公开(公告)号：US11632972B2

公开(公告)日：2023-04-25

申请号：US16635032

申请日：2018-07-31

申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.

发明人： Oren Tirosh ,  Joseph Kanner ,  Adi Spaizer-Katzenelson

IPC分类号： A23L3/3535 ,  A23L13/40 ,  A23B4/023 ,  A23B4/12 ,  A23B4/20 ,  A23L3/3418

摘要： The invention relates to a process for treating food, in particular for curing meat, comprising adding to the food a compound of Formula III, which is a derivative of S-nitroso-cysteine. Use of the compound of Formula III as food preservative and compositions for curing meat are also provided by the invention.

公开(公告)号：US11612607B2

公开(公告)日：2023-03-28

申请号：US16329501

申请日：2017-08-30

申请人： TARO PHARMACEUTICAL INDUSTRIES LTD. ,  Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

发明人： Wahid Khan ,  Helena Shifrin ,  Ron Schlinger ,  Avi Avramoff ,  Abraham Jacob Domb

IPC分类号： A61K31/55 ,  A61P17/06 ,  A61K9/00 ,  A61K9/06 ,  A61K9/12 ,  A61K9/70 ,  A61K45/06 ,  A61K47/06 ,  A61K47/10 ,  A61K47/12 ,  A61K47/32

摘要： Embodiments of stable topical compositions for administering fenoldopam (compound (I) or a pharmaceutically acceptable salt or solvate thereof are disclosed for immediate or continued slow release administration, over prolonged periods of time with safe minimal systemic exposure of fenoldopam (reducing the risk for lowering blood pressure). The compositions include those compositions that increase the stability and skin absorption of the drug, particularly anhydrous semi-solid compositions and creams. This is accomplished by incorporating fenoldopam in soluble or dispersed form into semi-solid compositions like ointments or anhydrous gels that are not irritative. Embodiments of methods for using the topical compositions in the treatment of dermatological disorders including psoriasis, alopecia atopic dermatitis and vitiligo are disclosed.

公开(公告)号：US20220347096A1

公开(公告)日：2022-11-03

申请号：US17765625

申请日：2020-10-01

申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD

发明人： Yechezkel BARENHOLZ ,  Ahuva CERN

IPC分类号： A61K9/127 ,  A61K47/40 ,  A61K31/352 ,  A61K47/42

摘要： The present disclosure provides prolonged release formulation of cannabinoids. The formulation comprises liposomes having a lipid membrane and an intraliposomal aqueous core, wherein said liposome comprises either an entrapped cannabinoid and at least one dispersing agent of said cannabinoid, said dispersing agent being other than a cyclodextrin (CD) compound; or an entrapped cannabinoid, at least a portion of said cannabinoid being entrapped in said lipid membrane, and wherein said lipid membrane comprises a mole ratio between said cannabinoid and said one or more liposome forming lipids in the range of 1 to 10. Also disclosed are methods of preparing and uses of the formulations for prolonged delivery of the cannabinoids and therapeutic treatments making use of same.

公开(公告)号：US11466323B2

公开(公告)日：2022-10-11

申请号：US16630593

申请日：2018-07-13

申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. ,  HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.

发明人： Yuval Dor ,  Ruth Shemer ,  Benjamin Glaser ,  Judith Magenheim

IPC分类号： C12Q1/6876 ,  C12Q1/6827 ,  C12Q1/686 ,  C12Q1/6869

摘要： A digital droplet PCR method of analyzing the methylation status of methylation sites of a double-stranded DNA molecule which comprises at least two methylation sites per single strand of the double-stranded DNA molecule is disclosed.

公开(公告)号：US11437501B2

公开(公告)日：2022-09-06

申请号：US17045892

申请日：2019-04-07

申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.

发明人： Yossef Paltiel ,  Ron Naaman ,  Karen Michaeli ,  Eilam Smolinsky

IPC分类号： G11C16/04 ,  H01L29/66 ,  G01N27/414 ,  G11C11/02 ,  H01L29/205 ,  H01L29/778 ,  H01L43/06 ,  H01L29/20

摘要： In a technique for inducing local electric field controlled magnetization, despite the absence of magnetic components, there is provided a novel heterostructure, a semiconductor device thereof, or an array of semiconductor devices. The heterostructure includes a semiconductor substrate carrying a plurality of layers forming at least one heterojunction and hosting a two-dimensional electron gas layer when one of the layer of the plurality of layers is bounded to an interacting layer being a chiral or a biological macromolecule assembly.

公开(公告)号：US20220251126A1

公开(公告)日：2022-08-11

申请号：US17597878

申请日：2020-08-05

申请人： Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

发明人： Dan GIBSON ,  Amrita SARKAR

IPC分类号： C07F15/00 ,  A61K47/55 ,  A61K47/54

摘要： The claimed subject matter provides for a method for conjugating an active material to a Pt complex.

公开(公告)号：US11357884B2

公开(公告)日：2022-06-14

申请号：US15111567

申请日：2015-01-14

申请人： NANYANG TECHNOLOGICAL UNIVERSITY ,  YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD

发明人： Terry W. J. Steele ,  Daniel Mandler

IPC分类号： A61B17/00 ,  A61L24/00 ,  A61L24/08 ,  H01B1/12 ,  A61L24/04

摘要： The present invention relates to electrochemically initiated bioadhesive compositions comprising biocompatible polymers containing derivatives of diazonium, arylsulfonium, or diaryliodonium in general, and to their use in tissue fixation, in particular.

公开(公告)号：US20220119474A1

公开(公告)日：2022-04-21

申请号：US17431867

申请日：2020-02-19

申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. ,  HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.

发明人： Rachel BAR-SHAVIT ,  Chaim GILON ,  Amnon HOFFMAN

IPC分类号： C07K14/705 ,  A61P35/00

摘要： The present invention provides peptides derived from the cytoplasmic region of protease-activated receptors 4 (PAR4) as well as analogs and cyclic analogs, such as backbone cyclic analogs, of these peptides. Pharmaceutical compositions comprising said peptides, analog, cyclic analogs and well as conjugates thereof are provides as well. The peptides, analogs and conjugates of the present invention and pharmaceutical composition comprising thereof have several uses including treating cancer and inhibiting interactions between PARs and protein comprising PH-domain.

公开(公告)号：US11304989B2

公开(公告)日：2022-04-19

申请号：US16753083

申请日：2018-10-02

申请人： Yissum Research Development Company of the Hebrew University of Jerusalem Ltd

发明人： Raymond Kaempfer ,  Gila Arad

IPC分类号： A61K38/08 ,  A61K31/215 ,  A61K31/351 ,  A61K45/06 ,  A61P31/16

摘要： Disclosed are peptides, compositions, combinations, kits and methods for the treatment of viral pathogen infection. Combinations and kits comprise the disclosed peptides together with an additional antiviral therapeutic agent.

公开(公告)号：US11297868B2

公开(公告)日：2022-04-12

申请号：US16304697

申请日：2017-05-29

申请人： The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center) ,  Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

发明人： Moshe Shemesh ,  Ram Reifen

IPC分类号： A23L33/135 ,  A61K35/742 ,  A61K35/747 ,  C12N1/20 ,  C12P39/00 ,  C12R1/25 ,  C12R1/125

摘要： A method of preparing a bacterial composition is disclosed. The method comprises: (a) in vitro co-culturing beneficial bacteria with biofilm-producing bacteria in a growth substrate under conditions that generate a biofilm which comprises the beneficial bacteria and the non-pathogenic bacteria; and (b) isolating the biofilm from the growth substrate.