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公开(公告)号：US20190256817A1
公开(公告)日：2019-08-22
申请号：US16347104
申请日：2017-11-03
发明人： Steven C. Gebhart , Robert W. McClellan , Nicholas C. Trotta , Nancy L. Allbritton , Peter Joseph Attayek , Paul Michael Armistead
摘要： Embodiments of the disclosed subject matter provide an automated method and system to isolate and collect cells using computerized analysis of images of cells and their surroundings obtained from a digital imaging device or system. Embodiments of the disclosed subject matter make use of a “microwell array,” which can comprise a formed, elastomeric grid of indentations or “wells.” Many, most, or all of the wells in a microwell array can contain a releasable, microfabricated element, which can be referred to as a “raft.” Embodiments of the disclosed subject matter provide a system and method for cell collection that includes computerized identification and collection of rafts with isolated single cells or a specific group or groups of cells, eliminating the need for continuous human identification and selection.
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公开(公告)号：US20230129210A1
公开(公告)日：2023-04-27
申请号：US17914000
申请日：2021-04-05
摘要： Described herein are binding proteins useful against ACE2-targeted viruses (e.g., SARS-CoV and SARS-CoV-2, etc.), and methods of using them. These binding proteins may include an extracellular portion of angiotensin-converting enzyme 2 (ACE2), excluding the collectrin domain, and a flexible polypeptide flexible linker coupling the ACE2 portion to a fragment crystallization (Fc) domain. These binding proteins dimerize, and the flexible linker may be chosen to be sufficiently long to permit concurrent interaction with multiple Spike (S) proteins on the ACE2-targeted virus.
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公开(公告)号：US20230127263A1
公开(公告)日：2023-04-27
申请号：US17762360
申请日：2020-09-20
发明人： Gianpietro Dotti , Yang Xu , Xingcong Ma
IPC分类号： A61K35/17 , C07K14/54 , C07K14/715 , A61P35/00
摘要： Disclosed herein are modified T cells comprising an IL12β p40 subunit. Also disclosed herein are methods of increasing T cell proliferation and/or methods of treating cancer by administering the modified T cells comprising an IL12β p40 subunit.
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公开(公告)号：US11617788B2
公开(公告)日：2023-04-04
申请号：US17259352
申请日：2019-07-09
申请人： Arizona Board of Regents on Behalf of The University of Arizona , The University of North Carolina at Chapel Hill , The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
发明人： Felicia Goodrum , Nathaniel Moorman , Jeremy Kamil
摘要： Viral promoters and compositions and methods of use thereof are provided. Compositions include viruses with impaired ability to reactivate from latency, and pharmaceutical compositions and method of use thereof. The genome of the viruses include one or more mutations that reduce expression from one or more promoters that regulate expression of viral genes during reactivation from latency. The mutation(s) are typically in a region of the viral genome that includes (i) promoter elements of the iP1 promoter of human cytomegalovirus, or the sequence of another virus corresponding thereto (e.g., an iP1 promoter homolog); (ii) promoter elements of the iP2 promoter of human cytomegalovirus, or sequence of another virus corresponding thereto (e.g., an iP2 promoter homolog); or (iii) a combination thereof. In some embodiments the virus encodes one or more heterologous antigens. The viruses can be used as vaccines to induce prophylactic and therapeutic immune responses in subjects in need thereof.
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5.发明授权公开(公告)号：US11607197B2
公开(公告)日：2023-03-21
申请号：US16767188
申请日：2018-11-27
发明人： Marie Muller , Paul Dayton , Aditya Joshi
摘要： Systems and methods for measuring micro-architectural properties of vascular networks are described herein. An example method can include injecting an ultrasound contrast agent into a medium, and transmitting a plurality of acoustic pulses into the medium using a ultrasound transducer array. Each respective acoustic pulse can be transmitted from one or more elements of the ultrasound transducer array. The method can also include receiving a plurality of backscattered signals with the ultrasound transducer array in response to each respective acoustic pulse, and obtaining a response matrix including the backscattered signals. The method can further include extracting a coherent or incoherent contribution to the backscattered signals from the response matrix, and quantifying a property of a vascular network based on the coherent or incoherent contribution to the backscattered signals.
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公开(公告)号：US20230082968A1
公开(公告)日：2023-03-16
申请号：US17799871
申请日：2021-02-11
IPC分类号： A61K47/61 , A61K31/427 , A61K31/546 , A61K31/496 , A61K38/12 , A61K31/407 , A61K31/7036 , A61P31/04
摘要： Disclosed are antimicrobial compositions and formulations directed against a broad range of bacteria and Pseudomonas aeruginosa biofilms. In an aspect, the compositions and formulations do not engender resistance. In an aspect, in combination with antibiotics, the compositions and formulations slow the development of antibiotic-resistance and greatly improve bacterial susceptibility to multiple classes of antibiotics.
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公开(公告)号：US20230078330A1
公开(公告)日：2023-03-16
申请号：US17759479
申请日：2021-01-19
申请人： VANDERBILT UNIVERSITY , THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , THE REGEBTS OF THE UNIVERSITY OF CALIFORNIA A CALIFORNIA
发明人： James E. CROWE, JR. , Ralph BARIC , Eva HARRIS
IPC分类号： C07K16/10 , G01N33/569 , A61P31/14
摘要： The present disclosure is directed to antibodies binding to and neutralizing dengue virus and methods for use thereof.
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公开(公告)号：US20230053681A1
公开(公告)日：2023-02-23
申请号：US17573145
申请日：2022-01-11
发明人： Barbara Vilen
摘要： The present invention provides compositions comprising molecules having multispecificity and method of their use.
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9.发明申请公开(公告)号：US20230042314A1
公开(公告)日：2023-02-09
申请号：US17882965
申请日：2022-08-08
发明人： Yen-Yu Shih , Martin John MacKinnon , Yuncong Ma , Wei-Tang Chang
摘要： This specification describes systems and methods for using Zero Echo Time (ZTE) magnetic resonance imaging (MRI) sequences for applications to functional MRI (fMRI). In some examples, a system for functional magnetic resonance imaging includes a magnetic resonance imaging (MRI) scanner and a control console implemented on at least one processor. The control console is configured for executing, using the MRI scanner, a zero echo time (ZTE) pulse sequence; acquiring, using the MRI scanner, magnetic resonance data in response to the ZTE pulse sequence; and constructing at least one MRI image using the magnetic resonance data and measuring tissue oxygenation (PtO2)-related T1 changes as a proxy of neural activity changes of a subject using the at least one MRI image.
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公开(公告)号：US11566213B2
公开(公告)日：2023-01-31
申请号：US16525191
申请日：2019-07-29
发明人： Nancy L. Allbritton , Yuli Wang , Christopher Sims
摘要： A microfabricated device having at least one gas-entrapping feature formed therein in a configuration that entraps air bubbles upon wetting the feature with a solvent or solution is described. The device includes a sacrificial residue in contact with the gas-entrapping feature, the dissolution of which guides the wetting of the gas-entrapping feature.
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