-
公开(公告)号：US11967496B2
公开(公告)日：2024-04-23
申请号：US17580917
申请日：2022-01-21
发明人： Paul Corkum , Alexander V. Loboda
IPC分类号： H01J49/04 , G01N33/68 , G02B21/33 , H01J37/20 , H01J37/28 , H01J49/00 , H01J49/02 , H01J49/06 , H01J49/10 , H01J49/14 , H01J49/16 , H01J49/40
CPC分类号： H01J49/0463 , G01N33/6848 , G01N33/6851 , G02B21/33 , H01J37/20 , H01J37/28 , H01J49/0004 , H01J49/0031 , H01J49/025 , H01J49/0418 , H01J49/067 , H01J49/105 , H01J49/142 , H01J49/161 , H01J49/164 , H01J49/40
摘要： The present invention relates to the high resolution imaging of samples using imaging mass spectrometry (IMS) and to the imaging of biological samples by imaging mass cytometry (IMC™) in which labelling atoms are detected by IMS. LA-ICP-MS (a form of IMS in which the sample is ablated by a laser, the ablated material is then ionised in an inductively coupled plasma before the ions are detected by mass spectrometry) has been used for analysis of various substances, such as mineral analysis of geological samples, analysis of archaeological samples, and imaging of biological substances. However, traditional LA-ICP-MS systems and methods may not provide high resolution. Described herein are methods and systems for high resolution IMS and IMC.
-
公开(公告)号：US11555210B2
公开(公告)日：2023-01-17
申请号：US17285654
申请日：2019-10-15
申请人： University of Ottawa
发明人： Kristin Baetz , Eugene Fletcher
摘要： Embodiments provide a modified microbe capable of growing in or fermenting a solution, or lignocellulosic hydrolysate, comprising ferulic acid and/or coniferyl aldehyde. The microbe has one or more modifications to provide: (a) a decrease in copy number or expression of a BNA7 gene; (b) an increase in copy number or expression of one or more pentose phosphate pathway genes; and/or (c) localization of one or more products of the pentose phosphate pathway genes to the mitochondria or endoplasmic reticulum. Also provided is a microbe having modified expression or copy number of BNA7 and/or one or more of the pentose phosphate pathway genes. The pentose phosphate pathway genes may in certain embodiments be selected from at least one of ZWF1, TKL1, RPE1 and GND1. Also provided is a method for fermenting a substrate comprising ferulic acid and/or coniferyl aldehyde to produce a fermentation product.
-
公开(公告)号：US20220223398A1
公开(公告)日：2022-07-14
申请号：US17580917
申请日：2022-01-21
发明人： Paul Corkum , Alexander V. Loboda
IPC分类号： H01J49/04 , G01N33/68 , G02B21/33 , H01J37/20 , H01J37/28 , H01J49/00 , H01J49/02 , H01J49/06 , H01J49/10 , H01J49/40 , H01J49/16 , H01J49/14
摘要： The present invention relates to the high resolution imaging of samples using imaging mass spectrometry (IMS) and to the imaging of biological samples by imaging mass cytometry (IMC™) in which labelling atoms are detected by IMS. LA-ICP-MS (a form of IMS in which the sample is ablated by a laser, the ablated material is then ionised in an inductively coupled plasma before the ions are detected by mass spectrometry) has been used for analysis of various substances, such as mineral analysis of geological samples, analysis of archaeological samples, and imaging of biological substances. However, traditional LA-ICP-MS systems and methods may not provide high resolution. Described herein are methods and systems for high resolution IMS and IMC.
-
公开(公告)号：US20220221422A1
公开(公告)日：2022-07-14
申请号：US17610986
申请日：2020-05-14
申请人： University of Ottawa
IPC分类号： G01N27/414
摘要： Systems, devices, and methods for detecting cannabinoids in liquid or gaseous samples. In one aspect, the present invention uses a sensor element and two electrical circuit elements. When the sensor element is in contact with a sample containing cannabinoid, interactions between the sensor element and the cannabinoid changes or affects the sensor element's electrochemical properties. Using the two electrical circuit elements, this change can be detected. An analog signal relating to the changed electrochemical properties can be measured using the two electrical circuit elements. In one implementation, there is provided an organic field effect transistor (OFET) whose signal changes when in contact with a cannabinoid containing sample.
-
公开(公告)号：US11339146B2
公开(公告)日：2022-05-24
申请号：US16877291
申请日：2020-05-18
发明人： Jean-Simon Diallo , Christopher Noyce Boddy , Mark Dornan , Ramya Krishnan , Rozanne Arulanandam , Fabrice Le Boeuf , Jeffrey Smith , Andrew Macklin
IPC分类号： A61K31/501 , C07D413/06 , C07D237/14 , C07D207/38 , C07D307/60 , C07D307/66 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/12 , C07D409/06 , C07D307/30 , C07D307/58 , C07D405/06 , A61K45/06 , C12N7/00 , C07D207/36 , C07D207/456 , C07D317/64 , C07D417/06 , C07D471/04 , A61P35/02 , C07D209/48 , C07D231/08 , A61K31/341
摘要： Provided are compounds of Formula (II) that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the antigen expression from a virus, gene or trans-gene expression from a virus, or virus protein expression in cells. Other uses, compositions and methods of using same are also provided.
-
公开(公告)号：US11298402B2
公开(公告)日：2022-04-12
申请号：US15743213
申请日：2016-07-08
申请人： University of Ottawa
发明人： Mohsen Amir Alipour , Zemin Yao
IPC分类号： A61K38/17 , A61K31/202 , A61K31/7088 , A61K39/395 , A61P3/06 , A61P3/00 , C07K14/47 , C12N15/113
摘要： Methods for modulating lysosome-mediated microautophagy of a lipid or protein substrate in a cell are provided herein. In certain embodiments, said methods may comprise increasing lysosome-mediated microautophagy by treating the cell with a microautophagy-enhancing agent which increases lysosomal association-dissociation events between lysosomes and the cellular lipid or protein substrate and/or increases lysosomal degradation capacity; or decreasing lysosome-mediated microautophagy by treating the cell with a microautophagy-reducing agent which reduces lysosomal association-dissociation events between lysosomes and the cellular lipid or protein substrate and/or decreases lysosomal degradation capacity; thereby modulating lysosome-mediated microautophagy of the lipid or protein substrate.
-
公开(公告)号：US20210032739A1
公开(公告)日：2021-02-04
申请号：US16938460
申请日：2020-07-24
申请人： UNIVERSITY OF OTTAWA
摘要： A method and apparatus for laser-induced forward transfer (LIFT) processing including a dynamic release mirror structure (DRMS) for desorbing delicate materials from a first surface and depositing a resultant formation of a portion of the materials on a second surface without damaging the material or coating the material with contaminants. The DRMS includes a lower-situated absorbing polymer layer on a transparent substrate. The lower-situated absorbing polymer layer is coated with a metal layer to reflect light of a laser pulse. The metal layer is topped by an upper-situated polymer cap layer. The 3-part layering of the metal layer sandwiched between the upper and lower polymer layers is variable in terms of materials and thickness to tune DRMS operational characteristics.
-
公开(公告)号：US10901161B2
公开(公告)日：2021-01-26
申请号：US16131842
申请日：2018-09-14
申请人： Toyota Motor Engineering & Manufacturing North America, Inc. , University of Ottawa , Broadcom Inc.
发明人： Ercan M. Dede , Christopher Valdivia , Matthew Wilkins , Karin Hinzer , Philippe-Olivier Provost , Denis Masson , Simon Fafard
摘要： An optical power transfer device with an embedded active cooling chip is disclosed. The device includes a cooling chip made of a semiconductor material, and a first subassembly and a second subassembly mounted on the cooling chip. The cooling chip comprises at least one metallization layer on a portion of a first surface of the cooling chip, at least one inlet through a second surface of the cooling chip, wherein the second surface is opposite to the first surface, at least one outlet through the second surface and one or more micro-channels extending between and fluidly coupled to the at least one inlet and the at least one outlet. A cooling fluid flows through the one or more micro-channels. The first subassembly is mounted on the at least one metallization layer and comprises a laser. The second subassembly comprises a phototransducer configured to receive a laser beam from the laser.
-
公开(公告)号：US10703695B2
公开(公告)日：2020-07-07
申请号：US16329603
申请日：2017-08-30
申请人： UNIVERSITY OF OTTAWA
摘要： The present application provides a hydrodefluorodimerization process, which is useful in the synthesis of, for example, fluoroölefins that can be used as refrigerants, blowers and the like. The process is an “early-stage fluorination” process, wherein precursors containing fluorine are assembled into the desired product using a zerovalent nickel catalyst. Also provided is a liquid composition comprising one or more fluoroölefin produced by this catalytic process.
-
公开(公告)号：US10526218B2
公开(公告)日：2020-01-07
申请号：US14043710
申请日：2013-10-01
IPC分类号： G01N27/447 , G01N33/48 , B01D63/08 , C02F1/469 , B01L3/00 , B01D71/02 , G01N33/487
摘要： Aspects of the present disclosure are directed to the flow of analytes, particles or other materials. As consistent with one or more embodiments described herein, an apparatus includes a membrane having one or more pores in a membrane. First and second electrodes facilitate electrophoretic flow of analytes through the pore, and a third electrode controls movement of the particles in the pore by modulating the shape of an electric double layer adjacent sidewalls of pore. This modulation controls the strength of an electroosmotic field that opposes the electrophoretic flow of the analytes via the pore.
-
-
-
-
-
-
-
-
-
搜索结果
251 条记录 (耗时 0.029 秒)
