract: Adeno-associated liquid and lyophilized pharmaceutical compositions are provided herein. In exemplary aspects, the pharmaceutical compositions comprise about 5 mM to about 25 mM L-histidine, about 0 mM to about 150 mM sodium chloride, about 0.001% (w/v) to about 0.01% (w/v) polysorbate 80 (PS80), and about 1% to about 10% (w/v) sucrose, trehalose, or combination thereof to AAV. In exemplary aspects, the pharmaceutical compositions further comprise glycine or mannitol. Methods of preparing a pharmaceutical composition comprising AAV, methods of treating a bleeding disorder in a subject, and methods of storing AAV compositions are also provided.

公开(公告)号：US20250051353A1

公开(公告)日：2025-02-13

申请号：US18927346

申请日：2024-10-25

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Kazuhiro MIWA

IPC: C07D495/04 ,  C07D333/38 ,  C07D409/12

Abstract: The present invention provides a production method of a thienopyrimidine derivative or a salt thereof which has a gonadotropin releasing hormone (GnRH) antagonistic action with high quality in high yield. The present invention provides a method of producing a thienopyrimidine derivative, which comprises reacting 6-(4-aminophenyl)-1-(2,6-difluorobenzyl)-5-dimethylaminomethyl-3-(6-methoxypyridazin-3-yl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione or salt thereof, 1,1′-carbonyldiimidazole or a salt thereof and methoxyamine or a salt thereof, and the like.

公开(公告)号：US12221460B2

公开(公告)日：2025-02-11

申请号：US18336436

申请日：2023-06-16

Applicant: Takeda Pharmaceutical Company Limited

Inventor： He Xu ,  Hong Myung Lee ,  Christopher Arendt

IPC: A61K47/68 ,  A61K31/7084 ,  A61K39/395 ,  A61P35/00 ,  C07H21/00

Abstract: The present disclosure provides antibody drug conjugates comprising STING modulators. Also provided are compositions comprising the antibody drug conjugates. The compounds and compositions are useful for stimulating an immune response in a subject in need thereof.

公开(公告)号：US12221441B2

公开(公告)日：2025-02-11

申请号：US18234608

申请日：2023-08-16

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Nikolaos Papaioannou ,  Jeremy Mark Travins ,  Sarah Jocelyn Fink ,  John Mark Ellard ,  Alastair Rae

IPC: C07D471/04 ,  A61P9/00 ,  A61P29/00 ,  C07D519/00

Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.

公开(公告)号：US12214161B2

公开(公告)日：2025-02-04

申请号：US17282042

申请日：2019-09-24

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Seth Dale Jones ,  Madeleine Clare Gibson ,  Daniel Edward Roush ,  Dhairya Kiritkumar Mehta ,  Sujit K. Basu ,  Jennifer Craig Cordova

IPC: A61M5/162 ,  A61M5/14 ,  A61M5/168

Abstract: A medicinal fluid pooling device may be used to pool multiple containers of medicinal fluid to facilitate administration of the medicinal fluid to a patient. A medicinal pooling device may include spikes covered by spike sheaths which are pierced when a container of medicinal fluid is inserted into the medicinal pooling device. The medicinal pooling device may also include a cover configured to cover the spikes. The medicinal pooling device may also include a fluidic interface which may be used to fluidly connect the medicinal pooling device to an infusion pump or syringe.

公开(公告)号：US12213998B2

公开(公告)日：2025-02-04

申请号：US17671479

申请日：2022-02-14

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Eduardo Bravo ,  Maria Pascual

IPC: A61K35/35 ,  A61K35/28

Abstract: Provided herein are expanded allogeneic adipose tissue-derived stromal stem cells for use in treating complex perianal fistulas in Crohn's Disease.

公开(公告)号：US12188948B2

公开(公告)日：2025-01-07

申请号：US17728285

申请日：2022-04-25

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Daniel J. Sexton ,  Malini Viswanathan ,  Ryan Faucette ,  Tripti Gaur

IPC: G01N33/68 ,  G01N33/74 ,  G01N33/82 ,  G01N33/92 ,  G01N33/94

Abstract: Provided herein are methods and kits for analyzing a biological sample obtained from a subject having, suspected of having, or being at risk for a disease associated with the contact activation system.