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公开(公告)号：US12173021B2
公开(公告)日：2024-12-24
申请号：US18120110
申请日：2023-03-10
Applicant: United Therapeutics Corporation
Inventor： Kenneth Robert Phares , Hitesh Batra , Liang Guo
IPC: C07F9/6574 , C07C59/72 , C07D207/16 , C07D211/60 , C07D265/30 , C07D317/40 , C07D321/12 , C07F9/09 , A61K9/00 , A61K45/06
Abstract: Provided are novel prodrugs of treprostinil, as well as methods of making and methods of using these prodrugs.
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公开(公告)号：US20240400487A1
公开(公告)日：2024-12-05
申请号：US18635756
申请日：2024-04-15
Applicant: United Therapeutics Corporation
Inventor： Hitesh BATRA , Vijay SHARMA , Sanmin YANG , Yi ZHANG
Abstract: Provided are novel treprostinil salts as well as methods for making treprostinil salts.
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公开(公告)号：US20240343673A1
公开(公告)日：2024-10-17
申请号：US18752445
申请日：2024-06-24
Applicant: United Therapeutics Corporation
Inventor： Peter LAING
IPC: C07C69/708 , A61K31/5575 , A61K31/558 , C07C67/08
CPC classification number: C07C69/708 , A61K31/5575 , A61K31/558 , C07C67/08 , C07C2603/14
Abstract: Disclosed herein are drug release polymer compounds and compositions comprising prostacyclin compounds of Formula (I), and methods of preparing the same. A preferred polymer has a repeating unit of the following structure:
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公开(公告)号：US12098116B2
公开(公告)日：2024-09-24
申请号：US18169016
申请日：2023-02-14
Applicant: United Therapeutics Corporation
Inventor： Kenneth Phares
IPC: C07C271/28
CPC classification number: C07C271/28 , C07B2200/13
Abstract: Described herein are crystalline forms of a prostacyclin (IP) receptor agonist compound, as well as pharmaceutical compositions thereof, and methods of use thereof in the treatment of diseases or conditions that would benefit from treatment with a prostacyclin (IP) receptor agonist compound.
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公开(公告)号：US12097028B2
公开(公告)日：2024-09-24
申请号：US16999213
申请日：2020-08-21
Applicant: United Therapeutics Corporation
Inventor： Jonathan Goldstein , Niles Fleischer , Nir Rotem , Lior Bar-Gat , Vladimir Piskosh
IPC: A61B5/157 , A61B5/15 , A61M5/142 , A61M5/145 , H01M50/102
CPC classification number: A61B5/157 , A61B5/15003 , A61B5/150992 , A61M5/1452 , A61M5/14526 , H01M50/102 , A61M2005/14204
Abstract: A displacement-generating battery cell for driving a drug-delivery device is described. The cell may include at least one volume-changing element. The cell may include a housing formed according to a concertina-shaped design with folds in the walls thereof and may contain an internal chemical reaction system. The chemical reaction system may include an electrode. The electrode may be the volume-changing element. The arrangement of said chemical reaction system may be such that an expansion of the volume-changing element in a direction lengthens the cell and thus reduces the extent of the folds. Drug-delivery devices including the displacement-generating battery cell are also described.
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Patent Agency Ranking
公开(公告)号：US12022823B2
公开(公告)日：2024-07-02
申请号：US16942170
申请日：2020-07-29
Applicant: United Therapeutics Corporation
Inventor： Ryan Bonvillain , John Cheadle , Thomas Petersen
CPC classification number: A01N1/0247 , A61L2/0017 , A61L27/36 , G01G19/00 , G01K13/02 , G01L7/00
Abstract: An automated bioreactor system for decellularizing an organ includes a main chamber for containing the organ. The system further includes a reagent chamber containing a liquid phase reagent. A reagent conduit delivers the liquid phase reagent to the main chamber, and a perfusion conduit delivers the reagent from the reagent outlet in the main chamber into the organ. A perfusion pump drives the flow of the reagent. A perfusion pressure sensor detects a pressure of the flowing reagent. A control system controls the perfusion pump to drive the flow of the reagent based on a received input representative of a desired pressure and a received input of the detected pressure. The control system may automatically perform all of the steps of a decellularization protocol based on sensor input. An automated waste decontamination system may also be provided.
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公开(公告)号：US12017989B2
公开(公告)日：2024-06-25
申请号：US17316094
申请日：2021-05-10
Applicant: United Therapeutics Corporation
Inventor： Peter Laing
IPC: C07C69/708 , A61K31/5575 , A61K31/558 , C07C67/08
CPC classification number: C07C69/708 , A61K31/5575 , A61K31/558 , C07C67/08 , C07C2603/14 , C07C67/08 , C07C69/708
Abstract: Disclosed herein are drug release polymer compounds and compositions comprising prostacyclin compounds of Formula (I), and methods of preparing the same. A preferred polymer has a repeating unit of the following structure:
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公开(公告)号：US20240139207A1
公开(公告)日：2024-05-02
申请号：US18497668
申请日：2023-10-30
Applicant: United Therapeutics Corporation
Inventor： Meredith Broderick , Andrew Nelsen
IPC: A61K31/5575 , A61K31/27 , A61K31/4965 , A61K31/5585 , A61K45/06 , A61P9/12
CPC classification number: A61K31/5575 , A61K31/27 , A61K31/4965 , A61K31/5585 , A61K45/06 , A61P9/12 , A61K9/0053
Abstract: The present disclosure provides for treating pulmonary hypertension by administering to a subject suffering from pulmonary hypertension a therapeutically effective amount of a non-oral therapeutic agent for treating pulmonary hypertension followed by an orally administered form of a therapeutic agent for treating pulmonary hypertension, wherein the amount of non-oral therapeutic agent is sufficient to allow for an increased amount of the orally administered therapeutic agent to thereafter be administered compared to a subject who is not previously treated with the non-oral therapeutic agent.
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公开(公告)号：US20240058287A1
公开(公告)日：2024-02-22
申请号：US18488342
申请日：2023-10-17
Applicant: United Therapeutics Corporation , MannKind Corporation
Inventor： Hitesh BATRA , Liang GUO , Patrick POISSON , Sri Harsha TUMMALA , Elizabeth Ann HARRIS
IPC: A61K31/192 , A61K47/54
CPC classification number: A61K31/192 , A61K47/545
Abstract: Provided are novel treprostinil based compounds, methods of treatment using the same, and their methods of making.
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公开(公告)号：US20240051979A1
公开(公告)日：2024-02-15
申请号：US18120110
申请日：2023-03-10
Applicant: United Therapeutics Corporation
Inventor： Kenneth Robert Phares , Hitesh Batra , Liang Guo
IPC: C07F9/6574 , C07C59/72 , C07D207/16 , C07D211/60 , C07D265/30 , C07D317/40 , C07D321/12 , C07F9/09
CPC classification number: C07F9/65744 , C07C59/72 , C07D207/16 , C07D211/60 , A61K9/0019 , C07D317/40 , C07D321/12 , C07F9/09 , C07D265/30
Abstract: Provided are novel prodrugs of treprostinil, as well as methods of making and methods of using these prodrugs.
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