公开(公告)号：US12121528B2

公开(公告)日：2024-10-22

申请号：US17944006

申请日：2022-09-13

申请人： Fenfei Leng ,  Eddy Alfonso ,  Zifang Deng

发明人： Fenfei Leng ,  Eddy Alfonso ,  Zifang Deng

IPC分类号： A61K31/7048 ,  A61K31/185 ,  A61K31/192 ,  A61K31/196 ,  A61K31/24 ,  A61K31/352 ,  A61K31/366 ,  A61K31/381 ,  A61K31/404 ,  A61K31/4155 ,  A61K31/4184 ,  A61K31/4196 ,  A61K31/427 ,  A61K31/429 ,  A61K31/433 ,  A61K31/443 ,  A61K31/473 ,  A61K31/475 ,  A61K31/496 ,  A61K31/498 ,  A61K31/513 ,  A61K31/519 ,  A61K31/52 ,  A61K31/5377 ,  A61K31/7076 ,  A61P31/04

CPC分类号： A61K31/7048 ,  A61K31/185 ,  A61K31/192 ,  A61K31/196 ,  A61K31/24 ,  A61K31/352 ,  A61K31/366 ,  A61K31/381 ,  A61K31/404 ,  A61K31/4155 ,  A61K31/4184 ,  A61K31/4196 ,  A61K31/427 ,  A61K31/429 ,  A61K31/433 ,  A61K31/443 ,  A61K31/473 ,  A61K31/475 ,  A61K31/496 ,  A61K31/498 ,  A61K31/513 ,  A61K31/519 ,  A61K31/52 ,  A61K31/5377 ,  A61K31/7076 ,  A61P31/04

摘要： The subject invention provides fluorophore-quencher nucleic acid molecules comprising relaxed or supercoiled DNA molecules, and their use in rapid and efficient high-throughput screening (HTS) assays to screen and identify compounds that inhibit DNA gyrases. These compounds can be used as antibiotics for treating bacterial infections, especially, multidrug resistant bacterial infections.

公开(公告)号：US20240342106A1

公开(公告)日：2024-10-17

申请号：US18292258

申请日：2022-07-27

申请人： UNIVERSITY OF MIAMI ,  THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES

发明人： Shanta DHAR ,  Nagesh KOLISHETTI ,  Bapurao SURNAR ,  Madhavan NAIR ,  Anuj SHAH ,  Michal TOBOREK

IPC分类号： A61K9/51 ,  A61K31/122 ,  A61K31/403 ,  A61K31/427 ,  A61K31/435 ,  A61K31/439 ,  A61K31/4418 ,  A61K31/4433 ,  A61K31/4439 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/4741 ,  A61K31/496 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/499 ,  A61K31/5025 ,  A61K31/505 ,  A61K31/506 ,  A61K31/513 ,  A61K31/519 ,  A61K31/52 ,  A61K31/522 ,  A61K31/536 ,  A61K31/5365 ,  A61K31/537 ,  A61K31/551 ,  A61K31/573 ,  A61K31/616 ,  A61K31/635 ,  A61K31/675 ,  A61K31/69 ,  A61K31/7072 ,  A61K38/16 ,  A61K38/18 ,  A61K39/395 ,  A61K47/54 ,  A61P31/18

CPC分类号： A61K9/5153 ,  A61K31/122 ,  A61K31/403 ,  A61K31/427 ,  A61K31/435 ,  A61K31/439 ,  A61K31/4418 ,  A61K31/4433 ,  A61K31/4439 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/4741 ,  A61K31/496 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/499 ,  A61K31/5025 ,  A61K31/505 ,  A61K31/506 ,  A61K31/513 ,  A61K31/519 ,  A61K31/52 ,  A61K31/522 ,  A61K31/536 ,  A61K31/5365 ,  A61K31/537 ,  A61K31/551 ,  A61K31/573 ,  A61K31/616 ,  A61K31/635 ,  A61K31/675 ,  A61K31/69 ,  A61K31/7072 ,  A61K38/16 ,  A61K38/18 ,  A61K39/3955 ,  A61K47/548 ,  A61P31/18

摘要： The present disclosure relates to nanoparticle compositions and uses thereof for treating or preventing HIV infection.

公开(公告)号：US12103071B2

公开(公告)日：2024-10-01

申请号：US18296572

申请日：2023-04-06

申请人： The Florida International University Board of Trustees

发明人： Arvind Agarwal ,  Cheng Zhang ,  Tanaji Paul ,  Sohail Mazher Ali Khan Mohammed ,  Denny John

IPC分类号： B22F1/05 ,  B22F1/054 ,  B22F1/103 ,  B22F10/64 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y70/10 ,  B82Y30/00 ,  B82Y40/00 ,  C22C21/00

CPC分类号： B22F1/0547 ,  B22F1/103 ,  B22F10/64 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y70/10 ,  B82Y30/00 ,  B82Y40/00 ,  C22C21/00 ,  B22F2301/052 ,  B22F2302/205 ,  B22F2304/10

摘要： Methods for large-scale additive manufacturing of high-strength boron nitride nanotubes (BNNT)/aluminum (Al) (e.g., reinforced Al alloy) metal matrix composites (MMCs) (BNNT/Al MMCs), as well as the BNNT/Al MMCs produced by the large-scale additive manufacturing methods, are provided. A combination of ultrasonication and spray drying techniques can produce good BNNT/Al alloy feedstock powders, which can be used in a cold spraying process.

公开(公告)号：US12102635B2

公开(公告)日：2024-10-01

申请号：US17938531

申请日：2022-10-06

申请人： University of South Florida ,  The Florida International University Board of Trustees

发明人： Robert Deschenes ,  Arunava Roy ,  Ahmed Ramadan ,  Subhra Mohapatra ,  Marcello Giulianotti

IPC分类号： A61K31/496 ,  A61P31/14

CPC分类号： A61K31/496 ,  A61P31/14

摘要： The present disclosure relates to methods of using palmitoylation inhibitors for reducing or treating enveloped virus infections.

公开(公告)号：US20240258012A1

公开(公告)日：2024-08-01

申请号：US18629524

申请日：2024-04-08

申请人： The Florida International University Board of Trustees

发明人： Carlos Riera Cercado ,  Markondeyaraj Pulugurtha ,  Juan Camilo Gomez ,  Veeru Jaiswal

IPC分类号： H01F27/245 ,  H01F3/02 ,  H01F27/28

CPC分类号： H01F27/245 ,  H01F3/02 ,  H01F27/28

摘要： Stacked magnetic cores that can achieve high density with a small footprint are provided. A stacked magnetic core can include a plurality of magnetic films with an adhesive film between each magnetic film and the adjacent magnetic film(s). That is, the magnetic films and adhesive films can be disposed in an alternating fashion. Each adhesive film can be a dielectric/insulating film such that each magnetic film is electrically insulated from every other magnetic film.

公开(公告)号：US20240213688A1

公开(公告)日：2024-06-27

申请号：US18315006

申请日：2023-05-10

申请人： Muhammad Hamza ,  Stavros Georgakopoulos ,  Constantinos L. Zekios

发明人： Muhammad Hamza ,  Stavros Georgakopoulos ,  Constantinos L. Zekios

IPC分类号： H01Q9/30 ,  H01Q9/28 ,  H01Q21/06

CPC分类号： H01Q9/30 ,  H01Q9/285 ,  H01Q21/062

摘要： Ultra-wideband (UWB) arrays that are fully planar are provided. Fully-planar inverted-L element (FILE) arrays that are tightly coupled arrays (TCAs) can realize UWB tightly coupled apertures in the W and higher millimeter wave (mmWave) bands. The unit cell architecture of the FILE array, (which can have any desired size, can be comprised of an inverted-L shaped antenna and a capacitively coupled via-fence.

公开(公告)号：US12005497B2

公开(公告)日：2024-06-11

申请号：US18065796

申请日：2022-12-14

申请人： The Florida International University Board of Trustees

发明人： Arvind Agarwal ,  Cheng Zhang ,  Tanaji Paul ,  Sohail Mazher Ali Khan Mohammed ,  Denny John

IPC分类号： B22F1/054 ,  B22F1/103 ,  B22F10/64 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y70/10 ,  B82Y30/00 ,  B82Y40/00 ,  C22C21/00

CPC分类号： B22F1/0547 ,  B22F1/103 ,  B22F10/64 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y70/10 ,  B82Y30/00 ,  B82Y40/00 ,  C22C21/00 ,  B22F2301/052 ,  B22F2302/205 ,  B22F2304/10

摘要： Methods for large-scale additive manufacturing of high-strength boron nitride nanotubes (BNNT)/aluminum (Al) (e.g., reinforced Al alloy) metal matrix composites (MMCs) (BNNT/Al MMCs), as well as the BNNT/Al MMCs produced by the large-scale additive manufacturing methods, are provided. A combination of ultrasonication and spray drying techniques can produce good BNNT/Al alloy feedstock powders, which can be used in a cold spraying process.

公开(公告)号：US11989932B1

公开(公告)日：2024-05-21

申请号：US18512559

申请日：2023-11-17

申请人： Malek Adjouadi ,  Mohammad Eslami ,  Solale Tabarestani

发明人： Malek Adjouadi ,  Mohammad Eslami ,  Solale Tabarestani

IPC分类号： G06T7/00 ,  A61B5/00 ,  G06T11/00 ,  G06V10/77 ,  G06V10/80 ,  G16H50/20

CPC分类号： G06V10/811 ,  A61B5/4088 ,  G06T7/0016 ,  G06T11/001 ,  G06V10/7715 ,  G16H50/20 ,  G06T2207/10024 ,  G06T2207/10088 ,  G06T2207/10104 ,  G06T2207/30016 ,  G06T2207/30204 ,  G06V2201/03

摘要： Systems and methods are provided for color-coded visualization to aid in diagnosis and prognosis of Alzheimer's disease (AD). The color-coded visualization mechanism can be driven by an integrated machine learning (ML) model, which can take as its inputs neuroimaging (e.g., magnetic resonance imaging (MRI), positron emission tomography (PET)) data, neuropsychological test scores, the cerebrospinal fluid (CSF) biomarker, and/or risk factors. With these inputs, the ML model can generate a color-coded visualization of the disease state.

公开(公告)号：US11958108B2

公开(公告)日：2024-04-16

申请号：US18296570

申请日：2023-04-06

申请人： The Florida International University Board of Trustees

发明人： Arvind Agarwal ,  Cheng Zhang ,  Tanaji Paul ,  Sohail Mazher Ali Khan Mohammed ,  Denny John

IPC分类号： B33Y10/00 ,  B22F1/00 ,  B22F1/054 ,  B22F1/103 ,  B22F10/64 ,  B33Y30/00 ,  B33Y70/10 ,  B82Y30/00 ,  B82Y40/00 ,  C22C21/00

CPC分类号： B22F1/0547 ,  B22F1/103 ,  B22F10/64 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y70/10 ,  B82Y30/00 ,  B82Y40/00 ,  C22C21/00 ,  B22F2301/052 ,  B22F2302/205 ,  B22F2304/10

摘要： Methods for large-scale additive manufacturing of high-strength boron nitride nanotubes (BNNT)/aluminum (Al) (e.g., reinforced Al alloy) metal matrix composites (MMCs) (BNNT/Al MMCs), as well as the BNNT/Al MMCs produced by the large-scale additive manufacturing methods, are provided. A combination of ultrasonication and spray drying techniques can produce good BNNT/Al alloy feedstock powders, which can be used in a cold spraying process.

公开(公告)号：US11953492B1

公开(公告)日：2024-04-09

申请号：US18477672

申请日：2023-09-29

申请人： Atorod Azizinamini ,  Amer I. Awwad

发明人： Atorod Azizinamini ,  Amer I. Awwad

IPC分类号： G01N33/38 ,  G01N3/06 ,  G01N3/12

CPC分类号： G01N33/383 ,  G01N3/06 ,  G01N3/12 ,  G01N2203/0298

摘要： Systems and methods are provided to simulate, approximate, or replicate conditions similar to concrete elements being placed under pressures equivalent to several hundred feet of ocean water and to provide information useful to assess relative durability of concrete without coring or other destructive actions. The quality of concrete can be assessed by measuring the pressure drop of water or other liquid to ingress through the concrete surface under high pressure over time. A rapid assessment of quality of existing concrete is provided. Systems and methods can efficiently assess long term durability of existing concrete elements such as those used in midrise buildings, parking garages, bridge decks, and the like.