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公开(公告)号：US12103929B2
公开(公告)日：2024-10-01
申请号：US17129983
申请日：2020-12-22
发明人： Haiquan Fang , Mingming Chen , Guiqun Yang , Yuelei Du , Yanping Wang , Tong Wu , Qinglong Li , Lei Zhang , Shaojing Hu
IPC分类号： C07D471/14 , A61P35/00
CPC分类号： C07D471/14 , A61P35/00 , C07B2200/05
摘要： Disclosed are tricyclic compounds as bromodomain and extra-terminal (BET) inhibitors which are shown as formula I, their synthesis and their use for treating diseases. More particularly, disclosed are fused heterocyclic derivatives useful as inhibitors of BET, methods for producing such compounds and methods for treating diseases and conditions wherein inhibition of one or more BET bromodomains provides a benefit.
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公开(公告)号：US12085575B2
公开(公告)日：2024-09-10
申请号：US17215980
申请日：2021-03-29
发明人： Shyamal D. Desai
IPC分类号： C12N15/11 , A61K31/52 , A61K31/713 , G01N33/68 , H04L67/1001 , A61P25/00
CPC分类号： G01N33/6896 , A61K31/52 , A61K31/713 , H04L67/1001 , A61P25/00 , G01N2333/56 , G01N2500/00 , G01N2800/2835 , G01N2800/52 , G01N2800/7047
摘要： This invention is directed to compositions and methods for detecting proteinopathies.
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公开(公告)号：US12070463B2
公开(公告)日：2024-08-27
申请号：US16739350
申请日：2020-01-10
申请人： Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College , UNIVERSIDAD DE ALCALÁ
IPC分类号： A61K31/5377 , A61K45/06 , A61P25/00 , A61P25/08 , A61P35/00 , C07D211/90
CPC分类号： A61K31/5377 , A61K45/06 , A61P25/00 , A61P25/08 , A61P35/00 , C07D211/90 , A61K31/5377 , A61K2300/00
摘要： Provided are compositions that include a platelet-activating factor antagonist, pharmaceutical compositions including the platelet-activating factor antagonist, methods of treating a modulating the proliferation of a glioma or a pathological condition resulting from patient having a glioma.
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公开(公告)号：US12060367B2
公开(公告)日：2024-08-13
申请号：US18314445
申请日：2023-05-09
发明人： Joachim Broeker , Jason Abbott , Jianwen Cui , Stephen W. Fesik , Julian Fuchs , Andreas Gollner , Lorenz Herdeis , Tim Hodges , Andrew Little , Andreas Mantoulidis , Jason Phan , Juergen Ramharter , Dhruba Sarkar , Christian Alan Paul Smethurst , Kevin Sokol , Heinz Stadtmueller , Qi Sun , Matthias Treu , Alex Waterson , Birgit Wilding , Tobias Wunberg
IPC分类号： C07D498/10 , A61P1/00 , A61P1/18 , A61P11/00 , A61P17/00 , A61P35/00 , C07D519/00
CPC分类号： C07D498/10 , A61P1/00 , A61P1/18 , A61P11/00 , A61P17/00 , A61P35/00 , C07D519/00
摘要： The present invention encompasses compounds of formula (I)
wherein R1a, R1b, R2a, R2b, Z, R3 to R5, A, p, U, V and W have the meanings given in the claims and specification, their use as inhibitors of KRAS, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.-
公开(公告)号：US11987630B2
公开(公告)日：2024-05-21
申请号：US17104287
申请日：2020-11-25
IPC分类号： G01N33/68 , A61K39/395 , A61K45/06 , C07K16/28 , C07K16/30 , G01N33/574 , A61K39/00
CPC分类号： C07K16/2827 , A61K39/39558 , A61K45/06 , C07K16/3015 , C07K16/3023 , C07K16/3038 , G01N33/57423 , G01N33/6854 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , G01N2800/7028
摘要： The present invention relates to antibodies and fragments that bind to a V-domain Ig Suppressor of T cell Activation (VISTA), and methods of eliciting certain biological responses using the antibodies. Methods of identifying anti-VISTA antibodies capable of eliciting certain biological responses are also included.
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公开(公告)号：US11981666B2
公开(公告)日：2024-05-14
申请号：US18367517
申请日：2023-09-13
发明人： Wenqiang Zhai , Zhimin Zhang , Zhe Wang , Hao Pan , Liubin Guo , Qian Wang
IPC分类号： C07D405/14
CPC分类号： C07D405/14
摘要： Provided are a GLP-1 receptor agonist compound and a composition and use thereof. The compound can be used for treating or preventing GLP-1 receptor-mediated diseases or disorders and related diseases or disorders.
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公开(公告)号：US11906523B2
公开(公告)日：2024-02-20
申请号：US16856589
申请日：2020-04-23
发明人： Nelson Alexander , William Day , Jerome W. Kosmeder, II , Mark Lefever , Larry Morrison , Anne M. Pedata , Stacey Stanislaw
CPC分类号： G01N33/581 , C12Q1/68 , C12Q1/682 , G01N33/53 , G01N33/542 , C07H21/02 , C07K14/00
摘要： Disclosed herein are embodiments of a signaling conjugate, embodiments of a method of using the signaling conjugates, and embodiments of a kit comprising the signaling conjugate. The disclosed signaling conjugate comprises a latent reactive moiety and a chromogenic moiety that may further comprise a linker suitable for coupling the latent reactive moiety to the chromogenic moiety. The signaling conjugate may be used to detect one or more targets in a biological sample and are capable of being covalently deposited directly on or proximally to the target. Particular disclosed embodiments of the method of using the signaling conjugate comprise multiplexing methods.
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公开(公告)号：US11891499B2
公开(公告)日：2024-02-06
申请号：US17261192
申请日：2019-07-19
申请人： KEMIRA OYJ
摘要： The present invention relates to a granular microfibrillated cellulose product comprising a microfibrillated cellulose originating from agricultural biomass, said microfibrillated cellulose product comprising ≤75 wt % of cellulose, preferably ≤70 wt %, based on dry solids content of said product, wherein said granular microfibrillated cellulose product has a bulk density of 500-1200 kg/m3; a flowability of 5-60 ml/s, measured by a Copley scientific powder flowability tester having a stainless steel cylinder with orifice 16 or funnel with orifice 15; and a water content of at most 60 wt %, based on total microfibrillated cellulose product. The present invention further relates to its manufacture and use in and manufacture of paper and paperboard products.
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9.发明授权公开(公告)号：US11857571B2
公开(公告)日：2024-01-02
申请号：US16994795
申请日：2020-08-17
发明人： Charles Sentman , Michael Battles
CPC分类号： A61K35/17 , A61K47/6835 , A61K51/1045 , A61K51/1096 , A61P35/00 , C07K16/2809 , C07K16/2833 , C07K16/2851 , A61K2039/505 , C07K2317/31 , C07K2317/622 , C07K2319/03
摘要： Antigen binding fragments, chimeric antigen receptors, and bi-specific T-cell engagers having specificity for MICA and methods for using the same in the diagnosis and treatment of disorders associated with MICA and/or MICB expression are provided.
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公开(公告)号：US11770681B2
公开(公告)日：2023-09-26
申请号：US17350142
申请日：2021-06-17
摘要： A communications hub providing a repository of vehicle crash information communicated by a mobile communications device and of vehicle crash data records provided by crash event servicers, in a crash detection, response and reporting system that determines a possible crash event by periodically evaluating (a) changes in a motion signal and (b) crash sound indicators of one or more of (i) motor vehicle glass breakage, (ii) metal folding, (iii) contact thud, and (iv) tires screeching, and upon a failure to respond within a predetermined period to a notice of possible crash event, communicating an identifier and crash incident information to a dispatch center as first notice of loss for dispatching a response servicer and maintaining the repository to facilitate resolution of the claims arising from the vehicle crash event.
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