公开(公告)号：US08623600B2

公开(公告)日：2014-01-07

申请号：US13025897

申请日：2011-02-11

Applicant: Paul L. Modrich ,  Ravi R. Iyer ,  Anna Pluciennik ,  Miaw-Sheue Tsai

Inventor： Paul L. Modrich ,  Ravi R. Iyer ,  Anna Pluciennik ,  Miaw-Sheue Tsai

IPC: C12Q1/68 ,  C07H21/04

CPC classification number: G01N33/57419 ,  G01N2500/02

Abstract: Disclosed are methods and kits for screening potential inhibitors of MutSβ by screening agents for the ability to selectively inhibit interaction between MutSβ and MutLα. Also disclosed are kits for performing the methods of the invention.

Abstract translation: 公开了通过筛选剂筛选MutSbeta的潜在抑制剂以选择性抑制MutSbeta和MutLalpha之间的相互作用的方法和试剂盒。 还公开了用于实施本发明的方法的试剂盒。

公开(公告)号：US08618133B2

公开(公告)日：2013-12-31

申请号：US12997511

申请日：2009-06-08

Applicant: Jianqi Li ,  Kai Gao ,  Wangping Cai ,  Yongyong Zheng

Inventor： Jianqi Li ,  Kai Gao ,  Wangping Cai ,  Yongyong Zheng

IPC: A61K31/445 ,  C07D211/18

CPC classification number: C07D211/18 ,  C07D211/44 ,  C07D211/58 ,  C07D211/70 ,  C07D211/72 ,  C07D401/06 ,  C07D409/06

Abstract: The present invention relates to an aralkyl alcohol piperidine derivative and use as antidepressant thereof. The said aralkyl alcohol piperidine derivative has a triple inhibition effect on the reuptaking of 5-HT, NA and DA. The derivative may be administered to the patient in need of such treatment in the form of composition by oral administration, injection and the like. The derivative is a compound having the following general formula or its salt:

Abstract translation: 本发明涉及芳烷基醇哌啶衍生物，用作其抗抑郁药。 所述芳烷基醇哌啶衍生物对5-HT，NA和DA的再次起始具有三重抑制作用。 衍生物可以通过口服给药，注射等方式以组合物的形式施用于需要这种治疗的患者。 该衍生物是具有以下通式的化合物或其盐：

公开(公告)号：USD694983S1

公开(公告)日：2013-12-03

申请号：US29430593

申请日：2012-08-28

Applicant: Joel Lederhause ,  Robert Krolski

Designer： Joel Lederhause ,  Robert Krolski

公开(公告)号：USD694913S1

公开(公告)日：2013-12-03

申请号：US29419205

申请日：2012-04-26

Applicant: Andrew J. Kopish ,  Robert M. Wittl ,  Scott A. Bosman ,  Joseph D. Vanderlinden ,  Nathan A. Quintal ,  James M. Durand

Designer： Andrew J. Kopish ,  Robert M. Wittl ,  Scott A. Bosman ,  Joseph D. Vanderlinden ,  Nathan A. Quintal ,  James M. Durand

公开(公告)号：US08596593B2

公开(公告)日：2013-12-03

申请号：US12272438

申请日：2008-11-17

Applicant: Mark Saffell ,  David Ritch

Inventor： Mark Saffell ,  David Ritch

IPC: F16M11/16 ,  F16M11/20 ,  A47B91/00 ,  A47B3/06 ,  A47B13/00 ,  A47G23/02 ,  F16L41/00

CPC classification number: F16B12/42 ,  A47B13/003 ,  A47B2013/022

Abstract: A worksurface leg mount is provided for interconnecting a support leg to a worksurface. The worksurface leg mount system includes an anchor plate attached to a lower surface of the worksurface, and a mounting plate attached to and optionally recessed in an upper end of the support leg. A fastener extends between and connects the anchor and mounting plates, which are spaced from each other. Loads that enter the mounting plate in discrete directions are transmitted through the fastener and into the anchor plate, where the loads are spread across the interfaces between the anchor plate and worksurface.

Abstract translation: 提供了一个工作表面支脚，用于将支撑腿与工作表面相互连接。 工作台腿安装系统包括附接到工作台面的下表面的锚板和附接到支撑腿的上端并任选地凹入支撑腿的上端的安装板。 紧固件在彼此间隔开的锚固件和安装板之间延伸并连接。 以离散方向进入安装板的载荷通过紧固件传递到锚板中，其中负载分布在锚板和工作台面之间的界面上。

公开(公告)号：USD694054S1

公开(公告)日：2013-11-26

申请号：US29453768

申请日：2013-05-02

Applicant: Krueger International, Inc.

Designer： John K. Blomstrom ,  Patrick W. Fricke ,  Jonathan M. Ries ,  Marc A. Gulko ,  Daniel J. Noll

公开(公告)号：US08591983B2

公开(公告)日：2013-11-26

申请号：US11614218

申请日：2006-12-21

Applicant: Stuart E. Lebo, Jr. ,  Thomas S. Winowiski

Inventor： Stuart E. Lebo, Jr. ,  Thomas S. Winowiski

IPC: A23K1/14 ,  A23K1/18 ,  A23K1/22

CPC classification number: A23K30/00 ,  A23K10/20 ,  A23K10/24 ,  A23K10/30 ,  A23K10/38 ,  A23K20/10 ,  A23K20/147 ,  A23K20/163 ,  A23K40/00 ,  A23K50/10 ,  A23K50/15 ,  A23V2002/00 ,  Y02P60/873 ,  A23V2250/542 ,  A23V2250/548 ,  A23V2250/5118

Abstract: To increase the efficiency of utilizing protein, lipid and starch by ruminants, feed and urea-formaldehyde polymer are mixed in quantities suitable for a crosslinking reaction. The mixture is heated at a temperature, moisture content and time sufficient to covalently bond the urea-formaldehyde polymer with the proteins and starches to thereby protect the proteins, starches and contained lipids from degradation by rumen microbes.

Abstract translation: 为了提高利用反刍动物利用蛋白质，脂质和淀粉的效率，将饲料和脲甲醛聚合物以适于交联反应的量混合。 将混合物在足够的温度，水分含量和时间加热，以将尿素 - 甲醛聚合物与蛋白质和淀粉共价键合，从而保护蛋白质，淀粉和含有脂质免于瘤胃微生物的降解。

公开(公告)号：US08580023B2

公开(公告)日：2013-11-12

申请号：US13100478

申请日：2011-05-04

Applicant: Mark P. Adams ,  Axel J. Dahlberg ,  Matthew L. Schneider

Inventor： Mark P. Adams ,  Axel J. Dahlberg ,  Matthew L. Schneider

IPC: B01D49/00

CPC classification number: B01D46/009 ,  F02M35/0201 ,  F02M35/0203 ,  F02M35/0205

Abstract: A run-safe filter system is provided for confirming installation of a qualified filter element in a housing. An electrical switch has a first electrical condition in response to a qualified filter element being installed in the housing, and a second electrical condition in response to the absence of a qualified filter element installed in the housing.

Abstract translation: 提供了一种运行安全的过滤系统，用于确认合格的过滤元件在外壳中的安装。 电开关响应于合格的过滤元件安装在壳体中而具有第一电气状态，响应于不存在安装在壳体中的合格的过滤器元件而具有第二电气状态。

公开(公告)号：US08579582B1

公开(公告)日：2013-11-12

申请号：US11385460

申请日：2006-03-21

Applicant: Kenneth C. Gehring

Inventor： Kenneth C. Gehring

IPC: F04D29/42

CPC classification number: F04D29/526 ,  F04D25/08 ,  F04D29/541 ,  F04D29/547 ,  F04D29/60

Abstract: A drying fan has a shroud with a shape selected to improve fan efficiency by designated fluid dynamics of air flow through the fan.

Abstract translation: 干燥风扇具有选择的形状的护罩，以通过通过风扇的空气流的指定流体动力学来改善风扇效率。

公开(公告)号：US08575136B2

公开(公告)日：2013-11-05

申请号：US11697414

申请日：2007-04-06

Applicant: Hector F. DeLuca ,  Lori A. Plum ,  Margaret Clagett-Dame ,  Rafal Barycki

Inventor： Hector F. DeLuca ,  Lori A. Plum ,  Margaret Clagett-Dame ,  Rafal Barycki

IPC: A61K31/59 ,  C07C401/00

CPC classification number: C07C401/00 ,  Y02P20/55

Abstract: Compounds of formula I are provided where X1 and X2 are independently selected from H or hydroxy protecting groups. Such compounds are used in preparing pharmaceutical compositions and are useful in treating a variety of biological conditions.

Abstract translation: 提供式I化合物，其中X 1和X 2独立地选自H或羟基保护基。 这些化合物用于制备药物组合物，并且可用于治疗各种生物学条件。