公开(公告)号：US08487126B2

公开(公告)日：2013-07-16

申请号：US13499724

申请日：2010-09-22

申请人： Hisao Nemoto ,  Tomoyuki Kawamura ,  Kenji Yatsuzuka ,  Masaki Kamiya

发明人： Hisao Nemoto ,  Tomoyuki Kawamura ,  Kenji Yatsuzuka ,  Masaki Kamiya

IPC分类号： C07C69/34 ,  C07C229/00

CPC分类号： C07D207/452 ,  C07C227/16 ,  C07C233/47 ,  C07C271/08 ,  C07C271/12 ,  C07C229/30

摘要： The objective of the present invention is to provide a process for simple and efficient preparation of an intermediate compound to synthesize a gadolinium complex having a substituent for improving a retention property in blood time and specificity to an intended organ. The objective of the present invention is also to provide an intermediate compound produced by the said production process. The process for preparation of the diethylenetriaminepentaacetic acid derivative (I): wherein R1 to R5 are independently C1-6 alkyl groups; comprising the steps of: reacting a diethylenetriaminepentaacetic acid pentaester with a halogenated ally compound in an aprotic solvent; removing the excess halogenated ally compound (III); and reacting a reaction product of the diethylenetriaminepentaacetic acid pentaester and the halogenated ally compound with a base in a solvent.

摘要翻译： 本发明的目的是提供简单有效地制备中间体化合物以合成具有取代基的钆络合物的方法，以提高血液时间的保留性和对预期器官的特异性。 本发明的目的还在于提供通过所述生产方法制备的中间体化合物。 制备二亚乙基三胺五乙酸衍生物（I）的方法：其中R 1至R 5独立地为C 1-6烷基; 包括以下步骤：使二亚乙基三胺五乙酸五酯与卤化烯化合物在非质子溶剂中反应; 除去过量的卤代烯化合物（III）; 并使二亚乙基三胺五乙酸五酯与卤代烯化合物的反应产物与碱在溶剂中反应。

公开(公告)号：US08455255B2

公开(公告)日：2013-06-04

申请号：US12303870

申请日：2007-06-07

申请人： Michihiro Nakamura

发明人： Michihiro Nakamura

IPC分类号： G01N33/552

CPC分类号： G01N33/588 ,  B82Y15/00 ,  B82Y30/00 ,  C08G77/02 ,  C08G77/06 ,  C08G77/28 ,  G01N33/585 ,  Y10T428/2982 ,  Y10T436/101666 ,  Y10T436/109163

摘要： The present invention presents a silica particle containing at least one silica compound selected from a group consisting of mercapto-propyl-trimethoxysilane (MPS), mercapto-propyl-triethoxysilane (MPES), mercapto-propyl-methyldimethoxysilane (MPDMS), trimethoxy[2-(7-oxabicyclo[4.1.0]-hepto-3-yl)ethyl]silane (EpoPS), thiocyanatopropyltriethoxysilane (TCPS), and acryloxypropyltrimethoxysilane (AcPS), which can be provided and utilized as a label, a marker, or the like for qualitative test and quantitative test for such as prophylactic agent, therapeutic agent, diagnostic agent, diagnostic and therapeutic agent or the like in dental, medical and veterinary fields regardless of fields.

摘要翻译： 本发明提供了含有选自巯基丙基三甲氧基硅烷（MPS），巯基丙基三乙氧基硅烷（MPES），巯基丙基甲基二甲氧基硅烷（MPDMS），三甲氧基[2- （7-氧杂双环[4.1.0] - 庚-3-基）乙基]硅烷（EpoPS），硫氰酸丙基三乙氧基硅烷（TCPS）和丙烯酰氧基丙基三甲氧基硅烷（AcPS），其可以提供和用作标记，标记等 用于牙科，医学和兽医领域的诸如预防剂，治疗剂，诊断剂，诊断和治疗剂等的定性测试和定量测试，不论其领域如何。

公开(公告)号：US20120203027A1

公开(公告)日：2012-08-09

申请号：US13499724

申请日：2010-09-22

申请人： Hisao Nemoto ,  Tomoyuki Kawamura ,  Kenji Yatsuzuka ,  Masaki Kamiya

发明人： Hisao Nemoto ,  Tomoyuki Kawamura ,  Kenji Yatsuzuka ,  Masaki Kamiya

IPC分类号： C07C227/16 ,  C07C229/30

CPC分类号： C07D207/452 ,  C07C227/16 ,  C07C233/47 ,  C07C271/08 ,  C07C271/12 ,  C07C229/30

摘要： The objective of the present invention is to provide a process for simple and efficient preparation of an intermediate compound to synthesize a gadolinium complex having a substituent for improving a retention property in blood time and specificity to an intended organ. The objective of the present invention is also to provide an intermediate compound produced by the said production process. The process for preparation of the diethylenetriaminepentaacetic acid derivative (I): wherein R1 to R5 are independently C1-6 alkyl groups; comprising the steps of: reacting a diethylenetriaminepentaacetic acid pentaester with a halogenated ally compound in an aprotic solvent; removing the excess halogenated ally compound (III); and reacting a reaction product of the diethylenetriaminepentaacetic acid pentaester and the halogenated ally compound with a base in a solvent.

摘要翻译： 本发明的目的是提供简单有效地制备中间体化合物以合成具有取代基的钆络合物的方法，以提高血液时间的保留性和对预期器官的特异性。 本发明的目的还在于提供通过所述生产方法制备的中间体化合物。 制备二亚乙基三胺五乙酸衍生物（I）的方法：其中R 1至R 5独立地为C 1-6烷基; 包括以下步骤：使二亚乙基三胺五乙酸五酯与卤化烯化合物在非质子溶剂中反应; 除去过量的卤代烯化合物（III）; 并使二亚乙基三胺五乙酸五酯与卤代烯化合物的反应产物与碱在溶剂中反应。

公开(公告)号：US07890323B2

公开(公告)日：2011-02-15

申请号：US11658685

申请日：2005-07-20

申请人： Norio Akamatsu

发明人： Norio Akamatsu

IPC分类号： G10L19/00

CPC分类号： G10L25/48 ,  G10L15/02 ,  G10L25/93

摘要： Included in the digital filtering equipment for extracting a feature quantity from a speech signal in order to execute a speech recognition based on an inputted speech signal are: a) an waveform determining section for obtaining an inputted speech signal and quantizing the speech signal waveform; b) a division value operating section for summing a quantized signal data in a prescribed adjoining region to divide the summation value by the number of summed data, with respect to a data quantized at each point by the waveform determining section, whereby a division value is obtained with the data being centered; c) a comparison section for comparing a division value calculated by the division value operating section and the quantized data calculated in the division value operating section to output logical truth of a comparison result, with respect to each data; and d) a conversion section for converting the quantized data into the selected data points based on an output from the comparison section. Thus, the feature quantity can be extracted only by applying an integer summation and comparison operation, so that performance of arithmetic operation is extremely simplified to be fast and inexpensive.

摘要翻译： 包括在用于从语音信号中提取特征量以便基于输入的语音信号执行语音识别的数字滤波设备中包括：a）波形确定部分，用于获得输入的语音信号并量化语音信号波形; b）分割值操作部分，用于对规定的邻接区域中的量化信号数据进行求和，以将求和值除以相加数据的数量，相对于由波形确定部分在每个点量化的数据，其中除法值为 以数据为中心获取; c）比较部分，用于将由分割值操作部分计算的分割值与在分割值操作部分中计算的量化数据相对于每个数据输出比较结果的逻辑真值; 以及d）转换部分，用于根据比较部分的输出将量化的数据转换成所选择的数据点。 因此，仅通过应用整数求和和比较操作才能提取特征量，使得算术运算的性能被极大地简化为快速和便宜。

公开(公告)号：US20100183202A1

公开(公告)日：2010-07-22

申请号：US12513842

申请日：2007-11-05

申请人： Yoshitake Takahashi ,  Tatsuya Takagi ,  Kousuke Okamoto ,  Masafumi Harada

发明人： Yoshitake Takahashi ,  Tatsuya Takagi ,  Kousuke Okamoto ,  Masafumi Harada

IPC分类号： G06K9/00

CPC分类号： G06K9/6251 ,  A61B5/024 ,  A61B5/055 ,  A61B5/14542 ,  A61B5/4082 ,  A61B5/4088 ,  A61B5/7267 ,  A61B6/037 ,  A61B6/501 ,  A61B6/507 ,  G06K9/6234 ,  G06K9/6269 ,  G06T7/0012 ,  G06T2207/10104 ,  G06T2207/10108 ,  G06T2207/30016

摘要： To provide a brain-image diagnosis supporting method or the like. The method is a statistical evaluation method excluding the subjective judgment of an examiner, and enables image diagnosis. The method can present stable judgment criteria with respect to data on brain images imaged by a predetermined method in order to discriminate difficult diseases to diagnose. The method is also effective with respect to relationships which can not be always explained with a simple linear relationship, for example, the relationship between data on brain images imaged by a predetermined method and a disease which is a variable. By applying a predetermined nonlinear multivariate analysis method to data on brain images of a plurality of examinees imaged by a predetermined method and by classifying the data, image diagnosis support using a computer performed with respect to the data on brain images is performed. For example, SOM method is applied as a predetermined nonlinear multivariate analysis method. Data on brain images of a plurality of examinees imaged by SPECT or the like are handled as input data vectors x, which are presented to neurons on a two-dimensional lattice array in the SOM method so as to perform image diagnosis support based on the two-dimensional SOM after a predetermined training length.

摘要翻译： 提供脑图像诊断支援方法等。 该方法是不包括审查员主观判断的统计评估方法，能够进行图像诊断。 该方法可以针对通过预定方法成像的脑图像的数据提供稳定的判断标准，以便将困难的疾病区分为诊断。 该方法对于不能总是以简单的线性关系解释的关系也是有效的，例如通过预定方法成像的脑图像上的数据与作为变量的疾病之间的关系。 通过将预定的非线性多元分析方法应用于通过预定方法成像的多个受检者的脑图像数据，并且通过对数据进行分类，执行使用关于脑图像数据执行的计算机的图像诊断支持。 例如，SOM方法被用作预定的非线性多变量分析方法。 将通过SPECT等成像的多个受检者的脑图像的数据作为输入数据向量x处理，其以SOM方式呈现给二维网格阵列上的神经元，以便基于两者进行图像诊断支持 预定训练长度后的三维SOM。

公开(公告)号：US20100062945A1

公开(公告)日：2010-03-11

申请号：US11915983

申请日：2006-05-31

申请人： Kiyoshi Inoue

发明人： Kiyoshi Inoue

IPC分类号： H01B12/10 ,  H01L39/24 ,  H01B12/04 ,  H01L39/00

CPC分类号： H01L39/2409 ,  Y10T29/49014

摘要： An Nb3Sn wire rod having a high Jc value is manufactured using an Ag—Sn alloy. A composite rod including a plurality of Nb core materials incorporated in an Ag—Sn alloy matrix material having an Sn concentration of 9.35 to 22.85 at % is prepared. Next, the composite rod is extruded and/or wire drawn while carrying out process annealing of 350 to 490° C., followed by heat treatment at 500 to 900° C. to produce an Nb3Sn filament. Thus, an Nb3Sn extrafine multi-core superconducting wire is manufactured.

摘要翻译： 使用Ag-Sn合金制造具有高Jc值的Nb 3 Sn线材。 制备复合棒，其具有并入Ag Sn合金基体材料中的Sn核心材料，其Sn浓度为9.35〜22.85at％。 接着，在进行350〜490℃的退火处理后，将该复合棒进行挤出和/或拉丝，然后在500〜900℃进行热处理，制作Nb3Sn长丝。 因此，制造Nb3Sn超细多芯超导线。

公开(公告)号：US20100062454A1

公开(公告)日：2010-03-11

申请号：US12461983

申请日：2009-08-31

申请人： Hiroshi Kido ,  Kaoru Terashima

发明人： Hiroshi Kido ,  Kaoru Terashima

IPC分类号： G01N33/53

CPC分类号： G01N33/6854 ,  G01N33/56983 ,  G01N33/582 ,  G01N2333/11 ,  G01N2800/50

摘要： An object of the present invention is to provide a method for predicting the risk of acquiring influenza, which is characterized by low price, low invasiveness, and applicability to total automation. The present invention provides a method for predicting the risk of acquiring influenza, which comprises measuring the ratio of anti-influenza IgA to the total IgA in a specimen collected from a subject.

摘要翻译： 本发明的目的是提供一种用于预测感冒风险的方法，其特征在于价格低廉，侵入性低，适用于全自动化。 本发明提供了一种预测获得流感的风险的方法，其包括测量从受试者收集的样本中抗流感IgA与总IgA的比例。

公开(公告)号：US20090068639A1

公开(公告)日：2009-03-12

申请号：US12230121

申请日：2008-08-22

申请人： Hideki Aizawa ,  Michio Ohkubo ,  Michihiro Nakamura ,  Hirokazu Miyoshi

发明人： Hideki Aizawa ,  Michio Ohkubo ,  Michihiro Nakamura ,  Hirokazu Miyoshi

IPC分类号： C12Q1/70 ,  G01N21/64 ,  G01N33/00 ,  C12Q1/68 ,  C12N5/06 ,  C12Q1/02 ,  G01N33/53

CPC分类号： G01N33/552 ,  G01N15/1459 ,  G01N21/6428 ,  G01N33/54313 ,  G01N33/582 ,  G01N2021/6421 ,  G01N2021/6441 ,  Y10T436/101666 ,  Y10T436/13 ,  Y10T436/143333

摘要： A system of quantitatively determining a biomolecule, which has: allowing fluorescent silica particles capable of emitting fluorescence detectable by a flow cytometer to capture a target biomolecule fluorescent-labelled for quantitative determination; detecting the fluorescence emitted from the fluorescent silica particles themselves by using the flow cytometer; and measuring the intensity of the fluorescence of the labelled target biomolecule, thereby quantitatively determining the target biomolecule.

摘要翻译： 一种定量测定生物分子的系统，其具有：允许荧光二氧化硅颗粒能够发射由流式细胞仪可检测的荧光，以捕获荧光标记的靶标生物分子用于定量测定; 使用流式细胞仪检测从荧光二氧化硅颗粒本身发出的荧光; 并测量标记的目标生物分子的荧光强度，从而定量测定目标生物分子。

公开(公告)号：US20080138611A1

公开(公告)日：2008-06-12

申请号：US11722054

申请日：2005-12-16

申请人： Mikito Yasuzawa ,  Takashi Koide

发明人： Mikito Yasuzawa ,  Takashi Koide

IPC分类号： B32B9/04 ,  B05D1/36

CPC分类号： C23C18/1225 ,  B05D7/51 ,  C09D183/16 ,  C23C18/122 ,  Y10T428/26 ,  Y10T428/265

摘要： A method for modifying the surface of a substrate includes the following steps: (1) a step for forming a polysilazane coating by applying a polysilazane onto the surface of a substrate; (2) a step for applying an organic compound of which main backbone comprises an organic group represented by the following formula [1]: —[(R)mO]n— (wherein R represents an alkylene group, and m and n respectively represent a positive number of not less than 1) onto the surface of the polysilazane coating; and (3) a step for heating the substrate having undergone the steps (1) and (2), thereby converting the polysilazane to silica and bonding the organic compound to the silica of the silica layer.

摘要翻译： 改性基材表面的方法包括以下步骤：（1）通过将聚硅氮烷涂覆在基材的表面上形成聚硅氮烷涂层的步骤; （2）主要骨架包含由下式[1]表示的有机基团的有机化合物的步骤： - [（R）m O] n < - （其中R表示亚烷基，m和n分别表示不小于1的正数）到聚硅氮烷涂层的表面上; 和（3）加热步骤（1）和（2）的基板的步骤，从而将聚硅氮烷转化为二氧化硅并将有机化合物粘合到二氧化硅层的二氧化硅上。

公开(公告)号：US20060216914A1

公开(公告)日：2006-09-28

申请号：US11368184

申请日：2006-03-03

申请人： Soo Lee ,  Rak Choi ,  Naoi Yoshiki ,  Sakai Shiro ,  Masayoshi Koike

发明人： Soo Lee ,  Rak Choi ,  Naoi Yoshiki ,  Sakai Shiro ,  Masayoshi Koike

IPC分类号： H01L21/20

CPC分类号： C30B29/406 ,  C30B25/02 ,  C30B25/18 ,  H01L21/0237 ,  H01L21/0242 ,  H01L21/02433 ,  H01L21/02458 ,  H01L21/0254 ,  H01L21/02609 ,  H01L21/0262

摘要： The invention provides a method of growing a non-polar a-plane gallium nitride. In the method, first, an r-plane substrate is prepared. Then, a low-temperature nitride-based nucleation layer is deposited on the substrate. Finally, the non-polar a-plane gallium nitride is grown on the nucleation layer. In growing the non-polar a-plane gallium nitride, a gallium source is supplied at a flow rate of about 190 to 390 μmol/min and the flow rate of a nitrogen source is set to produce a V/III ratio of about 770 to 2310.

摘要翻译： 本发明提供一种生长非极性a-平面氮化镓的方法。 在该方法中，首先，准备r面基板。 然后，在基板上沉积低温氮化物基成核层。 最后，在成核层上生长非极性a面平面氮化镓。 在生长非极性a面平面氮化镓的过程中，以约190〜390微摩尔/分钟的流量供给镓源，将氮源的流量设定为V / III比约为770〜 2310。