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公开(公告)号:US20230158209A1
公开(公告)日:2023-05-25
申请号:US18057125
申请日:2022-11-18
申请人: University of Southern California , Alfred E. Mann Institute for Biomedical Engineering at the University of Southern California
发明人: Yang Chai , Mengfei Yu
CPC分类号: A61L27/3834 , A61L27/24 , A61L27/26 , A61L27/54 , A61L27/58 , A61L27/222 , A61L27/227 , A61L27/3633 , A61L2300/412
摘要: Disclosed herein are compositions of biodegradable scaffolds combined with mesenchymal stem cells and methods of use thereof for the regeneration of cranial sutures and treatment of craniosynostosis, which can help reverse increased intracranial pressure and skull and neurocognitive abnormalities.
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公开(公告)号:US10646518B2
公开(公告)日:2020-05-12
申请号:US15500726
申请日:2015-08-07
申请人: Alfred E. Mann Institute for Biomedical Engineering at the University of Southern California , University of Southern California
发明人: Songtao Shi , Dawei Liu , Cunye Qu
IPC分类号: A61K35/28 , C12N5/0775 , A61K35/12 , A61K9/00
摘要: This disclosure relates to apoptotic bodies. The disclosure particularly relates to a composition comprising the apoptotic bodies. The disclosure further relates to preparation of apoptotic bodies from stem cells. The disclosure also relates to medical treatments comprising the use of the composition comprising the apoptotic bodies. The apoptotic bodies may comprise apoptotic stem cells. The apoptosis of a cell may be induced by a starvation method, an ultra-violet irradiation method, a thermal stress method, a staurosporine method, or a combination thereof.
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公开(公告)号:US20240324264A1
公开(公告)日:2024-09-26
申请号:US18669611
申请日:2024-05-21
发明人: Mark E. Thompson , Abegail Tadle , Muazzam Idris , Karim El Roz , Daniel Sylvinson Muthiah Ravinson , Stephen R. Forrest , Chan Ho Soh
IPC分类号: H10K50/11 , C07D233/58 , C07D401/10 , C09K11/06 , H10K50/125 , H10K85/30 , H10K85/60 , H10K101/00 , H10K101/10 , H10K101/30
CPC分类号: H10K50/11 , C07D233/58 , C07D401/10 , C09K11/06 , H10K50/125 , H10K85/322 , H10K85/654 , H10K85/6572 , C09K2211/1018 , H10K2101/10 , H10K2101/27 , H10K2101/30 , H10K2101/90
摘要: A hybrid emissive layer and OLED incorporating the same are provided. The hybrid emissive layer includes a first material having a triplet state energy level T1H and a singlet state energy level S1H, & second material having a triplet state energy level T1F and a singlet state energy level S1F; and a third material having a triplet state energy level T1P and a single state energy level S1P, where T1F≥T1H; S1F≤S1H; and T1P
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公开(公告)号:US20240323726A1
公开(公告)日:2024-09-26
申请号:US18124801
申请日:2023-03-22
发明人: Masaaki ITO , Issei KANNO , Kosuke YAMAZAKI , Andreas F. MOLISCH
IPC分类号: H04W24/10
CPC分类号: H04W24/10
摘要: A method performed by a processing apparatus of a cell-free communication system that includes a plurality of access points (APs) is provided. The method includes: transmitting, to a wireless device via a master AP among one or more APs included in a cluster associated with the wireless device, measurement information for the wireless device to determine a measurement target AP for which the wireless device measures a channel state; and receiving, as a response to the measurement information, channel state information indicating the channel state to the measurement target AP, via the master AP.
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公开(公告)号:US12098353B2
公开(公告)日:2024-09-24
申请号:US18124923
申请日:2023-03-22
发明人: Megan McCain , Joycelyn Yip , Ching-Ling Lien , Michael Harrison
CPC分类号: C12M23/16 , A01N1/0247 , B01L3/502715 , C12M23/22 , C12M23/24 , B01L2200/0684 , B01L2300/087 , B01L2300/0877 , B01L2300/12
摘要: Zebrafish are a powerful model for investigating cardiac repair due to their unique regenerative abilities, scalability, and compatibility with many genetic tools. However, characterizing the regeneration process in live adult zebrafish hearts has proved challenging because adult fish are opaque and explanted hearts in conventional culture conditions experience rapid declines in morphology and physiology. To overcome these limitations, we fabricated a fluidic device for culturing explanted adult zebrafish hearts with constant media perfusion that is also compatible with live imaging. Unlike hearts cultured in dishes for one week, the morphology and calcium activity of hearts cultured in the device for one week were largely similar to freshly explanted hearts. We also cultured injured hearts in the device and used live imaging techniques to continuously record the revascularization process over several days, demonstrating how our device enables unprecedented visual access to the multi-day process of adult zebrafish heart regeneration.
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公开(公告)号:US12094899B2
公开(公告)日:2024-09-17
申请号:US17333847
申请日:2021-05-28
发明人: Wei Wu , Tse-Hsien Ou , Yunxiang Wang , Hao Yang
IPC分类号: H01L27/146
CPC分类号: H01L27/1462 , H01L27/14685
摘要: A semiconductor-based sensor with enhanced light absorption, and in particular, enhanced infrared light absorption includes a semiconductor light sensor element and a patterned spatially inhomogeneous dielectric layer disposed over the semiconductor light sensor element. Characteristically, spatial inhomogeneity of the patterned spatially inhomogeneous dielectric layer is optimized to provide a maximized electric field in the semiconductor light sensor element such light absorption is enhanced.
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公开(公告)号:US20240298689A1
公开(公告)日:2024-09-12
申请号:US18657307
申请日:2024-05-07
发明人: Valter D. LONGO , Chia-Wei CHENG
IPC分类号: A23L33/00
CPC分类号: A23L33/30 , A23L33/40 , A23V2002/00
摘要: A method of alleviating symptoms of, or treating, pancreatic beta-cell damage in a subject includes a step of identifying a subject having pancreatic beta-cell damage. Multiple cycles of a diet protocol are administered to the subject. The diet protocol includes administering of a fasting mimicking diet and a re-feeding diet where the fasting mimicking diet is provided for a first time period and the re-feeding diet is provided for a second time period.
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公开(公告)号:US20240293668A1
公开(公告)日:2024-09-05
申请号:US18573421
申请日:2022-06-23
发明人: Yaniv Bar-Cohen , Gerald E. Loeb , Raymond A. Peck , Samuel Kohan , Tristan Lerner , Allison Hill , Jay D. Pruetz , Mark H. Shwayder , Michael J. Silka
IPC分类号: A61N1/05
CPC分类号: A61N1/0592 , A61N1/0568 , A61N1/059
摘要: Pacemakers and pacemaker delivery systems and methods are disclosed which use a modified cylindrical pacemaker body having a flat side which includes the anode/cathode and spikes to anchor the pacemaker in place within the pericardium.
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公开(公告)号:US20240293507A1
公开(公告)日:2024-09-05
申请号:US18669253
申请日:2024-05-20
IPC分类号: A61K38/17 , A61K39/395 , A61P35/00 , C07K7/64 , C07K14/47
CPC分类号: A61K38/1729 , A61K39/3955 , A61P35/00 , C07K7/64 , C07K14/4723
摘要: Compositions and methods for enhancing immune checkpoint inhibitor therapy of cancer by cotherapy with cyclic peptides are provided. Such cyclic peptides can be naturally occurring or of synthetic origin.
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公开(公告)号:US12081657B2
公开(公告)日:2024-09-03
申请号:US17638705
申请日:2020-08-26
发明人: Xiaowu Gai , Alex Ryutov , Tatyana Ryutov
CPC分类号: H04L9/0869 , H04L9/0618 , H04L2209/608
摘要: Examples are described for dynamically applying a digital watermark to a file, such as a dataset of genomic sequencing data. In one example, a method of dynamically applying a watermark to at least a portion of a file includes generating, using a secret key, a first random seed, generating, using the first random seed, an ordered pseudorandom set of integers, generating, using entity information and timing information, a second random seed, selecting, using the second random seed, a subset of the ordered pseudorandom set of integers, and modifying data at data locations in the file corresponding to at least a portion of the identifiers included in the subset to generate a watermarked file. The method may further include performing a check to determine whether the watermark is present in a file using a sequence of watermark elements that are generated based on the secret key.
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